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7605242 |
Process for the physical depolymerization of glycosaminoglycanes and products obtained therefrom
The invention relates to a process for the depolymerization of glycosaminoglycanes characterized by the use of UVC radiation. The invention also relates to the intermediate depolymerized heparin...
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7582737 |
Orthogonally protected disaccharide building blocks for synthesis of heparin oligosaccharides
Orthogonally protected disaccharide building blocks for synthesis of heparin oligosaccharide. The disaccharide building block has a formula (I), in which L is a leaving group, P 1 , P 2 , P 3 and...
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7575886 |
Analysis of sulfated polysaccharides
The invention relates to methods and products associated with analyzing and monitoring heterogeneous populations of sulfated polysaccharides. In particular therapeutic heparin products including...
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7553872 |
Compounds and compositions for delivering active agents
Carrier compounds and compositions therewith which are useful in the delivery of active agents are provided. Methods of administration and preparation are provided as well.
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7541445 |
Synthetic heparin pentasaccharides
Preparation of synthetic monosaccharides, disaccharides, trisaccharides, tetrasaccharides and pentasaccharides for use in the preparation of synthetic heparinoids.
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7538096 |
Treatment and prevention of abnormal cellular proliferation
This invention provides a method for inhibiting or preventing the abnormal growth of cells, including transformed cells, by administering an effective amount of O-acylated heparin derivative....
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7504113 |
Heparin-like compounds, their preparation and use to prevent arterial thrombosis associated with vascular injury and interventions
The present invention is related to heparin-like compounds characterized by their capacity of inhibiting collagen-induced platelet aggregation in flowing whole blood and their use for prophylactic...
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7494975 |
Anti-HIV composition, production method thereof and medicament
The present invention relates to an anti-HIV composition and to the method for producing it. The composition of the present invention comprises a polyanion and a molecule capable of inducing the...
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7468358 |
Method and medicament for sulfated polysaccharide treatment of heparin-induced thrombocytopenia (HIT) syndrome
A method and medicament for treating and preventing platelet activation or thrombosis in the presence of heparin-and platelet factor 4-complex reactive antibodies using a 2-O desulfated heparin...
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7468210 |
Cross-linked heparin coatings and methods
A thromboresistant coating for a medical device, method of coating and coated medical device, the coating including an in situ cross-linked co-polymer of a cross-linkable biomolecule, preferably an...
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7393938 |
Use of lipid conjugates in the treatment of diseases
This invention provides compounds represented by the structure of the general formula (A):
wherein L is a lipid or a phospholipid, Z is either nothing, ethanolamine, serine, inositol, choline,...
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7332480 |
Compositions for the regulation of cytokine activity
Substances comprising carboxylated and/or sulfated oligosaccharides in substantially purified form, including compositions containing same and methods of using same, are disclosed for the...
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7321034 |
Process for the physical depolymerization of glycosaminogylcanes and products obtained thereform
The invention relates to a process for the depolymerization of glycosaminoglycanes characterized by the use of electron beam radiation, optionally in the presence of an organic compound selected...
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7259152 |
Methods and compositions using sulodexide for the treatment of diabetic nephropathy
The present invention provides oral formulations of Sulodexide for the treatment of diabetic nephropathy in patients with both insulin dependent and non-insulin dependent diabetes mellitus. Oral...
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7214667 |
Drugs against articular failure
The object of the present invention is to provide a composition which exerts a higher effect on recovering health from articular disorders than that attained by amino sugars and glycosaminoglycans....
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7202230 |
Use of hyaluronic acid derivatives in the preparation of biomaterials with a physical haemostatic and plugging activity
The present invention describes the use of polysaccharide derivatives for the preparation of biocompatible and biodegradable biomaterials with absorbent properties for body fluids and physical...
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7129224 |
Hydrophobic multicomponent heparin conjugates, a preparing method and a use thereof
The present invention provides hydrophobic heparin conjugates that are soluble in organic solvents but not in water, a method of preparing them, and a method of using them. Particularly, the...
