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6872810 |
Biochemical sensor system with increased sensitivity by molecular amplification of signal
The present invention provides a simplified method for identifying differences in nucleic acid abundances (e.g., expression levels) between two or more samples. The methods involve providing an...
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6872816 |
Nucleic acid detection kits
The present invention relates to means for the detection and characterization of nucleic acid sequences, as well as variations in nucleic acid sequences. The present invention also relates to...
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6870039 |
Synthesis of oligonucleotides
Synthetic processes are provided for the solution phase synthesis of oligonucleotides, especially phosphorothioate oligonucleotides, and intermediate compounds useful in the processes....
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6867294 |
Gapped oligomers having site specific chiral phosphorothioate internucleoside linkages
Novel chiral compounds that mimic and/or modulate the activity of wild-type nucleic acids are disclosed. In general, the compounds are phosphorothioate oligonucleotides wherein the 5′, and the...
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6861506 |
Compositions and methods for the treatment and diagnosis of breast cancer
Compositions and methods for the detection and therapy of breast cancer are disclosed. The compounds provided include nucleotide sequences that are preferentially expressed in breast tumor tissue,...
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6861247 |
Salmonella secreted proteins and uses thereof
Substantially pure Salmonella secreted proteins (Ssp), the sercetion of which is dependent upon the expession of PrgH; methods of diagnosing Salmonella infection; and live attenuated vaccine...
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6858711 |
Labeling reagents
The present invention provides a simplified method for identifying differences in nucleic acid abundances (e.g., expression levels) between two or more samples. The methods involve providing an...
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6858392 |
Blocking of device for detecting biochemically active molecules
A process for blocking a device for detection of biochemically active molecules is performed by the steps of:
bringing in the presence of an aqueous medium a detection device having probe...
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6858721 |
Method for producing cytosine nucleoside compounds
The invention provides a method for producing a cytosine nucleoside compound from pentose-1-phosphate and cytosine or a derivative thereof using a nucleoside phosphorylase reactive to cytosine or a...
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6858390 |
Aptamers containing sequences of nucleic acid or nucleic acid analogues bound homologously, or in novel complexes
An aptamer contains at least two parallel or antiparallel heteropolymeric nucleobase-containing sequences bonded together by Watson-Crick complementary base interaction or by homologous base...
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6858722 |
Oligomer phosphoramidite compositions and processes for synthesizing the same
Synthetic processes are provided wherein oligomers are prepared using phosphoramidite compositions. Oligomers having phosphodiester, phosphorothioate, phosphorodithioate covalent linkages are...
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6855499 |
Magnetic isolation and purification of nucleic acids
A method for the isolation and purification of nucleic acids such as DNA, RNA, and PNA from various sources using magnetizable cellulose or its derivatives. Adjusting the concentrations of the salt...
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6855698 |
Topoisomerase I selective cytotoxic sugar derivatives of indolopyrrolocarbazoles
The present invention relates to fluoro sugar and other sugar derivatives of indolopyrrolocarbazoles, their salts and hydrates, which exhibit selective topoisomerase I (topo I) activity, are useful...
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6855519 |
Methods for enhancing the production of interferon in cell culture
Methods for enhancing the production of interferons in animal cell culture are described. These methods rely on the manipulation of the cellular levels of certain inducers of interferon production,...
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6852490 |
Methods of using an array of pooled probes in genetic analysis
The invention provides arrays of polynucleotide probes having at least one pooled position. A typical array comprises a support having at least three discrete regions. A first region bears a pool...
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6852531 |
Compositions and methods for reproducing and modulating mammalian messenger RNA decapping
An in-vitro system in which mammalian messenger RNA decapping occurs is provided, for use in identifying modulators, deficiencies, and other aspects of the regulation of RNA turnover.
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6849723 |
Oligonucleotide analogs having modified dimers
Modified dimers having a ribose sugar moiety in the 5′ nucleoside and a 2′ modified sugar in the 3′ nucleoside are provided. The modified dimers are useful in the preparation of...
