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7630837 |
Real-time gene quantification with internal standards
The present invention is directed to a nucleic acid quantification kit and method for determining the initial concentration or mass fraction of a target nucleic acid present in a sample....
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7629518 |
Plants and seeds of hybrid corn variety CH923156
According to the invention, there is provided seed and plants of the hybrid corn variety designated CH923156. The invention thus relates to the plants, seeds and tissue cultures of the variety...
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7629456 |
Modified L-nucleic acid
The present invention relates to a modified L-nucleic acid, comprising a L-nucleic acid part and a non-L-nucleic acid part, whereby the L-nucleic acid part is conjugated to the non-L-nucleic acid...
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7629449 |
Nucleic acid molecules encoding cysteine proteases
In particular aspects of the invention, nucleic acid molecules encoding novel proteases identified in the midgut of Diabrotica virgfera virgfera (i.e., western corn rootworm) are provided. The...
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7629448 |
Compositions for detection and analysis of polynucleotides using light harvesting multichromophores
Methods, compositions and articles of manufacture for assaying a sample for a target polynucleotide are provided. A sample suspected of containing the target polynucleotide is contacted with a...
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7629447 |
Dideoxynucleoside derivatives
The invention provides a 5′-amino-2′-fluoro-2′,5′-dideoxynucleoside compound represented by the formula [1]:
wherein R 1 represents a nucleic acid base which may have a protecting...
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7629446 |
Nucleic acid molecules encoding a novel ectoparasite saliva protein
The present invention is directed to a novel product and method for isolating ectoparasite saliva proteins, and a novel product and method for detecting and/or treating allergic dermatitis in an...
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7629445 |
Isolated nucleic acid sequence comprising SEQ ID NO: 14 and methods of using said nucleic acid sequence
The present invention provides methods of using Zven1 and Zven2 polypeptides to increase chemokine production. The present invention also provides methods for treating intestinal motility disorders...
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7629444 |
Nucleotide and amino acid sequences from Xenorhabdus bovienii strain Xs85831 and uses thereof
The present invention relates to nucleic acid sequences from Xenorhabdus , and, in particular, to genomic DNA sequences, and to nucleotide sequences that encode insecticidal proteins from ...
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7629326 |
Chromosomal modification involving the induction of double-stranded DNA cleavage and homologous recombination at the cleavage site
Methods of modifying, repairing, attenuating and inactivating a gene or other chromosomal DNA in a cell are disclosed. Also disclosed are methods of treating or prophylaxis of a genetic disease in...
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7629324 |
Antisense oligonucleotides for treating atopic diseases and neoplastic cell proliferation
The present invention relates to the use of antisense oligonucleotides directed against specific nucleic acid sequences coding for receptors, alone or in combination, in order to inhibit the...
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7629321 |
Oligoribonucleotides and ribonucleases for cleaving RNA
Oligomeric compounds including oligoribonucleotides and oligoribonucleosides are provided that have subsequences of 2′-pentoribofuranosyl nucleosides that activate dsRNase. The...
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7629164 |
Methods for genotyping polymorphisms in humans
The invention provides nucleic acid sequences that are complementary, in one embodiment, to a collection of human single nucleotide polymorphisms. The invention provides the sequences in such a way...
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7629160 |
Vectors and methods for enhanced cell longevity and protein expression
It is the object of the current invention to provide methods and compositions relating to the expression of vankyrin proteins in cell lines to increase their viability, longevity and capacity for...
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7629151 |
Method and apparatus for the automated generation of nucleic acid ligands
The present invention includes a method and device for performing automated SELEX. The steps of the SELEX process are performed at one or more work stations on a work surface by a robotic...
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7629144 |
Secreted epithelial colon stromal-1 molecules and uses thereof
The present invention provides novel Secreted Epithelial Colon Stromal-1 (Secs-1) polypeptides and nucleic acid molecules encoding the same. The invention also provides vectors, host cells,...
