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7211381 |
β2 andrenergic polymorphism detection
Nucleic acid sequences are provided that are useful as amplification primers and hybridization probes for amplifying and detecting target sequence from the β2 adrenergic receptor gene. The primers...
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7211399 |
Method for detecting leptin receptor ligands
The present invention relates to a method for detecting leptin receptor ligands using resonance energy transfer between fusion proteins comprising a leptin receptor and energy donor protein and a...
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7211386 |
Alpha-2A-adrenergic receptor polymorphisms
The present invention includes polymorphisms in nucleic acids encoding the alpha-2A adrenergic receptor and expressed alpha-2A adrenergic receptor molecule. The invention also pertains to methods...
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7211259 |
4-1BB polypeptides and DNA encoding 4-1BB polypeptides
Novel 4-1BB ligand (4-1BB-L) polypeptides and a human cell surface receptor designated 4-1BB that binds 4-1BB-L are provided. Isolated 4-1BB-L-encoding and human 4-1BB-encoding DNA sequences,...
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7211380 |
Physiologically active polypeptide and DNA
A physiologically active polypeptide derived from human brain and a DNA fragment comprising the base sequence encoding the polypeptide are disclosed. The polypeptide possesses excellent smooth...
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7211422 |
Polypeptide having α-isomaltosylglucosaccharide synthase activity
The object of the present invention is to provide a polypeptide which can be used to produce a saccharide having the structure of...
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7211406 |
Potassium channel
A novel polypeptide which is useful in searching for a therapeutic agent for diabetes, a polynucleotide encoding the polypeptide, an expression vector comprising the polynucleotide, a cell...
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7211649 |
Cartilage intermediate layer protein
A novel, N-oligosaccharide-substituted-specific protein of approximately 91.5 kDa was purified from extracts of human articular cartilage and designated Cartilage Intermediate Layer Protein (CILP)....
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7208316 |
Polynucleotide overexpressed in tumors
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid...
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7208267 |
Compositions and methods relating to breast specific genes and proteins
The present invention relates to newly identified nucleic acids and polypeptides present in normal and neoplastic breast cells, including fragments, variants and derivatives of the nucleic acids...
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7208583 |
Antibodies immunologically specific for a DNA repair endonuclease and methods of use thereof
An isolated nucleic acid molecule encoding a human DNA repair enzyme, MED1, is disclosed. Like other mismatch repair genes which are mutated in certain cancers, MED1, encoding nucleic acids,...
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7208273 |
Common polymorphism in scn5a implicated in drug-induced cardiac arrhythmia
The present invention is directed to a specific mutation in SCN5A which causes drug-induced torsade de pointes or ventricular fibrillation. Persons with the mutation are predisposed to developing...
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7208473 |
Nucleic acids and protein variants of hG-CSF with granulopoietic activity
The invention relates to novel granulopoietic activity (GPA) proteins and nucleic acids. The invention further relates to the use of the GPA proteins in the treatment of G-CSF related disorders.
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7208149 |
IL-16 antagonist peptides and DNA encoding the peptides
The present invention has found that a series of peptides having sequences that substantially correspond to specific regions of the C-terminus of IL-16 can inhibit the activity of IL-16. The...
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7208282 |
Rhesus monkey, dog and ferret melanin-concentrating hormone type 2 receptor
The present invention identifies the presence of MCH-2R in the dog, ferret and rhesus monkey. MCH-2R is a G-protein coupled receptor that responds to MCH and is distinct from MCH-1R. MCH-2R...
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7208591 |
G protein-coupled receptor-like receptors and modulators thereof
The invention provides neuropeptide ligands, G protein-coupled receptors and methods of screening for modulators of receptor activity. Identified modulators, including neuropeptide ligand mimetics,...
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7205139 |
Tissue plasminogen activator-like protease
The present invention relates to a novel t-PALP protein which is a member of the serine protease family. In particular, isolated nucleic acid molecules are provided encoding the human t-PALP...
