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7531333 |
Process for producing isoprenoid compounds by microorganisms and a method for screening compounds with antibiotic or weeding activity
The present invention provides a process for producing isoprenoid compounds or proteins encoded by DNA using DNA that contains one or more of the DNA encoding proteins having activity to improve...
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7531329 |
Carbonyl reductase, gene thereof and method of using the same
The present invention provides a novel polypeptide efficiently forming (R)-N-benzyl-3-pyrrolidinol, a polynucleotide coding for said polypeptide, and use of the same. The present invention relates...
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7531348 |
Recombinant yeast for lignocellulose raw materials
The present invention relates to a method for obtaining a recombinant yeast of Saccharomyces cerevisiae , which ferments lignocellulose raw materials to ethanol, including introducing DNA into a...
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7531339 |
Glyphosate-N-acetyltransferase (GAT) genes
Novel proteins are provided herein, including proteins capable of catalyzing the acetylation of glyphosate and other structurally related proteins. Also provided are novel polynucleotides capable...
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7531335 |
Modified cytochrome p450 monooxygenases
The present invention relates to modified cytochrome P450 monooxygenases with an altered substrate profile, to nucleic acid sequences coding therefor, to expression constructs and vectors, to...
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7527958 |
Truncated 1,3-1,4-β-D-glucanase
A truncated 1,3-1,4-β-D-glucanase. Also disclosed are related nucleic acid, vector, host cell, and preparation method.
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7528241 |
Methods and reagents for molecular cloning
The present invention provides compositions, methods, and kits for covalently linking nucleic acid molecules. The methods include a strand invasion step, and the compositions and kits are useful...
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7527785 |
Glutamic acid decarboxylase (GAD) chimera and methods of use
The invention relates to a novel Glutamic Acid Decarboxylase (GAD). More specifically, novel DNA and protein sequences relating to GAD. Additionally, the invention discloses a novel composition and...
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7527957 |
Methods of altering the sensitivity of a xylanase to a xylanase inhibitor
The present invention relates to a variant xylanase polypeptide, or fragment thereof having xylanse activity, comprising one or more amino acid modifications such that the polypeptide or fragment...
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7527956 |
Modified human acid sphingomyelinase having increased activity, and methods for making the same
Deficiencies in the enzymatic activity of acid sphingomyelinase (ASM) result in Niemann-Pick disease. A variety of modifications which eliminate the activity of the free thiol on the C-terminal...
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7527962 |
Human diacylglycerol acyltransferase 2 (DGAT2) family members and uses therefor
The present invention relates to compositions and methods for the diagnosis and treatment of obesity and related metabolic disorders. The invention provides isolated nucleic acids molecules,...
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7528244 |
Regulators of apoptosis
The invention provides methods and compositions relating to apoptosis regulating proteins, known as Casper proteins, and related nucleic acids. The proteins may be produced recombinantly from...
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7527953 |
Genes from Propionibacterium freudenreichii encoding enzymes involved in vitamin B12 biosynthesis
Four new genes, and the enzymes that they encode, are disclosed, which are present in Propionibacterium freudenreichii, and which are involved in at least five steps in the biosynthetic pathway...
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7527947 |
Signal peptide for producing a polypeptide
The present invention relates to a method for producing a polypeptide comprising using a signal peptide, to nucleic acid constructs comprising a first nucleotide sequence encoding the signal...
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7524660 |
Utilization of fructose in microbial production strains
A process has been developed for the utilization of fructose by PTS − microorganisms. Providing the microorganisms with increased fructokinase activity, and optionally with increased fructose...
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7524644 |
Method for oxygen regulated production of recombinant staphylokinase
The present invention relates to a nucleotide sequence of expression cassette OXY-1 of SEQ ID No. 1, a modified staphylokinase SAK-2 gene of SEQ ID No. 2, a peptide sequence of modified...
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7524667 |
Mutated 6-phosphogluconate dehydrogenase
The present invention relates to a polypeptide having a modified amino acid sequence of 6-phosphogluconate dehydrogenase (hereinafter abbreviated as GND) derived from a microorganism belonging to...
