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7385051 |
Fluorescent N2,N3-etheno-purine (2′-deoxy) riboside derivatives and uses thereof
The invention relates to fluorescent N 2 ,N3-etheno-purine (2′-deoxy) riboside derivatives and fluorescent oligonucleotide probes comprising one or more moieties thereof, their preparation and...
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7358353 |
Nucleic acid and corresponding protein named 158P1D7 useful in the treatment and detection of bladder and other cancers
A novel gene (designated 158P1D7) and its encoded protein are described. While 158P1D7 exhibits tissue specific expression in normal adult tissue, it is aberrantly expressed in multiple cancers...
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7342109 |
Human kinase interacting protein 2 (KIP2)-related gene variant associated with cancers
Nucleic acid and polypeptide sequences of one novel human KIP2-related gene variant (KIP2V), and the processes for producing the same are provided. Use of the nucleic acid and polypeptide sequences...
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7342108 |
De novo DNA cytosine methyltransferase genes, polypeptides and uses thereof
De novo DNA cytosine methyltransferase polynucleotides and polypeptides and methods for producing said polypeptides are disclosed. Also disclosed are methods for utilizing de novo DNA cytosine...
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7338932 |
Methods of modulating functions of polypeptide GalNAc-transferases and of screening test substances to find agents herefor, pharmaceutical compositions comprising such agents and the use of such agents for preparing medicaments
Attachment of O-glycans to proteins is controlled by a large family of homologous polypeptide GalNAc-transferases. Polypeptide GalNAc-transferases contain a C-terminal sequence with similarity to...
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7335766 |
Method for producing a chitosan containing salt having a function of lowering blood pressure
The present invention relates to a method for producing a chitosancontaining salt having the function of lowering blood pressure. The method comprises the steps of: (a) dissolving an acid-soluble...
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7312194 |
Delivery systems
The invention relates to compounds which are useful in the delivery of a wide variety of therapeutically useful molecules. In particular, the invention relates to compounds which are able to act as...
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7306910 |
Breast cancer prognostics
A method of providing a prognosis of breast cancer is conducted by analyzing the expression of a group of genes. Gene expresson profiles in a variety of medium such as microarrays are included as...
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7304148 |
Sugar chain asparagine derivatives, sugar chain asparagine, sugar chain, and processes for producing these
An asparagine-linked α2,3-oligosaccharide having undeca- to hepta-saccharides, an asparagine-linked α2,6-oligosaccharide having undeca- to hepta-saccharides and containing fluorine and an...
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7301016 |
Human transferase family members and uses thereof
The invention provides isolated nucleic acids molecules, designated 33877, 47179, 26886, 25552, 32132, 32244, 23680, 32624, 47174, 60491, 46743, 27417, 27960, 32252, and 53320 nucleic acid...
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7291462 |
TADG-15: an extracellular serine protease overexpressed in carcinomas
The present invention provides DNA encoding a TADG-15 protein as well as a TADG-15 protein. Also provided is a vector capable of expressing the DNA of the present invention adapted for expression...
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7288640 |
Processes for the production of aminoalkyl glucosaminide phosphate and disaccharide immunoeffectors, and intermediates therefor
This invention relates to processes for production of alkylamino glucosaminide phosphate compounds, and of disaccharide compounds, including various novel intermediates and intermediate processes....
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7276595 |
DNA sequence encoding a retinoic acid regulated protein
The present invention concerns a novel retinoic acid regulated gene whose expression product displays useful morphogenic/mitogenic properties. The present invention further concerns an isolated...
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7273934 |
Three-branched sugar-chain asparagine derivatives, the sugar-chain asparagines, the sugar chains, and processes for producing these
A 3-branched asparagine-linked oligosaccharide derivative of the formula (1) wherein the nitrogen of amino group of asparagine is modified with a lipophilic protective group, biotin group or FITC...
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7270980 |
Compounds for immunodiagnosis of prostate cancer and methods for their use
Compounds and methods for diagnosing prostate cancer are provided. The inventive compounds include polypeptides containing at least a portion of a prostate tumor protein. The inventive polypeptides...
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7262179 |
Wound care compositions
Compositions for the treatment of wounds and skin injuries are described. The compositions, which include gellan gum, increases in viscosity once applied to the wound to form an immobile gel. The...
