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6667394 |
Printing oligonucleotide arrays
A method and apparatus for selectively applying a print material onto a substrate for the synthesis of an array of oligonucleotides at selected regions of a substrate. The print material includes a...
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6664049 |
Method and device for cell lysis
Method and device for cell lysis in which a liquid mixture of bateria or eukaryoptic cells and of a lysing agent is produced continuously, and this mixture is caused to flow immediately in a steady...
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6664383 |
Polypeptides, cDNA encoding the same and utilization thereof
A new human polypeptide, a cDNA encoding the same and a pharmaceutical use of it. The polypeptides of the present invention possess hematopoiesis regulating activity, tissue...
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6664045 |
PNA probes, probe sets, methods and kits pertaining to the detection of microorganisms
This invention is related to novel PNA probes, probe sets, methods and kits pertaining to the detection of microorganisms. The probes, probe sets, methods and kits of this invention can be used to...
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6660845 |
Non-aggregating, non-quenching oligomers comprising nucleotide analogues; methods of synthesis and use thereof
The invention provides compositions and methods for improved hybridization analysis utilizing DNA, RNA, PNA and chimeric oligomers in which one or more purine bases are substituted by a...
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6660479 |
Process for preparing peptide nucleic acid probe using polymeric photoacid generator
Disclosed is a process for preparing arrays of oligopeptide nucleic acid probes immobilized on a solid matrix by employing polymeric photoacid generator. Arrays of peptide nucleic acid probes of...
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6660721 |
Anti-HCV nucleoside derivatives
The present invention comprises nucleoside derivatives for use in the treatment or prophylaxis of hepatitis C virus infections. In particular, the present invention discloses the novel use of known...
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6657052 |
Biomolecular labeling
A method for using an organic compound to label polynucleotides is described. The method utilizes an organic compound including an oligonucleotide, and electrophilic active site, an active complex,...
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6656682 |
Nucleic acid-immobilized substrate
A nucleic acid-immobilized substrate which comprises a carrier comprising a base material and a compound having a carbodiimide group or an isocyanate group carried by the base material, and the...
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6653070 |
Genomic analysis process and agent
A genomic analysis process is disclosed, in particular for analysing and localising hereditary properties in the genome. This process has applications in a large number of fields, in particular in...
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6653078 |
Multiplex method for nucleic acid detection
Processes are disclosed using the depolymerization of a nucleic acid hybrid to qualitatively and quantitatively analyze for the presence of predetermined nucleic acid target sequences using a...
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6653462 |
Nucleotide compounds including a rigid linker
A nucleoside/tide compound having the structure: NUC-L-S-LB/LG is described wherein NUC is a nucleoside/tide having a nucleobase portion B, L is a rigid linkage, S is a spacer; and LB/LG is a...
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6653290 |
Tumor proliferation inhibitors
The present invention concerns novel sugar derivatives of indolocarbazoles and pharmaceutical formulations thereof which exhibit topoisomerase-I activity and are useful in inhibiting the...
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6653458 |
Modified oligonucleotides
Modified oligonucleotides containing at least one 2′,5′-internucleotide linkage are provided. The oligonucleotides of the invention may also bear additional substituents at the 2′- and...
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6653080 |
Loop probe hybridization assay for polynucleotide analysis
Methods, compositions and articles of manufacture for assaying a sample for a target polynucleotide and/or an amplification product therefrom are provided. The methods comprise contacting a sample...
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6649591 |
Polydithicarbamate-containing non-targeting marcomolecules and the use thereof for therapeutic and diagnostic applications
In accordance with the present invention, there is provided a new class of drugs for therapeutic treatment of such indications as cerebral stroke and other ischemia/reperfusion injury. Thus, in...
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6646243 |
Nucleic acid reading and analysis system
A method and apparatus for preparation of a substrate containing a plurality of sequences. Photoremovable groups are attached to a surface of a substrate. Selected regions of the substrate are...
