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7452667 |
Diagnosis of mild osteoarthritis by determination of TNFAIP6 and TGFBI RNA levels
The invention relates to the identification and selection of sequences which demonstrate particular advantage in identifying individuals having osteoarthritis (OA). The invention also provides a...
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7449292 |
Methods for predicting relative efficacy of a beta blocker therapy based on a B1-adrenergic receptor polymorphism
Methods and compositions for the detection, diagnosis, and prevention of cardiac conditions are provided. Polymorphisms of β 1 -adrenergic receptor are provided. The Gly389 β 1 -adrenergic...
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7449543 |
Schizophrenia related protein
The invention relates to polynucleotides of the PAPAP gene, polypeptides encoded by the PAPAP gene, and antibodies directed specifically against such polypeptides. The invention also concerns...
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7449303 |
Use of JAG2 expression in diagnosis of plasma cell disorders
The present invention is based on the finding that plasma cell disorders such as Multiple Myeloma and Monoclonal Gammopathy of Unknown Significance are characterized by an increase in the...
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7446172 |
Cytokine protein family
The present invention relates to polynucleotide and polypeptide molecules for zcyto20, zcyto21, zcyto22, zycto24, and zcyto25 proteins which are most closely related to interferon-α at the amino...
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7445925 |
Aequorin as a reporter gene in yeast
A yeast transduction pathway-inducible expression cassette for aequorin and yeast cells containing the expression cassette are disclosed, as well as methods of using the yeast cells in screening...
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7446189 |
Nucleic acids encoding mutant human CD80 and compositions comprising the same
Improved vaccines and methods of using the same are disclosed Immunosuppressive compositions for treating individuals who have autoimmune diseases or transplants and methods of using the same are...
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7445913 |
Nucleic acid encoding a human allelic variant of interferon-like protein ZCYTO21
The present invention relates to polynucleotide and polypeptide molecules for Zcyto21, an interferon-like protein, which is most closely related to interferon-α at the amino acid sequence level....
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7442784 |
Ligand activated transcriptional regulator proteins
Fusion proteins for use as ligand-dependent transcriptional regulators are provided. The fusion proteins include a nucleotide binding domain operatively linked to a ligand-binding domain. They also...
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7442783 |
Natural IgM antibodies and inhibitors thereof
The invention provides natural IgM antibody inhibitors that may be used to treat various inflammatory diseases or disorders.
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7442767 |
α1D calcium channel expressed in atrium
Novel calcium channel nucleic acids and polypeptides are disclosed herein. Methods of using the novel nucleic acids and polypeptides are also disclosed.
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7442770 |
Human clnk-related polypeptide, MIST (Mast Cell Immunoreceptor Signal Transducer)
The present invention describes a newly discovered full-length polynucleotide encoding an SH2 domain-containing adapter protein, called human MIST, cloned, isolated and identified from a human...
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7442500 |
Methods of diagnosing susceptibility to obesity
A gene expression pattern analysis has identified genes the expression patterns of which are different in adipose cells of individuals who have Type 2 Diabetes Mellitus from the cells of...
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7442543 |
Mammalian selenoprotein differentially expressed in tumor cells
A 15 kDa selenium-containing protein (“selenoprotein”) is disclosed. The protein is shown to be differentially expressed in cancer cells, such as prostate cancer cells. There is a correlation...
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7442520 |
Gene BRCC-3 and diagnostic and therapeutic uses thereof
A gene that is a modulator of tumor growth and metastasis in certain cancer types is provided. This gene and corresponding polypeptide have diagnostic and therapeutic application for detecting and...
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7439332 |
Polypeptide having an activity to support proliferation or survival of hematopoietic stem or progenitor cells
A gene encoding a polypeptide having an activity to support proliferation or survival of hematopoietic stem cells or hematopoietic progenitor cells is isolated by comparing expressed genes between...
