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7420038 |
Compositions for controlling hair growth
FP-1 is a protein that is specifically expressed in the follicular papilla of the hair follicle. The nucleic acid and amino acid sequences of FP-1, as well as antibodies that specifically bind FP-1...
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7416849 |
HBM variants that modulate bone mass and lipid levels
The present invention relates to methods and materials used to express an HBM-like polypeptide derived from HBM, LRP5 or LRP6 in animal cells and transgenic animals. The present invention also...
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7416877 |
Receptor that causes cell death and recombinant production thereof
Isolated apoptosis inducing receptors, DNAs encoding such receptors, and pharmaceutical compositions made therefrom, are disclosed. The isolated receptors can be used to regulate an immune...
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7417134 |
IL-1 receptor based cytokine traps and method of using
The present invention provides a fusion polypeptide capable of binding interleukin-1 (O:-1) to form a nonfunctional complex. It also provides a nucleic acid sequence encoding the fusion polypeptide...
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7416848 |
DNA encoding SNORF25 receptor
This invention provides isolated nucleic acids encoding mammalian SNORF25 receptors, purified mammalian SNORF25 receptors, vectors comprising nucleic acid encoding mammalian SNORF25 receptors,...
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7414110 |
Human calcium channel compositions and methods
Isolated DNA encoding each of human calcium channel α 1- , α 2- , β- and γ-subunits, including subunits that arise as splice variants of primary transcripts, is provided. Cells and vectors...
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7414122 |
Nucleic acids encoding B7-Like molecules and uses thereof
The present invention provides B7-Like (B7-L) polypeptides and nucleic acid molecules encoding the same. The invention also provides selective binding agents, vectors, host cells, and methods for...
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7414120 |
Compounds and methods for modulating activation of NF-κB
Compositions and methods for modulating the activation of nuclear factor κB (NF-κB) are provided. The compositions comprise one or more agents that modulate ubiquitination of phosphorylated...
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7414035 |
hKIS composition and methods of use
Disclosed herein are novel composition and methods for altering the proliferation of a cell. Included are wild-type and mutant hKIS polypeptides along with cyclin kinase inhibitors containing...
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7413895 |
DNA encoding neutral amino acid transporter
A novel amino acid transporter molecule mediating transportation of amino acids, which are nutrients essentially required in the survival and proliferation of various normal cells constituting a...
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7414173 |
Isolated nucleic acid molecules encoding orally active androctonus amoreuxi pesticidal biopeptides
The present invention provides compositions and methods for isolated nucleic acid molecules encoding orally active Androctonus amoreuxi pesticidal polypeptides. Compositions include novel...
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7413860 |
Systemic carnitine deficiency gene and uses thereof
The gene responsible for systemic carnitine deficiency was found to be the OCTN2 gene involved in the transportation of organic cations. This invention enables tests for this disease by detecting...
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7411057 |
Nucleic acids encoding human monoclonal antibodies to CTLA-4
In accordance with the present invention, there are provided fully human monoclonal antibodies against human cytotoxic T-lymphocyte antigen 4 (CTLA-4). Nucelotide sequences encoding and amino acid...
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7410778 |
Estrogen receptor genes and utilization thereof
A gene coding for any of the following estrogen receptors (a) to (c): (a) an estrogen receptor comprising the amino acid sequence represented by amino acid numbers 153 to 602 in the amino acid...
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7410781 |
IL-4/IL-13 specific polypeptides and therapeutic uses thereof
Polypeptides and multimeric polypeptides capable of binding interleukin-4 (IL-4) and interluekin-13 (IL-13) which are useful therapeutically in methods of treating IL-4 and IL-13-related conditions...
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7411055 |
Attractin/mahogany-like polypeptides, polynucleotides, antibodies and methods of use thereof
The present disclosure provides attractin/mahogany-like polypeptides and fragments thereof, polynucleotides encoding such polypeptides and fragments, processes for production of recombinant forms...
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7411052 |
Methods and materials relating to stem cell growth factor-like polypeptides and polynucleotides
The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to a novel human secreted stem cell growth factor-like...
