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7422889 |
Dre recombinase and recombinase systems employing Dre recombinase
The invention provides a Dre/rox recombinase system. In particular, the invention provides Dre polypeptides that can catalyze site-specific recombination at rox sites but not at lox sites. The...
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7422847 |
Human E3α ubiquitin ligase family
The present invention relates to a novel polypeptide encoding a protein which is the full length human ortholog of E3α ubiquitin ligase. The invention also relates to vector, host cells,...
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7422884 |
Feedback-resistant mevalonate kinases
The present invention relates to modified mevalonate kinases that are less sensitive to feedback inhibition, and to polynucleotides encoding them. The invention further pertains to vectors...
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7422888 |
Thermotolerant ribonuclease H
Polypeptides having an RNase H activity highly useful in genetic engineering; genes encoding these polypeptides; and a process for genetic engineeringly producing these polypeptides.
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7420101 |
Nucleic acid sequences to proteins involved in tocopherol synthesis
Nucleic acid sequences and methods are provided for producing plants and seeds having altered tocopherol content and compositions. The methods find particular use in increasing the tocopherol...
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7419813 |
Fructosyl peptide oxidase
The present invention has an object of providing a novel fructosyl peptide oxidase having superior physicochemical properties such as stability that is useful as an enzyme for clinical diagnosis,...
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7419815 |
Inhibitors of plant peptide deformylase for use as broad-spectrum herbicides and methods for identifying the same
The invention relates to a method of identifying herbicides and to the use of inhibitors of plant peptide deformylase as broad spectrum herbicides.
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7419814 |
Mammalian sphingosine kinase type 2 isoforms, cloning, expression and methods of use thereof
Methods for detecting agents or drugs which inhibit or promote an activity of sphingosine kinase type 2 isoform involving providing a recombinant DNA construct into a cell such that sphingosine...
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7420103 |
Plant RNA transport and RNA-directed RNA polymerase proteins
This invention relates to an isolated nucleic acid fragment encoding a RNA-directed RNA polymerase. The invention also relates to the construction of a chimeric gene encoding all or a substantial...
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7416872 |
Taxoid oxygenases and their uses
Oxygenase enzymes and the use of such enzymes to produce paclitaxel (Taxol™), related taxoids, as well as intermediates in the Taxol biosynthetic pathway are disclosed. Also disclosed are nucleic...
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7416871 |
Thermo-stable lactate oxidase
A highly thermo-stable lactate oxidase has been provided by, in the lactate oxidase obtained from Aerococcus viridans , modifying the 6 amino acid residues.
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7417180 |
Genes for increasing grain yield and uses thereof
A gene that regulates the increase and decrease of the particle-bearing number (including glumous flowers, fruits, and seeds) of plants was successfully isolated and identified by a linkage...
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7416870 |
Methods of directing C-O bond formation utilizing a type II polyketide synthase system
The present invention provides methods of modifying a biological molecule by C—O bond formation utilizing a type II polyketide synthase (PKS) system from the nonactin biosynthesis gene cluster....
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7416866 |
Process for the overexpression of dehydrogenases
A process for the overexpression of dehydrogenases, especially for the overexpression of Δ 1 -dehydrogenases, in particular for the overexpression of 3-keto steroid-Δ 1 -dehydrogenases, as well...
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7416875 |
Cytotoxic ribonuclease variants
This invention relates to altered forms of members of the RNase A superfamily. An RNase A can be modified to be cytotoxic by altering its amino acid sequence so that it is not bound easily by the...
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7414120 |
Compounds and methods for modulating activation of NF-κB
Compositions and methods for modulating the activation of nuclear factor κB (NF-κB) are provided. The compositions comprise one or more agents that modulate ubiquitination of phosphorylated...
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7414119 |
Aldolases, nucleic acids encoding them and methods for making and using them
The invention provides novel aldolases, nucleic acids encoding them and methods for making and using them, including chemoenzymatic processes for making β,δ-dihydroxyheptanoic acid side chains...