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7629138 |
Estrogen receptor genes and utilization thereof
An estrogen receptor gene and utilization of the estrogen receptor gene. The estrogen receptor gene contains a nucleotide sequence coding for any of the following amino acid sequences: (a) the...
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7629123 |
Compositions and methods for diagnosing autism
Mutations located within the gene encoding the homeobox transcription factor, ENGRAILED 2 (EN2), have now been identified as molecular markers associated with susceptibility for autism and related...
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7629121 |
Notch1 variants associated with cardiovascular disease
Human individuals at increased risk for vascular pathology are identified by determining whether the individuals' genome comprises a Notch1 allele predetermined to be associated with an increased...
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7629120 |
Method for assembling PCR fragments of DNA
A process for assembling a series of DNA fragments generated by PCR into an ordered circular arrangement for replication and genetic work in cells. The PCR fragments are made with a modified...
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7629118 |
Method of testing wheat
A method of testing the presence/absence of wheat in a food by performing PCR with the use of primers which have been designed on the basis of data obtained from a part of a gene of wheat. This...
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7628994 |
S. epidermidis antigens
The present invention discloses isolated nucleic acid molecules encoding a hyperimmune serum reactive antigen or a fragment thereof as well as hyperimmune serum reactive antigens or fragments...
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7628990 |
Immunomodulatory compositions containing an immunostimulatory sequence linked to antigen and methods of use thereof
The invention provides classes of immunomodulatory compositions which comprise an average of one or more immunostimulatory sequence (ISS) containing polynucleotide conjugated, or attached, to...
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7626080 |
Plants with reduced activity of a class 3 branching enzyme
The present invention relates to plant cells and plants, which are genetically modified, wherein the genetic modification leads to the reduction of the activity of a Class 3 vegetable branching...
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7626015 |
Therapeutic uses of inhibitors of RTP801L
The present invention provides novel molecules, compositions, methods and uses for treating microvascular disorders, eye diseases respiratory conditions and hearing disorders based upon inhibition...
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7626014 |
Single-stranded and double-stranded oligonucleotides comprising a 2-arylpropyl moiety
The present invention provides single-stranded and double-stranded oligonucleotides comprising at least one aralkyl ligand that improves the pharmacokinetic properties of the oligonucleotides. The...
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7626012 |
Nucleic acid molecules which encode antibodies that bind CD40
The present invention relates to antibodies and antigen-binding portions thereof that specifically bind to CD40, preferably human CD40, and that function as CD40 agonists. The invention also...
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7626008 |
Anti-angiogenic polypeptides
Anti-angiogenic polypeptides A 61 or p22 are disclosed. Also disclosed are methods of making the polypeptides and methods of treating subjects having angiogenic diseases or conditions.
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7626007 |
Transcription factor regulating TNF-α
Disclosed herein is an isolated polypeptide comprising the amino acid sequence set forth in SEQ ID NO: 1. The isolated polypeptide binds to the DNA binding domain located from −550 to −487 in...
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7625874 |
Compositions and methods for treating diseases associated with T-box and N-Myc
The invention herein provides a mode of treating a disease associated with the regulation of T-Box and N-Myc gene which includes cancers and heart disease in human and other subjects by identifying...
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7625873 |
Antisense antibacterial method and compound
A method and antisense compound for inhibiting the growth of pathogenic bacterial cells are disclosed. The compound contains no more than 12 nucleotide bases and has a targeting nucleic acid...
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7625872 |
Branched immunomodulatory compounds and methods of using the same
The invention provides immunomodulatory compounds and methods for immunomodulation of cells and individuals using the immunomodulatory compounds.
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7625755 |
Conditional knockout method for gene trapping and gene targeting using an inducible gene silencer
A method for conditionally knocking out and altering gene function and genetic sequences that can be used in such methods, for use in gene trapping and gene targeting. Specifically, the genetic...
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7625750 |
Compositions for DNA mediated gene silencing
DNA compositions that mediate gene silencing via RNA interference are provided. The DNA compositions include an RNA polymerase III promoter, which drives expression of a nucleotide sequence...
