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7585649 |
Modified oligonucleotides and applications thereof
Disclosed, among other things, are primers containing certain modified nucleobases in the 3′ terminal region of the primers that provide reduced formation of primer-dimers during amplification...
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7585617 |
Method and device for thermal conditioning of a cell
The invention relates to methods and agents for thermal conditioning of a biological cell, methods and uses of said agents for releasing and insulating ingredients outside the biological cell, and...
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7585666 |
Polynucleotide constructs, pharmaceutical compositions and methods for targeted downregulation of angiogenesis and anticancer therapy
A novel nucleic acid construct for down-regulating angiogenesis in a tissue of a subject is provided. The nucleic acid construct includes: (a) a first polynucleotide region encoding a chimeric...
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7585632 |
Compositions and methods for the detection of a nucleic acid using a cleavage reaction
The invention relates to compositions and methods for generating a signal indicative of the presence of a target nucleic acid in a sample utilizing a primer-probe duplex.
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7585968 |
Compositions and their uses directed to thymus and activation-regulated chemokine (TARC)
Disclosed herein are compounds, compositions and methods for modulating the expression of TARC in a cell, tissue or animal. Also provided are methods of target validation. Also provided are uses of...
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7585630 |
Genetic variants in the TCF7L2 gene as diagnostic markers for risk of type 2 diabetes mellitus
Polymorphisms in the gene TCF7L2 are shown by association analysis to be a susceptibility gene for type II diabetes. Methods of diagnosis of susceptibility to diabetes, of decreased susceptibility...
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7585956 |
Quantitative trait loci and somatostatin
The disclosure relates to the use of genetic traits in livestock for determining breeding characteristics of livestock progeny, and for optimizing the management and marketing of livestock for...
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7586028 |
Maize variety PHR1R
A novel maize variety designated PHR1R and seed, plants and plant parts thereof. Methods for producing a maize plant that comprise crossing maize variety PHR1R with another maize plant. Methods for...
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7585629 |
Compositions and methods for spinocerebellar ataxia
The autosomal dominant spinocerebellar ataxias (SCAs) represent a growing and heterogeneous clinical phenotype with ongoing discovery of causative etiologies. Methods: The authors collected DNA and...
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7585657 |
Signal for packaging of influenza virus vector
The invention provides a packaging (incorporation) signal for influenza virus vectors, and methods of using the signal to transmit and maintain influenza viral and foreign nucleic acid in virus and...
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7585848 |
Methods and compositions for treating, inhibiting and reversing disorders of the intervertebral disc
Described herein are methods and compositions for inhibiting, treating and reversing intervertebral disc disorders using transcription factor inhibitors. In certain embodiments, the transcription...
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7585631 |
Method for obtaining purified RNA from viable oocysts
The present invention describes novel oligonucleotides targeted to nucleic acid sequences derived from Crytosporidium organisms, and Crytosporidium parvum organisms in particular, which are...
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7585964 |
Methods of analyzing chromosomal translocations using fluorescence in situ hybridization (FISH)
Probes and methods of using the probes to detect chromosomal rearrangements and/or deletions are provided. The methods utilize probes that are free of repeat sequences to provide greater...
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7585965 |
Metallic object with a nucleic acid coating and derivatives thereof and method for producing said object
A metallic object has a coating made of a thin metal oxide layer and nucleic acids or nucleic acid derivatives bonded thereto. The nucleic acid compounds have 5′-terminal or 3′-terminal...
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7585957 |
Site specific system for generating diversity protein sequences
This invention relates to the diversification of nucleic acid sequences by use of a nucleic acid molecule containing a region of sequence that acts as a template for diversification. The invention...
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7582475 |
Vectors and methods for high throughput co-expression
The present invention includes vectors and methods for high throughput co-expression.
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7582430 |
Immunoliposome-nucleic acid amplification (ILNAA) assay
Immunoliposomes and use thereof in highly specific and sensitive nucleic acid amplification assays relying on amplification of specific nucleic acid sequences released from encapsulation within a...
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7582744 |
Chemically modified oligonucleotides
This invention relates composition and methods for making and using chemically modified oligonucleotides agents for inhibiting gene expression.
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7582613 |
Adjuvant compositions and methods for enhancing immune responses to polynucleotide-based vaccines
The invention provides adjuvants, immunogenic compositions, and methods useful for polynucleotide-based vaccination and immune response. In particular, the invention provides an adjuvant of...
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7582421 |
Methods for determination of single nucleic acid polymorphisms using a bioelectronic microchip
This application includes methods for detecting single nucleotide polymorphisms (SNPs) in a sample using an electronically addressable microchip having a plurality of test sites. A sample nucleic...
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7582747 |
siRNA targeting inner centromere protein antigens (INCENP)
Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene...
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7582425 |
Atlastin
The present invention relates to methods and compositions of a novel gene and the peptide encoded by the gene. Mutations in the gene, named atlastin, are factors in the disease Hereditary Spastic...
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7582423 |
Population of polynucleotide sequence variants
We describe here an in vitro method of redistributing sequence variations between non-identical polynucleotide sequences, by making a heteroduplex polynucleotide from two non-identical...
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7582816 |
Maize variety PHW5F
A novel maize variety designated PHW5F and seed, plants and plant parts thereof. Methods for producing a maize plant that comprise crossing maize variety PHW5F with another maize plant. Methods for...
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7582807 |
Regulation of gene expression using chromatin remodelling factors
The invention provides a method to regulate expression of a gene of interest in a plant comprising, introducing into the plant a first nucleotide sequence comprising, the gene of interest...