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7413735 |
Pharmaceutical composition comprising arginine deiminase for inhibiting angiogenesis
The present invention relates to a pharmaceutical composition for inhibiting angiogenesis which comprises arginine deiminase as an active ingredient, where the arginine deiminase, obtained from ...
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7413888 |
Variants of beta-glucosidases
The present invention relates to variants of a parent beta-glucosidase, comprising a substitution at one or more positions corresponding to positions 142, 183, 266, and 703 of amino acids 1 to 842...
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7410638 |
Bacterial strains, genes and enzymes for control of bacterial diseases by quenching quorum-sensing signals
The present invention relates to isolated nucleic acid molecules encoding an autoinducer inactivation protein, wherein the encoded protein comprises an amino acid sequence selected from the group...
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7410786 |
Sulfated fucogalactan digesting enzyme gene
A gene encoding a polypeptide having an activity of digesting sulfated fucogalactan which is useful in sugar chain engineering reagents, analyzing the structures of sulfated fucose-containing...
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7410796 |
Proteinase inhibitor, precursor thereof and genetic sequences encoding same
The present invention relates generally to proteinase inhibitors, a precursor thereof and to genetic sequences encoding same. More particularly, the present invention relates to a nucleic acid...
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7411054 |
25869, 25934, 26335, 50365, 21117, 38692, 46508, 16816, 16839, 49937, 49931 and 49933 molecules and uses therefor
The invention provides isolated nucleic acids molecules, designated 25869, 25934, 26335, 50365, 21117, 38692, 46508, 16816, 16839, 49937, 49931 and 49933 nucleic acid molecules. The invention also...
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7407785 |
Human DNase I hyperactive variants
The present invention relates to amino acid sequence variants of human DNase I that have increased DNA-hydrolytic activity. The invention provides nucleic acid sequences encoding such hyperactive...
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7407786 |
Lipase genes
New lipase enzymes (both nucleic acids and polypeptides) are provided. Compositions which include these polypeptides, proteins, nucleic acids, recombinant cells, as well as methods involving the...
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7407677 |
Enzymes having alpha amylase activity and methods of use thereof
The invention relates to alpha amylases and to polynucleotides encoding the alpha amylases. In addition methods of designing new alpha amylases and methods of use thereof are also provided. The...
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7407788 |
BGL7 beta-glucosidase and nucleic acids encoding the same
The present invention provides a novel β-glucosidase nucleic acid sequence, designated bgl7, and the corresponding BGL7 amino acid sequence. The invention also provides expression vectors and host...
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7407783 |
Fructosylamine oxidase
The present invention provides a fructosylamine oxidase which is obtainable by culturing Fusarium proliferatum , and purifying two types of fructosylamine oxidase (FAO) with different substrate...
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7407784 |
L-amino acid oxidase with cytotoxic activity from Aplysia punctata
The present invention relates to a cytotoxic polypeptide which is an L-amino acid oxidase isolated from the ink of the sea hare Aplysia punctata.
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7407780 |
Process for producing glycerol in recombinant bacterial host cells
The invention provides methods for producing products comprising improved host cells genetically engineered to have uncoupled productive and catabolic pathways. In particular, the present invention...
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7407792 |
Compositions, organisms and methodologies employing a novel human kinase
This invention provides compositions, organisms and methodologies employing a novel human protein kinase, HPK3P23. The novel human kinase has sequence homology to the catalytic domains of several...
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7407664 |
Peptide vaccines against group A streptococci
This invention, in one aspect, relates to synthetic immunoreactive peptides. These peptides are approximately 20-25 amino acids in length which are portions of the N termini of the M proteins of...
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7407787 |
Lactobacillus acidophilus nucleic acids encoding fructo-oligosaccharide utilization compounds and uses thereof
Fructooligosaccharide (FOS)-related protein nucleic acid molecules and polypeptides and fragments and variants thereof are disclosed in the current invention. In addition, FOS-related fusion...
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7405287 |
Method of treating a cancer
The present invention provides isolated nucleic acids encoding delta DNA methyltransferase 3B molecules that are involved in the treatment and prevention of cancers such as, but not limited to,...
