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6737521 |
Delivery and expression of a hybrid surface protein on the surface of gram positive bacteria
Process is described for the delivery and expression of hybrid surface proteins to the surface of bacteria. The transformed bacteria are useful as vaccines, for the delivery of other active...
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6733761 |
Mycobacterial isocitrate lyase gene and uses thereof
The present invention provides a purified and isolated nucleic acid encoding mycobacterial isocitrate lyase, as well as mutated forms of the nucleic acid. Further provided are purified and isolated...
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6733976 |
Detection of bacterial kidney disease
A real-time PCR method for detecting and quantifying the presence or absence of Renibacterium salmoninarum , the causative organism of Bacterial Kidney Disease, in a sample. The method includes...
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6733963 |
Methods for the identification of inhibitors of 3-isopropylmalate dehydratase as antibiotics
The present inventors have discovered that 3-Isopropylmalate dehydratase is essential for fungal pathogenicity. Specifically, the inhibition of 3-Isopropylmalate dehydratase gene expression in...
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6730508 |
Protein participating in the activation of nitrile hydratase and gene encoding the same
The invention provides a nitrile hydratase activation protein participating in activation of nitrile hydratase derived from Pseudonocardia thermophila JCM3095, and a gene sequence encoding the...
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6730479 |
Detection of nucleic acid hybrids
Processes are disclosed using the depolymerization of a nucleic acid hybrid to qualitatively and quantitatively analyze for the presence of a predetermined nucleic acid. Applications of those...
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6727084 |
Cold-active beta-galactosidase, the process for its preparation and the use thereof
A purified cold-active beta galactosidase enzyme, specific for lactose, having a stable enzymatic activity at a temperature below 8° C. In the presence of lactose, a purified cold-active beta...
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6723540 |
Manufacture of xylitol using recombinant microbial hosts
Novel methods for the synthesis of xylitol are described.
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6720167 |
Insecticidal bacteria, and methods for making and using them
The invention relates to the discovery that nucleic acid sequences comprising a BtI or BtII promoter, or a combination of a BtI and a BtII promoter, a bacterial STAB-SD sequence, and a sequence...
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6717035 |
Transgenic plants expressing photorhabdus toxin
Novel polynucleotide sequences that encode insect toxins TcdA and TcbA have base compositions that differ substantially from the native genes, making them more similar to plant genes. The new...
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6713617 |
Cloning, sequencing and expression of a gene encoding an eukaryotic amino acid racemase, and diagnostic, therapeutic, and vaccination applications of parasite and viral mitogens
A method of preventing or inhibiting infection by a parasite or virus in vivo comprises administering to a human in need thereof a parasite or virus mitogen in a sub-mitogenic amount sufficient to...
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6713254 |
DNA probes, method and kit for identifying antibiotic-resistant strains of bacteria
The invention relates to a method for identifying antibiotic-resistant strains of bacteria, especially strains of Streptococcus pneumoniae. According to the invention, the method is based on a...
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6713289 |
Nucleotide sequences which code for the eno gene
The present invention is directed to nucleotide sequences coding for a bacterial enolase enzyme. These sequences may be used in improved methods for the fermentative preparation of amino acids...
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6713620 |
Oligonucleotide primers for phosphotidyl inositol in bacillus cereus
The present invention provides novel oligonucleotide primers for phosphotidyl inositol in B. cereus the primer comprising PI-1 (F) 5′ AGTATGGGGAATGAG 3′ PI-1 (F) 5′ ACAATTTTCCCACGA 3′...
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6706495 |
Staphylococcal GTPase obg nucleotide sequence encoding Staphylococcal GTP-binding protein
The present invention provides an isolated Staphylococcal GTPase obg gene and a Staphylococcal GTP-binding protein encoded thereby. A recombinant expression vector and an engineered host cell are...
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6706860 |
Toxins
Novel bacterial insecticidal proteins and equivalents thereof were isolated. These proteins and the DNA sequences encoding them are useful to make insecticidal compositions or transgenic plants to...
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6706872 |
Polynucleotides encoding Plasmodium vivax blood stage antigens
This invention is directed to polynuclectides encoding novel species-specific P. vivax malarial peptide antigens which are proteins or fragments of proteins secreted into the plasma of a...
