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7521230 |
Nucleic acid encoding a Brain Derived Tau Kinase polypeptide and methods of use thereof
The present invention provides materials and methods for treating Alzheimer's disease and other tau related neurodegenerative disorders. A tau kinase, Brain Derived Tau Kinase (BDTK) is provided....
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7521222 |
Farnesyl dibenzodiazepinone and processes for its production
This invention relates to a novel farnesylated dibenzodiazepinone, named ECO-04601, its pharmaceutically acceptable salts and derivatives, and to methods for obtaining such compounds. One method of...
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7521595 |
Repressor-mediated regulation system for control of gene expression in plants
The invention provides a method for selectively controlling the transcription of a gene of interest, comprising producing one or more plants that express either a first, a second, or both the first...
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7517644 |
Method and compositions for cellular reprogramming
The present invention provides methods and compositions useful in treating certain diseases herein termed “Aberrant Programming Diseases,” including cancer and AIDS. According to one aspect of...
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7517684 |
Nucleic acid and amino acid sequences relating to Pseudomonas aeruginosa for diagnostics and therapeutics
The invention provides isolated polypeptide and nucleic acid sequences derived from Pseudomonas aeruginosa that are useful in diagnosis and therapy of pathological conditions; antibodies against...
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7518034 |
Compositions and methods for the modification of gene expression
Novel isolated plant polynucleotide promoter sequences are provided, together with genetic constructs comprising such polynucleotides. Methods for using such constructs in modulating the...
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7517971 |
Muteins of human telomerase reverse transcriptase lacking telomerase catalytic activity
The invention provides compositions and methods related to human telomerase reverse transcriptase (hTRT), the catalytic protein subunit of human telomerase. The polynucleotides and polypeptides of...
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7517952 |
Compositions and methods for the therapy and diagnosis of prostate cancer
Compositions and methods for the therapy and diagnosis of cancer, such as prostate cancer, are disclosed. Compositions may comprise one or more prostate-specific proteins, immunogenic portions...
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7517970 |
Nucleic acids encoding kinase and phosphatase enzymes, expression vectors and cells containing same
Methods for expressing active enzymes are described that involve co-expressing a first enzyme with a second enzyme that has an enzymatic activity that reverses a modification on the first enzyme...
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7517969 |
Process for isolating nucleic acid with chaotrope agents and ammonium compounds
A process for isolating nucleic acid from a nucleic acid-containing sample, which comprises: (a) providing a chaotrope; (b) providing a nucleic acid binding solid phase capable of binding nucleic...
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7517863 |
Enhanced secretion/retention of growth hormone releasing hormone (GHRH) from muscle cells by species-specific signal peptide
One aspect of the current invention is a method designing and using species-specific or synthetic signal peptides and GHRH sequences for the purpose of preventing and/or treating chronic illness in...
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7518041 |
Plants and seeds of corn variety I932310
According to the invention, there is provided seed and plants of the corn variety designated I932310. The invention thus relates to the plants, seeds and tissue cultures of the variety I932310, and...
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7517864 |
RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (siNA)
This invention relates to compounds, compositions, and methods useful for modulating VEGF and/or VEGFR gene expression using short interfering nucleic acid (siNA) molecules. This invention also...
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7518042 |
Plants and seeds of corn variety I428355
According to the invention, there is provided seed and plants of the corn variety designated I428355. The invention thus relates to the plants, seeds and tissue cultures of the variety I428355, and...
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7517646 |
Functional molecule and process for producing the same
A process for producing a functional molecule includes a forming step which forms a modified nucleotide n-mer (where, n represents an integer) containing a modified nucleoside prepared by...
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7518035 |
Promoter molecules for use in plants
The present invention provides nucleic acid molecules isolated from Zea mays and Oryza sativa and useful for expressing transgenes in plants. The present invention also provides expression...
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7517645 |
Detection of high grade dysplasia in cervical cells
Methods of using probes and probe sets for the detection of high grade dysplasia and carcinoma in cervical cells are described. Methods of the invention include hybridizing one or more chromosomal...