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7439224 |
Indications of mannan-binding lectin (MBL) in the treatment of immuno-compromised individuals
The present invention relates to the use of a composition comprising at least one mannan-binding lectin (MBL) subunit, or at least one mannan-binding lectin (MBL) oligomer comprising the at least...
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7435808 |
Polynucleotides encoding novel adiponectin receptor variant, AdipoR2v2
The present invention provides novel polynucleotides encoding human AdipoR2v1 polypeptides, mouse AdipoR2v1 polypeptides, human AdipoR3 polypeptides, human AdipoR2v2 polypeptides, human AdipoR3v1...
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7432363 |
Ly6H gene
The invention provides a brain-specific gene useful in treating Alzheimer's disease, for instance, which comprises a nucleotide sequence cording for the amino acid sequence shown in SQ ID NO:1 and...
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7432350 |
Recombinant biotin carboxylase domains for identification of Acetyle CoA carboxylase inhibitors
A peptide comprising an Acetyl CoA carboxylase (ACCase) having a deleted biotin binding domain, having a deleted carboxy transferase domain, and having a functional biotin carboxylase (BC) domain...
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7432419 |
Compositions and methods for the treatment of Pierce's disease
Chimeric anti-microbial proteins, compositions, and methods for the therapeutic and prophylactic treatment of plant diseases caused by the bacterial pathogen Xylella fastidiosa are provided. The...
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7432078 |
Estrogen receptor genes and utilization thereof
The present invention relates to an estrogen receptor gene, characterized by comprising a nucleotide sequence coding for any one of the following amino acid sequences:
(a) the amino acid...
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7429484 |
Nucleic acid molecules encoding osteogenic proteins
Disclosed are 1) osteogenic devices comprising a matrix containing osteogenic protein and methods of inducing endochondral bone growth in mammals using the devices; 2) amino acid sequence data,...
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7429648 |
IREN protein, its preparation and use
There are provided DNA sequences encoding TRAF binding proteins, proteins encoded thereby, and their use in the treatment or prevention of pathological conditions associated with NF-κB induction,...
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7427487 |
Constitutively active CXCR3 G protein-coupled chemokine receptor and modulators thereof for the treatment of inflammatory disorders
The invention disclosed in this patent document relates to transmembrane receptors, particularly to a human G protein-coupled receptor, more particularly to a CXC chemokine receptor subtype 3...
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7427492 |
Polynucleotides encoding human tumor necrosis factor receptor-like2
The present invention relates to novel members of the Tumor Necrosis Factor family of receptors. The invention provides isolated nucleic acid molecules encoding a human TR2 receptor and two splice...
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7427661 |
Canine IL-5 proteins and fragments thereof
The present invention relates to canine interleukin-5 proteins; canine interleukin-5 nucleic acid molecules, including those that encode canine interleukin-5 proteins; to antibodies raised against...
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7427488 |
Purified and isolated platelet calcium channel nucleic acids and polypeptides and therapeutic and screening methods using same
Isolated and purified platelet voltage dependent calcium channel (VDCC) α 1 subunit polypeptides, and nucleic acid molecules encoding the same. Recombinant host cells, recombinant nucleic acids,...
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7427671 |
Compositions of alpha platelet derived growth factor receptor nucleic acid and protein and method of making
A DNA sequence which encodes a human type α platelet derived growth factor receptor protein which preferentially binds to the AA homodimer and AB heterodimer forms of platelet derived growth...
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7427498 |
Composition, methods and reagents for the synthesis of a soluble form of human PHEX
This invention relates to a soluble form of PHEX, PHEX being a type II integral membrane glycoprotein. This enzyme is the gene product of a phosphate-regulating gene with homologies to...
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7427494 |
Nucleic acid encoding cytokine receptor zcytor17
Novel polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17, a novel cytokine receptor. The polypeptides may be used within...
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7425414 |
Method of prognosis of metastasis by detection of FRA12E fragile site within the SMRT gene/locus at chromosome 12q24
Provided are methods for prognostic prediction of metastasis. The method comprises identifying the presence or absence of a fragile site FRA12E on chromosome 12q24 at the SMRT gene locus. The...
