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7390881 |
Recombinant therapeutic fusion proteins
A recombinant bifunctional fusion protein comprises a first component which is the antigenic ectodomain of measles virus hemagglutinin protein (MeaH) genetically modified not to bind to human...
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7385051 |
Fluorescent N2,N3-etheno-purine (2′-deoxy) riboside derivatives and uses thereof
The invention relates to fluorescent N 2 ,N3-etheno-purine (2′-deoxy) riboside derivatives and fluorescent oligonucleotide probes comprising one or more moieties thereof, their preparation and...
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7385043 |
Homogeneous multiplex screening assays and kits
Highly multiplexed homogeneous in vitro screening assays for numerous possible nucleic acid targets, any of which might be present in a sample, utilize fluorescent hybridization probes that are...
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7381807 |
Immunostimulatory oligonucleotides and uses thereof
Oligonucleotides containing the non-palindromic sequence motif:
X 1 X 2 X 3 X 4 X 5 X 6 X 7 X 8 ,
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7375198 |
Modified nucleic acid probes
Oligonucleotide analogue arrays attached to solid substrates and methods related to the use thereof are provided. The oligonucleotide analogues hybridize to nucleic acids with either higher or...
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7374945 |
Method for enhancing the association rates of polynucleotides
The present invention features a method and associated kit for increasing the association rate between polynucleotides having complementary, single-stranded regions, where the method includes...
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7368241 |
Cotton event PV-GHBK04 (757) and compositions and methods for detection thereof
The present invention provides a cotton event PV-GHBK04 (757), a cotton plant that contains PV-GHBK04 (757) DNA molecules and its progeny thereof, and methods for producing cotton event PV-GHBK04...
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7361746 |
Methods and compositions for detection of Mycobacterium avium complex species
Methods of detecting Mycobacterium avium complex (MAC) organisms using in vitro nucleic acid amplification with amplification oligonucleotides specific for 16S rRNA or DNA sequences encoding 16S...
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7358353 |
Nucleic acid and corresponding protein named 158P1D7 useful in the treatment and detection of bladder and other cancers
A novel gene (designated 158P1D7) and its encoded protein are described. While 158P1D7 exhibits tissue specific expression in normal adult tissue, it is aberrantly expressed in multiple cancers...
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7345031 |
Pharmaceutical dopamine glycoconjugate compositions and methods of their preparation and use
Hydrophilic transportable N-linked glycosyl dopaminergic prodrug compounds according to FORMULA V and methods of their use,
wherein,
Ring 1 comprises an aryl or heteroaryl ring having 4...
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7342108 |
De novo DNA cytosine methyltransferase genes, polypeptides and uses thereof
De novo DNA cytosine methyltransferase polynucleotides and polypeptides and methods for producing said polypeptides are disclosed. Also disclosed are methods for utilizing de novo DNA cytosine...
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7341738 |
Lipid-encapsulated polyanionic nucleic acid
Methods for the preparation of a lipid-nucleic acid composition are provided. According to the methods, a mixture of lipids containing a protonatable or deprotonatable lipid, for example an amino...
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7339038 |
Heparanase specific molecular probes and their use in research and medical applications
A variety of heparanase specific molecular probes which can be used for research and medical applications including diagnosis and therapy. Specific applications include the use of a heparanase...
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7338932 |
Methods of modulating functions of polypeptide GalNAc-transferases and of screening test substances to find agents herefor, pharmaceutical compositions comprising such agents and the use of such agents for preparing medicaments
Attachment of O-glycans to proteins is controlled by a large family of homologous polypeptide GalNAc-transferases. Polypeptide GalNAc-transferases contain a C-terminal sequence with similarity to...
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7335765 |
Nucleoside and oligonucleotide analogues
A compound of the formula (1):
wherein R 1 and R 2 are the same or different and represent a hydrogen atom, a hydroxyl protecting group, a phosphate group, or —P(R 3 )R 4 , wherein R 3 and...
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7329493 |
One-tube nested PCR for detecting Mycobacterium tuberculosis
The present invention relates to a kit and method for detecting M. tuberculosis of suspected patient. The present invention also relates to primers and probe used to detect M. tuberculosis by...
