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6489159 |
Polymeric arrays and methods for their use in binding assays
Arrays of a plurality of different heterogeneous polymeric target compositions immobilized on the surface of a solid support are provided. In the subject arrays, the constituent polymeric targets...
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6489456 |
Isolated human secreted proteins, nucleic acid molecules encoding human secreted proteins, and uses thereof
The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the secreted peptides of the present invention. The present invention specifically...
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6489120 |
System and method for a parallel immunoassay system
A method and system for detecting a target antigen using massively parallel immunoassay technology. In this system, high affinity antibodies of the antigen are covalently linked to small beads or...
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6489466 |
C-3′ protected monomeric nucleotides and synthesis of oligonucleotides on solid support
Immobilized nucleotide primers of this invention include a modified nucleotide tethered to a support substrate through a linking group. In particular, the modified nucleotide is constructed such...
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6486286 |
Use of hexahydrolupulones as antibacterial agents
Provided are functionalized silicon compounds and methods for their synthesis and use. The functionalized silicon compounds include at least one activated silicon group and at least one...
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6482641 |
DNA-based integrated circuit
This Invention, a kind of DNA-based integrated circuit, with the DNA dyeing technology, the inlaying principle between anti-cancer medicine and DNA molecules, can change energy gap of DNA molecules...
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6482589 |
Nucleic acid probes for the detection of genital mycoplasmas
Nucleic acids having approximately 10 to 250 nucleotides which are capable of hybridizing to rRNA and RDNA of mycoplasma etiological agents of nongonococcal urethritis, pelvic inflammatory disease,...
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6482592 |
Methods and kits for isolating primer extension products using modular oligonucleotides
The invention provides a method of improving the binding of a series of consecutive nucleotide bases to a complementary target nucleic acid molecule in a sample, wherein said method comprises at...
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6482639 |
Microelectronic device and method for label-free detection and quantification of biological and chemical molecules
Molecular recognition-based electronic sensor, which is gateless, depletion mode field effect transistor consisting of source and drain diffusions, a depletion-mode implant, and insulating layer...
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6475730 |
Detecting nucleic acids
The present invention relates to a method of detecting nucleic acids and particularly to a method of analyzing for the presence and/or amount of a nucleic acid.
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6475736 |
Methods for genetic analysis of DNA using biased amplification of polymorphic sites
Methods for determining genotypes and haplotypes of genes are described. Also described are single nucleotide polymorphisms and haplotypes in the ApoE gene and methods of using that information.
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6475721 |
Sequence specific detection of nucleic acids using a solid carrier bound with nucleic acid analog probes
A method for the detection of point mutation and polymorphisms in nucleic acids or for sequencing of unknown nucleic acids by a simple procedure using arrays uses nucleic acid analoges as sequence...
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6475737 |
Method of automatically selecting oligonucleotide hybridization probes
A method for automatically selecting oligonucleotide hybridization probes for detecting a mutation causing a mismatch in a DNA duplex is based on a thermodynamic nearest-neighbour model for...
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6475722 |
Surface treatments for DNA processing devices
The present invention discloses methodologies for the treatment of the surface(s) of DNA processing devices so as to greatly reduce DNA adsorption to the surface(s) exposed to the DNA-containing...
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6472141 |
Kinase assays using polycations
Methods, systems, kits for carrying out a wide variety of different assays that comprise providing a first reagent mixture which comprises a first reagent having a fluorescent label. A second...
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6472185 |
Use of selective DNA fragment amplification products for hybridization-based genetic fingerprinting, marker assisted selection, and high-throughput screening
Methods of genotyping amplified mixtures of DNAs, nucleic acid markers and methods of obtaining markers, kits, recombinant plants, positional cloning and integrated systems for making genotypes and...
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6472172 |
DNA encoding a novel human inhibitor-of-apoptosis protein
The present invention relates to novel human inhibitor-of-apoptosis polypeptides, designated HIAP3, polynucleotides encoding the polypeptides, methods for producing the polypeptides, expression...
