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6225458 |
Process for the production of DNA comprising the genome of the hepatitis B virus and vector including it
The invention relates to a process for producing DNA corresponding to that of the DNA of the virus of B hepatitis. It comprises cloning in bacteria the latter DNA, previously repaired by means of...
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6225060 |
Baculovirus expression system and method for high throughput expression of genetic material
The present invention provides novel recombinant baculovirus expression systems for expressing foreign genetic material in a host cell. Such expression systems are readily adapted to an automated...
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6225122 |
Human spinal cord cell lines and methods of use therefor
Conditionally-immortalized human spinal cord cell lines are provided. Such cell lines, which may be clonal, may be used to generate neurons, including motoneurons. The cell lines and/or...
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6224878 |
Mutants and vaccines of the infectious bovine rhinotracheitis virus
A recombinant virus is provided which is obtained from a BHV virus originally having the gI gene whose DNA sequence is delimited by nucleotides 172 and 1311 of SEQ ID NO:1 herein and which has been...
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6224879 |
Alphavirus expression vector
The present invention is directed to alphavirus expression vectors comprising at least part of an alphavirus genome and heterologous RNA inserted downstream of an alphavirus base sequence having...
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6225111 |
Recombinant equine herpesviruses
The present invention relates to a non-naturally occurring, recombinant equine herpesvirus. The invention also relates to a recombinant equine herpesvirus capable of replication which comprises...
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6221362 |
Avian polynucleotide formula
The avian vaccine formula comprises at least three polynucleotide vaccine valencies each comprising a plasmid integrating, so as to express it in vivo in the host cells, a gene with one avian...
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6222095 |
Sequences from auxin-induced gene products targeting fusion proteins for degradation
The present invention provides isolated nucleic acid molecules comprising a polynucleotide sequence encoding a primary auxin response protein degradation signal linked to a heterologous eukaryotic...
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6221577 |
Seroreactive regions on HPV 16-proteins E1 and E2
The invention relates to seroreactive regions on protein E1 and E2 of human papillomavirus (HPV) 16. The application also relates to a vaccine which contains such peptides which contain the...
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6210962 |
Nucleotide and peptide sequences of an isolate of the hepatitis C virus, diagnostic and therapeutic applications thereof
This invention relates to oligonucleotides encoding HCV E1 peptides, labeled oligonucleotide probes, recombinant DNA molecules comprising HCV E1 nucleotides, plasmid, expression vectors and...
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6207166 |
Polynucleotide formulation against pathologies of the horse
Disclosed and claimed is: an immunogenic or vaccine composition for inducing in an equine host an immunological response against equine rhinopneumonitis virus (EHV) containing at least one plasmid...
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6207168 |
Vaccine composition for herpes simplex virus and methods of using
The present invention discloses a new vaccine composition for Herpes Simplex comprising a whole live HSV-2 virus having the oncogene deleted. Methods of using the vaccine composition are also...
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6207165 |
Polynucleotide formula against porcine reproductive and respiratory pathologies
The present invention relates to a vaccine formula allowing in particular the vaccination of pigs against reproductive and respiratory pathologies. It also relates to a corresponding method of...
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6204028 |
Methods for identifying antiviral agents against human herpesviruses
A method of screening compounds for antiviral activity against a selected human herpesvirus by measuring inhibition of DNA synthesis by DNA polymerase and processivity factor of the selected human...
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6200576 |
Swine vesicular disease virus and mutant strains and preparation process and use thereof
The present invention relates to a gene of swine vesicular disease virus (SVDV) and the mutant strains of the gene, and the expression plasmids, the preparation process thereof. The invention also...
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6200577 |
Anti-herpesviral agents and assays therefor
There is described an antiviral agent capable of disrupting the association of two viral structural proteins required for maturation, replication and infection of herpesviruses. The agents are...
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6198022 |
Transgenic plants belonging to the species Cucumis melo
Procedure for the production of transgenic seedlings starting from genetically transformed buds, the said seedlings belonging to the species Cucumus melo and containing at least one gene introduced...
