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6140114 |
Defective viral vaccine particles obtained in vivo or ex vivo
The present invention relates to a vaccine consisting of defective viral particles as are obtained in vivo or ex vivo, in individuals infected or capable of being infected with a virus, after...
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6140087 |
Adenovirus vectors for gene therapy
The invention comprises a series of adenovirus-based vectors having deletions in the E1 and/or E3 regions, and also insertions of pBR322 sequences, which can be used to deliver nucleic acid inserts...
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6140103 |
Regulated protein expression in stably transfected mammalian cells
The invention is in the field of recombinant genetic materials, especially for use in gene therapy. Vectors used for transferring additional genetic information to cells in the field of gene...
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6136528 |
Multiple sclerosis virus
The present invention provides a polynucleotide in substantially isolated form comprising a sequence of nucleotides which is capable of selectively hybridizing to the genome of the human multiple...
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6136322 |
Hepatitis A virus deletion mutants and vaccine formulations containing the same
Disclosed are live hepatitis A virus deletion mutants having a deletion mutation in the 5' nontranslated region of the viral genome. The deletion mutation may be selected from the group consisting...
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6136527 |
Polypeptides derived from proteins of the hepatitis C virus, test kits containing these polypeptides and vaccines against infections of hepatitis C viruses
The cloning and sequencing of different polypeptides from the genome of a hepatitis C virus is disclosed. The polypeptides are prepared as non-fusion proteins in good yield. The polypeptide...
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6132731 |
Murine leukemia virus vectors
A proteinaceous particle comprises a capsid enveloped by ecotropic Murine Leukemia virus envelope proteins characterized in that a heterologous peptide which binds to a non-murine cell is inserted...
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6133025 |
Compact Epstein-Barr virus replicons
Disclosed herein are nucleic acid sequences which support episomal replication in a mammalian cell. These nucleic acid sequences, which have a length of less than 3 kb, include (a) an OriP sequence...
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6129922 |
Methods for adjuvant free hepatitis A virus vaccination
The invention provides the use of Hepatitis A virus capsid, or a mucosally immunogenic fragment or epitope thereof, for the manufacture of a mucosal vaccine composition for administration to a...
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6130066 |
Vectors having enhanced expression and methods of making and uses thereof
Disclosed and claimed are vectors having enhanced expression and methods for making and using them. Enhancement of expression is from substantially co-temporal expression of at least one first...
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6127112 |
Avian herpesvirus-A antigen precursor gene
A gene encoding for A antigen precursor, derived from a Avian herpesvirus, is described. The gene is preferably isolated from a Marek's disease herpesvirus virus (MDHV) and is approximately 1.8-1.9...
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6127164 |
Human papilloma virus type 57, diagnosis of HPV 57 infections and method therefor
The invention describes the isolation for the first time of human papilloma virus (HPV) 57, the partial characterization of its genome and its cloning in pUC 19. This opens up a way of diagnosing...
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6127175 |
Cells for the production of recombinant adenoviruses
The invention relates to cells usable for the production of defective adenoviruses comprising, inserted into their genome, a portion of the region E4 of an adenovirus genome carrying the reading...
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6127601 |
Plants resistant to C strains of cucumber mosaic virus
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6123948 |
Polypeptides useful as immunotherapeutic agents and methods of polypeptide preparation
Fusion polypeptides and aggregates of polypeptides comprising papillomavirus-derived antigens, and compositions thereof and their use e.g. with adjuvants for immunogenic and vaccine purposes in...
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6120773 |
Recombinant herpes simplex viruses vaccines and methods
A recombinant herpes simplex virus genome having modified γ 1 34.5 genes incapable of expressing an active ICP34.5 gene product, vaccines comprising the recombinant herpes simplex virus genome...
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6120989 |
Isolated human cytomegalovirus polypeptides and uses thereof
Diagnostically relevant polypeptides and fusion proteins comprising an amino acid sequence which originates from cytomegalovirus and corresponds to a region of the major DNA-binding protein or of...
