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7479554 |
AAV5 nucleic acids
The present invention provides an adeno-associated virus 5 (AAV5) virus and vectors and particles derived therefrom. In addition, the present invention provides methods of delivering a nucleic acid...
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7476391 |
Anti-bacterial vaccine compositions
Gram negative bacterial virulence genes are identified, thereby allowing the identification of novel anti-bacterial agents that target these virulence genes and their products, and the provision of...
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7473554 |
Polynucleotides encoding novel Bt toxin receptors from lepidopteran insects
The invention relates to Bt toxin resistance management. The invention particularly relates to the isolation and characterization of nucleic acid and polypeptides for a novel Bt toxin receptor. The...
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7473762 |
Proteins and polypeptides from coagulaslase-negative staphylococci
Proteins and polypeptides from coagulase-negative staphylococcal bacteria such as S. epidermidis , including proteins designated SdrF, SdrG and SdrH, and their effective fragments such as their...
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7473553 |
Polynucleotides encoding novel Bt toxin receptors from lepidopteran insects
The invention relates to Bt toxin resistance management. The invention particularly relates to the isolation and characterization of nucleic acid and polypeptides for a novel Bt toxin receptor. The...
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7468190 |
Reduction in the virulence of Mycobacterium tuberculosis and protection against tuberculosis by means of phoP gene inactivation
The construction of a mutant in the phoP gene by means of homologous recombination from a clinically isolated Mycobacterium tuberculosis reduces the virulence thereof in mouse bone marrow...
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7468185 |
Vaccine for periodontal disease
The present invention relates to novel bacterial isolates identified by their 16S rRNA DNA, that cause periodontal disease in companion animals, polynucleotide sequences contained therein,...
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7468256 |
Tools for detecting Moraxella catarrhalis
The present invention provides compositions and methods useful for detecting Moraxella catarrhalis . The compositions are antibodies, proteins or nucleic acid sequences specific to Moraxella...
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7465574 |
Recombinant RSV virus expression systems and vaccines
The present invention relates to genetically engineered recombinant RS viruses and viral vectors which contain heterologous genes which for the use as vaccines. In accordance with the present...
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7465568 |
Essential fungal polynucleotides, polypeptides, and methods of use
The presnt invention provides essential fungal polynucleotides and their encoded polypeptides, homologues thereof and their uses. Additionally, the invention provides methods for the identification...
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7462707 |
Nucleic acids encoding a recombinant 250 kDa antigen from sporozoites/merozoites of Eimeria maxima and their uses
The present invention provides an isolated nucleic acid comprising a nucleotide sequence encoding a 250 kDa polypeptide from Sporozoites/Merozoites of Eimeria maxima , or encoding a homolog of the...
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7459153 |
Viral vectors for gene therapy
Adenovirus types 11p and 4p show a higher binding affinity and infectivity than type 5 for endothelial and carcinoma cell lines. Adenovirus type 11p shows a stronger binding to cells for neural...
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7459165 |
Polypeptides of Pseudomonas aeruginosa
The present invention relates to polypeptides of Pseudomonas aeruginosa which may be used to prevent, diagnose and/or treat Pseudomonas aeruginosa infection.
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7456272 |
Neurotoxins with enhanced target specificity
Modified neurotoxins that contain protease cleavage sites susceptible uniquely to proteases present in certain tissues are described. The toxins can be selectively activated by proteases in muscle...
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7453025 |
Reproductive ablation constructs
The present invention relates to the regulation of reproductive development, particularly to the genetic ablation of reproductive tissues in angiosperm and gymnosperm species....
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7449178 |
Attenuated gram negative bacteria
Disclosed and claimed are a mutant of a gram negative bacterium, wherein said bacterium has at least one mutation in a nucleotide sequence which codes for a polypeptide having an identity which is...
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7449310 |
Recombinant Fusobacterium necrophorum leukotoxin vaccine and preparation thereof
The F. necrophorum gene expressing leukotoxin was sequenced and cloned. The leukotoxin open reading frame (lktA) is part of a multi-gene operon containing 9,726 bp, and encoding a protein...