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7582431 |
Enhanced sequencing by hybridization using pools of probes
The invention provides methods for sequencing by hybridization (SBH) using pools of probes that allow greater efficiency in conducting SBH by reducing the number of separate measurements of...
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7582434 |
Corn event PV-ZMGT32(nk603) and compositions and methods for detection thereof
The present invention provides a DNA construct that confers tolerance to transgenic corn plant. Also provided are assays for detecting the presence of the PV-ZMGT32(nk603) corn event based on the...
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7582739 |
Negatively charged minor groove binders
The present invention provides a negatively charged minor groove binding compound, oligonucleotide conjugates comprising the same, and methods for using the same. The negatively charged minor...
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7582809 |
Sorghum aluminum tolerance gene, SbMATE
The major aluminum tolerance gene, the SbMATE gene, encodes a root citrate efflux transporter that is Al-inducible at the level of gene transcription and is also Al-activated at the level of...
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7582427 |
Method of estimating drug metabolic activity by analyzing mutations in glucuronosyl transferase gene
An object of this invention is to provide a method for assaying, predicting or assessing drug metabolism by effectively detecting (a) mutation(s) in a gene coding for UGT. A gene coding for UGT...
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7582432 |
Dark quenchers for donor-acceptor energy transfer
The present invention provides a family of dark quenchers, termed Black Hole Quenchers (“BHQs”), that are efficient quenchers of excited state energy but which are themselves substantially...
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7582740 |
Methods and kits for detecting SARS-associated coronavirus
The present invention provides a synthetic nucleic acid sequence comprising 10-30 nucleotides of the N gene region and/or the 3′ non-coding region of the SARS-associated coronavirus genome, and a...
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7582470 |
Device for amplifying and detecting a target nucleic acid
Compositions, methods and devices for detecting nucleic acids. The invention particularly regards composite arrays of immobilized amplification primers and hybridization probes. Also disclosed are...
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7582746 |
siRNA targeting complement component 3 (C3)
Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene...
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7582448 |
84P2A9: a prostate and testis specific protein highly expressed in prostate cancer
A novel gene (designated 84P2A9) and its encoded protein is described. While 84P2A9 exhibits prostate and testis specific expression in normal adult tissue, it is aberrantly expressed multiple...
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7582304 |
Groups of Borrelia burgdorferi and Borrelia afzelii that cause Lyme Disease in humans
The present invention is drawn to an immunogenic composition comprising OspC polypeptides from Lyme Disease causing Borrelia. In one embodiment, the immunogenic composition of the present...
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7582615 |
Antisense antiviral compound and method for treating arenavirus infection
The invention provides antisense antiviral compounds and methods of their use and production in inhibition of growth of viruses of the Arenaviridae family and in the treatment of a viral infection....
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7582741 |
Conditional disruption of dicer1 in cell lines and non-human mammals
The present invention is based, at least in part, on the generation of cells, cell lines and non-human mammals that contain a synthetic conditional allele of the Dicer1 gene. Many of the...
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7579458 |
siRNA targeting synuclein, alpha (SNCA-1)
Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene...
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7579454 |
Method for detecting gram-positive bacteria
The present invention relates to a method for detecting and/or identifying Gram-positive bacteria with high GC content, in particular mycobacteria. The method comprises a nucleic acid amplification...
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7579453 |
Variants of human taste receptor genes
Identified herein are different forms of bitter receptor genes that occur in different humans. These alleles are generated by numerous coding single nucleotide polymorphisms (cSNP's) that occur...
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7579155 |
Method for identifying the sequence of one or more variant nucleotides in a nucleic acid molecule
The invention relates to methods for identifying the sequence of one or more variant nucleotides in nucleic acid molecules. The method involves cleaving a double-stranded nucleic acid molecule...
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7579169 |
Hereditary hemochromatosis gene
The invention relates generally to the gene, and mutations thereto, that are responsible for the disease hereditary hemochromatosis (HH). More particularly, the invention relates to the...
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7579530 |
Inbred maize line PHHCA
A novel inbred maize variety designated PHHCA and seed, plants and plant parts thereof. Methods for producing a maize plant that comprise crossing inbred maize variety PHHCA with another maize...
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7579326 |
Gene switch systems employing regulators with decreased dimerization
Disclosed is a novel inducible expression system characterized by undetectable biological effect in the absence of an inducer, but which exhibits efficient inducibility in the presence of an inducer.
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7579141 |
Proteins expressed by Mycobacterium tuberculosis and not by BCG and their use as diagnostic reagents and vaccines
The invention provides polypeptides encoded by open reading frames present in the genome of Mycobacterium tuberculosis but absent from the genome of BCG and diagnostic and prophylactic...
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7579457 |
siRNA targeting carbonic anhydrase II
Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rationale design, one can maximize the generation of an effective gene...
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7579154 |
Annealing control primer and its uses
The present invention relates to an annealing control primer for improving annealing specificity in nucleic acid amplification and its applications to all fields of nucleic acid...
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7579529 |
AP2 domain transcription factor ODP2 (ovule development protein 2) and methods of use
Methods and compositions for modulating plant development are provided. Nucleotide sequences and amino acid sequences encoding Ovule Development Protein 2 (ODP2) proteins are provided. The...
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7579450 |
Nucleic acid ligands specific to immunoglobulin E and their use as atopic disease therapeutics
The invention discloses aptamers capable of binding to Immunoglobulin E (“IgE”) useful as therapeutics in and diagnostics of atopic disease and/or other diseases or disorders in which IgE has...
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