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7411056 |
Polynucleotides encoding cytokine receptor zalpha11
Novel polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zalpha11, a novel cytokine receptor. The polypeptides may be used within...
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7407751 |
Methods for the detection and prognosis of breast tumors
This invention relates to the production of specific antibodies for the detection of human tumor associated urokinase-type plasminogen activator receptor (uPAR) deletion variants in biological...
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7408038 |
Secreted immunomodulatory proteins
The invention concerns cDNA molecules encoding TANGO 191 and TANGO 195, both of which are transmembrane proteins. The nucleic acids and polypeptides of the present invention are useful as...
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7407756 |
Methods for detecting mutations associated with familial dysautonomia
This invention relates to methods and compositions useful for detecting mutations which cause Familial Dysautonomia. Familial dysautonomia (FD; Riley-Day syndrome), an Ashkenazi Jewish disorder, is...
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7405289 |
Pancreatic islet transcription factor and uses thereof
The present invention provides a pancreatic islet transcription factor and methods of treating and diagnosing diabetes.
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7405290 |
Nucleic acid and corresponding protein entitled 161P2F10B useful in treatment and detection of cancer
A gene (designated 161P2F10B) and its encoded protein are described wherein 161P2F10B exhibits tissue specific expression in normal adult tissue, it is aberrantly expressed in the cancers listed in...
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7402563 |
EPF derived peptides and therapeutic compositions
The present invention provides assays for the study of the interaction of EPF and its EPF-related peptides with a hDRR receptor. The assays are useful to identify whether a test compound can bind...
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7402388 |
Expression analysis of FKBP54 in assessing prostate cancer therapy
The invention relates to compositions, kits, and methods for detecting, characterizing, preventing, and treating prostate cancer. FKBP markers are provided, wherein changes in the levels of...
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7402413 |
Method of expressing long-chain prenyl diphosphate synthase
The present invention provides a method of producing a long-chain prenyl diphosphate synthase (in particular decaprenyl diphosphate synthase and solanesyl diphosphate synthase) using a gene and a...
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7402666 |
Nucleotide encoding canine 5T4 antigen
Canine and feline 5T4 polypeptide sequences and nucleotide sequences encoding them are provided. A vector system comprising a nucleic acid encoding 5T4 and a 5T4-specific agent are also provided.
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7402409 |
Cell fusion method
The invention provides methods for fusing a first cell with a second cell to form a hybrid cell. The methods involve incubating a first parental cell producing a first partner of a fusogenic...
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7402387 |
Methods and compositions for detecting dihydropyrimidine dehydrogenase splicing mutations
The present invention provides compositions, methods, and kits for the detection of genetic polymorphisms or mutations of the dihydropyrimidine dehydrogenase deficiency (DPDD). The polymorphisms or...
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7402659 |
Thymic stromal lymphopoietin receptor molecules and uses thereof
The present invention provides Thymic Stromal Lymphopoietin Receptor (TSLPR) polypeptides and nucleic acid molecules encoding the same. The invention also provides selective binding agents,...
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7402665 |
Nucleic acid encoding a poly-(ADP) ribose polymerase enzyme and uses thereof
Poly(ADP)-ribose polymerase (PARP) becomes activated at sites of DNA damage and is thought to promote repair by modifying local chromatin proteins and transcription factors. Disclosed is an isoform...
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7402406 |
Methods of evaluating phosphatase inhibitors
The present invention identified OVARC1000473 (SEQ ID NO: 1) and NT2RM1000377 (SEQ ID NO: 3) as clones showing suppression of CREB activation by forskolin, and provides evaluation methods using...
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7399465 |
Pharmaceutical compositions for treating arthritis and inflammatory disease
The biological effects of the cytokine TNF are mediated by binding to receptors on the surface of cells. This disclosure describes new proteins and polynucleotides that promote enzymatic cleavage...