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7524666 |
Reductase gene and use thereof
Provided are genes coding a protein having an ability of asymmetrically reducing a 2-oxo-4-phenylbutyrate to produce a (R)-2-hydroxy-4-phenylbutyrate advantageously from the industrial standpoint,...
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7524659 |
Isogenic strain line of bacterium for producing polyhydroxyalkanoate in which polyhydroxyalkanoate synthase gene is disrupted and method for producing polyhydroxyalkanoate using the same
A host-vector system which is equipped with a substrate supply system enzyme for polyhydroxyalkanoate synthase and which is suitable for evolutionary engineering modification of...
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7524664 |
Regio- and enantioselective alkane hydroxylation with modified cytochrome P450
Cytochrome P450 BM-3 from Bacillus megaterium was engineered using a combination of directed evolution and site-directed mutagenesis to hydroxylate linear alkanes regio- and enantioselectively...
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7524494 |
Degradation of hydrophobic ester pesticides and toxins
The present invention relates to methods and enzymes for degrading hydrophobic ester pesticides and toxins. In particular, the present invention relates to the use of insect esterases, and mutants...
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7524654 |
Isomaltulose synthases, polynucleotides encoding them and uses therefor
The invention is directed to novel enzymes that convert sucrose to isomaltulose. More particularly, the present invention discloses novel sucrose isomerases, polynucleotides encoding these sucrose...
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7524945 |
Plant diacyglycerol acyltransferases
This invention relates to an isolated nucleic acid fragment encoding a diacylglycerol acyltransferase. The invention also relates to the construction of a chimeric gene encoding all or a portion of...
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7521217 |
Carbonic anhydrase having increased stability under high temperature conditions
The present invention relates to polynucleotide and polypeptide sequences of carbonic anhydrase variants having increased stability under high temperature conditions compared to native carbonic...
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7521216 |
Nitrilases and methods for making and using them
The invention relates to nitrilases and to nucleic acids encoding the nitrilases. In addition methods of designing new nitrilases and method of use thereof are also provided. The nitrilases have...
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7521188 |
Optical monitoring of cleaving enzyme activity
A marker molecule for monitoring cleaving enzyme activity is disclosed. The marker molecule includes a protein, a peptide, or an oligonucleotide. A co-factor is conjugated to the protein, the...
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7521230 |
Nucleic acid encoding a Brain Derived Tau Kinase polypeptide and methods of use thereof
The present invention provides materials and methods for treating Alzheimer's disease and other tau related neurodegenerative disorders. A tau kinase, Brain Derived Tau Kinase (BDTK) is provided....
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7521215 |
Human aminoacyl-tRNA synthetase polypeptides useful for the regulation of angiogenesis
Compositions comprising truncated tryptophanyl-tRNA synthetase polypeptides useful for regulating angiogenesis, as well as nucleic acids encoding such tRNA synthetase polypeptides are described....
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7521222 |
Farnesyl dibenzodiazepinone and processes for its production
This invention relates to a novel farnesylated dibenzodiazepinone, named ECO-04601, its pharmaceutically acceptable salts and derivatives, and to methods for obtaining such compounds. One method of...
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7521595 |
Repressor-mediated regulation system for control of gene expression in plants
The invention provides a method for selectively controlling the transcription of a gene of interest, comprising producing one or more plants that express either a first, a second, or both the first...
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7517971 |
Muteins of human telomerase reverse transcriptase lacking telomerase catalytic activity
The invention provides compositions and methods related to human telomerase reverse transcriptase (hTRT), the catalytic protein subunit of human telomerase. The polynucleotides and polypeptides of...
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7517676 |
Human cyclooxygenase-3 enzyme and uses thereof
The present invention provides nucleic acid and polypeptide sequences describing a neve isozyme of the cyclooxygenase enzyme, herein named as human cyclooxygenase 3. The isolated nucleic acid or...
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7517677 |
Recombinant D-amino acid oxidases
The present invention discloses two novel D-amino acid oxidases, whose activities of converting cephalosporin C to glutaryl-7-aminocephalosporanic acid are at least 25% higher than that of...