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7101859 |
Use of lipid conjugates in the treatment of diseases
The invention provides novel methods for treating disease based upon the medicinal use of lipids and phospholipids covalently bound to physiologically acceptable monomers or polymers....
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7091337 |
Process for the physical depolymerization of glycosaminoglycanes and products obtained therefrom
The invention relates to a process for the depolymerization of glycosaminoglycanes characterized by the use of high-energy radiation in the presence of an organic compound selected from the group...
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7034127 |
Hydrophilic biopolymer-drug conjugates, their preparation and use
Disclosed are methods of conjugating biologically active substances, particularly, alpha-interferon, with a hyaluronan or a mixture of a hyaluronan with at least one other hydrophilic polymer...
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7034006 |
Use of lipid conjugates in the treatment of disease
The invention provides novel methods for treating disease based upon the medicinal use of lipids and phospholipids covalently bound to physiologically acceptable monomers or polymers....
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7011953 |
Diagnostic assay for type 2 heparin-induced thrombocytopenia
Methods for detecting the presence of antibodies to PF4/heparin/TSP-1 complexes in a biological sample and for diagnosing Type 2 heparin-induced thrombocytopenia are described.
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7008933 |
Process for prophylaxis and therapy of thrombotic processes employing heparin having particular average molecular weights
A process for prophylaxis and therapy of thrombotic processes includes preparing heparin having an average molecular weight ranging from 10 to 11.5 kd; formulating a pharmaceutical preparation...
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7005508 |
Nitroderivatives of polysaccharides
The present invention provides a new class of compounds presenting a high compatibility with tissues and organic fluids. Such new compounds are polysaccharides essentially formed of units of uronic...
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7005426 |
Folic acid-polysaccharide complex, its preparation method and pharmaceutical composition containing the same as active component
The present invention relates to folic acid-polysaccharide complexs and method of preparation thereof, more particularly relates to folic acid-Dextran complexs, method of preparation thereof,...
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6969705 |
Compositions of polysaccharides derived from heparin, their preparation and pharmaceutical compositions containing them
Alkali and alkali-earth metal salts of polysaccharides derived from heparin, their method of preparation and the pharmaceutical compositions containing them.
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6953784 |
Cross-linked polysaccharide drug carrier
A carrier and a method for preparing it are provided for use in the delivery of therapeutic agents. A polysaccharide is reacted with an oxidizing agent to open sugar rings on the polysaccharide to...
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6943154 |
Water insoluble derivatives of polyanionic polysaccharides
A water insoluble, biocompatible composition that is formed by a method which combines, in an aqueous mixture, a polyanionic polysaccharide, a nucleophile, and an activating agent, under conditions...
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6933372 |
Method to produce a solid form of heparin
The present invention provides a new method to process a solution containing heparin; heparin salts or heparin complexes in a solvent or a mixture of solvents to a solid form of heparin products...
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6926910 |
Hydrophobe biomolecular structure
The present invention relates to a new hydrophobe biomolecular structure, which is compacted due to the passing of the structure over its point of collapse, a method for the preparation of the...
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6924273 |
Chondroprotective/restorative compositions and methods of use thereof
The instant invention provides a method of treating or preventing osteoarthritis, joint effusion, joint inflammation and pain, synovitis, lameness, post operative arthroscopic surgery,...
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6921811 |
Bioactive coating composition and methods
The present invention provides a bioactive coating composition, method and devices for bodily fluid-contacting surfaces. The coating comprises a complex of Formula II: wherein R 1 is an C 1-18...
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RE38743 |
Mixtures of particular LMW heparinic polysaccharides for the prophylaxis/treatment of acute thrombotic events
Heterogeneous intimate admixtures of sulfated heparinic polysaccharides, well suited for the prophylaxis/treatment of acute thrombotic episodes in a human patient, comprise immixture of sulfated...