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7259152 |
Methods and compositions using sulodexide for the treatment of diabetic nephropathy
The present invention provides oral formulations of Sulodexide for the treatment of diabetic nephropathy in patients with both insulin dependent and non-insulin dependent diabetes mellitus. Oral...
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7253278 |
Purification process for manufacturing a high pure acarbose
A process for purifying and preparing highly pure acarbose from acarbose-containing fermentation broth. The acarbose is purified through steps of alcohol precipitation, a strongly acidic cation...
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7244830 |
Glycopolymers and free radical polymerization methods
A glycopolymer composition is provided comprising glycopolymer molecules having a polymer backbone; a first pendent unit comprising a linking group connected to said polymer backbone and a...
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7235647 |
Intermediate and process for preparing of β- anomer enriched 21-deoxy,21,21-difluoro-D-ribofuranosyl nucleosides
The present invention provides a highly stereoselective, simple and economical glycosylation process for preparation of β-anomer enriched 2 1 -deoxy-2 1 ,2 1 -D-ribofuranosyl difluoronucleosides...
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7235533 |
Compounds and their uses
Compounds having a mimetic or antagonistic property of an inositol phosphoglycan, and the uses of these compounds are disclosed, together with the use, e.g. to treat a condition ameliorated by...
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7235370 |
Site-specific aminoglycoside derivatives for use in immunodiagnostic assays
A method of making a derivatized aminoglycoside includes reacting an aminoglycoside with at least 2 equivalents of a divalent metal ion in an aprotic solvent to complex two neighboring amino group...
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7227019 |
Process for the preparation of rebeccamycin and analogs thereof
The present invention relates to a method for making an indolopyrrolocarbazole of the general formula [I], where the method includes the step of reacting a bisindolylmaleimide compound with an...
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7217696 |
Glycuronamides, glycosides and orthoester glycosides of fluoxetine, analogs and uses thereof
Disclosed are glycosides, orthoester glycosides and glycuronamides of fluoxetine and analogs thereof to treat conditions and diseases such as depression.
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7211663 |
Synthesis of oligosaccharides, reagents and methods related thereto
One aspect of the present invention relates to differentially protected glycosyl phosphates. Another aspect of the present invention relates to the preparation of glycosyl phosphates from glycal...
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7202230 |
Use of hyaluronic acid derivatives in the preparation of biomaterials with a physical haemostatic and plugging activity
The present invention describes the use of polysaccharide derivatives for the preparation of biocompatible and biodegradable biomaterials with absorbent properties for body fluids and physical...
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7199231 |
Isolated nucleic acid molecules coding for tumor rejection antigen precursor MAGE-4 and 41 and uses thereof
The invention relates to nucleic acid molecules which code for the tumor rejection antigen precursor MAGE-4 and 41. Also disclosed are vectors, cell lines, and so forth, which utilize the nucleic...
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7196178 |
Sugar-derived gellant for hydrogel formation
A gelatinizer having gel-forming capability in both organic solvents and water, is provided. The hydrogelatinizer is represented by:
(where, A is a sugar residue, and R is an alkyl group).
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7183261 |
Galactosylceramide analogs, and β-glucocerebrosidase activators, external skin preparations and method of activating β-glucocerebrosidase using the analogs
Galactosylceramide analogues represented by the following formula (1) or (2).
(wherein X and Y each represent S or O, R 1 and R 2 each represent an alkyl group or an alkenyl group each having...
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7157444 |
Aminosalicylate derivatives for treatment of inflammatory bowel disease
Therapeutic 5-aminosalicylic acid derivative compositions having general formula (I), wherein R is a 1-deoxy sugar residue or a poly(ethylene glycol) chain-containing residue, are provided. The...
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7156989 |
Separating agent including polysaccharide derivative having a polycyclic structure
The present invention provides a separating agent for enantiomeric isomers, which has an excellent ability to identify asymmetry. That is, the present invention relates to a separating agent for...
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7138386 |
Preventives or remedies for arthritis
The present invention relates to pharmaceuticals, foods and drinks, food additives, animal feeds and feed additives comprising an N-acylated hydroxyproline derivative or a salt thereof, and an...
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7138377 |
Topoisomerase inhibitors
The present invention concerns novel sugar derivatives of indolocarbazoles and pharmaceutical formulations thereof which exhibit topoisomerase-I activity and are useful in inhibiting the...
