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7632932 |
Oligonucleotides comprising a ligand tethered to a modified or non-natural nucleobase
One aspect of the present invention relates to a double-stranded oligonucleotide comprising at least one ligand tethered to an altered or non-natural nucleobase. In certain embodiments, the...
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7632663 |
Method for microbially producing L-valine
The present invention relates to a process for the microbial production of L-valine in which the dihydroxy acid-synthase (ilvD) activity and/or the ilvD gene expression is intensified in a...
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7632938 |
siRNA targeting superoxide dismutase 1 (SOD1)
Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene...
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7632931 |
Endogeneous nucleic acid fragment associated with an autoimmune disease, labeling method and reagent
The invention concerns an endogenic nucleic fragment, such as an isolated retrovirus, integrated in the human DNA genome, the fragment being characterized in that it comprises, or consists of, at...
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7632516 |
Moraxella catarrhalis BASB115 polypeptides
The invention provides BASB115 polypeptides and polynucleotides encoding BASB115 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are diagnostic,...
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7632659 |
Use of Shigella invaplex to transport functional proteins and transcriptionally active nucleic acids across mammalian cell membranes in vitro and in vivo
The in vivo and in vitro use of Invaplex to transport materials, including functional proteins and biologically active nucleic acids, across eukaryotic cell membranes. The eukaryotic cells include...
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7632934 |
Oligonucleotides for amplifying Trichomonas vaginalis-derived nucleic acid
Oligonucleotides useful for determining the presence of Trichomonas vaginalis in a test sample. The oligonucleotides may be incorporated into detection probes, helper probes, capture probes and...
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7632933 |
Corticotropin releasing factor 2 receptor agonists
Isolated corticotropin releasing factor derivatives, and nucleic acids encoding the same, are effective for treating corticotropin releasing factor 2 receptor modulated disorders such as muscular...
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7632824 |
Compositions and methods for modulation of Mcl-1 expression
Disclosed herein are compounds, compositions and methods for modulating the expression of Mcl-1 in a cell, tissue or animal. Also provided are methods of target validation. Also provided are uses...
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7632641 |
Hybridization chain reaction
The present invention relates to the use of nucleic acid probes to identify analytes in a sample. In the preferred embodiments, metastable nucleic acid monomers are provided that associate in the...
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7629123 |
Compositions and methods for diagnosing autism
Mutations located within the gene encoding the homeobox transcription factor, ENGRAILED 2 (EN2), have now been identified as molecular markers associated with susceptibility for autism and related...
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7629448 |
Compositions for detection and analysis of polynucleotides using light harvesting multichromophores
Methods, compositions and articles of manufacture for assaying a sample for a target polynucleotide are provided. A sample suspected of containing the target polynucleotide is contacted with a...
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7629456 |
Modified L-nucleic acid
The present invention relates to a modified L-nucleic acid, comprising a L-nucleic acid part and a non-L-nucleic acid part, whereby the L-nucleic acid part is conjugated to the non-L-nucleic acid...
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7630837 |
Real-time gene quantification with internal standards
The present invention is directed to a nucleic acid quantification kit and method for determining the initial concentration or mass fraction of a target nucleic acid present in a sample....
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7629518 |
Plants and seeds of hybrid corn variety CH923156
According to the invention, there is provided seed and plants of the hybrid corn variety designated CH923156. The invention thus relates to the plants, seeds and tissue cultures of the variety...
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7629326 |
Chromosomal modification involving the induction of double-stranded DNA cleavage and homologous recombination at the cleavage site
Methods of modifying, repairing, attenuating and inactivating a gene or other chromosomal DNA in a cell are disclosed. Also disclosed are methods of treating or prophylaxis of a genetic disease in...
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7629144 |
Secreted epithelial colon stromal-1 molecules and uses thereof
The present invention provides novel Secreted Epithelial Colon Stromal-1 (Secs-1) polypeptides and nucleic acid molecules encoding the same. The invention also provides vectors, host cells,...