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6849402 |
Method and device to quantify DNA and RNA
The invention relates to a device and a method for the detection, especially on line detection, of an amplification of a DNA and/or RNA sequence in a sample. The amplification of the DNA and/or RNA...
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6849726 |
Non-nucleotide containing RNA
The present invention relates to RNA molecules containing one or more non-nucleotide mimetics.
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6846807 |
Colorectal neoplasia prophylaxis
Development of colorectal neoplasia in a patient subject or predisposed to colorectal neoplasia is reduced by the steps of (a) determining a patient is subject or predisposed to colorectal...
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6846918 |
Nucleoside modifications by palladium catalyzed methods
This invention discloses a method for the preparation of 2′-modified nucleosides, using a palladium catalyst and an alkene functionalized with a heteroatom. Included in the invention are the...
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6846629 |
Methods and apparatus for improved luminescence assays using microparticles
Microparticles comprising a core and electrochemiluminescent moieties within the core and methods of using the same in assays.
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6841351 |
High-throughput transcriptome and functional validation analysis
Methods for correlating genes and gene function are provided. Such methods generally involve selecting a candidate gene that appears to be correlated with a particular cellular state or activity...
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6841675 |
Piperazine-based nucleic acid analogs
A novel nucleoside analog is disclosed which comprises a piperazine ring in the place of the ring ribose or deoxyribose sugar. Monomers utilizing a broad variety of nucleobases are disclosed, as...
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6838242 |
Modifying double stranded DNA to enhance separations by matched ion polynucleotide chromatography
Covalently bound non-polar tags are used to increase the retention times of double stranded polynucleotides on Matched Ion Polynucleotide Chromatography (MIPC) columns. In doing so, separations of...
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6838244 |
Fluorescent oligonucleotides and uses thereof
Oligonucleotide molecules labeled with a plurality of fluorophores of one or more types embedded in the backbone of said oligonucleotide, wherein at least one of said fluorophores is not located at...
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6838243 |
Methods and compositions for polynucleotide analysis using generic capture sequences
Methods, compositions and articles of manufacture for assaying a sample for an amplification product from a target polynucleotide are provided. An amplification reaction is used to produce the...
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6835820 |
Polyhydroxyalkanoate biosynthesis associated proteins and coding region in bacillus megaterium
A 7,916 base pair nucleic acid fragment from Bacillus megaterium is disclosed. The fragment encodes five proteins, PhaP, PhaQ, PhaR, PhaB, 09 and PhaC, shown or inferred to be involved in the...
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6835819 |
Sequences and their use
Novel non-coding sequences isolated upstream of the human IRS-2 gene are disclosed as markers for the prediction and/or diagnosis of IRS-2 related metabolic disorders or diseases, such as diabetes....
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6835827 |
Labelled oligonucleotides synthesized on solid-supports
Methods and compositions to label oligonucleotides and analogs directly on a solid-support having the structure where S is a solid-support, A is a cleavable linker, X is a moiety with three or...
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6835395 |
Composition containing small multilamellar oligodeoxynucleotide-containing lipid vesicles
Lipidic compositions with superior characteristics for in vivo delivery of oligodeoxynucleotides (ODN) can easily and efficiently be made in the form of small multilamellar vesicles. The...
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6833446 |
Compositions and methods for the modification of gene transcription
Novel isolated polynucleotides that encode plant transcription factors are provided, together with DNA constructs comprising such polynucleotides. Methods for using such constructs in modulating...
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6828434 |
Oligonucleotide and nucleotide amine analogs, methods of synthesis and use
Novel amine compounds are provided by the present invention. Methods of preparing and using said novel amine compounds are also provided.
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6825338 |
Labeled oligonucleotides, methods for making same, and compounds useful therefor
Selectively functionalized oligonucleotides, methods for making same, and compounds useful therefor are disclosed. The oligonucleotides can be selectively functionalized with a first conjugate...
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6825339 |
Apparatus for preparing polynucleotides on a solid support
The present invention relates to an apparatus for preparing polynucleotides on a solid support in a reactor comprising a column containing an immobilized solid support that is functionalized for...