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6472157 |
Methods for detection of promoter polymorphism in a UGT gene promoter
The present invention is directed to methods for detecting the presence of genetic polymorphisms that correlate with altered gene expression. More specifically, the present invention is directed to...
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6472155 |
Species specific identification of spore-producing microbes using the gene sequence of small acid-soluble spore coat proteins for amplification based diagnostics
PCR (polymerase chain reaction) primers for the detection of certain Bacillus species, such as Bacillus anthracis . The primers specifically amplify only DNA found in the target species and can...
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6468748 |
Methods of screening nucleic acids using volatile salts in mass spectrometry
This invention relates to methods for screening nucleic acids for mutations by analyzing nonrandomly fragmented nucleic acids using mass spectrometric techniques and to procedures for improving...
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6469151 |
PNA-DNA chimeric probe arrays and methods of use
The invention provides methods, kits, and compositions for ligation of PNA-DNA chimeric probes and oligonucleotides when they are hybridized adjacently to template nucleic acids using ligases and...
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6469149 |
Production of ascorbic acid in plants
The present invention relates to a polynucleotide in isolated form, which polynucleotide codes for a protein with the activity of the enzyme L-galactono-γ-lactone dehydrogenase, which...
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6465175 |
Oligonucleotide probes bearing quenchable fluorescent labels, and methods of use thereof
Methods are provided for reducing background signals encountered in nucleic acid hybridization assays and other assays that involve hybridization of a labeled oligomer to its complement. The method...
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6465641 |
One pot synthesis of 5′-hydroxy phosphorylated nucleoside derivatives, and compounds formed thereby
A method for the preparation of 5′-hydroxy phosphorylated nucleoside derivatives in a single reaction vessel is provided. The method includes contacting phosphorous oxychloride with a halophenyl...
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6461571 |
Method for prolonged storage of DNA molecules and packaging implementing said method
A process for the long-term preservation of DNA molecules and a packaging for practicing the same provides for extraction, purification and dehumidification of the DNA by any suitable technique...
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6462184 |
Compounds, processes and intermediates for synthesis of mixed backbone oligomeric compounds
Synthetic processes are provided wherein mixed backbone oligomeric compounds are prepared having at least one phosphodiester internucleoside linkage in addition to one or more phosphorothioate,...
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6458537 |
Methods of DNA typing with tandem repeats
Methods useful for multiplex amplifying a plurality of loci or genetic systems comprise at least two loci. The at least two loci may be selected from the group consisting of D9S302, D22S683,...
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6458539 |
Photoselection of nucleic acid ligands
Methods are described for the identification and preparation of high-affinity nucleic acid ligands to bFGF. Included in the invention are specific DNA ligands to bFGF identified by the photoSELEX...
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6458584 |
Customized oligonucleotide microchips that convert multiple genetic information to simple patterns, are portable and reusable
This invention relates to using customized oligonucleotide microchips as biosensors for the detection and identification of nucleic acids specific for different genes, organisms and/or individuals...
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6458534 |
Gene associated with Nijmegen breakage syndrome, it's gene product and methods for their use
The present invention relates to a novel gene, NBS1, and its gene product, nibrin. In addition, it relates to methods for detecting mutations or polymorphisms of the gene that are associated with...
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6458531 |
Leptin receptor gene as a genetic marker for leanness in pigs
Disclosed herein are genetic markers for pig leanness, methods for identifying such markers, and methods of screening pigs to determine those more or less likely to be obese and more or less likely...
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6455248 |
Reagents and kits for detecting fungal pathogens in a biological sample
The present invention provides novel methods and materials for detecting the presence of a fungus in a biological sample. The inventive methods and materials exploit the fact that the amino acid...
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6455255 |
Method of performing subtractive hybridization using RDA
The subject invention relates to improvements in nucleic acid isolation, and more particularly, relates to modifications to the subtractive hybridization method and to reagents such as...