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7449289 |
Methods for detection and identification of methicillin-resistant Staphylococcus aureus
The present invention describes novel SCCmec right extremity junction sequences for the detection of methicillin-resistant Staphyloccocus aureus (MRSA). It relates to the use of these DNA...
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7446192 |
Gene participating in acetic acid tolerance, acetic acid bacteria bred using the gene, and process for producing vinegar with the use of the acetic acid bacteria
The present invention is intended to provide novel genes participating in acetic acid tolerance of acetic acid bacteria, and a method of improving acetic acid tolerance of microorganisms,...
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7445895 |
Methods, kits and assay system for detecting drug-resistant Mycobacterium tuberculosis
The present invention relates to methods, kits and assay system for detecting drug-resistant Mycobacterium tuberculosis of suspected patient. The system of the present invention largely reduces...
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7439034 |
Alginases, systems containing alginases and methods of cloning, purifying and/or utilizing alginases
The present invention relates to cell wall degradative systems, in particular to systems containing enzymes that bind to and/or depolymerize cellulose. These systems have a number of applications.
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7438912 |
S.agalactiae antigens I + II
The present invention discloses isolated nucleic acid molecules encoding a hyperimmune serum reactive antigen or a fragment thereof as well as hyperimmune serum reactive antigens or fragments...
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7438916 |
Therapeutic target for protozoal diseases
A novel Fasciclin Related Adhesive Protein (FRAP) from Plasmodium and related parasites is provided as a target for therapeutic intervention in diseases caused by the parasites. FRAP has been...
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7432095 |
Formate dehydrogenase tolerant to halogen compounds and process for producing the same
The invention provides a formate dehydrogenase having high specific activity, small Km values for formate and NAD, broad temperature and pH ranges of stability, broad temperature and pH ranges for...
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7432350 |
Recombinant biotin carboxylase domains for identification of Acetyle CoA carboxylase inhibitors
A peptide comprising an Acetyl CoA carboxylase (ACCase) having a deleted biotin binding domain, having a deleted carboxy transferase domain, and having a functional biotin carboxylase (BC) domain...
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7432353 |
Fluorescent indicator proteins
A protein biosensor having increased signal intensity to sugar concentration and the use thereof. A fluorescent indicator protein is described, in which fluorescent proteins of different emission...
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7432366 |
Moraxella catarrhalis BASB034 polypeptides and used thereof
Provided are Moraxella catarrhalis BASB034 polypeptides and immunogenic fragments of BASB034 polypeptides. Preferably, the immunogenic fragments have at least 15 amino acids that match an aligned...
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7432081 |
Ehrlichia disulfide bond formation proteins and uses thereof
Novel genes encoding homologous immunoreactive thio-disulfide oxidoreductases, or disulfide bond formation (Dsb) proteins from Ehrlichia chaffeensis and Ehrlichia canis are disclosed. While the...
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7432365 |
DNA molecules encoding beta clamp proteins of gram positive bacteria
The present invention relates to beta protein-encoding genes from Gram positive bacterium. Expression systems and host cells containing these genes are also disclosed.
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7429654 |
Cold-shock regulatory elements, constructs thereof, and method of use
Regulatory elements of the 5′UTR of cold-shock inducible genes that prolong the expression of cold-shock inducible genes under conditions that elicit the cold-shock response in a bacterium,...
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7427604 |
DNA encoding an antigenic protein of Eimeria apical membrane antigen 1 and use thereof
This invention provides a novel DNA for preventing avian coccidiosis and use thereof. The novel DNA encodes an antigenic protein of Eimeria apical membrane antigen 1, and is used for DNA vaccine...
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7422873 |
Mutant carotenoid ketolase
CrtW carotenoid ketolases are provided useful for the production of astaxanthin. The ketolases genes of the present invention exhibit improved ketolase activity when converting cyclic hydroxylated...
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7422754 |
Neisseria meningitidis compounds and anti-infection applications thereof
The invention provides novel Neisseria meningitides (Nm) polypeptides and polynucleotides which cover the Nm genetic diversity, and which correspond to polypeptide of Nm outer membrane and/or...