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7425613 |
PRO1375 polypeptides
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid...
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7425545 |
Modulation of C-reactive protein expression
Compounds, compositions and methods are provided for modulating the expression of C-reactive protein. The compositions comprise oligonucleotides, targeted to nucleic acid encoding C-reactive...
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7425531 |
Bone polypeptide-1
The present invention relates to a bone polypeptide, particularly bone polypeptide-1 and nucleic acid molecules encoding the same. The present invention provides the human primary sequence of bone...
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7425443 |
Treatment of diabetes with synthetic beta cells
Disclosed is a method for obtaining glucose-regulated expression of active insulin in the cells of a mammalian subject. The method involves delivering into the subject a genetic construct...
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7425324 |
Antagonists of MCP proteins
Novel antagonists of MCP proteins, in particular of MCP-1 protein, can be obtained by generating MCP mutants whose GAG binding site, located at the N-terminal of MCP proteins, is eliminated...
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7425446 |
Antibody composition-producing cell
The present invention relates to a cell for the production of an antibody molecule such as an antibody useful for various diseases having high antibody-dependent cell-mediated cytotoxic activity, a...
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7422886 |
Method for determining modulation of P110Δ activity
The invention relates to a novel lipid kinase which is part of the PI3 Kinase family. PI3 Kinases catalyze the addition of phosphate to inositol generating inositol mono, di and triphosphate....
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7422887 |
Phospholipase A2 and gene thereof
To provide a novel phospholipase A 2 (PLA 2 ) associated with psoriasis, a nucleic acid encoding the same, a method for characterizing, identifying or screening an inhibitor for the PLA 2 or a...
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7423134 |
Protein AMSH and cDNA thereof
This application provides a human protein AMSH having the amino acid sequence of SEQ ID No. 1 which is a novel signal transduction molecule interacting with the SH3 domain of cytokine based signal...
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7423130 |
PRO1158 polypeptides
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid...
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7422898 |
Nucleic acid encoding monkey Gpr103
There are provided non-human primate and rat GPR103 genes and proteins and a compound evaluation method employing the genes or proteins. There are also provided highly useful novel ligands for...
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7419800 |
Estrogen receptor genes
The present invention relates to an estrogen receptor gene, characterized by comprising a nucleotide sequence coding for any one of the following amino acid sequences:
(a) the amino acid...
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7420047 |
Non-anaphylactogenic IgE fusion proteins
The present invention provides compositions and methods for the use of antigenic peptides derived from the Fc portion of the epsilon heavy chain of IgE molecules from two unrelated species as...
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7419804 |
CASH (Caspase Homologue) with death effector domain, modulators of the function of FAS
Proteins capable of modulating or mediating the function of MORT-1 are disclosed. Also disclosed are DNA sequences encoding these proteins, the recombinant production of these proteins as well as...
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7420048 |
Human skeletal muscle-specific ubiquitin-conjugating enzyme
An isolated and purified human skeletal muscle-specific ubiquitin-conjugating enzyme comprising the amino acid sequence shown in SEQ ID NO: 22 is disclosed. The use of the genes make it possible to...
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7419815 |
Inhibitors of plant peptide deformylase for use as broad-spectrum herbicides and methods for identifying the same
The invention relates to a method of identifying herbicides and to the use of inhibitors of plant peptide deformylase as broad spectrum herbicides.
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7419799 |
Compositions and methods for the treatment of immune related diseases
The present invention relates to compositions containing a novel protein and methods of using those compositions for the diagnosis and treatment of immune related diseases.
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7419793 |
Flea octopamine receptor nucleic acid molecules, proteins and uses thereof
The present invention relates to tick octopamine receptor nucleic acid molecules; to tick octopamine receptor proteins encoded by such nucleic acid molecules; to antibodies raised against such...
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