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6121043 |
Recombinant herpesvirus of turkeys comprising a foreign DNA inserted into a non-essential region of the herpesvirus of turkeys genome
The present invention provides a hybrid, nonprimate herpesvirus comprising DNA which includes a sequence essential for viral replication of the hybrid, nonprimate herpesvirus, at least a portion of...
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6117640 |
Recombinant vaccine made in E. coli against dengue virus
A recombinant protein encompassing a C-terminal protion from the structural envelope glycoprotein and an N-terminal portion from non-structural protein one of dengue type 2 virus was expressed in...
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6118048 |
Trans-dominant inhibition of geminiviral DNA replication by geminivirus rep gene mutants
A genetic construct comprising a trans-dominant inhibitor of geminiviral replication is disclosed. When expressed in a plant cell, this inhibitor is able to dramatically reduce replication of...
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6113950 |
Process for coating biological pesticides and compositions therefrom
A pesticidal composition comprising particles of biological pesticides and particles of durable TiO 2 in an amount sufficient to substantially coat the particles of biological pesticides and...
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6107022 |
Hop mosaic virus gene and method for detecting hop mosaic virus
The hop mosaic virus (HMV) gene has been isolated and purified, and the base sequence thereof elucidated. HMV can be detected by simple and accurate methods using nucleic sequences from the...
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6107021 |
Synthetic peptide vaccines for foot-and-mouth disease
The present invention relates to the use of a peptide composition as an immunogen, with each peptide contained therein comprising a target antigenic site derived from the VP1 capsid protein of...
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6107062 |
Antisense viruses and antisense-ribozyme viruses
Antisense viruses and antisense ribozyme viruses are disclosed. The novel artificial viruses, their synthesis and their use in preventing and treating viral infections are presented.
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6103519 |
Antigens and methods therefor
A composite particle comprising at least two polypeptides corresponding to all or part of a protein having the biological activity of one of the hepatitis B surface antigens, wherein the particle...
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6103878 |
Antibody to carboxy-terminus of human herpesvirus 6 immediate early protein
An antibody raised against an epitope of a peptide having an amino acid sequence selected from a group consisting of Leu Asp Gly Tyr Pro Ser Asp Tyr Asp Pro Phe Val Glu Asn Ala Gln Ile Tyr (SEQ ID...
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6100064 |
Secreted viral proteins useful for vaccines and diagnostics
The present invention relates generally to modified secreted viral proteins, to the genes which express these proteins and to antibodies produced against such proteins, and to the use of these...
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6100088 |
Viral vaccines
A vaccine effective against Marek's disease virus (MDV) comprises (a) an MDV attenuated by virtue of being TK- or (b) a host expressing an MDV antigen, namely the respective MDV homologues of the...
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6099847 |
Chimeric Gag pseudovirions
The present invention provides, inter alia, recombinant chimeric nucleic acids encoding a Gag-fs-fusion partner fusion protein; a pseudovirion comprising a retroviral Gag protein and a fusion...
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6093553 |
Immortalized brain endothelial cells
A brain microvessel endothelial cell having a Middle-T antigen gene from papovirus is disclosed. The brain microvessel endothelial cell exhibits normal cell phenotype, maintains the phenotype in...
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6090590 |
Reducing nontemplated 3' nucleotide addition to polynucleotide transcripts
Non-template 3' nucleotide addition to a transcript is reduced by transcribing a transcript from a template comprising an ultimate and/or penultimate 5' ribose having a C'2 substituent such as...
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6090584 |
Baculovirus artificial chromosomes and methods of use
An baculovirus artificial chromosome is disclosed which has the lef-8 gene inactivated. The baculovirus artificial chromosome allows the cloning and expression of heterologous genes in insect and...
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6087162 |
Transgenic plants resistant to geminivirus infection
A method for producing genetically transgenic plants exhibiting resistance to a geminivirus such as tomato yellow leaf curl virus. In another aspect, the invention embraces chimeric plant genes,...