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7517949 |
Livin-derived peptides, compositions and uses thereof
The present invention relates to livin-derived peptides with pro-apoptotic activity. More specifically, the present invention provides peptides p30-Livin α and p28-Livin β, derived from Livin α...
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7517650 |
Method of diagnosing breast cancer and compositions therefor
A method of diagnosing breast cancer in an individual aged younger than 41 or older than 54 is provided. The method comprises obtaining a nucleic acid from the individual and determining a...
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7514414 |
Suppressors of CpG oligonucleotides and methods of use
The present disclosure relates to oligodeoxynucleotides that suppress an immune response. Methods are disclosed for preventing or treating an immune-mediated disorder, such as, but not limited to,...
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7514238 |
Growth factor homolog zvegf4
Polypeptide growth factors, methods of making them, polynucleotides encoding them, antibodies to them, and methods of using them are disclosed. The polypeptides comprise an amino acid segment that...
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7514219 |
Method for distinguishing between head and neck squamous cell carcinoma and lung squamous cell carcinoma
The present invention is a method distinguishing between head and neck squamous cell carcinoma and lung squamous cell carcinoma. In particular, a 10-gene classifier has been identified which can be...
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7514218 |
Processes for purifying and for detecting target double-stranded DNA sequences by triple helix interaction
The present invention relates to novel target double-stranded DNA sequences capable of interacting with a third strand and of forming a stable triple helix. The present invention also relates to a...
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7514550 |
siRNA targeting myeloid cell leukemia sequence 1
Efficient sequence specific gene silencing of myeloid cell leukemia sequence 1 is possible through the use of siRNA technology. By selecting particular siRNAs directed to myeloid cell leukemia...
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7514211 |
Genomic DNAs participating in rheumatoid arthritis, method of diagnosing the same, method of judging onset risk and diagnostic kit for detecting the same
A genomic DNA involved in rheumatoid arthritis, a method of diagnosing rheumatoid arthritis or a method of judging onset risk of rheumatoid arthritis, and a diagnostic kit for diagnosing rheumatoid...
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7514542 |
Collagen-like protein CLAC, precursor thereof and genes encoding the same
A novel human collagen-like protein CLAC occurring in brain amyloid and its precursor CLAC-P; genes encoding the same; cDNA of mouse CLAC-P and its deduced amino acid sequence; antibodies specific...
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7514087 |
Methods and reagents for immunization which generate a CD8 T cell immune response
New methods and reagents for vaccination are described which generate a CD8 T cell immune response against malarial and other antigens such as viral and tumor antigens. Novel vaccination regimes...
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7514549 |
Tumor inhibition by modulating sprouty expression or activity
Methods are provided for identifying compounds that decrease the expression or activity of an overexpressed Sprouty protein in certain cancers. Such compounds can be useful for treating cancers in...
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7514593 |
Animal model for chronic obstructive pulmonary disease and cystic fibrosis
A nonhuman transgenic mammal is described whose genome comprises a promoter construct operably linked to a heterologous DNA encoding an epithelial sodium channel β subunit, wherein said promoter...
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7514543 |
Polynucleotides encoding immunoadhesins comprising a glycoprotein VI domain
The present invention provides a fusion protein comprising (a) the extracellular domain of glycoprotein VI or a variant thereof that is functional for binding to collagen and (b) the Fc domain of...
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7514551 |
Multisignal labeling reagents, and processes and uses therefor
The present invention provides multisignal labeling reagents and these are useful in a number of biochemical applications, including the manufacture of biomolecular probes and their use in...
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7514548 |
Methods of inhibiting COX-2
The present invention provides RNA molecules (e.g., antisense, RNAi, or siRNA) specific for COX-2, and further provides methods of reducing expression of COX-2 in cells (e.g., cancer cells).