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7205398 |
Eta-1 gene and methods for use
The present application relates to osteopontin (Eta-1) polypeptides, nucleic acids that encode Eta-1, antibodies that specifically bind to Eta-1, and methods for enhancing an immune response in an...
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7205109 |
Method for detecting hepatocarcinoma susceptibility by detecting a tumor related gene in the region of human chromosome 17 p. 13. 3
The invention provides a method for diagnosing susceptibility of individual cancer (e.g. liver cancer), comprising the steps of detecting individual HC56 gene, transcript and/or protein, and...
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7205142 |
Nucleic acid sequence encoding ovarian antigen, CA125, and uses thereof
The present invention provides an isolated nucleic acid molecule comprising sequences encoding the CA125 protein or a portion thereof. This invention also provides a method to detect ovarian cancer...
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7205108 |
Trp8, Trp9 and Trp10, novel markers for cancer
The present invention relates to gene expression in normal cells and cells of malignant tumors and particularly to novel markers associated with cancer, Trp8, Trp9 and Trp10, and the genes encoding...
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7205397 |
Proteins and methods for producing the proteins
A protein which inhibits osteoclast differentiation and/or maturation and a method for producing the protein. The protein is produced by human embryonic lung fibroblasts and has a molecular weight...
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7205143 |
Feline IL-12 single chain nucleic acid molecules
The present invention relates to canine and feline proteins. In particular, the present invention discloses feline interleukin-18, feline caspase-1, feline interleukin-12 single chain and canine...
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7205146 |
Nucleotide and amino acid sequences relating to respiratory diseases and obesity
This invention relates to genes identified from human chromosome 12q23-qter, which are associated with various diseases, including asthma. The invention also relates to the nucleotide sequences of...
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7202054 |
DNA molecules encoding L-glutamate-gated chloride channels from Rhipicephalus sanguineus
The present invention relates in part to isolated nucleic acid molecules (polynucleotides) which encode Rhipicephalus sanguineus glutamate gated chloride channels. The present invention also...
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7202056 |
Polynucleotides encoding a human cell surface protein with immunoglobulin folds, BGS-19
The present invention provides novel polynucleotides encoding BGS-19 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic...
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7201899 |
Materials and methods for management of hyperacute rejection in human xenotransplantation
Human pre-formed xenoantibodies play an important role in the hyperacute rejection response in human xenotransplantation. Disclosed are materials and methods for removing or neutralizing such...
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7202029 |
Nucleic acids encoding human TANGO 195
The invention concerns cDNA molecules encoding TANGO 191 and TANGO 195, both of which are transmembrane proteins. The nucleic acids and polypeptides of the present invention are useful as...
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7202057 |
DNAs encoding rat histamine receptors of the H4 subtype
DNAs encoding the mammalian histamine H4 receptors have been cloned and characterized. These recombinant molecules are capable of expressing biologically active histamine H4 receptor protein. The...
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7198913 |
Nucleic acids encoding a tumor necrosis factor homolog
The present invention is directed to novel polypeptides having homology to members of the tumor necrosis factor receptor family and to nucleic acid molecules encoding those polypeptides. Also...
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7198914 |
Guanosine triphosphate (GTP)-binding protein-coupled receptor protein, BG37
The present inventors conducted a similarity search of the amino acid sequence of known G protein-coupled receptor proteins in GenBank, and obtained a novel human GPCR gene “BG37”. cDNA...
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7198916 |
Green fluorescent proteins and blue fluorescent proteins
This invention relates to novel fluorescent GFPs and BFPs. A novel BFP according to this invention has an F64L mutation as well as a L236R mutation and is provided with improved fluorescence....
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7198933 |
Thermotoga neapolitana xylose isomerase polypeptides and nucleic acids encoding same
The present invention provides novel isolated polynucleotides encoding a novel xylose isomerases capable of catalyzing the conversion of glucose to fructose and nucleic acids encoding for such...
