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7396536 |
Parasitic helminth cuticlin proteins and uses thereof
The present invention relates to: parasitic helminth cuticlin proteins; parasitic helminth cuticlin nucleic acid molecules, including those that encode such cuticlin proteins; antibodies raised...
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7390639 |
Staphylococcal nuclease fusion proteins for the production of recombinant peptides
Peptides are produced as fusions with a suitable carrier protein. The carrier protein disclosed herein are adapted from the N-terminal domain of staphylococcus nuclease. This novel carrier...
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7390892 |
Nucleic acids encoding novel cyclic GMP dependent protein kinases from Elmeria maxima
The present invention relates to novel protozoal cyclic GMP dependent protein kinases and genes encoding same that have been isolated from Eimeria maxima and Plasmodium falciparum . Nucleic acid...
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7388089 |
Anti-arthropod vector vaccines method of selecting and uses thereof
The present invention provides methods of selecting and uses of anti-arthropod vector vaccines to prevent Leishmaniasis. The present invention also provides compositions for vaccines to prevent...
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7387894 |
Recombinant viral-based malaria vaccines
The present invention relates to novel vaccines against malaria infections, based on recombinant viral vectors, such as alpha viruses, adenoviruses or vaccinia viruses. The recombinant viral-based...
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7384768 |
Nucleic acids and polypeptides specific for pathogenic strains of the Neisseria genus
The invention concerns nucleic acids coding for polypeptides specific of the Neisseria genus pathogenic strains, the corresponding polypeptides, and their diagnostic and therapeutic applications.
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7384640 |
Mutant cholera holotoxin as an adjuvant
A mutant cholera holotoxin featuring a point mutation at amino acid 29 of the A subunit, wherein the glutamic acid residue is replaced by an amino acid other than aspartic acid, is useful as an...
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7384775 |
Streptococcus pneumoniae open reading frames encoding polypeptide antigens and uses thereof
The present invention relates to newly identified open reading frames comprised within the genomic nucleotide sequence of Streptococcus pneumoniae , wherein the open reading frames encode...
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7384741 |
Molecular identification of Aspergillus species
Novel techniques for the detection of Aspergillus in samples are disclosed. These techniques relate to PCR amplification and/or detection of Aspergillus ITS1 rDNA sequences, and the...
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7378257 |
Bacterial superantigen vaccines
The present invention relates to genetically attenuated superantigen toxin vaccines altered such that superantigen attributes are absent, however the superantigen is effectively recognized and an...
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7368547 |
Use of novel virulence-specific genes as targets for diagnosis and potential control of virulent strains of Listeria monocytogenes
A method for identifying virulent strains of L. monocytogenes that includes the use of primers or probes in a PCR assay or hybridization technique that employs primers or probes, which are...
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7368276 |
Polynucleotide constructs encoding aspartate kinase, aspartate-semialdehyde dehydrogenase, and dihydrodipicolinate reductase and related constructs, products, and methods
The invention relates to production of lysine, and provides several isolated polynucleotide molecules useful for the production of L-lysine. One such polynucleotide encodes an aspartate kinase...
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7368261 |
Conserved Neisserial antigens
To ensure maximum cross-strain recognition and reactivity, regions of proteins that are conserved between different Neisserial species, serogroups and strains can be used. The invention provides...
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7368556 |
DNA and proteins or peptides specific of bacteria of the Neisseria meningitidis species, methods for obtaining them and biological applications thereof
The DNA of the invention are characterised in that they concern the whole or part of genes, with their reading frame, to be found in Neisseria meningitidis , but not in Neisseria gonorrhoeae , or...
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7365184 |
B. anthracis prevention and treatment: mutant B. anthracis lacking luxS activity and furanone inhibition of growth, AI-2 quorum sensing, and toxin production
The present invention pertains to the discovery that B. anthracis possesses a luxS gene that encodes a functional LuxS polypeptide, and that B. anthracis synthesizes a functional AI-2...
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7361750 |
Streptoccal inhibitor of complement-mediated lysis, protein SIC
A protein from Streptococcus pyogenes, serotype M1 has been characterized. This protein, called protein SIC, plays a role in S. pyogenes pathogenicity and virulence. It inhibits hemolysis by...