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6455692 |
Method of concentrating polynucleotides using MIPC
The present invention is directed to improved methods for detection of mutations in DNA using Denaturing Matched Ion Polynucleotide Chromatography (DMIPC). The invention includes the following...
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6451526 |
Simplified mutation detection
The invention involves methods and materials for detecting a mutation in the genome of an organism. Specifically, the invention provides compositions of oligonucleotides and diagnostic kits that...
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6451968 |
Peptide nucleic acids
Novel peptide nucleic acids and novel linked peptide nucleic acids, form triple stranded structures with nucleic acids. The peptide nucleic acids include ligands such as naturally occurring...
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6451540 |
2′-O-alkylthioalkyl and 2′-C-alkythioalkyl containing nucleic acids
A compound having the formula: wherein, R1 represents 2′-O-alkylthioalkyl or 2′-C-alkylthioalkyl; X represents a base or H; Y represents a phosphorus-containing group; and R2 represents H,...
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6448064 |
Integrated circuit biochip microsystem
The present invention discloses a self-contained miniature DNA biosensor designed to detect specific molecular targets, particularly suitable for detection of nucleic acids. For example, hybridized...
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6448065 |
Integrated sequencing device
The invention is based on the discovery that the sequence of monomers in a polymeric biomolecule can be determined in a self-contained, high pressure reaction and detection apparatus, without the...
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6448373 |
Phosphate linked oligomers formed of monomeric diols and processes for preparing same
Novel ethylene glycol compounds bearing various functional groups are used to prepare oligomeric structures. The ethylene glycol monomers can be joined via standard phosphate linkages including...
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6448015 |
Probe for detecting point mutations in DNA utilizing fluorescence energy transfer
A method for detecting point mutations in DNA using a fluorescently labeled oligomeric probe and Forster resonance energy transfer (FRET) is disclosed. The selected probe is initially labeled at...
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6444806 |
Conjugates and methods of forming conjugates of oligonucleotides and carbohydrates
Oligonucleotides conjugated to carbohydrates and methods for their production are described. These oligonucleotide-carbohydrate conjugates are resistant to degradation by nucleases, are able to...
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6444423 |
Nucleosides comprising polydentate ligands
The present invention provides for the selective covalent modification of nucleic acids with redox active moieties such as transition metal complexes. Electron donor and electron acceptor moieties...
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6444430 |
Ndr2-related proteins
The invention provides cDNA which encode Ndr2-related proteins. It also provides for the use of the cDNAs, fragments, complements, and variants thereof and of the encoded proteins, portions thereof...
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6444461 |
Microfluidic devices and methods for separation
Integrated systems, apparatus, software, and methods for performing biochemical analysis, including DNA sequencing, genomic screening, purification of nucleic acids and other biological components...
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6440707 |
Fluorescence polarization in nucleic acid analysis
A new method for DNA diagnostics based on template-directed primer extension and detection by fluorescence polarization is described. In this method, amplified genomic DNA fragments containing...
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6440697 |
Ring finger protein zapop3
The present invention relates to polynucleotide and polypeptide molecules for zapop3, a novel human member of the RING finger protein family. The polypeptides, and polynucleotides encoding them,...
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6440671 |
Use of continuous/contiguous stacking hybridization as a diagnostic tool
A method for detecting disease-associated alleles in patient genetic material is provided whereby a first group of oligonucleotide molecules, synthesized to compliment base sequences of the disease...
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6440676 |
Diagnostic assay for cancer
The invention is directed towards gene expression characteristic for cancer, in particular brain cancers such as glioblastoma. Compositions, methods and kits encompassing such therein.
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6440943 |
Oligonucleotides having site specific chiral phosphorothioate internucleoside linkages
Novel chiral compounds that mimic and/or modulate the activity of wild-type nucleic acids are disclosed. In general, the compounds are phosphorothioate oligonucleotides wherein the 5′, and the...
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