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6197944 |
DNA molecules stabilized by modifications of the 3'-terminal phosphodiester linkage
The use of oligodeoxynucleotides modified at the 3'-terminal internucleotide link as therapeutic agents by a method of hybridizing the modified oligonucleotide to a complementary sequence within a...
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6193982 |
Anti-cyanovirin antibody with an internal image of gp120, a method of use thereof, and a method of using a cyanovirin to induce an immune response to gp120
The present invention provides an anti-cyanovirin antibody with an internal image of gp120, a method of using an anti-cyanovirin antibody with an internal image of gp120 to induce an immune...
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6193984 |
Pharmaceutical composition of herpes simplex virus typ-1 (HSV-1) glycoproteins
The present invention relates to the field of infectious diseases and ophthalmology. More particularly, the invention relates to compositions and methods for vaccination against Herpes Simplex...
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6193983 |
Equine herpesvirus glycoproteins
A vaccine for the selective immunization of horses against EHV4 and/or EHV1 is provided comprising at least one of (i) EHV4 virus wherein a portion of the gG gene of the EHV4 virus that elicits a...
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6190859 |
Method and kit for detection of dengue virus
An inactivated dengue virus vaccine to immunize and protect humans against dengue fever is described. The vaccine is based on dengue viruses which have been propagated to high titers in suitable...
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6190862 |
Identification, purification and detection of WSBV baculovirus associated with white spot syndrome
This invention relates to the identification, purification and detection of a new infectious viral agent in arthropods, especially shrimps. The virus is named as WSBV (Baculovirus associated with...
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6187320 |
Equine herpesviruses (EHV) which contain foreign DNA, process for the preparation thereof and the use thereof in vaccines
The invention relates to equine herpesviruses (EHV) which contain foreign DNA elements in addition to the genome sequences necessary for the replication thereof, to process for the preparation...
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6183753 |
Recombinant chimeric virus and uses thereof
This invention provides a recombinant herpesvirus of turkeys-Marek's disease virus chimera comprising a herpesvirus of turkeys unique long viral genome region and a Marek's disease virus unique...
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6184025 |
Viral isolates associated with multiple sclerosis
Composition comprising two pathogenic and/or infective agents associated with multiple sclerosis, namely a first agent which consists of a human virus possessing reverse transcriptase activity and...
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6180385 |
Picornavirus I proteinase and methods of making and using thereof
Methods of making and using Picornavirus L proteinase peptides (PLPPs) are provided, including, but not limited to, expression of DNA encoding all or a portion thereof, such as a Picornavirus L...
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6180369 |
Varicella-zoster virus antigen
The present invention relates to the construction of a recombinant plasmid which is capable of expressing a secretory truncated glycoprotein (Tgp) of Varicella-zoster virus (VZV) in mammalian...
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6177080 |
Polypeptides encoded by Kaposi sarcoma-associated herpes virus the use thereof in diagnosis and therapy
The invention relates to polypeptides of the Kaposi sarcoma-associated herpes virus which have a part-sequence of at least 10 consecutive amino acids from the sequence TBL Met Ser...
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6174532 |
L2 immunogenic peptides of papillomavirus
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6171854 |
Yellow fever infectious cDNA and plasmids
The present invention is related to a vaccine composition for humans against YF infections consisting essentially of a recombinant YF virus, YFiv5.2/DD, which is regenerated from YF infectious...
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6169171 |
Hybrid protein between CS from plasmodium and HBSAG
Isolated DNA sequences encoding a novel hybrid protein are provided which comprise a portion of the CS protein of P. falciparum and the surface antigen of Hepatitis B virus. Vectors and host cells...
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6168943 |
Methods for making modified recombinant vesiculoviruses
The invention provides recombinant replicable vesiculoviruses. The invention provides a method which, for the first time, successfully allows the production and recovery of replicable...
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6169175 |
Preparation and use of recombinant influenza A virus M2 construct vaccines
The present invention provides a method of increasing the recombinant expression and solubility of influenza A virus M2 polypeptide comprising nucleic acids encoding variants of the M2 protein of...
