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6602668 |
Decoy probes
The present invention features inhibitors of target-independent amplification and the use of such inhibitors for enhancing an amplification protocol. The inhibitors are believed to enhance an...
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6596483 |
System and method for detecting molecules using an active pixel sensor
In a molecule detection system and method, a sample containing target molecules is added to an array of test sites, with each test site containing distinct probe molecules. The probe molecules bind...
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6596707 |
Monovalent saccharides and uses thereof
The subject invention relates to monovalent oligosaccharides and their use, for example, in the treatment and prevention of mammalian disease caused by infection with Shiga toxin (ST) or Shiga-like...
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6593462 |
Purified β1,2-xylosyltransferase and uses thereof
The present invention provides a purified, homogeneous plant enzyme that adds a β-1,2-linked xylose to the β-linked mannose on the N-linked oligosaccharides of storage glycoproteins. This...
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6590091 |
Nucleic acid sequence detection employing amplification probes
Methods and compositions are provided for detecting nucleic acid sequences. In particular, pairs of probes are employed, where the pair defines a substantially contiguous sequence on a target...
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6590086 |
Mutants of the Rb and p53 genes and uses thereof
The present invention provides mutants of the Rb and p53 genes and methods utilizing these mutants therapeutically. Along with mutated Rb genes and p53 genes, the present invention provides mutated...
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6589735 |
Simple SNP analysis using mass spectrometry
The invention relates to a method of investigating by mass spectrometry the genetic material deoxyribonucleic acid (DNA) replicated by polymerase chain reaction (PCR), for the identification of...
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6590094 |
Superparamagnetic bead polymers
The invention relates to crosslinked bead polymers doped with superparamagnetic iron oxide, to a process for the preparation of the bead polymers, and to the use thereof in nucleic acid diagnosis.
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6589778 |
Method and apparatus for performing biological reactions on a substrate surface
The present invention provides an apparatus for performing biological reactions on a substrate layer having a multiplicity of oligonucleotide binding sites disposed thereon. The invention provides...
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6589736 |
Photocleavable agents and conjugates for the detection and isolation of biomolecules
This invention relates to agents and conjugates that can be used to detect and isolate target components from complex mixtures such as nucleic acids from biological samples, cells from bodily...
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6586577 |
Telomere repeat binding factors and diagnostic and therapeutic use thereof
The present invention relates to a novel nucleotide sequence encoding a telomeric protein which binds a repeat region of telomeric sequences, and to the protein encoded thereby. Also included...
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6586184 |
Chimeric mutational vectors
The invention is based on the discovery that recombinagenic oligonucleobases are active in prokaryotic cells that contain a strand transfer activity (RecA) and mismatch repair activity (MutS)....
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6586178 |
Nucleic acid probe
A nucleic acid probe which is a single-stranded nucleic acid complementary to a specific nucleic acid sequence and is labeled so as to give off a measurable fluorescent signal on hybridization with...
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6586232 |
Substrate preparation for chemical-species-specific binding
A mass biosensor uses an intermediate avidin layer to facilitate binding of a biotinylated antibody to a measurement surface of the biosensor. The avidin layer can be added by the manufacturer of...
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6582921 |
Nanoparticles having oligonucleotides attached thereto and uses thereof
The invention provides methods of detecting a nucleic acid. The methods comprise contacting the nucleic acid with one or more types of particles having oligonucleotides attached thereto. In one...
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6582911 |
Candida albicans KRE9 and uses thereof
The present invention to an isolated DNA which codes for a gene essential for cell wall glucan synthesis of Candida albicans , wherein the gene is referred to as CaKRE9, wherein the sequence of...
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6582918 |
Platelet derived growth factor (PDGF) nucleic acid ligand complexes
This invention discloses a method for preparing a complex comprised of a PDGF Nucleic Acid Ligand and a Non-Immunogenic, High Molecular Weight Compound or Lipophilic Compound by identifying a PDGF...