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7517668 |
Process for the production of protein products in aspergillus
A process for expression of a protein product in Aspergillus oryzae is disclosed. The process comprises transforming Aspergillus oryzae with a vector system comprising DNA-sequences encoding...
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7517680 |
Production of clavulanic acid by genetic engineering of Streptomyces clavuligerus
Genetically engineered Streptomyces clavuligerus strains with improved capabilities to produce clavulanic acid are provided. The strains are genetically engineered by disrupting newly identified...
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7517673 |
Process for producing alpha1,4-galactosyltransferase and galactose-containing complex carbohydrate
The present invention can provide a process for producing a protein having α1.4-galactosyltransferase activity using a transformant comprising a DNA encoding a protein having...
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7517679 |
Recombinant watermelon (Citrullus lanatus) hydroperoxide lyase and uses thereof
Recombinant watermelon ( Citrullus lanatus )hydroperoxide lyase protein, DNA sequences encoding the protein, vectors containing the DNA sequences and hosts containing the vectors are provided,...
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7514110 |
Talaromyces xylanases
Novel polypeptides possessing (endo) xylanase activity are disclosed which can degrade cellulose in plant extracts and plant materials. The polypeptides can cleave β-D-xylan polymers at internal...
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7514251 |
O-methyltransferases of tetrahydrobenzylisoquinoline alkaloid biosynthesis in Papaver somniferum
The present invention relates to methyl transfer enzymes involved in alkaloid biosynthesis in opium poppy. More particularly, the invention relates to proteins having (R,S)-reticuline...
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7514210 |
Compartmentalised self replication method for in vitro evolution of molecular libraries
We describe a method of selecting an enzyme having replicase activity, the method comprising the steps of: (a) providing a pool of nucleic acids comprising members each encoding a replicase or a...
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7510857 |
Thermostable cellulase and methods of use
A Clostridium thermocellum thermostable cellulase enzyme with both endocellulase activity and exocellulase activity that is able to degrade cellulose in the absence of scaffolding and other...
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7511005 |
Lipolytic enzyme elip
The present invention provides a novel nucleic acid sequence, designated ELIP, encoding a lipolytic enzyme and the corresponding encoded amino acid sequences. The invention also provides expression...
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7510854 |
Corynebacterium glutamicum genes encoding metabolic pathway proteins
Isolated nucleic acid molecules, designated MP nucleic acid molecules, which encode novel MP proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic...
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7510860 |
Xylanases with enhanced thermophilicity and alkalophilicity
The present invention provides a xylanase, or a modified xylanase enzyme comprising at least one substituted amino acid residue at a position selected from the group consisting of amino acid 11,...
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7511191 |
Raffinose synthase genes and their use
Raffinose synthase genes coding for proteins capable of producing raffinose by combining a D-galactosyl group through an α(1→6) bond with a hydroxyl group attached to the carbon atom at position...
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7510851 |
Compositions and methods for diagnosing and treating diabetes, insulin resistance and dyslipidemia
The present invention provides compositions and methods for diagnosing and treating diabetes, insulin resistance and dyslipidemia. In particular, the invention provides methods of identifying...
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7510859 |
Subtilisin variants with improved perhydrolase activity
The invention relates to novel perhydrolases, derived from the protease Carlsberg by amino acid exchange in positions 11, 15, 21, 38, 50, 54, 58, 77, 83, 89, 93, 96, 107, 117, 120, 134, 135, 136,...
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7511130 |
Chimeric rice Os-TubA-3 promoter and methods of use
The present invention provides polynucleotide molecules relating to a chimeric rice Os-TubA-3 promoter useful for expressing transgenes in plants. The present invention also provides expression...
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7510858 |
IRAK 1c splice variant and its use
IRAK 1c [Interleukin-1 Receptor-Associated Kinase 1c] splice variants and their preparation and use are described. The splice variants may be used in drug screening assays and methods for...
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7507570 |
Recombinant chondroitinase ABC I and uses thereof
The invention relates to chondroitinase ABC I and uses thereof. In particular, the invention relates to recombinant and modified chondroitinase ABC I, their production and their uses. The...
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