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7129219 |
Immunoeffector compounds
This invention provides compounds containing a 2-deoxy-2-amino-β-D-glucopyranose (glucosamine) glycosidically linked to a cyclic aminoalkyl (aglycon) group. The invention further provides methods...
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7125859 |
Nucleic acid antioxidant compositions, methods for obtaining such compositions and formulations thereof
Compositions containing purified nucleic acid wherein the nucleic acid acts as an antioxidant. Such compositions also include materials subject to oxidative damage such as antioxidants, vitamins,...
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7122653 |
Reagents and methods useful for detecting diseases of the prostate
A set of contiguous and partially overlapping RNA sequences and polypeptides encoded thereby, designated as PS190 and transcribed from prostate tissue is described. These sequences are useful for...
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7122635 |
Method and composition for angiogenesis inhibition
The invention describes methods for inhibiting angiogenesis in a tissue by administering an antagonist that specifically binds to a proteolyzed or denatured collagen but not to native triple...
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7122526 |
Indolocarbazole anticancer agents and methods of using same
The present invention relates to anti-tumor compounds, compositions and methods. In particular, the invention relates to indolocarbazole analogues of the following general formulas that inhibit...
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7119079 |
Bioadhesive pharmaceutical compositions
Disclosed are compounds having the formula
wherein R 2 is hydrogen, a monomeric glycoside or an oligomeric glycoside, R 3 is hydrogen, a monomeric glycoside, an oligomeric glycoside, or a...
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7115721 |
Microorganism, its product and utilization thereof
There are provided a novel microorganism Enterobacter sp. B20 strain which produces (E)-4-(2-isocyanovinyl)phenyl α-rhamnopyranoside having a favorable effect of inhibiting melanogenesis and...
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7115588 |
Methods for treating a breach or puncture in a blood vessel
The present invention relates to compositions comprising semi-crystalline β-1-4-N-acetylglucosamine polymers (p-GlcNac) and methods utilizing such polymers modulation of vascular structure and/or...
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7115577 |
Colorectal neoplasia prophylaxis
Development of colorectal neoplasia in a patient subject or predisposed to colorectal neoplasia is reduced by the steps of (a) determining a patient is subject or predisposed to colorectal...
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7105661 |
Process for manufacturing morpholino-nucleotides, and use thereof for the analysis of and labelling of nucleic acid sequences
The invention relates to the use of morpholino-nucleosides of formula:
in which R 1 represents a nucleic base and R 2 represents a group corresponding to one of the following formulae:
...
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7105492 |
Camptothecin derivatives having antitumor activity
Camptothecin derivatives of camptothecin of formula (I)
exhibit antitumor activity and show a good therapeutic index and are used in the treatment of tumors, viral infections and antiplasmodium...
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7101859 |
Use of lipid conjugates in the treatment of diseases
The invention provides novel methods for treating disease based upon the medicinal use of lipids and phospholipids covalently bound to physiologically acceptable monomers or polymers....
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7098194 |
Composition and method to homogeneously modify or cross-link chitosan under neutral conditions
In accordance with the present invention there is provided a new composition and method for chemically modifying chitosan, including N-substituting or N-cross-linking, under homogeneous conditions...
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7098188 |
Anticonvulsant derivative salts
The invention relates to novel pharmaceutically acceptable salts of anticonvulsant derivatives, processes for preparation of and pharmaceutical compositions containing said salts, useful in the...
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7094763 |
Substituted fused heterocyclic C-glycosides
This invention relates to substituted fused heterocyclic C-glycosides, compositions containing them, and methods of using them, for example, for the treatment or prophylaxis of diabetes and...
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7091039 |
Kunitz domain polypeptide zkun6
Proteinase inhibitors comprising a Kunitz domain are disclosed. The Kunitz domain comprises a sequence of amino acid residues as shown in SEQ ID NO:3, wherein the sequence is at least 80% identical...
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7081526 |
Process for manufacturing morpholino-nucleotides, and use thereof for the analysis of and labelling of nucleic acid sequences
The invention relates to the use of morpholino-nucleosides of formula:
in which R 1 represents a nucleic base and R 2 represents a group corresponding to one of the following formulae:
...
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