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6087115 |
Methods of identifying negative antagonists for G protein coupled receptors
The present invention is directed to a constitutively active G protein coupled receptor of human herpesvirus 8, as well as a method of identifying negative antagonists of a constitutively active G...
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6087127 |
Marek's disease herpesvirus DNA segment encoding glycoproteins, gD, gI and gE
DNA encoding glycoproteins gD, gI and gE from Marek's disease herpesvirus is described. The DNA is useful for probes to detect the DNA in the herpesvirus, for expression to produce the...
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6083716 |
Chimpanzee adenovirus vectors
A recombinant vector comprises chimpanzee adenovirus sequences and a heterologous gene under the control of regulatory sequences. A cell line which expresses chimpanzee adenovirus gene(s) is also...
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6080408 |
Human immunodeficiency virus type 1 nucleic acids devoid of long terminal repeats capable of encoding for non-infectious, immunogenic, retrovirus-like particles
Non-infectious, retrovirus-like particles contain mutations to reduce gag-dependent RNA-packaging of the gag gene product, eliminate reverse transcriptase activity of the pol gene product,...
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6080578 |
Cytopathic adenoviral E1B mutated viruses for therapy and prophylaxis of neoplasia
Methods and compositions for treating neoplastic conditions by viral-based therapy are provided. Mutant virus lacking viral proteins which bind and/or inactivate p53 or RB are administered to a...
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6077662 |
Virus-like particles, methods and immunogenic compositions
The present disclosure provides retrovirus-like particles which comprise retrovirus env proteins, immunogenic compositions comprising retrovirus-like particles, methods for the production of...
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6074649 |
Recombinant composition containing feline herpes virus type 1, particularly for treating feline infectious peritonitis
The recombinant live vaccine comprises, as vector, a feline herpesvirus comprising and expressing at least one nucleotide sequence encoding a polypeptide, this sequence being inserted into the ORF5...
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6074816 |
NANBV diagnostics: polynucleotides useful for screening for hepatitis C virus
A family of cDNA sequences derived from hepatitis C virus (HCV) are provided. These sequences encode antigens which react immunologically with antibodies present in individuals with non-A non-B...
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6066324 |
Carboxyl terminal of papilloma virus L1 region is not required for formation of virus-like particles
Recombinant papilloma virus-like particles result from the expression of viral structural protein L1 and/or L2 in which one or several sections of the L1 and/or L2 protein are deleted. The ability...
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6063627 |
Methods and vectors for site-specific recombination
The present invention provides methods for site-specific recombination in a cell, as well as vectors which can be employed in such methods. The methods and vectors of the present invention can be...
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6060595 |
Inhibition of viral replication
The invention relates to methods and compositions for inhibition of viral replication in animal cells. In particular, inhibition of viral replication in a target cell is achieved by introducing...
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6057095 |
Screening procedure for inhibitors of HIV Rev function
This invention provides a method of screening for inhibitors of HIV Rev function, comprising introducing into a cell a nucleic acid construct comprising a reporter gene positioned in the construct...
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6057492 |
Plants resistant to tospoviruses
Plant transformation vectors comprising a polynucleotide effective to render resisitance or tolerance to infection by a tospovirus, and a microbiological process for making virus tolerant or...
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6057152 |
Recombinant viral vector system
The present invention relates to a system for replication and encapsidation of recombinant DNA fragments into virus particles comprised of adenovirus associated viral (AAV) capsid proteins. The...
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6054281 |
Binding assays
Disclosed is a method of testing a substance for the ability to affect the formation or oligomerization of a complex comprising members of a specific binding pair, a first member of the binding...
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6054573 |
Highly infectious rubella virus clones and methods of production
Highly infectious rubella virus cDNA clones that are chimeric constructs of an infectious cDNA clone having a low specific infectivity and nucleic acid molecule fragments from a second rubella...
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6051428 |
Rapid production of autologous tumor vaccines
An autologous vaccine to tumor cells is produced by transducing the tumor cells with a herpes simplex virus amplicon containing the gene for an immunomodulatory protein to provide transient...
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