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7405346 |
Gene capable of imparting salt stress resistance
This invention provides a novel gene that can impart salt stress tolerance to plants for a long period of time and salt stress tolerant transgenic plants to which such gene has been introduced....
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7405344 |
Elevation of oil levels in Brassica plants
This present invention provides a method for increasing oil levels in the tissues of Brassica sp. plants by expression of a heterologous multifunctional fatty acid synthase (mfFAS) within the...
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7402309 |
Phage-associated lytic enzymes for treatment of Bacillus anthracis and related conditions
The present disclosure relates to methods, compositions and articles of manufacture useful for the treatment of Bacillus anthracis and B. cereus bacteria and spores, and related conditions. The...
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7402418 |
Genes participating in the synthesis of fatty acid having trans-11-,cis-13-conjugated double bond and utilization thereof
An object of the present invention is to clone a gene which is involved in synthesis of fatty acid having trans-11-, cis-13-conjugated double bonds from fatty acid having a double bone at position...
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7402417 |
P450 oxygenases and methods of use
This disclosure provides the nucleic acid and protein sequences of novel P450 oxygenases that utilize, at least, taxoid substrates, including taxadiene isomers. The disclosed oxygenases, such as a...
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7402387 |
Methods and compositions for detecting dihydropyrimidine dehydrogenase splicing mutations
The present invention provides compositions, methods, and kits for the detection of genetic polymorphisms or mutations of the dihydropyrimidine dehydrogenase deficiency (DPDD). The polymorphisms or...
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7402412 |
Mutated D-aminotransferase and method for producing optically active glutamic acid derivatives using the same
A D-aminotransferase can be modified so as to efficiently produce (2R, 4R)-monatin having high sweetness intensity from 4-(indol-3-ylmethyl)-4-hydroxy-2-oxoglutaric acid by substituting an amino...
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7402415 |
Method for the production of glycerol by recombinant organisms
Recombinant organisms are provided comprising genes encoding a glycerol-3-phosphate dehydrogenase and/or a glycerol-3-phosphatase activity useful for the production of glycerol from a variety of...
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7402310 |
Deoxyribonuclease, gene encoding same and use thereof
This invention provides a novel acid DNase (DLAD) which is an endonuclease capable of cleaving DNA independently from divalent cations, under acidic conditions, which retains its activity in acidic...
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7402419 |
Phosphite dehydrogenase mutants for nicotinamide cofactor regeneration
Phosphite dehydrogenase mutant enzymes were generated that provide relaxed cofactor specificity and increased thermostability over the wild type enzyme. The mutant enzymes are useful for...
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7402406 |
Methods of evaluating phosphatase inhibitors
The present invention identified OVARC1000473 (SEQ ID NO: 1) and NT2RM1000377 (SEQ ID NO: 3) as clones showing suppression of CREB activation by forskolin, and provides evaluation methods using...
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7402420 |
Nucleic acid molecules encoding alternansucrase
Nucleic acid molecules encoding an alternansucrase are provided. Moreover, vectors, host cells and plant cells transformed by the herein-described nucleic acid molecules and plants containing them...
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7399476 |
Nucleic acid free ghost preparations
The invention relates to preparations of bacterial ghosts which are substantially free of living bacterial cells and/or nucleic acids and their use in pharmaceutical preparations.
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7399618 |
Method for producing L-histidine using bacteria of Enterobacteriaceae family
A method is provided for producing L-histidine using bacterium of the Enterobacteriaceae family, wherein the L-amino acid productivity of the bacterium is enhanced by enhancing an activity of the...
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7399623 |
Modified forms of pullulanase
The present invention relates to modified pullulanases useful in the starch industry. The present invention provides methods for producing the modified pullulanase, enzymatic compositions...
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7399624 |
Cephalosporin C acylases
Enzymes with cephalosporin C acylase activity obtained by site-directed, random or “site-saturation” mutagenesis of a native sequence optimised for expression in E. coli.
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