|
Match
|
Document |
Document Title |
|
|
7385032 |
Bimer or an oligomer of a dimer, trimer, quadromer or pentamer of recombinant fusion proteins
The invention relates to oligomers of a dimer, trimer, quatromer or pentamer of recombinant fusion proteins. The oligomers are characterized in that the recombinant fusion proteins have at least...
|
|
|
7384915 |
Chimeric insulin-gad proteins for treating patients with type 1 diabetes or at risk of developing type 1 diabetes
Novel chimeric fusion proteins comprising immunodominant epitopes of GAD and insulin are provided. Also provided are immunomodulatory methods for the use of such proteins for both the prevention...
|
|
|
7384735 |
Retinoblastoma nucleic acids
This invention relates to nucleic acid, or fragments thereof, encoding the retinoblastoma polypeptide, the retinoblastoma polypeptide itself, methods of detecting a defective retinoblastoma gene in...
|
|
|
7384638 |
Compounds and methods for treatment and diagnosis of Chlamydial infection
Compounds and methods for the diagnosis and treatment of Chlamydial infection are disclosed. The compounds provided include polypeptides that contain at least one antigenic portion of a Chlamydia ...
|
|
|
7381544 |
Nucleic acid that encodes a fusion protein
This invention provides fusion polypeptides that include a glycosyltransferase catalytic domain and a catalytic domain from an accessory enzyme that is involved in making a substrate for a...
|
|
|
7378512 |
Production of proteins by autoproteolytic cleavage
The present invention relates to a process for the production of a heterologous polypeptide with homogeneous N-terminus in a bacterial host cell, wherein the heterologous polypeptide is...
|
|
|
7378492 |
CD40-related receptor that binds CD40L
Various embodiments of the invention provide human receptors and membrane-associated proteins (REMAP) and Q polynucleotides which identify and encode REMAP. Embodiments of the invention also...
|
|
|
7378095 |
Methods of treating type I diabetes by blocking VEGF-mediated activity
Methods of treating diabetes in mammals, particularly humans, by blocking or inhibiting VEGF-mediated activity. A preferred inhibitor of VEGF-mediated activity is a VEGF antagonist such as the VEGF...
|
|
|
7375203 |
Canine cold- and menthol-sensitive receptor 1
The present invention provides nucleic acid and polypeptide sequences describing a novel canine cold- and menthol-sensitive receptor, herein named as canine CMR1 (cCMR1). The isolated nucleic acid...
|
|
|
7374912 |
Nucleic acids encoding chimeric interleukin-6 soluble receptor/ligand protein, analogs thereof and uses thereof
Chimeric proteins constructed from the fusion of the naturally occurring form of the soluble IL-6 receptor and IL-6 which are useful for treatment of cancer and liver disorders, enhancement of bone...
|
|
|
7368554 |
Polynucleotides encoding BSL2v1c2-Ig
The present invention provides nucleic acids encoding B7-related factors that modulate the activation of immune or inflammatory response cells, such as T-cells. Also provided are expression vectors...
|
|
|
7365181 |
Probes for chondrogenesis
Markers for detecting and staging chondrogenesis in cells are provided. In one aspect the markers are isolated polynucleotides, referred to hereinafter as CZF-1 and CZF-2, and fragments thereof. In...
|
|
|
7361487 |
Enzyme fusion proteins and their use
Cellulase fusion proteins comprising an endoglucanase core region and a heterologous cellulose binding domain are described. The fusion proteins may be produced by recombinant techniques using...
|
|
|
7358354 |
Polynucleotides encoding BSL3
The present invention provides nucleic acids encoding B7-related factors that modulate the activation of immune or inflammatory response cells, such as T-cells. Also provided are expression vectors...
|
|
|
7358086 |
Mammalian two-hybrid system for screening for modulators of the accumulation of metabolic products
This invention utilizes a two-hybrid system to screen for agents that modulate the ability of a cell to degrade or to accumulate a metabolic product or to selective kill a cell or to selectively...
|
|
|
7358084 |
Enhanced secretion of a polypeptide by a microorganism
Described herein are methods for the enhanced production of secreted proteins. The secretion of a protein of interest having a substantially non-polar carboxy tail is enhanced by the placement of...