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7423137 |
Nucleic acids encoding recombinant 56 and 82 kDa antigens from gametocytes of Eimeria maxima and their uses
The present invention provides the recombinant cloning and sequencing of two of the major Eimeria maxima gametocyte antigens having molecular weights of 56 and 82 kDa and the expression of these...
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7419672 |
Genes and proteins, and their use
According to the present invention, a series of genes are identified in Group B Streptococcus, the products of which may be associated with the outer surface of the organism. The genes, or...
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7419810 |
Arginine repressor deficient strain of coryneform bacterium and method for producing L-arginine
L-Arginine is produced by culturing a coryneform bacterium in which an arginine repressor involved in L-arginine biosynthesis is deleted by disrupting a gene coding for the repressor, and which has...
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7419824 |
BASB006 polypeptides from Neisseria meningitidis and immunogenic compositions thereof
The invention provides BASB006 polypeptides and polynucleotides encoding BASB006 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are diagnostic,...
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7417138 |
PNA chip for determining genotypes of mycobacterial species using plastic substrate coated with epoxy group-containing polymer and method of determining genotypes of mycobacterial species using the PNA chip
Provided are a PNA chip for determining the genotypes of mycobacterial species in which probe PNAs having DNA sequences of SEQ ID NOs: 5-28 are immobilized on a plastic substrate coated with an...
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7417135 |
Plasmidic gene, ways of acquiring this gene, the amylolytic enzyme it encodes and its application
The object of the invention is a novel plasmidic gene encoding an amylolytic enzyme which after introduction into a microbial strain, favorably bacterial, especially Lactococcus lactis , enables...
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7410648 |
Polypeptides of Moraxella (Branhamella) catarrhalis
The present invention relates to polypeptides, more particularly polypeptides of Moraxella ( Branhamella ) catarrhalis which may be used to prevent, diagnose and/or treat Moraxella (...
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7410645 |
Moraxella (Branhamella) catarrhalis antigens
The present invention relates to polypeptides of Moraxella ( Branhamella ) catarrhalis which may be useful for prophylaxis, diagnosis and/or therapy purposes.
1 ATGGACACTG ACATGAAACA...
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7410647 |
Antigenic polypeptides
A method for the identification of antigenic polypeptides, typically opsonic antigens, expressed by pathogenic microbes; vaccines comprising said antigens; and therapeutic antibodies directed to...
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7408053 |
Recombinant DNA constructs for GAG polypeptides and polypeptides produced thereby
Polynucleotide sequences are provided for the diagnosis of the presence of retroviral infection in a human host associated with lymphadenopathy syndrome and/or acquired immune deficiency syndrome,...
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7407758 |
HCV variants
HCV variants are described. The variants include polynucleotides comprising non-naturally occurring HCV sequences and HCV variants that have a transfection efficiency and ability to survive...
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7407664 |
Peptide vaccines against group A streptococci
This invention, in one aspect, relates to synthetic immunoreactive peptides. These peptides are approximately 20-25 amino acids in length which are portions of the N termini of the M proteins of...
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7399476 |
Nucleic acid free ghost preparations
The invention relates to preparations of bacterial ghosts which are substantially free of living bacterial cells and/or nucleic acids and their use in pharmaceutical preparations.
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7399623 |
Modified forms of pullulanase
The present invention relates to modified pullulanases useful in the starch industry. The present invention provides methods for producing the modified pullulanase, enzymatic compositions...
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7396536 |
Parasitic helminth cuticlin proteins and uses thereof
The present invention relates to: parasitic helminth cuticlin proteins; parasitic helminth cuticlin nucleic acid molecules, including those that encode such cuticlin proteins; antibodies raised...
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7390639 |
Staphylococcal nuclease fusion proteins for the production of recombinant peptides
Peptides are produced as fusions with a suitable carrier protein. The carrier protein disclosed herein are adapted from the N-terminal domain of staphylococcus nuclease. This novel carrier...
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7390892 |
Nucleic acids encoding novel cyclic GMP dependent protein kinases from Elmeria maxima
The present invention relates to novel protozoal cyclic GMP dependent protein kinases and genes encoding same that have been isolated from Eimeria maxima and Plasmodium falciparum . Nucleic acid...
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