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6949633 |
Primers useful for sizing nucleic acids
The present invention provides modified oligonucleotide primers designed to incorporate a cleavable moiety so that a 3′ portion of the primer (linked to an extension product) can be released from...
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6949339 |
Method of diagnosing, monitoring, and staging colon cancer
The present invention provides a new method for detecting, diagnosing, monitoring, staging, and prognosticating colon cancer.
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6946575 |
Trityl-type compounds and their use
The present invention pertains to trityl-type compounds comprising, bonded to the same atom, three aryl groups, of which at least one is a fluorophore and at least one has a substituent including a...
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6942967 |
Target for treating athersclerosis, obesity and type II diabetes
The invention concerns the use of the apobec-1 protein or associated proteins for treating atherosclerosis and obesity, type II diabetes (non-insulin-dependent), or other diseases, characterised in...
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6936702 |
Charge-switch nucleotides
The present invention provides compounds, methods and systems for sequencing nucleic acid using single molecule detection. Using labeled NPs that exhibit charge-switching behavior, single-molecule...
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6936709 |
Method for purifying protected 2′-deoxycytidines and hydrated crystals thereof
A protected 2′-deoxycytidine is purified by precipitating the protected 2′-deoxycytidine represented by general formula (3) in the form of a hydrated crystal from a solution containing the...
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6936596 |
Adenosine derivatives and use thereof
2-(6-Cyano-1-hexyn-1-yl)adenosine, 2-(6-cyano-1-hexyn-1-yl)adenosine 5′-monophosphate, or salts thereof; and drugs containing the same as an active ingredient. The compounds have excellent...
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6933111 |
Glufosinate tolerant rice
This invention pertains to plants, plant material and seeds characterized by harboring a specific transformation event particularly by the presence of the bar gene under control of a CaMV 35S...
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6930097 |
Matrix metalloproteinase and tumor necrosis factor inhibitors
A compound of formula 1-[3,4-dihydroxy-5-(2-hydroxyethyl)tetrahydrofuran-2-yl]pryi
midine-2,4(1H,3H)-dione has inhibitory effects of matrix metalloproteinase-2 (gelatinase A) enzyme and binding of...
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6924109 |
High-throughput transcriptome and functional validation analysis
Methods for correlating genes and gene function are provided. Such methods generally involve selecting a candidate gene that appears to be correlated with a particular cellular state or activity...
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6924113 |
Method and kit for isolating DNA probes that bind to activated transcription factors
Methods, arrays and kits are provided for rapidly and efficiently identifying and quantifying multiple different activated transcription factors in a biological sample at the same time. In one...
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6924107 |
Four dimensional biochip design for high throughput applications and methods of using the four dimensional biochip
The present invention provides a 4D biochip containing m 3D biochips having n capillaries, wherein the n capillaries each contain a biological factor, and methods for preparing and using the 4D...
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6921640 |
Process for labeling a ribonucleic acid
The present invention relates to a process for labeling a synthetic or natural ribonucleic acid (RNA). It also relates to RNA fragments, which have been labeled by fragmenting the RNA to free a...
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6919175 |
System for releasing and isolating nucleic acids
A procedure for the release and isolation of nucleic acids from biological compartments of a sample always uses an instrument that can hold one or more sample processsing vessels, maintain the...
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6919445 |
Methods of labelling polynucleotides with dibenzorhodamine dyes
Dibenzorhodamine compounds having the structure
are disclosed, including nitrogen- and aryl-substituted forms thereof. In addition, two intermediates useful for synthesizing such compounds are...
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6916613 |
Compositions, methods, kits and apparatus for determining the presence or absence of target molecules
The present invention is directed to methods, compositions, kits and apparatus to identify and detect the presence or absence of target analytes. The embodiments of the present invention have...
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6916612 |
Sets of oligonucleotide-binding e-tag probes
Probe sets for the multiplexed detection of known, selected nucleotide target sequences are provided. Detection involves the release of identifying tags as a consequence of target recognition. The...
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6913880 |
Method for determining transcription factor activity and its technical uses
Certain transcription factors (enhancer binding proteins) significantly increase transcription rates from genes by nicking a single DNA strand in the vicinity of their DNA binding sites, thereby...
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6911535 |
Biomolecule/polymer conjugates
The present invention is directed to methods for immobilizing natural or synthetic biomolecules to surfaces. The methods comprise covalently linking the natural or synthetic biomolecule to a mono-...
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6905823 |
Cellular arrays and methods of detecting and using genetic disorder markers
A method is disclosed for rapid molecular profiling of tissue or other cellular specimens by placing a donor specimen in an assigned location in a recipient array, providing copies of the array,...
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6905817 |
Ret-independent signaling pathway for GDNF
Methods for screening for agonists and antagonists of GPI-anchored independent intracellular signaling resulting in [Ca 2+ ] i elevation, ERK1, ERK2 and CREB phosphorylation, and Src family kinase...
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6905826 |
Methods and compositions for microarray control
This invention relates to assay for detecting or determining the amount of target molecules in a sample. In certain embodiments, the invention relates to nucleic acid arrays and controls used in...
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6902893 |
Lyme disease vaccines
The present invention relates to novel vaccines for the prevention or attenuation of Lyme disease. The invention further relates to isolated nucleic acid molecules encoding antigenic polypeptides...
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6902903 |
Helicobacter pylori diagnostics
Novel methods, membrane supports and immunodiagnostic test kits for diagnosing Helicobacter pylori infection, are disclosed. The methods can also be used to monitor the progress of treatment of...
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6903183 |
Compositions and methods for regulation of steroidogenesis
Compositions and methods relating to the regulation of transport of cholesterol into the mitochondria of a cell and, therefore, for the regulation of steroidogenesis are provided. Compositions...