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7323310 |
Methods and compositions for RNA amplification and detection using an RNA-dependent RNA-polymerase
Methods and compositions are provided for amplifying RNA from an RNA template. Methods and compositions are further provided for detecting an RNA in an RNA containing sample. Compositions used for...
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7312057 |
Method for reducing binding of organic material to hydrophobic surfaces
Hydrophobic polymer surfaces whose level of protein binding is less than about 50-80 ng/cm 2 are achieved by: (1) applying a coating solution composed of a solvent and a non-ionic surfactant...
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7309567 |
Method for reducing fluorescence quenching in bioassays
The invention relates to a process for reducing the fluorescence quenching caused by the measuring medium, in a fluorescence assay for an analyte using at least one fluorescent label, characterized...
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7306910 |
Breast cancer prognostics
A method of providing a prognosis of breast cancer is conducted by analyzing the expression of a group of genes. Gene expresson profiles in a variety of medium such as microarrays are included as...
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7306909 |
Canola event pv-bngt04(rt73) and compositions and methods for detection thereof
The present invention provides assays for detecting the presence of the PV-BNGT04(RT73) canola event based on the DNA sequence of the recombinant construct inserted into the canola genome and of...
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7301016 |
Human transferase family members and uses thereof
The invention provides isolated nucleic acids molecules, designated 33877, 47179, 26886, 25552, 32132, 32244, 23680, 32624, 47174, 60491, 46743, 27417, 27960, 32252, and 53320 nucleic acid...
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7297778 |
Complexity management of genomic DNA
The presently claimed invention provides for novel methods and kits for analyzing a collection of target sequences in a nucleic acid sample. A sample is amplified under conditions that enrich for a...
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7294467 |
Quantitative analysis of DNA
The present invention is related to a novel approach for quantitation of DNA based on the stoichiometric existence of phosphorus (P) in DNA.
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7291462 |
TADG-15: an extracellular serine protease overexpressed in carcinomas
The present invention provides DNA encoding a TADG-15 protein as well as a TADG-15 protein. Also provided is a vector capable of expressing the DNA of the present invention adapted for expression...
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7285384 |
Parallel genotyping of multiple patient samples
The present invention relates to parallel genotyping (or other sample analysis) of multiple patients by direct sample immobilization onto microspheres of an array. The patient beads can then be...
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7285242 |
Biochemical analysis unit and biochemical analyzing method using the same
A biochemical analysis unit includes a substrate made of a material capable of attenuating radiation energy and/or light energy and formed with a plurality of holes, and a plurality of absorptive...
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7282333 |
Methods and compositions for nucleic acid analysis
The present invention relates to improved methods and composition for nucleic acid analysis. In particular, the present invention provides improved methods and compositions for carrying out nucleic...
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7279563 |
Compounds for protecting hydroxyls and methods for their use
A hydrocarbyldithiomethyl-modified compound of the Formula:
R 1 —O—CH 2 —S—S—R 2
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7276595 |
DNA sequence encoding a retinoic acid regulated protein
The present invention concerns a novel retinoic acid regulated gene whose expression product displays useful morphogenic/mitogenic properties. The present invention further concerns an isolated...
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7276357 |
Compositions and methods for enhancing polynucleotide amplification reactions
Compositions and methods for enhancing PCR and other polynucleotide replication reactions are disclosed. These comprise the addition of low molecular weight organic amides, sulfones or sulfoxides...
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7273934 |
Three-branched sugar-chain asparagine derivatives, the sugar-chain asparagines, the sugar chains, and processes for producing these
A 3-branched asparagine-linked oligosaccharide derivative of the formula (1) wherein the nitrogen of amino group of asparagine is modified with a lipophilic protective group, biotin group or FITC...
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7270980 |
Compounds for immunodiagnosis of prostate cancer and methods for their use
Compounds and methods for diagnosing prostate cancer are provided. The inventive compounds include polypeptides containing at least a portion of a prostate tumor protein. The inventive polypeptides...
