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8182996 |
Compositions and methods for detecting Klebsiella pneumoniae
Four highly conserved genes, encoding translation elongation factor Tu, translation elongation factor G, the catalytic subunit of proton-translocating ATPase and the RecA recombinase, are used to...
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8178310 |
Babesia microti genomic clones containing novel antigens useful in the diagnosis of Babesios
Disclosed are the cloning and expression of novel antigens in Babesia microti. The recombinant polypeptides are highly immunogenic. The polypeptides of the present invention provide the basis of a...
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8178337 |
Lactobacillus acidophilus nucleic acid sequences encoding carbohydrate utilization-related proteins and uses therefor
Carbohydrate utilization-related and multidrug transporter nucleic acids and polypeptides, and fragments and variants thereof, are disclosed in the current invention. In addition, carbohydrate...
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8173137 |
Polycistronic HIV vector constructs
The present disclosure relates to vectors comprising polynucleotide sequences that encode HIV polypeptides. In particular, the disclosure relates polycistronic vector constructs comprising...
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8168863 |
Methods for accumulating heterologous polypeptides in plant stover utilizing a vacuole sorting signal
Compositions and methods for increasing the expression and/or accumulation of cellobiohydrolase enzyme in the vacuoles of plant cells are provided. The method involves targeting the enzyme to the...
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8168770 |
Cloning, sequencing and expression of a gene encoding an eukaryotic amino acid racemase, and diagnostic, therapeutic, and vaccination applications of parasite and viral mitogens
A method of preventing or inhibiting infection by a parasite or virus in vivo comprising administering to a human in need thereof a parasite or virus mitogen in a sub-mitogenic amount sufficient to...
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8153415 |
Reduced by-product accumulation for improved production of isobutanol
The present invention relates to recombinant microorganisms comprising biosynthetic pathways and methods of using said recombinant microorganisms to produce various beneficial metabolites. In...
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8153397 |
Recombinant light chains of botulinum neurotoxins and light chain fusion proteins for use in research and clinical therapy
The present invention relates to the construction, expression, and purification of synthetic or recombinant light chain (LC) botulinum neurotoxin genes from all botulinum neurotoxin serotypes. The...
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8153412 |
Variants of Bacillus sp. TS-23 alpha-amylase with altered properties
Variants of Bacillus sp. TS-23 strain alpha-amylases exhibit improved enzymatic performance, including increased themostability, reduced calcium dependence, increased washing/cleaning performance,...
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8148136 |
Diagnostics and vaccines for mycobacterial infections of animals and humans
This invention relates to the protein, Mycobacterium paratuberculosis acylase (mpa) and the gene encoding mpa, which we have identified in the pathogen Mycobacterium paratuberculosis Mptb (also...
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8143036 |
Genetically modified microorganisms for producing itaconic acid with high yields
Genetically modified microorganisms that produce itaconic acid at high yields and uses thereof.
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8143482 |
Polypeptides having endoglucanase activity and polynucleotides encoding same
The present invention relates to isolated polypeptides having endoglucanase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs,...
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8143476 |
DGAT genes from Yarrowia lipolytica combined with plastidic phosphoglucomutase down regulation for increased seed storage lipid production and altered fatty acid profiles in oilseed plants
Transgenic soybean seed having increased total fatty acid content of at least 20% and altered fatty acid profiles when compared to the total fatty acid content of non-transgenic, null segregant...
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8143024 |
Chlamydia trachomatis genomic sequence and polypeptides, fragments thereof and uses thereof, in particular for the diagnosis, prevention and treatment of infection
The subject of the invention is the genomic sequence and the nucleotide sequences encoding polypeptides of Chlamydia trachomatis, such as cellular envelope polypeptides, which are secreted or...
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8143387 |
Engineered antibody-stress protein fusions
Provided are fusion polypeptides comprising an engineered antibody and a stress protein that bind to antigens with high affinity, are highly immunogenic, exhibit MHC class I priming and are able to...
