Matches 351 - 400 out of 639 < 1 2 3 4 5 6 7 8 9 10 11 12 13 >
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5470843 Carbohydrate-containing polymers, their preparation and use  
Carbohydrate-containing polymers which can have an HLB* of from about 10 to about 20 are disclosed. The compounds comprise a hydrophilic polymer portion, a carbohydrate portion comprising from 1 to...
5468849 Rebeccamycin analogs by tryptophan analogs feeding  
Addition of certain tryptophan analogs to the culture medium during fermentation of a rebeccamycin-producing strain of Saccharothrix aerocolonigenes results in production of new rebeccamycin...
5451579 1-β-methyl-carbapenem, compositions containing same and methods of use  
A carbapenem antibiotic of the formula I ##STR1## is disclosed. The variable X .crclbar . represents a counterion. Pharmaceutical compositions and methods of use are also disclosed.
5449781 Fluorescent or UV vizualizable tagging agents for oligosaccharides  
Fluorescent tagging compounds of the formula: ##STR1## wherein A is a member selected from the group consisting of an aromatic ring, a heteroaromatic ring, and a heterocyclic ring, and R is a...
5441932 Sugar compounds for inhibition of the biosynthesis of sugar chains containing sialic acid  
An inhibitor of the biosynthesis of sugar chains containing sialic acid that is excellent in the suppression of inflammation or allergy, which comprises as an active ingredient a sugar compound of...
5438125 Sialic acid derivatives  
Sialic acid compounds of formula ##STR1## wherein X is hydrogen, a lower alkyl group or benzyl, Y is hydrogen or acetyl, Ac is acetyl, and the wavy line represents that the compound of the formula...
5438131 3-nitropyrrole nucleoside  
Oligonucleotides having at least ten nucleosides, at least two of which are selected from the group consisting of A, T, C and G, and at least one nucleoside being a universal nucleoside of the...
5434266 Monosaccharide analog-based glycosidase inhibitors  
Broad spectrum glycosidase inhibitors are produced from monosaccharide lactams by conversion to amidines, amidrazones, or amidoximes. The inhibitors have the general formula: ##STR1## wherein the N...
5432167 Cell proliferation matrix and use thereof  
A cell proliferation matrix consisting of an aqueous gel of hyaluronic acid or a pharmaceutically acceptable salt thereof which is free from production-related animal DNA and RNA and which is in a...
5416198 Selective sorbent removal system using polycation activated substrates  
A polycationic system for the removal of polyanions from a fluid medium is formed by, first, activating a biocompatible hydroxylated support with an organic sulfonyl chloride, such as...
5412082 Conversion of amines to hydroxylamines  
Oxidation of primary amines to primary hydroxylamines using a dialkyl dioxirane is described. This new method is utilized to prepare aliphatic non-axial hydroxylamines from corresponding primary...
5407800 Reverse transcription with Thermus thermophilus polymerase  
Methods are provided for the replication and amplification of RNA sequences by thermoactive DNA polymerases. Reverse transcription of RNA is catalyzed by, for example, 94 kDa Taq, 62 kDa Taq, and...
5401839 Process of preparing N-substituted aldonamides having improved color and color stability  
A process of preparing N-substituted aldonamides, the process including the steps of mixing and reacting an aldonolactone and an amine in an organic polar solvent, in the presence of an antioxidant...
5399675 Acidic polycyclic ether antibiotics and microorganisms useful in the production thereof  
This invention relates to novel acidic polycyclic ether antibiotics CP-91,243 and CP-91,244 of the formula ##STR1## wherein R is H in CP-91,243 and R is CH 3 in CP-91,244. The invention also...
5393741 Acetal derivatives of aromatic aldehydes  
New compounds having the general formula I ##STR1## wherein Y may be H or D; and A is H, D, alkyl with 1-4 C-atoms, halogen, nitro, amino, monoalkyl amino or dialkyl amino wherein the alkyl groups...
5393737 Cytotoxic drug conjugates for treatment of neoplastic diseases  
A novel composition of matter comprising a ligand-carbohydrate-cytotoxic drug conjugate is produced by the steps of (1) reacting a carbohydrate with a ligand, (2) reacting the product of step (1)...
5384401 Chemical product usable as a non-radioactive carrier  
A radioactive diagnostic agent which comprises (1) the unit of a polyformyl compound having at least three formyl groups per molecule, (2) at least two units of an amino group-containing chelating...