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7625735 |
Recombinant kinase from insect cells for the synthesis of nucleoside monophosphates
A recombinant Drosophila melanogaster deoxynucleoside kinase that remains stable during the synthesis of nucleoside monophosphate without the addition of stabilizing SH reagents or stabilizing...
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7625706 |
Methods and apparatus for characterizing polynucleotides
Systems and methods for analysis of polymers, e.g., polynucleotides, are provided. The systems are capable of analyzing a polymer at a specified rate. One such analysis system includes a structure...
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7625705 |
Methods and compositions for detection of a target nucleic acid sequence utilizing a probe with a 3′ flap
The invention provides compositions, kits and methods of generating a signal indicative of the presence of a target nucleic acid sequence in a sample by forming a cleavage structure. The cleavage...
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7625703 |
Calpastatin (CAST) alleles
Disclosed herein are novel alleles characterized by polymorphisms in the CAST gene. The alleles may be used to genetically type animals. In a preferred embodiment, the alleles may be used as...
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7625702 |
Helical wrapping of single-walled carbon nanotubes by genomic DNA
A structure and method for forming single-stranded DNA segments/single-wall carbon nanotube complexes and a method of preparing single-stranded DNA segments. The method for forming single-stranded...
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7625701 |
Charge switch nucleotides
The present invention provides compounds, methods and systems for sequencing nucleic acid using single molecule detection. Using labeled NPs that exhibit charged-switching behavior, single-molecule...
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7625700 |
In vivo library-versus-library selection of optimized protein-protein interactions
The present invention describes a rapid and efficient in vivo library-versus-library screening strategy for identifying optimally interacting pairs of heterodimerizing polypeptides. It allows for...
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7625699 |
Genetic polymorphisms associated with coronary stenosis, methods of detection and uses thereof
The present invention is based on the discovery of genetic polymorphisms that are associated with coronary stenosis. In particular, the present invention relates to nucleic acid molecules...
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7625697 |
Methods for constructing subarrays and subarrays made thereby
A method and device for detecting or monitoring the treatment status of a selected physiological state or disease condition. The device has a subarray of genes which show a statistically...
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7625559 |
Antibodies against Clostridium difficile toxins and uses thereof
Antibodies that specifically bind to toxins of C. difficile , antigen binding portions thereof, and methods of making and using the antibodies and antigen binding portions thereof are provided...
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7622658 |
Compositions and methods for altering tocotrienol content
The invention provides isolated nucleic acids and their encoded polypeptides that alter tocotrienol content in seeds. The invention further provides expression cassettes, host cells and transformed...
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7622636 |
Dehydrin gene from Avicennia marina responsible for conferring salt tolerance in plants
The present invention relates to a method of producing salt-stress tolerant plants by transforming the plants with an isolated nucleic acid sequences encoding a dehydrin (DHN) protein. The...
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7622634 |
Use of genes encoding membrane transporter pumps to stimulate the production of secondary metabolites in biological cells
The invention relates to the field of secondary metabolite production in plants and plant cell cultures. More specifically, the invention relates to the use of transporters and more particularly...
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7622574 |
IL-14α RNA inhibitors and antibodies to IL-14α for treatment of autoimmune diseases and lymphomas
Provided are antisense poly-2′-O-(2,4-dinitrophenyl)oligoribonucleotides which are complementary to the IL-14α gene and/or transcribed IL-14α mRNA. Also provided are monoclonal antibodies...
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7622568 |
Isolated nucleic acid molecules encoding cancer associated antigens, the antigens per se, and uses thereof
The invention relates to newly identified cancer associated antigens. It has been discovered that each of these molecules provokes antibodies when expressed by a subject. The ramifications of this...
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7622567 |
Multidimensional organization of heteromolecules by robust DNA motifs
Two dimensional polynucleic acid arrays are assembled from robust nucleic acid motifs as polygonal units. The polygonal units in an array have edges composed of nucleic acid multi-crossover domains...
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