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6706501 |
Polynucleotide encoding a propionibacterium linoleate isomerase and uses thereof
The present invention provides an isolated (trans,cis)-10,12-linoleate isomerase and its nucleic acid and amino acid sequences. The present invention also provides a method for producing conjugated...
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6706524 |
Method of improving the primary energy metabolism of mammalian cell lines
The invention relates to a method of improving the primary energy metabolism of mammalian cell lines, in which by means of genetic engineering a structural gene for a cytoplasmic yeast pyruvate...
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6703541 |
Nematode-upregulated peroxidase gene promoter from nematode-resistant maize line Mp307
The present invention provides a nematode inducible promoter sequence from maize inbred line Mp307, and DNA constructs and transcription cassettes comprising said promoter sequence, a gene encoding...
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6703540 |
Transformation of plants with a chloroperoxidase gene to enhance disease resistance
The present invention provides a method of making plants resistant to plant pathogens by transformation of host cells with a nucleic acid encoding a nonheme haloperoxidase. Transgenic plants which...
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6699970 |
Mutacin I biosynthesis genes and proteins
According to the present invention, an isolated and purified DNA sequence which encodes a lantibiotic, mutacin I, is disclosed. The nucleic acid sequence is set forth in SEQ ID No: 1 and the amino...
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6699482 |
Leptospira rare outer membrane proteins
The present invention presents novel leptospiral membrane lipoproteins, LipL1 and LipL2, associated with pathogenic strains of Leptospira. LipL1 is of about 35 kDa, and LipL2 is of about 41 kDa....
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6699690 |
Molecular constructs with a carcinoembryonic antigen (CEA) transcriptional regulatory sequence
Novel molecular chimaeras produced by recombinant DNA techniques are described. They comprise a target-tissue specific transcriptional regulatory sequence (TRS) linked and controlling the...
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6696293 |
Process for producing carotenoids and biological materials useful therefor
A process for producing carotenoids, which involves cultivating a microorganism obtained by treating a parent microorganism that produces carotenoids under conditions that induce a reduction in...
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6696268 |
Production and use of antimicrobial agents
A method for identifying antimicrobial agents comprises the steps of: (i) contacting a sample containing non-mammalian PPAT enzyme with a suitable substrate and a potential antimicrobial or...
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6693186 |
Neisseria meningitidis polypeptide, nucleic acid sequence and uses thereof
The invention discloses the Neisseria meningitidis NMASP polypeptide, polypeptides derived therefrom (NMASP-derived polypeptides), nucleotide sequences encoding said polypeptides, and antibodies...
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6692951 |
Secretion factors for gram-positive micoorganisms, genes encoding them and methods of using it
Heterologous protein secretion from Gram-positive bacteria, in particular from Bacilli has, with few exceptions, met with little success. Incompatibility of the heterologous proteins with the...
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6692750 |
Alphavirus expression vector
The present invention is directed to alphavirus expression vectors comprising at least part of an alphavirus genome and heterologous RNA inserted downstream of an alphavirus base sequence having...
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6689364 |
Borrelia burgdorferi polypeptides and uses thereof
The present invention provides novel polypeptides which are substantially free of a B. burgdorferi spirochete or fragments thereof and which are thus useful in compositions and methods for the...
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6686333 |
Inhibition of HIV replication using soluble Tat peptide analogs
Methods and compositions for inhibiting replication of HIV in a mammalian cell. The compositions can be a peptide, or a nucleic acids encoding a peptide, which inhibits transactivation of the HIV...
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6686181 |
Method for the production of L-amino acids from their racemic N-aceytyl-D, L-derivatives by enzymatic racemate cleavage by means of isolated recombinant enzymes
Process for the preparation of L -amino acids from their racemic N-acetyl-D,L derivatives by enzymatic resolution by means of isolated, recombinant enzymes A process for the preparation of...
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6680060 |
Hepatitus A virus vaccines
A live hepatitis A virus adapted to growth in MRC-5 cells, which HAV is preferably characterized by suitable attenuation for effective vaccine administration to humans and animals without...