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7399847 |
Nucleic acids encoding artificial P-selectin ligands
Disclosed herein are organic molecules to which are covalently bonded a sialyl-Le x determinant and a sulfated determinant, at least one of these determinants being positioned at a non-naturally...
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7399848 |
Polynucleotides encoding growth differentiation factor-8
Disclosed are polynucleotides encoding growth differentiation factor-8 (GDF-8) useful for increasing the muscle mass in chickens.
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7399829 |
Variants of RANKL protein
The present invention relates to novel, soluble, recombinant variants RANKL (Receptor Activator of Nuclear Factor—κB Ligand) proteins, which may be expressed solubly in E. coli, variants that...
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7396663 |
Isolated polynucleotide encoding a G-protein coupled receptor
The invention provides human G-protein coupled receptors (GCREC) and polynucleotides which identify and encode GCREC. The invention also provides expression vectors, host, cells, antibodies,...
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7396682 |
Method for cell adhesion and wound healing
The present invention relates to a method for cell adhesion and wound healing with internal domains of βig-h3. Particularly, the present invention relates to the method of using recombinant...
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7396905 |
Calcipressins: endogenous inhibitors of calcineurin, uses and reagents related thereto
This invention discloses endogenous calcineurin inhibitors, Calcipressin, Csp1, Csp2, and Csp3, as shown in SEQ ID Nos: 4-5, or 24. This invention also discloses nucleic acid sequences that can...
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7396666 |
Glycosyltransferase, nucleic acid encoding the glycosyltransferase and method of testing canceration using the nucleic acid
A tumor marker nucleic acid of the present invention is concerned with a nucleic acid hybridizing under stringent conditions to a nucleotide sequence described in SEQ ID NO: 1 or a complementary...
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7396669 |
Mammalian endonucleases and methods of use
Isolated mammalian Mus81-Eme endonuclease complexes comprise an Mus81 protein portion and an Eme protein portion. A method of identifying a chemical compound that modulates mammalian cellular...
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7393663 |
Expressed sequence tags and encoded human proteins
The sequences of 5′ ESTs derived from mRNAs encoding secreted proteins are disclosed. The 5′ ESTs may be to obtain cDNAs and genomic DNAs corresponding to the 5′ ESTs. The 5′ ESTs may also...
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7393682 |
Polynucleotides encoding promyostatin polypeptides
The present invention provides isolated polynucleotides encoding promyostatin polypeptides or a peptide portion thereof, polynucleotides complementary thereto, and oligonucleotides that can...
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7393660 |
CC-chemokine binding tick proteins
A novel CC-chemokine binding protein is isolated from the saliva of Rhipicephalus sanguineus . Compounds prepared in accordance with the present invention can be used as anti-inflammatory...
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7393643 |
Method of detecting ivermectin sensitivity in a canine subject by identifying a mutation in a MDR1-encoding sequence
This invention provides the identification of a truncation polymorphism of the mdr1 gene that is linked to ivermectin sensitivity in subjects, such as collies. Also provided are methods for...
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7393939 |
Placental organic anion transporter and gene thereof
A novel organic anion transporter gene participating in organic anion transport in the placenta; and an organic anion transporter which is a polypeptide encoded by the gene. A placental organic...
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7393944 |
T-bet compositions and methods of use thereof
Isolated nucleic acid molecules encoding T-bet, and isolated T-bet proteins, are provided. The invention further provides antisense nucleic acid molecules, recombinant expression vectors containing...
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7393831 |
Peptide compositions and their use against HCV
The invention relates to novel peptide compositions. In particular, the invention relates to a peptide composition comprising at least two peptides which are selected from among the following...
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7393655 |
Methods of identifying melanin concentrating hormone receptor antagonists
This invention provides an isolated nucleic acid encoding a human MCH1 receptor, a purified human MCH1 receptor, vectors comprising isolated nucleic acid encoding a human MCH1 receptor, cells...
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7393943 |
Polynucleotides encoding a human chemotactic cytokine I
Human chemotactic cytokine I polypeptides and DNA (RNA) encoding such chemotactic cytokines and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed...
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