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7355027 |
Bacillus anthracis protective antigen
A polynucleotide sequence is provided, comprising: a nucleic acid sequence having at least 75% identity to SEQ ID NO: 1, wherein said nucleic acid sequence encodes recombinant Bacillus anthracis ...
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7355032 |
Genes coding for metabolic pathway proteins
The invention relates to novel nucleic acid molecules, to the use thereof for constructing genetically improved microorganisms and to methods for preparing fine chemicals, in particular amino...
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7355031 |
Genes encoding carbon metabolism and energy-producing proteins
The invention relates to novel nucleic acid molecules, to the use thereof for constructing genetically improved microorganisms and to methods for preparing fine chemicals, in particular amino...
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7351568 |
EGVI endoglucanase and nucleic acids encoding the same
The present invention provides a novel endoglucanase nucleic acid sequence, designated egl6, and the corresponding EGVI amino acid sequence. The invention also provides expression vectors and host...
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7351550 |
Exoenzyme toxin of Aeromonas salmonicida, and uses thereof
A protein toxin named Aeromonas salmonicida exoenzyme T (AcxT), which belongs to the family of ADP-ribosylating toxins, is disclosed as is a Calcium (or other cation concentration) dependent...
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7348015 |
Antigen modified cancer cell vaccines for cancer therapy
Disclosed are methods for treating cancers, particularly tumorigenic types. Cancer cells are modified to express highly immunogenic antigens so that the cells will generate a defensive response in...
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7348161 |
Macrolide efflux genetic assembly
Macrolide resistance associated with macrolide efflux (mef) in Streptococcus pneumoniae has been defined with respect to the genetic structure and dissemination of a novel mefE-containing...
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7348421 |
Methods for production of p-hydroxybenzoate in bacteria
This invention relates to the isolation of a novel tonB operon from Pseudomonas putida . These genes are useful to render the cells more sensitive to antibiotics, toluene, pHBA, aromatic...
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7344871 |
BGL5 β-glucosidase and nucleic acids encoding the same
The present invention provides a novel β-glucosidase nucleic acid sequence, designated bgl5, and the corresponding BGL5 amino acid sequence. The invention also provides expression vectors and host...
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7344719 |
Homologous 28-kilodalton immunodominant protein genes of Ehrlichia canis and uses thereof
The present invention is directed to the cloning, sequencing and expression of homologous immunoreactive 28-kDa protein genes, p28-1, -2, -3, -5, -6, -7, -9, from a polymorphic multiple gene family...
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7338786 |
Nucleic acid and amino acid sequences relating to Streptococcus pneumoniae for diagnostics and therapeutics
The invention provides isolated polypeptide and nucleic acid sequences derived from Streptococcus pneumoniae that are useful in diagnosis and therapy of pathological conditions; antibodies...
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7339043 |
Compositions and methods for affecting virulence determinants in bacteria
A novel sarR gene and sarR gene product which down regulates the expression of sarA and the resulting virulence determinants in Staphylococcus aureus is provided. Methods for modulating the...
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7335370 |
Chlamydia antigens and corresponding DNA fragments and uses thereof
The present invention provides a method of immunizing a host against disease caused by infection by a strain of Chlamydia , specifically C. pneumoniae . The method involves nucleic acid...
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7335733 |
Tissue cement proteins from Rhipicephalus appendiculatus
The present invention relates to tissue cement proteins produced by certain species of blood-feeding ectoparasites. These proteins and compositions comprising these proteins are particularly useful...
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7332598 |
Non-oligomerizing tandem fluorescent proteins
Non-oligomerizing fluorescent proteins, which are formed by operatively linking two or more monomers of a fluorescent protein, or which are derived from a fluorescent protein having at least one...
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7332338 |
Vectors for making genomic modifications
Methods and vectors (both DNA and retroviral) are provided for the construction of a Library of mutated cells. The Library will preferably contain mutations in essentially all genes present in the...
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7332649 |
Changing the fine chemical content in organisms by genetically modifying the shikimate pathway
The present invention relates to a process for the production of fine chemicals, in particular vitamin E, vitamin K and/or ubiquinone by culturing organisms, in particular plants, whose shikimate...