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6582917 |
Method for controlling quality in the construction of oligomer grids
The present invention relates to a method for controlling the quality of oligomer arrays, which is characterized in that a phosphate unit is fused to certain array positions, said phosphate unit...
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6583122 |
Nucleosides and oligonucleotides containing boron clusters
Carboranyl-containing nucleosides and oligonucleotides are provided for use in boron neutron capture therapy (BNCT) and for other therapeutic and diagnostic purposes.
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6582938 |
Amplification of nucleic acids
The present invention relates to the amplification of nucleic acids, preferably from mRNA. A primer and promoter are added to a target sequence to be amplified and then the target is amplified in...
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6582902 |
Method for deriving epitopes
A method of generating a nucleic acid species which are immunologically cross-reactive with non-nucleic acid immunogens is disclosed. The method comprises combining an antigen binding protein which...
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6579680 |
Method for label-free detection of hybridized DNA targets
A method for the detection and analysis of genetic polymorphisms using arrays that do not require labeling of a target nucleic acid sequence. Hybridization of a perfectly complementary nucleic acid...
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6576426 |
Tag reagent and assay method
This invention provides reagents, libraries and sets of the reagents, and assay methods using the reagents, the reagents comprising an analyte moiety and a tag moiety, wherein the tag moiety...
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6573046 |
Eukaryotic use of improved chimeric mutational vectors
The invention is based on the reaction of recombinagenic oligonucleotides in a cell-free system containing a cytoplasmic cell extract and a test duplex DNA on a plasmid. The reaction specifically...
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6573045 |
Methods and kits for discovery of RNA-binding compounds
The invention relates to a solution-based assay for identifying RNA binding compounds, based on competition. The assay comprises a reporter molecule carrying a fluorescent or chromogenic group that...
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6573048 |
Degradable nucleic acid probes and nucleic acid detection methods
Nucleic acid probes that are susceptible to chemical or enzymatic degradation are described herein. In addition, assays and methods using such probes in the detection of target nucleic acid...
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6569671 |
Pattern exposure method, exposure device, formation of nucleic acid array, and formation of peptide array
This invention provides a pattern exposure method which may be used for effectively preparing, for example, a DNA or peptide array with a lower cost and a device therefor. Specifically, the method...
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6569648 |
Method for selection of insertion mutations
The present invention provides a highly-efficient method for the selection and identification of insertional mutants. In the technique, a non-selective amplification is used to isolate a plurality...
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6569622 |
Nucleic acids encoding a protein conferring an inducible resistance to glycopeptide, particularly in gram-positive bacteria
The invention relates to a protein VanB involved, in Gram-positive bacteria, in resistance to glycopeptides, particularly to vancomycine, said resistance being of the type inducible by the...
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6569630 |
Methods and compositions for aptamers against anthrax
The present invention concerns methods of preparing nucleic acid ligands against anthrax spores, compositions comprising anthrax specific nucleic acid ligands and methods of use of such ligands for...
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6566069 |
Gene sequencer and method for determining the nucleotide sequence of a chromosome
A method for determining the nucleotide sequence of a chromosome. The chromosome is hydrolyzed to form a mixture of oligonucleotides having unknown nucleotide sequences. The mixture is exposed to a...
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6566058 |
Assay involving looped nucleic acid
Disclosed is a method of detecting the presence of a nucleic acid target sequence of interest in a sample, comprising the steps of: (a) reacting the sample containing the target sequence of...
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6562957 |
Genomic sequence encoding endoglin and fragments thereof
A method of diagnosing hereditary haemorrhagic telangiectasia (HHT) which includes the steps of: obtaining a sample of genomic DNA from a patient or fetus; and determining whether the DNA contains...
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6562572 |
Methods for amplifying nucleic acid sequences
Methods for identifying differentially expressed mRNA molecules are described, as well as methods for amplifying nucleic acid sequences.