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6900301 |
Backbone modified oligonucleotide analogues
Therapeutic oligonucleotide analogues which have improved nuclease resistance and improved cellular uptake are provided. Replacement of the normal phosphorodiester inter-sugar linkages found in...
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6900010 |
Compositions and methods for detecting human immunodeficiency virus
Methods are provided for screening natural and synthetic anti-HIV agents using recombinant cells that are rendered susceptible to productive infection of various strains, subtypes or clades of HIV...
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6900299 |
Interrupting the interaction of intercellular adhesion molecule-1 and respiratory syncytial virus for prevention and treatment of infection
There is provided a method of preventing a respiratory infection by administering an effective amount of an agent for regulating ICAM-1 expression. Also provided is a composition for the prevention...
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6900298 |
Process for producing nucleic acid derivative
A process for efficiently producing a nucleic acid derivative by condensing a specific nitrogen-containing heterocyclic compound such as a dinitrogen 6-membered heterocyclic compound or a...
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6897021 |
Reactive probe chip, composite substrate and method for fabrication of the same
A reaction probe chip which is prepared by loading a reactive probe on fine pieces of carrier such as particles, tile-like plates and then arraying and immobilizing the reactive probe-loaded...
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6897051 |
β, β-carotene 15, 15′-monooxygenases, nucleic acid sequences coding therefor and their use
Nucleic acid sequences coding for a protein having β,β-carotene 15,15′-monooxygenase activity and their uses in diagnostics, the synthesis of vitamin A and methods for the introduction of the...
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6893821 |
Agents that modulate DNA-PK activity and methods of use thereof
The present invention provides methods for modulating cell death in a eukaryotic cell, and methods for reducing DNA damage in a eukaryotic cell. The methods generally comprise modulating a...
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6890736 |
Methods for producing proteins in cultured cells
The invention provides a method for increasing production of a protein by cultured mammalian cells comprising adding a DNA demethylating agent, for example a cytidine analogue, to the mammalian...
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6887664 |
Asynchronous primed PCR
An asynchronous thermal cycling protocol for nucleic acid amplification uses two primers with thermal melting temperatures different by about 10 to 30° C. After the higher melting primer has...
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6887667 |
Method and apparatus to identify small variations of biomolecules
Many diseases are related to variations in the genetically specified structure of proteins synthesized by cells. Genetic engineering is now able to identify the structural variations and to...
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6887707 |
Induction of viral mutation by incorporation of miscoding ribonucleoside analogs into viral RNA
The present invention is directed to the identification and use of ribonucleoside analogs to induce the mutation of an RNA virus, including BVDV, HIV and HCV, or a virus which otherwise replicates...
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6884583 |
Determination of a genotype of an amplification product at multiple allelic sites
A method is provided for genotyping a target sequence at at least two allelic sites by a 5′ nuclease amplification reaction. In one embodiment, the method includes performing a nucleic acid...
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6884576 |
Methods of monitoring HIV drug resistance
A method is provided for detecting a presence of HIV virus in a sample comprising: taking a culture of recombinant cells which (a) are capable of cell division, (b) express CD4 receptor and one or...
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6884881 |
2′-Substituted RNA preparation
A process for the preparation of a compound of formula (1):
is provided, which comprises the reaction a compound of formula (2):
with a compound of formula Al(OR) 3 under substantially...
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6884880 |
Process for the preparation of 9-β-anomeric nucleoside analogs
A process for substantially enhancing the regio and stereoselective synthesis of 9-β-anomeric nucleoside analogs is described. The introduction of the sugar moiety onto a 6-substituted purine base...
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6881544 |
Method of amplifying or detecting HIV-1 RNA
A simple, speedy and sensitive method of detecting HIV-RNA using an oligonucleotide which can bind to an intramolecularly free region of the genomic RNA of HIV-1 at relatively low and constant...
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6881571 |
Qualitative differential screening
The invention concerns a method for identifying and/or cloning nucleic acid regions representing qualitative differences associated with alternative splicing events and/or with insertions,...
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6881555 |
AKT nucleic acids, polypeptides, and uses thereof
The present invention relates to human Akt3 proteins and polypeptides. The invention also relates to isolated nucleic acids encoding human Akt3, to vectors containing them and to their therapeutic...
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6878693 |
Hydrophilic complexes of lipophilic materials and an apparatus and method for their production
This invention provides a soluble inclusion complex formed of a water-insoluble lipophilic compound and an amphiphilic polymer and which demonstrated improved solubility and stability. The...
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6875859 |
Heterocyclic compounds and their use in the detection of nucleic acids
The invention concerns compounds of the general formula (I) in which the residues R 1 to R 7 have the meanings given in the application as well as methods for their preparation. The compounds are...
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6875750 |
Aziridine compounds and methods of making and using them
Aziridine derivatives of formula (I)
are disclosed which can be used as cofactor for S-adenosyl-L-methionine-dependent methyltransferases.
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6875857 |
Reagent for the isolation of RNA
The present invention provides RNA extraction reagents, methods and kits that are especially useful for extracting RNA. The reagents, methods and kits of the present invention are especially useful...
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6875572 |
Nucleic acid detection assays
The present invention relates to means for the detection and characterization of nucleic acid sequences, as well as variations in nucleic acid sequences. The present invention also relates to...
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6875850 |
Reagent for labelling nucleic acids
The present invention concerns a labelling reagent in which the label is bound via an amide bond and a linker to a residue of the molecule which is essentially characterized in that the N atom of...
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6872550 |
Immunogenic formulation of OspC antigen vaccines for the prevention and treatment of lyme disease and recombinant methods for the preparation of such antigens
A novel approach to Borrelia vaccine formulation taking into account serological, genotypic and epidemiological information by which OspC proteins from different strains of B. burgdorferi are...
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