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7332340 |
Process for identifying a novel target for use for the development of therapeutic modalities and drugs effective against tuberculosis
The present invention relates to a process for identifying a novel target for use for the development of therapeutic modalities and drugs effective against tuberculosis comprising testing M....
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7332597 |
Primers and probe to identify mycobacterium tuberculosis complex
Methods and nucleic acids for rapid, reliable and sensitive detection of Mycobacterium tuberculosis (MTB) complex pathogen in a biological sample. Oligonucleotides are provided which amplify MTB...
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7332596 |
Antifungal proteins and methods for their use
A novel protein was isolated from Fusarium culmorum and characterized. The protein, termed FCWP1, demonstrated significant antifungal activity against several fungal species. Mutations in...
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7332595 |
DNA sequences encoding peptide sequences specific for the hepatic stages of P. falciparum bearing epitopes capable of stimulating the T lymphocytes
The invention discloses isolated DNA sequences encoded by polypeptides characterized by the presence in their structure of one or more sequences bearing all or part of one or more T epitopes, and...
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7329518 |
Enzyme for producing optically active pyridineethanol derivatives
The present invention relates to a method of producing an optically active pyridineethanol derivative. More particularly, it relates to a method of producing an optically active polycyclic...
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7329732 |
HCV RNA-dependent RNA polymerase
The present invention features NS5B polypeptides from different clinically important HCV genotypes. The polypeptides can be used individually, or as part of a panel of RNA-dependent RNA...
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7329527 |
Serine proteases from gram-positive microorganisms
The present invention relates to the identification of novel serine proteases in Gram-positive microorganisms. The present invention provides the nuclei acid and amino acid sequences for the ...
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7329523 |
Phosphoserine phosphatase of coryneform bacteria and variants thereof
The present invention provides a DNA coding for a protein defined in the following (A) or (B) is obtained from Brevibacterium flavum chromosomal DNA library by cloning a DNA fragment that...
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7326543 |
Gene encoding protein from merozoite of Babesia caballi, recombinant protein obtained with said gene and use thereof
The present invention provides a gene encoding a protein from merozoite of Babesia caballi , a recombinant protein of Babesia caballi , and an antibody capable specifically binding to a 48 kDa...
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7326782 |
Metabolic engineering of viomycin biosynthesis
The invention provides a nucleic acid molecule comprising at least a functional fragment of the viomycin biosynthetic gene cluster, functional proteins encoded by the cluster, expression cassettes...
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7323559 |
Genes encoding genetic stability, gene expression and folding proteins
The invention relates to novel nucleic acid molecules, to the use thereof for constructing genetically improved microorganisms and to methods for preparing fine chemicals, in particular amino...
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7320794 |
Transporter protein
A novel protein which has an activity to transport hydantoin compounds is described, as well as a recombinant expressing this transporter protein. From Microbacterium liquefaciens strain AJ3912,...
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7320886 |
BGL4 beta-glucosidase and nucleic acids encoding the same
The present invention provides a novel β-glucosidase nucleic acid sequence, designated bgl4, and the corresponding BGL4 amino acid sequence. The invention also provides expression vectors and host...
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7319033 |
Adenovirus vectors specific for cells expressing androgen receptor and methods of use thereof
Replication-competent adenovirus vectors specific for cells which allow a probasin transcriptional response element (PB-TRE) to function, such as cells which express the androgen receptor (AR), and...
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7314924 |
Polynucleotide encoding a genetically engineered P30 antigen
The present invention relates to a genetically engineered P30 antigen and a combination or mixture of antigens (e.g., the genetically engineered P30 antigen and P35) that may be used in the...
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7314744 |
Hyperthermostable protease gene
There are provided hyperthermostable proteases having an amino acid sequences represented by SEQ ID Nos. 1, 3 and 5 of the Sequence Listing or functional equivalents thereof and hyperthermostable...
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7314625 |
Chimeric protein comprising non-toxic Pseudomonas exotoxin A and Type IV pilin sequences
The invention provides chimeric proteins comprising a non-toxic Pseudomonas exotoxin A sequence and a Type IV pilin loop sequence, wherein the Type IV loop sequence is inserted within the...
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