|
|
|
7355019 |
Cysteine-containing peptide tag for site-specific conjugation of proteins
The present invention is directed to a biological conjugate, comprising: (a) a targeting moiety comprising a polypeptide having an amino acid sequence comprising the polypeptide sequence of SEQ ID...
|
|
|
7355018 |
Modified IGF1 polypeptides with increased stability and potency
A targeting fusion protein comprising a component that comprises a (i) ligand or derivative or fragment thereof that binds a pre-selected target surface protein, such as a receptor, and (ii) an...
|
|
|
7354582 |
Use of VEGF antagonists for the treatment of malignant gliomas
Methods for treating a human patient suffering from a brain tumor, including glioblastoma, by administering an effective amount of a vascular endothelial growth factor (VEGF) inhibitor to the human...
|
|
|
7354581 |
Therapeutic combination of a VEGF antagonist and anti-hypertensive agent
Disclosed are compositions and methods for treating a disease or condition related to angiogenesis with a vascular endothelial growth factor (VEGF) inhibitor and one or more anti-hypertensive...
|
|
|
7354579 |
Method of treating cancer with a VEGF antagonist and an anti-proliferative agent
Methods of treating cancer and/or reducing or inhibiting tumor growth in a subject in need thereof, comprising administering pharmaceutical composition comprising a vascular endothelial cell growth...
|
|
|
7354578 |
Method of tumor regression with VEGF inhibitors
Methods of regressing or inhibiting a tumor in a subject by administering an agent capable of blocking, inhibiting, or ameliorating vascular endothelial growth factor (VEGF)-mediated activity to a...
|
|
|
7351535 |
Compositions and methods for increasing cholesterol efflux and raising HDL using ATP binding cassette transporter protein ABC1
The present invention relates to novel ABC1 polypeptides and nucleic acid molecules encoding the same. The invention also relates to recombinant vectors, host cells, and compositions comprising...
|
|
|
7351411 |
Methods of treating anemia by inhibition of vascular endothelial growth factor (VEGF)
Methods of treating anemic disorders in human subjects comprising administering a VEGF antagonist comprising a fusion polypeptide having an immunoglobulin-like (Ig) domain 2 of the VEGF receptor...
|
|
|
7348422 |
Fused protein, gene therefor, recombinant vector, recombinant virus, and its use
A DNA coding for a fusion protein comprising a polypeptide having the antigenicity of Mycoplasma gallisepticum and a polypeptide derived from Herpesvirus outer membrane protein, in which the...
|
|
|
7348409 |
Antimicrobially active peptide
An antimicrobially active peptide comprises the DCD protein or a fragment of DCD, preferably derived from the C-terminal region.
|
|
|
7344870 |
3-phosphoinositide-dependent protein kinase
The present invention provides for a substantially pure human or rabbit 3-phosphoinositide-dependent protein kinase.
|
|
|
7344860 |
Polynucleotide encoding a novel human P2X7 splice variant, HBMYP2X7v
The present invention provides novel polynucleotides encoding HBMYP2X7v polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and...
|
|
|
7339042 |
Gene delivery to tumors
Disclosed are methods and compositions for gene therapy for tumors. Cytotoxic agents are selectively expressed in endothelial cells of tumor blood vessels, and delivered to tumor cells adjacent to...
|
|
|
7335759 |
Recombinant immunogens for the generation of antivenoms to the venom of scorpions of the genus Centruroides
The invention concerns genes and fusion of genes that code for scorpion toxins and the corresponding polypeptides. The invention also concerns the use of the polypeptides as immunogens for the...
|
|
|
7335733 |
Tissue cement proteins from Rhipicephalus appendiculatus
The present invention relates to tissue cement proteins produced by certain species of blood-feeding ectoparasites. These proteins and compositions comprising these proteins are particularly useful...
|
|
|
7332595 |
DNA sequences encoding peptide sequences specific for the hepatic stages of P. falciparum bearing epitopes capable of stimulating the T lymphocytes
The invention discloses isolated DNA sequences encoded by polypeptides characterized by the presence in their structure of one or more sequences bearing all or part of one or more T epitopes, and...
|
|
|
7332574 |
MDL-1 polypeptides
The purification and isolation of various genes which encode mammalian cell surface polypeptides. Nucleic acids, proteins, antibodies, and other reagents useful in modulating development of cells,...