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6641814 |
Nucleic acids fragments and polypeptide fragments derived from M. tuberculosis
The present invention is based on the identification and characterization of a number of M. tuberculosis derived novel proteins and protein fragments (SEQ ID NOs: 2, 4, 6, 8, 10, 12, 14, 16,...
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6642367 |
Process for the synthesis of 2′-O-substituted pyrimidines and oligomeric compounds therefrom
Oligonucleotide analogs are disclosed having pyrimidine monomeric sub-units therein that are modified at the 2′ and 5′ positions. Monomeric sub-units having these modifications may be further...
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6638913 |
Concentrated injection and infusion solution for intravenous administration
Additives to concentrated injection and infusion solutions that avoid or mitigate acute or delayed hypersensitivity reactions as well as injection and infusion solutions that contain these...
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6635426 |
Mixed intercalator and electrochemical detection of DNA using same
Described in the present invention are a highly sensitive method for electrochemically detecting a DNA using a novel mixed intercalator and a detection kit useful for practicing said method.
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6635452 |
Releasable nonvolatile mass label molecules
Using nonvolatile, releasable, mass-labels, the present invention provides for the synthesis and use of mass-labeled compounds to specifically interact with biomolecular targets. Following binding...
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6635424 |
Method for generating libraries of antibody genes comprising amplification of diverse antibody DNAs and methods for using these libraries for the production of diverse antigen combining molecules
A method of producing libraries of genes encoding antigen-combining molecules or antibodies is described. In addition, a method of producing antigen-combining molecules which does not require an in...
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6632641 |
Method and apparatus for performing large numbers of reactions using array assembly with releasable primers
The present invention relates to a method and apparatus for performing a large number of reactions using array assembly. In particular, the present invention features a method and apparatus for...
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6632938 |
Processes of purifying oligonucleotides
Methods for preparing purified oligonucleotides by treating a solution comprising an oligonucleotide with an aggregating agent and a precipitation enhancer under conditions sufficient to form an...
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6632607 |
Mycobacterium antibiotic resistance detection
Method for the detection of the antibiotic resistance spectrum of Mycobacterium species present in a sample, possibly caused to the identification of the Mycobacterium species involved, comprising...
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6632935 |
Genome DNA of bacterial symbiont of aphids
The present invention provides a genomic DNA of Buchnera. That is, this invention provides genes derived from Buchnera sp., comprising DNA of the following (a) or (b); (a) a DNA selected from a...
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6632612 |
Synthesis of chemical tags
A method for forming a biological chemical tag. At least one double stranded DNA molecule is provided. At least a portion of the at least one double stranded DNA molecule is denatured. At least one...
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6630581 |
Monomers for solid phase synthesis of oligonucleotides using carbonate protecting groups and alpha-effect nucleophile deprotection
The invention provides a method for synthesizing oligonucleotides using carbonate protection of hydroxyl groups and nucleophilic deprotection reagents. The deprotection reagents irreversibly cleave...
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6627794 |
Polyphenyl oxidase genes from banana
The present invention provides genetic sequences encoding polyphenol oxidase enzymes of lettuce, banana, tobacco and pineapple plants, and recombinant vectors comprising same, and methods of...
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6627416 |
5′-modified nucleotides and the application thereof in molecular biology and medicine
The invention relates to 5′-modified nucleotides and to nucleic acids which contain these nucleotides. Processes for incorporating the 5′-modified nucleotides into nucleic acids, and the...
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6627397 |
Measuring chip for surface plasmon resonance biosensor and method for producing the same
An objective of the present invention is to provide a measuring chip for a surface plasmon resonance sensor that can detect a small amount of target substances in high sensitivity. The present...
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6627456 |
Method for selecting functional deoxyribonucleotide derivatives
Improvements are disclosed for in vitro selection methods that yield ligands and catalysts through partitioning libraries of oligonucleotides. These improvements all increase the diversity and...
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6623931 |
Diagnostic assay for antibiotic tolerance
Allelic variation in the vex2, pep27 and vncS genes of bacteria responsible for tolerance to antibiotics such as penicillin and vancomycin, is taught. Methods for identifying antibiotic tolerant...