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7270956 |
Methods and compositions for detection and analysis of polynucleotides using light harvesting multichromophores
Methods, compositions and articles of manufacture for assaying a sample for a target polynucleotide are provided. A sample suspected of containing the target polynucleotide is contacted with a...
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7264931 |
Method for sequencing nucleic acid sequences without chain termination
A method is provided for determining the sequence of a nucleic acid sequence via incubation of a primer extended product of the nucleic acid sequence in separate pools of semi-random...
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7262007 |
Dye-labeled oligonucleotide for labeling a nucleic acid molecule
The invention relates to an oligonucleotide which serves as a nucleic acid probe comprising a loop section with a loop sequence complementary to the target sequence of the nucleic acid molecule; a...
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7258980 |
Determining non-nucleic acid molecule binding to target by competition with nucleic acid ligands
A competitive binding assay is used to determine whether a non-nucleic acid molecule from a library of non-nucleic acid molecules binds to a target. The non-nucleic acid molecule competes with a...
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RE39793 |
Compositions for sorting polynucleotides
The invention provides a method of tracking, identifying, and/or sorting classes or subpopulations of molecules by the use of oligonucleotide tags. Oligonucleotide tags of the invention each...
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7253254 |
Polypeptide variants with increased heparin-binding capacity
The invention pertains to polypeptide variants with increased heparin-binding ability. Increased heparin-binding ability is achieved by addition, insertion, and/or substitution of an amino acid...
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7252936 |
Method for the detection of the antibiotic resistance spectrum of Mycobacterium species
Method for the detection of the antibiotic resistance spectrum of Mycobacterium species present in a sample, possibly coupled to the identification of the Micobacterium species involved,...
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7244602 |
Polymerase chimeras
The invention concerns polymerase chimeras which are composed of amino acid fragments representing domains and which combine properties of naturally occurring polymerases that are advantageous with...
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7238505 |
Immobilized DNA polymerase
The present invention relates to a DNA polymerase immobilized by covalent bonding. More particularly, the present invention relates to an immobilized DNA polymerase whose activity is maximally...
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7227019 |
Process for the preparation of rebeccamycin and analogs thereof
The present invention relates to a method for making an indolopyrrolocarbazole of the general formula [I], where the method includes the step of reacting a bisindolylmaleimide compound with an...
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7220846 |
DNA polymorphisms in sterol regulator element binding proteins
The invention relates to DNA polymorphisms in sterol regulator element binding proteins (SREBP) that are characteristic of a higher risk of genetic diseases in humans such as hyperchlolesterolemia....
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7217805 |
Bicyclonucleoside analogues
Bicyclonucleoside analogues which exhibit anti-AIDS activity and intermediates to produce oligonucleotide analogues which have anti-sense or anti-gene activity as well as in vivo stability....
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7217508 |
Cloned DNA sequence related to genomic RNA of human immunodeficiency virus (HIV-1)
This invention is in the field of lymphadenopathy virus, which has been designated Human Immunodeficiency Virus Type 1 (HIV-1). This invention relates to a diagnostic means and method to detect the...
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7214783 |
Universal bases for nucleic acid analyses, methods for using universal bases, and kits comprising universal bases
Compounds, methods and kits for making and analyzing primer extension products incorporating one or more universal bases are described, including methods and kits for nucleic acid sequencing and...
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7211384 |
Comparative genomic hybridization assays using immobilized oligonucleotide targets with initially small sample sizes and compositions for practicing the same
Comparative genomic hybridization assays and compositions for use in practicing the same are provided. In the subject methods, at least first and second genomic templates are prepared from first...
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7205399 |
Methods and reagents for oligonucleotide synthesis
The present invention features novel compositions, linkers, derivatized solid supports, and methods for the efficient solid phase synthesis of oligonucleotides, including RNA, DNA, RNA-DNA...
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7202022 |
Method for identification, separation and quantitative measurement of nucleic acid fragments
The invention relates to a new method for sequence-specific identification, separation and quantitative measurement of nucleic acid fragments. The invention is based on the use of restriction...
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