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8143386 |
Fusion proteins of mycobacterium tuberculosis antigens and their uses
The present invention relates to fusion proteins containing at least two Mycobacterium tuberculosis antigens. In particular, it relates to bi-fusion proteins which contain two individual M....
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8143049 |
Modified beta-glucosidases with improved stability
Provided are modified beta-glucosidase enzymes, derived from the Trichoderma reesei Cel3A beta-glucosidase, that exhibit improved stability at low pH, low pH and high aeration, low pH and high...
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8137944 |
Modified amylases from pseudomonas species, methods of making and uses thereof
Variant polypeptides derivable from a parent polypeptide having non-maltogenic exoamylase activity, in which the variant polypeptides comprise an amino acid mutation at one or more positions...
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8137951 |
Methods for producing hyaluronan in a recombinant host cell
The present invention relates to methods for producing a hyaluronic acid, comprising: (a) cultivating a Bacillus host cell under conditions suitable for production of the hyaluronic acid, wherein...
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8138324 |
Expression system for proteins
The invention provides a novel system for the tunable expression of nucleic acids encoding e.g., polypeptides such as recombinant proteins in prokaryotic systems. The system is based on the ability...
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8133498 |
Use of polynucleotides encoding small acid-soluble spore protein for inhibiting bacterial cell growth and/or treating bacterial infections
A polypeptide having α/β type SASP activity, for use as a medicament.
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8133715 |
Reduced by-product accumulation for improved production of isobutanol
The present invention relates to recombinant microorganisms comprising biosynthetic pathways and methods of using said recombinant microorganisms to produce various beneficial metabolites. In...
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8129594 |
Bacillus thuringiensis gene with lepidopteran activity
The invention provides nucleic acids, and variants and fragments thereof, obtained from strains of Bacillus thuringiensis encoding polypeptides having pesticidal activity against insect pests,...
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8129589 |
Protoporphyrinogen oxidase having activity of imparting resistance against acifluorfen and gene thereof
Protoporphyrinogen oxidase having an activity of imparting acifluorfen resistance and gene thereof are provided. Cyanobacterium protoporphyrinogen oxidase gene is identified by introducing a...
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8129590 |
Polypeptides having acetylxylan esterase activity and polynucleotides encoding same
The present invention relates to isolated polypeptides having acetylxylan esterase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid...
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8129591 |
Polypeptides having xylanase activity and polynucleotides encoding same
The present invention relates to isolated polypeptides having xylanase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs,...
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8124842 |
Plants having an increased content of amino sugars
The present invention relates to plant cells and plants having an increased content of N-acetylated glucosamine derivatives. Furthermore, the present invention relates to plant cells and plants...
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8124055 |
Compositions and methods to control angiogenesis with cupredoxins
The present invention relates to compositions comprising cupredoxins, and their use to inhibit angiogenesis in mammalian cells, tissues, and animals, and particularly the angiogenesis that...
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8124357 |
Lipophilic dye-based fret assays for clostridal toxin activity
Compositions useful for detecting Clostridial toxin activity comprising a cell that comprises a membrane-associated Clostridial toxin substrate comprising a first member of a fluorescence resonance...
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8124750 |
Recombinant protective protein from Streptococcus pneumoniae
The present invention discloses amino acid sequences and nucleic acid sequences relating to a Streptococcus pneumoniae surface associated Pneumo Protective Protein (PPP) having a molecular weight...
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8119380 |
Methods and materials for making and using transgenic dicamba-degrading organisms
The invention provides isolated and at least partially-purified dicamba-degrading enzymes, isolated DNA molecules coding for dicamba-degrading enzymes, DNA constructs coding for dicamba-degrading...
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8119857 |
Polypeptides having endoglucanase activity and polynucleotides encoding same
The present invention relates to isolated polypeptides having endoglucanase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs,...
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8114976 |
Cryptosporidium hominis genes and gene products for chemotherapeutic, immunoprophylactic and diagnostic applications
Cryptosporidium hominis genes and gene products are provided. The genes and gene products are useful for chemotherapeutic, immunotherapeutic, immunoprophylactic and diagnostic applications.