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6677146 |
Thermophilic polymerase III holoenzyme
The present invention relates to gene and amino acid sequences encoding DNA polymerase III holoenzyme subunits and structural genes from thermophilic organisms. In particular, the present invention...
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6676949 |
Two-step immunization procedure against Chlamydia infection
A host is immunized against infection by a strain of Chlamydia by initial administration of an attenuated bacteria harbouring a nucleic acid encoding a Chlamydia protein followed by administration...
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6676943 |
Human complement C3-degrading protein from Streptococcus pneumoniae
The present invention relates to the identification and use of a family of human complement C3-degrading proteinases expressed by S. pneumoniae . The proteinase has a molecular weight of about 24...
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6673356 |
Compounds and methods for the diagnosis and treatment of ehrlichia infection
Compounds and methods for the diagnosis and treatment of Ehrlichia infection, inparticular human granulocytic ehrlichiosis, are disclosed. The compounds provided include polypeptides that contain...
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6673916 |
Compositions of parasitic helminth PLA2 nucleic acid molecules and uses thereof
The present invention relates to parasitic helminth PLA2 proteins; to parasitic helminth PLA2 nucleic acid molecules, including those that encode such proteins; to antibodies raised against such...
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6673569 |
DsbA/DsbB/DsbC/DsbD expression plasmid
An artificial operon comprising polynucleotides encoding each of DsbA, DsbB, DsbC and DsbD; an expression plasmid carrying the above artificial operon, usable for expression of DsbA, DsbB, DsbC and...
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6673585 |
Heat-stable DNA polymerase of archaeobacteria of genus pyrococcus sp.
A purified thermostable DNA polymerase of archaeobacteria of the genus Pyrococcus sp. having a molecular weight of around 89,000-90,000 daltons is disclosed.
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6670130 |
Oligonucleotide for detection and identification of Mycobacteria
This invention relates to oligonucleotides sequence of probes or primers for detection or identication of Mycobacterium. In the claimed invention, oligonucleotide sequences of ITS (Internal...
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6667038 |
Prevention, diagnosis and treatment of lyme disease
The present invention provides compositions and methods related to Borrelia burgdorferi toxin and antitoxin preparations. In particular, the present invention provides methods and compositions...
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6667169 |
Polypeptides having acid phosphatase activity and nucleic acids encoding same
The present invention relates to isolated polypeptides having acid phosphatase activity and isolated nucleic acid sequences encoding the polypeptides. The invention also relates to nucleic acid...
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6664097 |
Polynucleotide encoding a Lactobacillus gasseri beta-glucuronidase polypeptide
The present invention provides isolated β-Glucuronidase (GUS) having activity at acidic pH and nucleic acids encoding the same. The nucleic acids may be isolated from any suitable species, and in...
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6664386 |
System for efficient secretion of recombinant proteins
Provided is a signal peptide comprising an amino acid sequence at least 90% homologous to the amino acid sequence as shown in SEQ ID NO:1. Further provided is a fusion protein comprising the signal...
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6660478 |
CYP2A6 gene judgment methods
There are provided a method of determining a genotype of CYP2A6 gene on the basis of a difference in gene structures of a wild-type gene of CYP2A6 and at least one kind of mutant-type gene...
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6657106 |
Removal of metals from contaminated substrates by plants
A method of removing metal from a metal-containing substrate is provided. The method comprises (1) providing modified plants having an improved metal accumulating capability compared to unmodified...
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6656917 |
Compositions and methods for targeted enzymatic release of cell regulatory compounds
Novel pro-drugs and methods for their use to alter the growth and biological characteristics of living cells, tissues, or whole organisms are described. The methods allow for selective activation...
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6653115 |
D-sorbitol dehydrogenase gene
Polynucleotides encoding proteins with D-sorbitol dehydrogenase activity or which function to activate D-sorbitol dehydrogenase proteins, in vivo, vectors and recombinant organisms which contain...
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6653463 |
Biocidal protein
The invention relates to novel nucleic acid and protein sequences from the mung bean Vigna radiata . The nucleic acid sequence, isolated from a bruchid resistant mung bean line, encodes a...
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