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7629121 |
Notch1 variants associated with cardiovascular disease
Human individuals at increased risk for vascular pathology are identified by determining whether the individuals' genome comprises a Notch1 allele predetermined to be associated with an increased...
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7629324 |
Antisense oligonucleotides for treating atopic diseases and neoplastic cell proliferation
The present invention relates to the use of antisense oligonucleotides directed against specific nucleic acid sequences coding for receptors, alone or in combination, in order to inhibit the...
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7628990 |
Immunomodulatory compositions containing an immunostimulatory sequence linked to antigen and methods of use thereof
The invention provides classes of immunomodulatory compositions which comprise an average of one or more immunostimulatory sequence (ISS) containing polynucleotide conjugated, or attached, to...
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7629118 |
Method of testing wheat
A method of testing the presence/absence of wheat in a food by performing PCR with the use of primers which have been designed on the basis of data obtained from a part of a gene of wheat. This...
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7629164 |
Methods for genotyping polymorphisms in humans
The invention provides nucleic acid sequences that are complementary, in one embodiment, to a collection of human single nucleotide polymorphisms. The invention provides the sequences in such a way...
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7629445 |
Isolated nucleic acid sequence comprising SEQ ID NO: 14 and methods of using said nucleic acid sequence
The present invention provides methods of using Zven1 and Zven2 polypeptides to increase chemokine production. The present invention also provides methods for treating intestinal motility disorders...
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7629449 |
Nucleic acid molecules encoding cysteine proteases
In particular aspects of the invention, nucleic acid molecules encoding novel proteases identified in the midgut of Diabrotica virgfera virgfera (i.e., western corn rootworm) are provided. The...
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7629446 |
Nucleic acid molecules encoding a novel ectoparasite saliva protein
The present invention is directed to a novel product and method for isolating ectoparasite saliva proteins, and a novel product and method for detecting and/or treating allergic dermatitis in an...
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7629160 |
Vectors and methods for enhanced cell longevity and protein expression
It is the object of the current invention to provide methods and compositions relating to the expression of vankyrin proteins in cell lines to increase their viability, longevity and capacity for...
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7629120 |
Method for assembling PCR fragments of DNA
A process for assembling a series of DNA fragments generated by PCR into an ordered circular arrangement for replication and genetic work in cells. The PCR fragments are made with a modified...
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7629447 |
Dideoxynucleoside derivatives
The invention provides a 5′-amino-2′-fluoro-2′,5′-dideoxynucleoside compound represented by the formula [1]:
wherein R 1 represents a nucleic acid base which may have a protecting...
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7629138 |
Estrogen receptor genes and utilization thereof
An estrogen receptor gene and utilization of the estrogen receptor gene. The estrogen receptor gene contains a nucleotide sequence coding for any of the following amino acid sequences: (a) the...
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7628994 |
S. epidermidis antigens
The present invention discloses isolated nucleic acid molecules encoding a hyperimmune serum reactive antigen or a fragment thereof as well as hyperimmune serum reactive antigens or fragments...
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7629321 |
Oligoribonucleotides and ribonucleases for cleaving RNA
Oligomeric compounds including oligoribonucleotides and oligoribonucleosides are provided that have subsequences of 2′-pentoribofuranosyl nucleosides that activate dsRNase. The...
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7629151 |
Method and apparatus for the automated generation of nucleic acid ligands
The present invention includes a method and device for performing automated SELEX. The steps of the SELEX process are performed at one or more work stations on a work surface by a robotic...
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7629444 |
Nucleotide and amino acid sequences from Xenorhabdus bovienii strain Xs85831 and uses thereof
The present invention relates to nucleic acid sequences from Xenorhabdus , and, in particular, to genomic DNA sequences, and to nucleotide sequences that encode insecticidal proteins from ...