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6165471 |
Homogeneous human papillomavirus capsomere containing compositions, methods for manufacture, and use thereof as diagnostic, prophylactic or therapeutic agents
The present invention relates to stable HPV capsomeres which express at least one virus-neutralizing conformational epitope of a native HPV L1 protein which are substantially incapable of assembly...
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6159729 |
Synthetic HPV6/11 hybrid L1 DNA encoding human papillomavirus type 11 L1 protein
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6159708 |
Chaperone expression plasmids
An artificial operon comprising polynucleotides encoding each of chaperones DnaK, DnaJ and GrpE; an expression plasmid carrying the operon; a cotransformant prepared by introducing the expression...
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6159477 |
Canine herpesvirus based recombinant live vaccine, in particular against canine distemper, rabies or the parainfluenza 2 virus
Disclosed and claimed is a recombinant canine herepes virus (CHV). The recombinant CHV includes and expresses at least one heterologous nucleotide sequence encoding an antigen. The antigen can be...
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6159478 |
Recombinant canine herpesviruses
The present invention includes novel recombinant canine herpes virus (CHV) and novel recombinant CHV genomes, and particularly to those CHV and CHV genomes that contain heterologous nucleic acid...
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6160201 |
Lettuce infectious yellows virus genes
The present invention provides an isolated nucleic acid which contains a nucleotide sequence which encodes at least one of five LIYV proteins: the coat protein, the heat shock protein-70, RNA...
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6156314 |
Chimeric infectious bursal disease virus cDNA clones, expression products and vaccines based thereon
Chimeric cDNA for the expression of immunogenic polypeptides include the genetic epitopic determinants for a base infectious bursal disease virus strain and at least one other infectious bursal...
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6156303 |
Adeno-associated virus (AAV) isolates and AAV vectors derived therefrom
The present invention provides isolated adenovirus-associated viruses ("AAV"), including AAV isolates designated AAV3B and AAV6. The invention also provides nucleic acid molecules of AAV3B (SEQ ID...
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6156538 |
Heterologous gene expression with poliovirus replicon
The replication machinery of polio virus is used to express heterologous gene products, such as chloramphenicol acetyl transferase, in mammalian cells. Detectable expression following DNA...
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6153435 |
Nucleic acid that encodes a chimeric adenoviral coat protein
The present invention provides a chimeric adenoviral coat protein (particularly a chimeric adenovirus hexon and/or fiber protein). The chimeric adenovirus coat protein has a decreased ability or...
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6153392 |
Devices and methods comprising an HBcAg from hepatitis B virus
A complex comprised of the HBcAg and an albumin or an unprocessed structural protein from a positive stranded RNA virus. Pursuant to such complexing, the antigenicity of the HBcAg is enhanced when...
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6150585 |
Nucleic acids encoding tospovirus genome and expression thereof
Recombinant DNA constructs comprising a DNA coding for transcription into an RNA sequence of tospoviruses or into RNA sequences related thereto, the use of such DNA constructs to transform plants...
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6147278 |
Plant vectors
The invention relates to novel plant plasmid vectors comprising geminivirus DNA or a portion thereof having inserted therein a heterologous DNA sequence or gene, to processes and DNA intermediates...
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6146642 |
Recombinant new castle disease virus RNA expression systems and vaccines
This invention relates to genetically engineered Newcastle disease viruses and viral vectors which express heterologous genes or mutated Newcastle disease viral genes or a combination of viral...
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6146641 |
Avian leukosis virus subgroup J envelope gene product for diagnosis and immunogenic composition
The envelope (env) gene from avian leukosis virus subgroup J (ALV-J) strain Hc1 has been isolated, sequenced and cloned into an expression vector. The ALV-J Hc1 env gene and expressed protein are...
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6146885 |
Cell-type specific gene transfer using retroviral vectors containing antibody-envelope fusion proteins
The present invention pertains to retroviral vector particles having target cell specificity which comprise a retroviral vector having an antigen binding site of an antibody fused to the envelope...
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