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6900311 |
O-sulphated bacterial polysaccharides and their use
The present invention refers to the preparation of O-sulphated, N-sulphatated or N-acetylated derivatives, both epimerised or non epimerised, of K5, K4, and optionally defructosilated K4 and K40...
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6891035 |
Process for bulk autoclaving
Process for bulk autoclaving of polysaccharides, wherein the process includes: a) dissolving the polysaccharides in an aqueous solution and mixing until a homogeneous solution is obtained; b)...
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6844329 |
Polysaccharides with antithrombotic activity comprising at least a covalent bond with biotin or a biotin derivative
The present invention relates to novel synthetic polysaccharides with antithrombotic activity exhibiting at least one covalent bond with biotin or a biotin derivative and to a process employing...
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6812221 |
FGF-affinity chromatography
The present invention relates to a method and apparatus for isolating anticoagulant heparin or heparan sulfate by binding the anticoagulant heparin or anticoagulant heparan sulfate onto an affinity...
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6809086 |
Process for producing desulfated polysaccharide, and desulfated heparin
A method of increasing proliferation of cells which comprises adding to cells a cellular proliferating amount of a primary hydroxyl group of N-acetylglucosamine selectively desulfated heparin...
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6777398 |
Process for the preparation of chondroitin sulfates from K4 polysaccharide and obtained products
New process for the preparation of chondroitin sulfates from the bacterial origin polysaccharide named K4, by defructosilation followed by selective sulfation.
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6756125 |
Biocompatible medical articles and process for their production
An article of metal, glass, ceramics or plastics having a surface for contact with tissue or with circulating blood, has a surface coating of an organopolysiloxane and heparin, in which coating the...
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6734298 |
Cross-linking process of carboxylated polysaccharides
A process for the preparation of cross-linked polysaccharides containg carboxy groups. The process comprises a first step of activating the carboxy groups in an anhydrous aprotic solvent and then...
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6680304 |
Disaccharides with anti-arthrosic properties
The invention relates to novel disaccharides of formula (I), wherein R 1 is selected from the group consisting of hydrogen, linear or branched (C 1 -C 4 ) alkyl, phenylalkyl with less than ten...
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6670339 |
Use of sulfated oligosaccharides in lowering blood triglyceride levels
The present invention relates generally to sulfated oligosaccharides, and in particular to the use of certain sulfated oligosaccharides as agents for lowering blood levels of triglycerides such as,...
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6656922 |
Oral delivery of macromolecules
Polysaccharides, which are widely used as an anticoagulation drugs, especially heparin, are clinically administered only by intravenous or subcutaneous injection because of their strong...
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6630580 |
Silyl and Heparin compositions
The present invention provides an anti-thrombogenic and cellular-adhesion coating composition for blood-contacting surfaces. The coating comprises a covalent complex of from 1 to 30 hydrophobic...
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6617316 |
Oligosaccharides, their preparation and pharmaceutical compositions containing them
The present invention relates to oligosaccharides of formula: to mixtures thereof, to diastereoisomers thereof, to a process for preparing them, to pharmaceutical compositions containing them,...
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6608044 |
Inhibition of TNF activity
The bioactivity of TNF is inhibited by administering heparin or a derivative thereof along with a soluble TNF receptor. The heparin or derivative thereof can be administered simultaneously with the...
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6608042 |
Pharmaceutical compositions containing oligosaccharides, the novel oligosaccharides and preparation thereof
The present invention relates to pharmaceutical compositions containing as an active ingredient at least one oligosaccharide of formula: to novel oligosaccharides of formula (I), to mixtures...
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6596699 |
Nucleic acid coating compositions and methods
A nucleic acid coating composition including a polyanion bound, directly or through one or more intermediates, to a medical device surface, with a condensate comprising a polycation and nucleic...
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6589943 |
Formulation of amphiphilic heparin derivatives for enhancing mucosal absorption
Formulations for enhanced mucosal absorption of heparin are disclosed. In one embodiment, a powdered heparin composition is made by dissolving an amphiphilic heparin derivative including heparin...
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