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7626014 |
Single-stranded and double-stranded oligonucleotides comprising a 2-arylpropyl moiety
The present invention provides single-stranded and double-stranded oligonucleotides comprising at least one aralkyl ligand that improves the pharmacokinetic properties of the oligonucleotides. The...
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7625703 |
Calpastatin (CAST) alleles
Disclosed herein are novel alleles characterized by polymorphisms in the CAST gene. The alleles may be used to genetically type animals. In a preferred embodiment, the alleles may be used as...
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7625697 |
Methods for constructing subarrays and subarrays made thereby
A method and device for detecting or monitoring the treatment status of a selected physiological state or disease condition. The device has a subarray of genes which show a statistically...
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7625700 |
In vivo library-versus-library selection of optimized protein-protein interactions
The present invention describes a rapid and efficient in vivo library-versus-library screening strategy for identifying optimally interacting pairs of heterodimerizing polypeptides. It allows for...
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7626015 |
Therapeutic uses of inhibitors of RTP801L
The present invention provides novel molecules, compositions, methods and uses for treating microvascular disorders, eye diseases respiratory conditions and hearing disorders based upon inhibition...
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7625706 |
Methods and apparatus for characterizing polynucleotides
Systems and methods for analysis of polymers, e.g., polynucleotides, are provided. The systems are capable of analyzing a polymer at a specified rate. One such analysis system includes a structure...
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7625705 |
Methods and compositions for detection of a target nucleic acid sequence utilizing a probe with a 3′ flap
The invention provides compositions, kits and methods of generating a signal indicative of the presence of a target nucleic acid sequence in a sample by forming a cleavage structure. The cleavage...
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7625699 |
Genetic polymorphisms associated with coronary stenosis, methods of detection and uses thereof
The present invention is based on the discovery of genetic polymorphisms that are associated with coronary stenosis. In particular, the present invention relates to nucleic acid molecules...
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7626007 |
Transcription factor regulating TNF-α
Disclosed herein is an isolated polypeptide comprising the amino acid sequence set forth in SEQ ID NO: 1. The isolated polypeptide binds to the DNA binding domain located from −550 to −487 in...
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7625872 |
Branched immunomodulatory compounds and methods of using the same
The invention provides immunomodulatory compounds and methods for immunomodulation of cells and individuals using the immunomodulatory compounds.
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7625874 |
Compositions and methods for treating diseases associated with T-box and N-Myc
The invention herein provides a mode of treating a disease associated with the regulation of T-Box and N-Myc gene which includes cancers and heart disease in human and other subjects by identifying...
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7626080 |
Plants with reduced activity of a class 3 branching enzyme
The present invention relates to plant cells and plants, which are genetically modified, wherein the genetic modification leads to the reduction of the activity of a Class 3 vegetable branching...
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7625873 |
Antisense antibacterial method and compound
A method and antisense compound for inhibiting the growth of pathogenic bacterial cells are disclosed. The compound contains no more than 12 nucleotide bases and has a targeting nucleic acid...
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7625702 |
Helical wrapping of single-walled carbon nanotubes by genomic DNA
A structure and method for forming single-stranded DNA segments/single-wall carbon nanotube complexes and a method of preparing single-stranded DNA segments. The method for forming single-stranded...
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7626012 |
Nucleic acid molecules which encode antibodies that bind CD40
The present invention relates to antibodies and antigen-binding portions thereof that specifically bind to CD40, preferably human CD40, and that function as CD40 agonists. The invention also...
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7625750 |
Compositions for DNA mediated gene silencing
DNA compositions that mediate gene silencing via RNA interference are provided. The DNA compositions include an RNA polymerase III promoter, which drives expression of a nucleotide sequence...
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7625735 |
Recombinant kinase from insect cells for the synthesis of nucleoside monophosphates
A recombinant Drosophila melanogaster deoxynucleoside kinase that remains stable during the synthesis of nucleoside monophosphate without the addition of stabilizing SH reagents or stabilizing...
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