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8183038 |
Composition comprising recombinant nucleic acid encoding Sox2, Oct-4, Nanog and Lin28
The present invention relates to methods for reprogramming a somatic cell to pluripotency by administering into the somatic cell at least one or a plurality of potency-determining factors. The...
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8183353 |
Breast cancer prognostics
A method of providing a prognosis of breast cancer is conducted by analyzing the expression of a group of genes. Gene expression profiles in a variety of medium such as microarrays are included as...
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8183036 |
Luciferase biosensor
A modified beetle luciferase protein which is an environmentally sensitive reporter protein is provided.
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8178660 |
Vaccines and immunotherapeutics using codon optimized IL-15 and methods for using the same
Nucleic acid molecules that encode IL-15 or fragments thereof, which express protein at a higher level than nucleic acid molecules with native coding sequences for IL-15 are disclosed. Nucleic acid...
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8178299 |
Method to determine the risk for side effects of an SSRI treatment in a person
A new method is found to determine an increased risk for side effects of an SSRI treatment in a person by genotyping the person for the presence of the 102 C/C DNA sequence in the 5-HT2A receptor...
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8173793 |
Nucleic acids encoding modulators of body weight
The present invention relates generally to the control of body weight of animals including mammals and humans, and more particularly to nucleic acids encoding materials identified herein as...
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8173859 |
Epilepsy model animal
An epilepsy model animal (CHRNA4:S284L) developing spontaneous epileptic seizure during sleep, which is a nonhuman animal established by ontogenesis of a totipotent cell into which a polynucleotide...
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8173395 |
Mussel bioadhesive
The present invention relates to a bioadhesive derived from mussel. In particular, it relates to a novel Mytilus galloprovincialis foot protein type 5 (MGFP-5) and a recombinant protein that is a...
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8173602 |
Detecting CYP24 expression level as a marker for predisposition to cancer
This invention pertains to the discovery that an amplification of the CYP24 gene or an increase in CYP24 activity is a marker for the presence of, progression of, or predisposition to, a cancer...
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8173779 |
Neutralizing human anti-IGFR antibody
The present invention includes fully human, neutralizing, monoclonal antibodies against human Insulin-like Growth Factor Receptor-I (IGFR1). The antibodies are useful for treating or preventing...
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8168383 |
Gene defects and mutant ALK kinase in human solid tumors
Novel gene deletions and translocations involving chromosome 2 resulting in fusion proteins combining part of Anaplastic Lymphoma Kinase (ALK) kinase with part of a secondary protein have now been...
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8168593 |
Mutated netrin-4, fragments thereof and their use as medicines
A peptide fragment of the netrin-4 protein and nucleic acids coding for the peptide are described. The peptide can inhibit endothelial cell proliferation and cell migration, as well as activate the...
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8168426 |
Multiple inducible gene regulation system
The present invention relates to the field of biotechnology or genetic engineering. More specifically, the present invention relates to a multiple inducible gene regulation system that functions...
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8163279 |
IL3Rα antibody conjugates and uses thereof
The present invention provides antibodies that bind to the IL-3 receptor alpha subunit alpha (Il3Rα) chain, and compositions comprising such antibodies. The present invention provides methods for ...
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8163884 |
Interleukin-21 receptor binding proteins
The present invention provides binding proteins and antigen-binding fragments thereof that specifically bind to the human interleukin-21 receptor (IL-21R). The binding proteins can act as, e.g.,...
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8163879 |
Fusion molecules and IL-15 variants
The instant invention provides soluble fusion protein complexes and IL-15 variants that have therapeutic and diagnostic use, and methods for making the such proteins. The instant invention...
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8163878 |
Tumor Endothelial Marker 5-α molecules and uses thereof
The present invention provides Tumor Endothelial Marker 5α (TEM5α) polypeptides and nucleic acid molecules encoding the same. The invention also provides selective binding agents, vectors, host c...
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8158351 |
Method for determining inflammatory disease
It is an object of the present invention to provide a method for determining inflammatory diseases including myocardial infarction as a typical example, which involves identifying polymorphisms...