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8114656 |
Thermostable neutral metalloproteases
The present invention provides methods and compositions comprising at least one neutral metalloprotease enzyme that has improved storage stability. In some embodiments, the neutral metalloprotease...
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8115060 |
Means and methods of controlling plant seed germination
A method of controlling germination of seed is provided in which a nucleic acid encoding a protein which causes inhibition of germination is transformed into a plant, operably linked with a...
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8114417 |
Recombinant protective protein from Streptococcus pneumoniae
The present invention discloses amino acid sequences and nucleic acid sequences relating to a Streptococcus pneumoniae surface associated Pneumo Protective Protein (PPP) having a molecular weight...
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8110201 |
Fusion proteins of mycobacterium tuberculosis
The present invention relates to compositions and fusion proteins containing at least two Mycobacterium sp. antigens, and nucleic acids encoding such compositions and fusion proteins. The...
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8106256 |
Methods and means for producing hyaluronan
The present invention relates to plant cells and plants which synthesize an increased amount of hyaluronan, and to methods for preparing such plants, and also to methods for preparing hyaluronan...
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8101193 |
Tuberculosis vaccines comprising antigens expressed during the latent infection phase
The invention is related to an immunogenic composition, vaccine or pharmaceutical composition for preventing, boosting or treating infection caused by a species of the tuberculosis complex (M....
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8101738 |
ABFB-2 gene from Penicillium funiculosum
The invention relates to the abfB-2 gene of Penicillium funiculosum that codes for a type B α-L-arabinofuranosidase and has a cellulose binding domain. The enzyme α-L-arabinofuranosidase can be i...
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8101347 |
Method and compositions for immunization with the Pseudomonas V antigen
A method of inhibiting, moderating or diagnosing Pseudomonas aeruginosa infection is disclosed. In one embodiment, this method comprises inoculating a patient with an effective amount of PcrV antigen.
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8101392 |
Glucoamylase variants
The invention relates to a variant of a parent fungal glucoamylase, which exhibits improved thermal stability and/or increased specific activity using saccharide substrates.
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8097446 |
Staphylococus aureus strain CYL1892
This disclosure presents embodiments of novel strains of Staphylococcus aureus that through genetic engineering produce type 5 capsular polysaccharide at greater levels than Staphylococcus aureus...
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8097772 |
Polypeptides having beta-glucosidase activity and polynucleotides encoding same
The present invention relates to isolated polypeptides having beta-glucosidase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid...
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8097453 |
Recombinant viral-based malaria vaccines
Described are vaccines against malarial infections, which are based on recombinant viral vectors, such as alpha viruses, adenoviruses, or vaccinia viruses. The recombinant viral-based vaccines can...
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8093029 |
Bilirubin oxidase mutant having thermal stability
A heat-resistant bilirubin oxidase mutant is disclosed. The bilirubin oxidase mutant is obtained by deletion, replacement, addition or insertion of at least one amino acid residue of a wild type...
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8093456 |
Transgenic cover plants containing hemicellulase and cellulase which degrade lignin and cellulose to fermentable sugars
The present invention provides transgenic cover crop plants which after harvest degrade the hemicellulose and cellulose therein to fermentable sugars which can further be fermented to ethanol or...
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8088909 |
Ex vivo animal or challenge model as method to measure protective immunity directed against parasites and vaccines shown to be protective in the method
The invention relates to an ex vivo animal or challenge model as a method to identify protective (recombinant) proteins and rapidly measure protective immunity in intestinal segments directed...
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8088394 |
Mutated E. coli heat-labile enterotoxin
This invention relates to a mutant E. coli heat-labile enterotoxin (LT) subunit A that can be used as an adjuvant. This subunit A mutant contains an amino acid substitution at a position...
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8084666 |
Chloroplast transit peptides for efficient targeting of DMO and uses thereof
The invention provides for identification and use of certain chloroplast transit peptides for efficient processing and localization of dicamba monooxygenase (DMO) enzyme in transgenic plants....
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