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6824980 |
Isometric primer extension method and kit for detection and quantification of specific nucleic acid
A method for detecting and/or quantifying a target DNA or RNA present in a sample by a isometric primer extension method is disclosed. The method includes carrying out a primer extension reaction...
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6825178 |
Methods and products for treating pseudomonas infection
Methods and products for upregulating cystic fibrosis transmembrane conductance regulators are provided, including methods and products for the treatment of P. aeruginosa infection. The products...
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6821727 |
Hybridization assay using self-quenching fluorescence probe
A hybridization assay is provided which uses an oligonucleotide probe which includes a fluorescent reporter molecule and a quencher molecule capable of quenching the fluorescence of the reporter...
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6821771 |
Device for thermo-dependent chain reaction amplification of target nucleic acid sequences, measured in real-time
The present invention concerns a device for amplifying target nucleic acids, reaction cartridge s for use in the device, and modes of use of the device.
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6821737 |
Method for screening for drug candidates for modulating transcription factor activity
Method and kits are provided for screening for transcription factor modulators efficiently. In one aspect, the method can be employed to profile multiple, different transcription factors activated...
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6818759 |
2′-O-alkylthioalkyl and 2′-C-alkylthioalkyl-containing nucleic acids
A compound having the formula: wherein, R1 represents 2′-O-alkylthioalkyl or 2′-C-alkylthioalkyl; X represents a base or H; Y represents a phosphorus-containing group; and R2 represents H,...
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6815441 |
Reaction products of taurultam and glucose
Reaction products of taurultam and glucose are useful as antineoplastic agents. They are produced by reacting an aqueous solution of taurultam and glucose at about 100 degrees Celsius for about 30...
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6815165 |
METHOD FOR IDENTIFYING MYCOBACTERIUM TUBERCULOSIS AND MYCOBACTERIA OTHER THAN TUBERCULOSIS, TOGETHER WITH DETECTING RESISTANCE TO AN ANTITUBERCULOSIS DRUG OF MYCOBACTERIA OBTAINED BY MUTATION OF RPOB GENE
The present invention provides a method for identifying Mycobacterium tuberculosis and non-tuberculosis Mycobacterium (MOTT), and for the determination of drug susceptibility of M. tuberculosis ...
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6811980 |
Process for immobilization of nucleic acid molecules on a substrate
The present invention relates to a process for immobilization of nucleic acid molecules on a substrate, wherein the substrate is treated with atomic oxygen plasma prior to immobilizing the nucleic...
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6812335 |
Human polypeptide receptors for lysophospholipids and sphingolipids and nucleic acids encoding the same
Human Edg4 and Edg5 polypeptides and their respective amino acid and nucleic acid sequences are provided for use in investigating cytoprotection, apoptosis, cellular proliferation, and other...
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6808873 |
Screening assays using intramitochondrial calcium
The invention provides methods for screening for agents that modulate mitochondrial function and in particular mitochondrial regulation of intracellular calcium. The methods may be used to detect...
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6808888 |
Universal nucleic acid amplification system for nucleic acids in a sample
Methods for amplifying nucleic acid in a sample comprising providing the sample with a set of primers to enable synthesis of at least one nucleic acid strand complementary to at least part of the...
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6806052 |
Planar arrays of microparticle-bound polynucleotides
An apparatus and system are provided for simultaneously analyzing a plurality of analytes anchored to microparticles. Microparticles each having a uniform population of a single kind of analyte...
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6806361 |
Methods of enhancing functional performance of nucleic acid arrays
Methods are provided for preparing nucleic acid arrays on a support. In these methods a plurality of nucleic acids are synthesized on the support and the synthesis steps are followed by drying...
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6806051 |
Arrays of partially nonhybridizing oligonucleotides and preparation thereof using focused acoustic energy
Partially nonhybridizing oligonucleotides are provided that contain two or more hybridizing segments, with any two hybridizing segments separated by a nonhybridizing spacer segment, i.e., a...
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