|
|
|
7332316 |
Plant cytokinin oxidase
The present invention relates to methods for stimulating root growth and/or enhancing the formation of lateral or adventitious roots and/or altering root geotropism comprising expression of a plant...
|
|
|
7329744 |
Fusion genes associated with acute megakaryoblastoc leukemias
The invention relates to human nucleotide sequences which occur as a result of the t(1;22)(p13;q13) chromosomal translocation event which is known to occur almost invariable in young children with...
|
|
|
7329530 |
Chimaeric phages
The invention relates to the field of generating helper phages and phage display libraries for the identification of binding molecules. The invention provide chimaeric phages having a coat...
|
|
|
7326781 |
Polynucleotides encoding the human citron kinase polypeptide, BMSNKC—0020/0021
The present invention describes a novel human protein kinase related to citron kinase, and its encoding polynucleotide. Also described are expression vectors, host cells, antisense molecules, and...
|
|
|
7326548 |
Polypeptides having glucoamylase activity and polynucleotides encoding same
The present invention relates to polypeptides having glucoamylase activity and isolated polynucleotides encoding said polypeptides. The invention also relates to nucleic acid constructs, vectors,...
|
|
|
7321028 |
Molecules of the pyrin domain protein family and uses thereof
Novel NBS-1 or PYRIN-1 polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated NBS-1 or PYRIN-1 proteins, the invention further provides NBS-1 or PYRIN-1 fusion...
|
|
|
7320796 |
Isolation, identification and characterization of tmst2, a novel member of the TNF-receptor supergene family
Novel TNF receptor polypeptides are disclosed, along with polynucleotides encoding the polypeptides and uses thereof.
|
|
|
7320795 |
Rodent hepatitis B virus core proteins as vaccine platforms and methods of use thereof
The present invention relates to hepatitis virus core proteins and nucleic acids. In particular, the present invention provides compositions and methods comprising recombinant hepatitis virus core...
|
|
|
7319144 |
Polynucleotides encoding a multiple epitope fusion antigen for use in an HCV antigen/antibody combination assay
The invention relates to a method of detecting HCV infection in a biological sample, the method comprising providing an immunoassay solid support, comprising an HCV anti-core antibody, an antigen...
|
|
|
7319143 |
Genetically-engineered MHC molecules
The invention provides DNA molecules encoding a chimeric polypeptide comprising (a) a component of a MHC molecule capable of association on a cell surface with an endogenous MHC molecule component...
|
|
|
7317099 |
Polynucleotides encoding stem cell growth factor-like polypeptides
The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to a novel human secreted stem cell growth factor-like...
|
|
|
7316924 |
Twin-arginine translocation in Bacillus
Described herein are methods to enhance protein secretion in a host cell. In preferred embodiment, the host cell is a gram-positive microorganism such as a Bacillus . In another preferred...
|
|
|
7314925 |
Constructs and methods for expression of recombinant HCV envelope proteins
The current invention relates to vectors and methods for efficient expression of HCV envelope proteins in eukaryotic cells. More particularly said vectors comprise the coding sequence for an avian...
|
|
|
7314868 |
Compositions and methods for elimination of unwanted cells
Disclosed are compositions comprising a recombinant nucleic acid vector including a nucleotide sequence encoding a syncytium-inducing polypeptide expressible on a eukaryotic cell surface, and a...
|
|
|
7314864 |
Humanin, a polypeptide suppressing neuronal death
The present invention provides polypeptides that suppresses neuronal death associated with Alzheimer's disease. Using a neuronal cell system, wherein the expression of familial Alzheimer's disease...
|
|
|
7314753 |
Cytoplasmic expression of antibodies, antibody fragments and antibody fragment fusion proteins in E. coli
The invention relates to the cytoplasmic expression of antibodies, antibody fragments and antibody fragment fusion molecules in E. coli . In particular, antibody fragment fusion molecules having...
|
|
|
7314747 |
SMRT co-repressors, transcriptional co-repressors that interact with nuclear hormone receptors
The present invention relates to isolated polynucleotides encoding a family of silencing mediators of retinoic acid and thyroid hormone receptor (SMRT) isoforms, including vertebrate and...
|