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6562563 |
Compositions and mehtods for determining interactions of mitochondrial components, and for identifying agents that alter such interactions
Compositions and methods are provided for identifying agents that alter mitochondrial membrane permeability transition. The screening methods generally detect agents that alter the interaction...
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6558907 |
Methods and compositions for arraying nucleic acids onto a solid support
The present invention provides a method for depositing a nucleic acid on a solid support. The method comprises contacting a solid support with a solution of nucleic acid, the solution comprising...
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6558905 |
Diagnostics and therapeutics for osteoporosis
Diagnostics and therapeutics for osteoporosis, which are based on the identification of the subject's IL-1 haplotype pattern are described.
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6558921 |
Promoters of the genes glutamate deshydrogenase, β-N-acetylhexosaminidase and &ggr -actin and their use in filamentous fungi expression, secretion and antisense systems
An isolated DNA having the promoter sequence of the hex gene of P. chrysogenum or a DNA fragment that is hybridizable to the complement of the promoter sequence under stringent conditions and is...
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6559299 |
Preparation and isolation of indolocarbazole glycosides
The present invention relates to a novel process to make indolocarbazole glycosides in high purity which inhibit the growth of tumor cells and are therefore useful in the treatment of cancer in...
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6559295 |
Mycobacterium fol A gene that encodes for the enzyme dihydrofolate reductase
The invention relates to the nucleic acid sequence and amino acid sequence of dihydrofolate reductase (DHFR) from mycobacteria and to expression of recombinant DHFR protein. Utilizing the...
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6555693 |
Charged compounds comprising a nucleic acid binding moiety and uses therefor
Charged compounds are provided that comprise one or more regions of localized positive charge, compositions comprising such compounds, methods of synthesizing such compounds, methods of screening...
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6555668 |
Non-nucleotide containing enzymatic nucleic acid
Enzymatic nucleic acid molecule containing one or more non-nucleotide mimetics, and having activity to cleave an RNA or DNA molecule.
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6555349 |
Methods for amplifying and sequencing nucleic acid molecules using a three component polymerase
The present invention is directed to a method for amplifying or sequencing a nucleic acid molecule with a three component polymerase comprising a DNA polymerase component, a sliding clamp...
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6552176 |
Salt forms of 6-n-butylamino-6-deoxy-α-L-sorbofuranose
The invention is a process for producing N-substituted glucamines, a process for oxidizing an N-substituted glucamine with an oxidizing microbe or extract thereof, and a process for oxidizing an...
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6551812 |
Compositions and methods relating to the peroxisomal proliferator activated receptor-α mediated pathway
The present invention describes polynucleotides and polypeptides associated with PPARα-mediated pathways that are useful as therapeutic compositions in method for the treatment of peroxisomal...
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6552182 |
Method for photolytically deprotecting immobilized nucleoside derivatives, especially in the production of DNA chips
The invention relates to a method for the specific photolytic deprotection of nucleoside derivatives that are immobilized on a substrate, especially for use in the production of DNA chips. Said...
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6548255 |
Molecular combing process for detecting macromolecules
The subject of the present invention is a process for aligning a macromolecule (macromolecules) on the surface S of a support, characterized in that the triple line S/A/B (meniscus) resulting from...
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6548253 |
Method of isolating plasmid DNA
The invention relates to a method of isolating plasmid DNA from microorganism cultures with the aid of solid-phase bodies. The solid-phase bodies can be silica gels, silicates, or glass-like...
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6548650 |
Nucleic acid encoding melanoma differentiation associated gene-9
This invention provides a method for producing a temporally paced subtracted cDNA library comprising: a) isolating temporally spaced RNAs from cells; b) generating cDNA inserts from the RNAs...
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6545162 |
Method for the synthesis of pyrrole and imidazole carboxamides on a solid support
The present invention describes a novel method for the solid phase synthesis of polyamides containing imidazole and pyrrole carboxamides. The polyamides are prepared on a solid support from...
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