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6620586 |
Methods and compositions for analyzing nucleic acids
The present invention relates to methods and compositions for analyzing nucleic acids. In particular, the invention provides for methods and combinations for analyzing nucleic acids in a plurality...
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6620588 |
Method of identifying inhibitors of topoisomerase DNA religation
The present invention provides methods for screening compounds capable of modulating nucleic acid-modifying enzymatic activity, including topoisomerase activity.
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6617107 |
Specific oligonucleotide primers for detection of bovine male chromosome presence by polymerase chain reaction and method
This invention is a specific set of oligonucleotide Polymerase chain reaction (PCR) primers [5′-GTGATCCGGCATATAGCTGAGA-3′ (SEQ ID No. 1) and 5′-TGGTCGCTGATCAGGATGGAA-3′ (SEQ ID No. 2)] for...
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6613526 |
Systematic evolution of ligands by exponential enrichment: tissue selex
This invention discloses high-affinity oligonucleotide ligands to complex tissue targets, specifically nucleic acid ligands having the ability to bind to complex tissue targets, and the methods for...
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6610663 |
Compositions and methods for modulating RNA
Compositions and methods for modulating the activity of RNA are disclosed. In accordance with preferred embodiments, antisense compositions are prepared comprising targeting and reactive portions....
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6610487 |
Method of diagnosing gummy stem blight in plants using a polymerase chain reaction assay
The present invention provides a sensitive test for objectively diagnosing the presence of Didymella bryoniae , the causative agent of gummy stem blight, and differentiating it from similar,...
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6610506 |
Transferrin binding proteins of Pasteurella haemolytica and vaccines containing same
Novel transferrin binding proteins from Pasteurella haemolytica , and nucleic acid molecules encoding the novel proteins are disclosed. Antibodies against the novel proteins are disclosed. The...
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6610842 |
Processes for the synthesis of oligomers using phosphoramidite compositions
Synthetic processes are provided wherein oligomers are prepared using phosphoramidite compositions. Oligomers having phosphodiester, phosphorothioate, phosphorodithioate covalent linkages are...
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6610481 |
Cascade nucleic acid amplification reaction
A process for generating multiple linear complements of a single strand, circular nucleic acid template containing at least one cleavage site is described. The process consists of combining the...
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6610482 |
Support bound probes and methods of analysis using the same
The present invention provides methods and apparatus for sequencing, fingerprinting and mapping biological macromolecules, typically biological polymers. The methods make use of a plurality of...
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6607889 |
Methods, kits and compositions pertaining to detection complexes
This invention is directed to methods, kits and compositions which utilize Detection Complexes to detect or identify the presence, absence or quantity of a target molecule in a sample of interest....
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6607723 |
Methods and compositions for attenuating antibody-mediated xenograft rejection in human recipients
Antibody-mediated xenograft rejection is attenuated by (1) removing preformed antibodies to various identified carbohydrate xenoantigens from the recipient's circulation prior to transplantation by...
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6607908 |
Supports for immobilizing DNA or the like
A subject of the present invention is to provide a support with immobilized DNA as a DNA library and particularly to a support suitable for reproducing DNA in accordance with a DNA amplification...
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6605611 |
Base analogues
Nucleoside analogues or base analogues having structure (I), where X=O or NH or S, Y=N or CHR 6 or CR 6 , W=N or NR 6 or CHR 6 or CR 6 or S, n=1 or 2; each R 6 is independently H or O or alkyl...
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6605428 |
Method for the direct, exponential amplification and sequencing of DNA molecules and its application
A method is described for the direct, exponential amplification and sequencing (“DEXAS”) of a DNA molecule from a complex mixture of nucleic acids, wherein truncated DNA molecules as well as...
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6602952 |
Hydrogels derived from chitosan and poly(ethylene glycol) or related polymers
The invention provides a polymeric structure comprising a multifunctional poly(alkylene oxide), such as a poly(ethylene glycol) derivative, covalently cross-linked to a polymer selected from the...
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