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7198789 |
Methods and compositions for modulating interleukin-21 receptor activity
Methods and compositions for modulating interleukin-21 (IL-21)/IL-21 receptor (MU-1) activity using agonists or antagonists of IL-21 or IL-21 receptor (“IL-21R” or “MU-1”), are disclosed....
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7198912 |
Polynucleotides encoding a human G-protein coupled receptor, HGPRBMY39
The present invention provides novel polynucleotides encoding HGPRBMY39 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and...
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7198911 |
Identification and cloning of a novel human gene, RET16, involved in the intracellular signaling cascade
The present invention describes a newly discovered polynucleotide encoding a protein involved in the cell signaling cascade, called RET16, cloned, isolated and identified from TNF-alpha stimulated...
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7198899 |
Use of NRG4, or inhibitors thereof, in the treatment of colon and pancreatic cancers
This invention relates to compositions and uses of NRG4, and to variants thereof and to polynucleotides encoding NRG4, for therapeutic and diagnostic purposes, particularly related to colon and...
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7198910 |
Nucleic acid encoding melanin-concentrating hormone receptor
The present application features two different forms of the human MCH receptor: (1) MCH-R2 and (2) MCH-R3. Such MCH receptors provide a target for achieving a beneficial affect in a patient and...
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7198942 |
Acetylcholine receptor subunits
The invention relates to modified acetylcholine receptor subunits, to nucleic acids coding modified acetylchloine receptor subunits, and to methods for finding active ingredients for crop...
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7198918 |
Nucleic acid encoding a human serrate-1 polypeptide
A polypeptide which contains the amino acid sequence described in SEQ ID NO: 1 in the Sequence Listing encoded by a gene originating in human being. Because of serving as a chemical efficacious in...
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7199234 |
Regulatory segments of the human gene for telomerase reverse transcriptase
The invention provides compositions and methods related to human telomerase reverse transcriptase (hTRT), the catalytic protein subunit of human telomerase. The polynucleotides and polypeptides of...
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7199231 |
Isolated nucleic acid molecules coding for tumor rejection antigen precursor MAGE-4 and 41 and uses thereof
The invention relates to nucleic acid molecules which code for the tumor rejection antigen precursor MAGE-4 and 41. Also disclosed are vectors, cell lines, and so forth, which utilize the nucleic...
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7196187 |
Method for producing antibody fragments
An expression library comprising a repertoire of nucleic acid sequences cloned from a non-immunised source, each nucleic acid sequence encoding at least part of a variable domain of a heavy chain...
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7196068 |
Method for treating cancer using p38/JTV-1 and method for screening pharmaceutical composition for treating cancer
The present invention relates to a method for treating cancer using p38/JTV-1 and a method for screening pharmaceutical composition for treating cancer. More particularly, this invention relates to...
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7195903 |
Methods for the treatment of thrombosis
A fibrinolytically active metalloproteinase polypeptide (called “novel acting thrombolytic”) which is useful for blood clot lysis in vivo and methods and materials for its production by...
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7196164 |
Secreted protein HHTLF25
The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells,...
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7196174 |
PRO1557 polypeptide encoded by a nucleic acid highly expressed in esophageal and kidney tumors
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid...
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7195767 |
Method to detect IgE
The present invention includes a method to detect IgE using a human Fc epsilon receptor (Fc ε R) to detect IgE antibodies in a biological sample from a cat, a dog, or a horse. The present...
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7196184 |
Double-stranded RNA (DSRNA) and method of use for inhibiting expression of the AML-1/MTG8 fusion gene
The present invention relates to the specific inhibition of expression of a fusion gene in mammals using a short double stranded RNA. The dsRNA is approximately 19–24 nucleotides in length, and...
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7195910 |
Human tyrosine hydroxylase promoter and uses thereof
The present invention provides an isolated, purified and characterized human tyrosine hydroxylase (hTH) promoter nucleic acid sequence. The invention further provides a method of selecting TH...
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