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8158352 |
Screening of a novel hepatic syndrome and its uses
The invention concerns methods of screening for a hepatic syndrome occurring in the young adult and associating cholesterol biliary microlithiasis, intrahepatic cholestasis and several mutations of...
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8158769 |
Members of the capsaicin/vanilloid receptor family of proteins and uses thereof
The invention provides isolated nucleic acids molecules, designated hVR-1, hVR-2, and rVR-2 nucleic acid molecules, which encode novel members of the Capsaicin/Vanilloid receptor family. The...
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8158603 |
Fragments of secreted frizzled related protein
The invention stems from the discovery that sFRP and fragments thereof can bind to members of the Wnt family of proteins and cause an increase in Wnt biological activity. Furthermore, fragments of...
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8158362 |
Methods of diagnosing susceptibility to myocardial infarction and screening for an LTA4H haplotype
Polymorphisms in the FLAP and LTA4H gene are shown by genetic association analysis to be susceptibility markers for myocardial infarction (MI) and ACS, as well as stroke and PAOD. Pathway targeting...
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8153764 |
Biomarker specific to brain/nerve or specific to neuronal differentiation
The invention provides a polypeptide and a specific partial peptide thereof, as well as a polynucleotide and a specific partial nucleotide thereof, that can be used as a biomarker specific for the...
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8153775 |
Kits for detecting rank
Isolated receptors, DNAs encoding such receptors, and pharmaceutical compositions made therefrom, are disclosed. The isolated receptors can be used to regulate an immune response. The receptors are...
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8153774 |
Human T1R2 taste receptor nucleic acids and cells containing these nucleic acids
Newly identified mammalian taste-cell-specific G protein-coupled receptors, and the genes and cDNA encoding said receptors are described. Specifically, T1R G protein-coupled receptors active in...
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8153398 |
Polynucleotides encoding signal peptide-containing molecules
The invention provides human signal peptide-containing proteins (HSPP) and polynucleotides which identify and encode HSPP. The invention also provides expression vectors, host cells, antibodies,...
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8153586 |
FGF homologs compositions and uses thereof
The present invention relates to methods of using zFGF5 compositions to proliferate chondrocytes and their progenitors, and to induce deposition of cartilage. zFGF5 compositions are disclosed for...
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8148507 |
Nucleic acid encoding TNFx protein
Nucleic acids encoding mammalian, e.g., primate or rodent, genes, purified proteins and fragments thereof. Antibodies, both polyclonal and monoclonal, are also provided. Methods of using the...
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8148074 |
IRF-5 haplotypes in systemic lupus erythematosus
Methods and materials involved in diagnosing SLE are provided herein. The methods and materials can be used to diagnose SLE and/or assess a mammal's susceptibility to develop SLE, based on the...
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8148061 |
Endometriosis-related markers and uses thereof
The present invention relates to markers of endometriosis which are differentially expressed in the endometrial cells of females with endometriosis compared to endometriosis-free females. The...
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8148106 |
Antagonist anti-Notch3 antibodies and their use in the prevention and treatment of Notch3-related diseases
The present invention relates to antagonist antibodies that specifically bind to Notch 3 and inhibit its activation. The present invention includes antibodies binding to a conformational epitope...
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8147844 |
Mpl ligand (thrombopoietin), nucleic acids encoding such, and methods of treatment using mpl ligand
Isolated thrombopoietin (TPO), isolated DNA encoding TPO, and recombinant or synthetic methods of preparing and purifying TPO are disclosed. Various forms of TPO are shown to influence the...
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8143005 |
Nucleic acids encoding sodium channel SCN1A alpha subunit proteins and mutations associated with epilepsy
The present invention relates to epilepsy. More particularly, the present invention relates to idiopathic generalized epilepsy (IGE) and to the identification of three genes mapping to chromosome...