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7514209 |
Diagnosis and prognosis of breast cancer patients
The present invention relates to genetic markers whose expression is correlated with breast cancer. Specifically, the invention provides sets of markers whose expression patterns can be used to...
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7514415 |
Method of treating inflammatory arthropathies with suppressors of CpG oligonucleotides
The present disclosure relates to oligodeoxynucleotides that suppress an immune response. Methods are disclosed for preventing or treating inflammatory arthropathies by administering a...
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7510834 |
Gene mapping method using microsatellite genetic polymorphism markers
The present invention provides a gene mapping method which involves analysis of a DNA sample from a test subject and from a control subject for the presence of an allelic form of a plurality of...
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7511025 |
Compositions and methods for inhibiting the synthesis or expression of MMP-1
The present invention relates to the specific inhibition of matrix metalloproteinase 1 (MMP-1) using agents which inhibit the synthesis or expression of MMP-1. Such agents are useful for...
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7511132 |
Functional and hyperfunctional siRNA directed against Bcl-2
Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rationale design, one can maximize the generation of an effective gene...
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7511128 |
Codon-optimized genes for the production of polyunsaturated fatty acids in oleaginous yeasts
The present invention relates to fatty acid desaturases and elongases able to catalyze the conversion of linoleic acid (LA) to γ-linolenic acid (GLA); α-linoleic acid (ALA) to stearidonic acid...
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7510853 |
Nucleic acids encoding DCRS5
Nucleic acids encoding mammalian, e.g., primate, receptors, purified receptor proteins and fragments thereof. Antibodies, both polyclonal and monoclonal, are also provided. Methods of using the...
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7511125 |
Pyrimidine derivatives for labeled binding partners
Compounds having structure (1)
wherein R 1 is —H a protecting group, a linker or a binding partner; and R 2 and R 34 are as defined in the specification. The invention also provides...
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7510868 |
Chimeric adenoviruses for use in cancer treatment
The present invention relates to oncolytic adenoviruses having therapeutic applications. Recombinant chimeric adenoviruses, and methods to produce them are provided. The chimeric adenoviruses of...
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7510829 |
Multiplex PCR
Compositions and methods for nucleic acid amplification are provided that minimize the formation and amplification of spurious products, particularly in multiplex amplification reactions. Linear...
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7511127 |
Compositions, methods and systems for inferring bovine breed
Provided herein are methods to discover and use single nucleotide polymorphisms (SNP) for identifying breed, or line and breed, or line composition of a bovine subject. The present invention...
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7510835 |
Methods for identifying risk of breast cancer and treatments thereof
Provided herein are methods for identifying risk of breast cancer in a subject and/or a subject at risk of breast cancer, reagents and kits for carrying out the methods, methods for identifying...
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7511024 |
Factor VII or VIIA-like molecules
Conjugates of Factor VII (FVII) and Factor VIIa (FVIIA) are provided, as are methods for preparing them. Methods for producing novel polypeptides contributing to the production of such conjugates...
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7510874 |
Stable cell lines expressing HERG1a and HERG1b
A line of cultured mammalian cells includes HERG1b subunits and optionally HERG1a subunits.
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7511126 |
Position-independent and tissue specific expression of a transgene in milk of transgenic animals
The present invention relates to an isolated insulator DNA molecule consisting of the 5′ and 3′ regions of the porcine wrap gene locus and a method for insulating the expression of an...
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7507810 |
Compositions and their uses directed to IL-4R alpha
Disclosed herein are compounds, compositions and methods for modulating the expression of IL-4R alpha in a cell, tissue or animal. Also provided are methods of target validation. Also provided are...
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7507802 |
Immune stimulating and controlling composition comprising bacterial chromosomal DNA fragments and non-toxic lipopolysaccharides
The present invention relates to immune stimulating and controlling composition comprising bacterial chromosomal DNA fragments and non-toxic lipopolysacchararides. The composition of the present...
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7507789 |
Detection of Anaplasma platys
The invention provides compositions and methods for the detection of Anaplasma platys polynucleotides and polypeptides.
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