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8143387 |
Engineered antibody-stress protein fusions
Provided are fusion polypeptides comprising an engineered antibody and a stress protein that bind to antigens with high affinity, are highly immunogenic, exhibit MHC class I priming and are able to...
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8143384 |
Mutation of PRPS1 gene causing CMTX5 disease and the use thereof
Disclosed is a gene mutation associated with peripheral neuropathy associated with sensorineural hearing loss and optic neuropathy. More specifically, disclosed are: a polynucleotide comprising a...
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8138323 |
Isolated cDNA encoding tumor necrosis factor binding protein II, its purification, and vectors, hosts and processes using such cDNA
An isolated DNA molecule has the sequence of encoding a fragment of encoding Tumor Necrosis Factor (TNF) Binding Protein II. It has a length sufficient to serve as an immunogen for raising...
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8138322 |
Human T1R2 nucleic acid sequences and polypeptides
Binding assays for identifying compounds that modulate human T1R2 polypeptide associated taste are disclosed. These assays detect the specific binding of compounds to a human T1R2 polypeptide or...
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8138320 |
Fluorescent proteins and methods for using same
The present invention provides nucleic acid molecules encoding novel red fluorescent proteins from Entacmaea quadricolor and mutants thereof. Also of interest are proteins that are substantially...
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8133724 |
Human androgen receptor alternative splice variants as biomarkers and therapeutic targets
The present invention relates to novel androgen receptor splice variants (AR3, AR4, AR4b, AR5 and AR8) and variants and fragments thereof which have a role in the progression of androgen...
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8133679 |
Methods of identifying agents that diminish cellular toxicity associated with an α-synuclein polypeptide of Parkinson's disease in yeast
Methods of screening candidate agents to identify lead compounds for the development of therapeutic agents for the treatment of a neurodegenerative disease, such as Huntington's Disease and...
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8129161 |
Bardet-Biedl susceptibility gene and uses thereof
The present invention relates to the identification of a gene, now designated negevin (ngvn), that is involved in the genetic disease Bardet Biedl Syndrome (BBS), which is characterized by such...
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8129334 |
Methods and compositions for treating neurodegenerative disorders and Alzheimer'S disease and improving normal memory
The disclosure relates generally to neurodegenerative disorders and more specifically to a group of presenilin/G-protein/c-src binding polypeptides and methods of use for modulating signaling and...
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8129142 |
Mutations in ion channels
A method of identifying a subject predisposed to a disorder associated with ion channel dysfunction, comprising ascertaining whether at least one of the genes encoding ion channel subunits in said...
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8129167 |
UL16 binding protein 4
ULBP4, a novel member of the ULBP family has been isolated and characterized. ULBP4 is a useful activator of immune effector cells, particularly of NK cells. Nucleic acids encoding ULBP4, vectors,...
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8124588 |
Chimeric plasminogen activators and their pharmaceutical use
The present invention relates to recombinant chimeric proteins comprising a surfactant protein precursor N-terminally fused to a plasminogen activator or comprising a mature surfactant protein...
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8124749 |
Targeted cell death
The present invention provides compositions and methods for studying neuropathy. The compositions and methods provided herein are particularly useful for screening agents of therapeutic and/or...
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8124378 |
Murine zcytor17 ligand polynucleotides
The present invention relates to zcytor17lig polynucleotide, polypeptide and anti-zcytor17 antibody molecules. The zcytor17lig is a novel cytokine. The polypeptides may be used within methods for...
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8124733 |
Tumor suppressor gene
A full-length cDNA encoding novel proteins involved in the control of cell proliferation (human Gros1-L and S) was successfully isolated from the human testis cDNA libraries. A full-length cDNA...
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8124842 |
Plants having an increased content of amino sugars
The present invention relates to plant cells and plants having an increased content of N-acetylated glucosamine derivatives. Furthermore, the present invention relates to plant cells and plants...
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8124052 |
Method for identifying targeting domains and methods and compositions comprising the same
The present invention is directed to a method of identifying tissue targeting domains. In particular, the invention relates to methods for identifying a polynucleotide encoding a targeting domain...
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