5380716 Sulfated polysaccharides as inhibitors of smooth muscle cell proliferation  
Highly sulfated oligosaccharides in the form of hexasaccharide and octasaccharide compounds which have antiproliferative activity with respect to smooth muscle cells are useful in treatment of...
5372816 Trehalostatin and process for the preparation thereof  
This invention relates to the substance Trehalostatin which is a white powder soluble in water but hardly or only slightly soluble in hexane, benzene, ethers and petroleum ether, shows no...
RE34805 Benzonaphthalene derivatives and their use in therapeutic and cosmetic compositions  
A benzonaphthalene compound has the formula ##STR1## wherein R 1 represents ##STR2## or (ii) --CH 2 OH; R 6 represents ##STR3## or OR 7 wherein R 7 represents hydrogen, alkyl having 1-20...
5371203 Process for the stereoselective preparation of β-fucopyranosyl phosphates and very pure GDP-fucose  
The invention relates to a process for the stereoselective preparation of β-L-fucopyranosyl phosphates via the trichloroacetimidates of protected L-fucose and the synthesis and purification of...
5367062 Disubstituted and deoxydisubstituted derivatives of α-d-lyxofuranosides having anti-inflammatory and anti-proliferative activity  
Derivatives of disubstituted and deoxydisubstituted α-D-lyxofuranosides and intermediates for preparing these derivatives are described. These compounds exhibit significant antiinflammatory and...
5360792 Anti-proliferative and anti-inflammatory compounds: 5- or 6-deoxy hexose monosaccharides having a saturated nitrogen-containing heterocycle at the 5- or 6-position bound through the nitrogen atom  
The compounds of this invention are 5- or 6-deoxy hexose monosaccharides having a saturated nitrogen-containing heterocycle at the 5- or 6-position bound through the nitrogen atom. The saturated...
5358853 Liquid thromboplastin reagent  
The invention is a stable liquid thromboplastin reagent used for measuring the performance of the coagulation system, with a shelf life of greater than 16 months, and a method of producing this...
5349089 Reagent for preparing polycationic polysaccharides  
Cationic polysaccharide derivatives are prepared by reacting a polysaccharide with a polycationic reagent having one polysaccharide reactive group and at least two cationic groups. Suitable...
5332756 3-deoxy-mannosamine derivatives  
The present invention relates to 3-deoxy-derivatives of D-mannosamine of formula ##STR1## wherein R is --NH 2 or a C 2 - 5 alkanoyl-NH-- or CF 3 CONH-- group; each of R 1 and R 2 ...
5332809 Partial esters of gellan  
The present invention is directed to total and partial esters of gellan in which the esterifying alcohol component is derived from aliphatic, araliphatic, cycloaliphatic or heterocyclic alcohols,...
5324828 1-amino-1-deoxyoligosaccharides and derivatives thereof  
A derivatized 1-amino-1-deoxyoligosaccharide prepared by reacting, at a pH of at least 6.5, a glycopeptide or glycoprotein containing one or more Asn-linked oligosaccharides with a...
5319078 α-amylase assay using modified oligosaccharide and process for producing said modified oligosaccharide  
α-Amylase activity can be determined rapidly and precisely by using as a substrate a modified oligo-saccharide wherein a benzylozymethyl group or a halo-methyl group is bonded to the C 6 position...
5304380 Glucosamine derivative and liposome containing the same as membrane constituent  
Disclosed are a glucosamine derivative represented by the following formula [I] or a pharmacologically acceptable salt thereof, and a liposome containing the glucosamine derivative as a membrane...
5302514 Maltooligoside derivative, reagent for determining α-amylase activity containing the same as effective ingredient and a process for determining the α-amylase activity using same  
The present invention provides a maltooligoside derivative represented by the formula: ##STR1## wherein n denotes an integer 3-5, R represents an aromatic chromophoric group, X represents a group...
5298494 Monosaccharides having anti-proliferation and anti-inflammatory activity, compositions and uses thereof  
Derivatives of simple monosaccharides which exhibit anti-proliferative and/or anti-inflammatory activity and are useful for treating mammals having inflammatory disorders and/or autoimmune...
5288859 Process for the preparation of glycosyl azides  
A process for stereospecific preparation of glycosyl azides by reacting a metal azide with a glycosyl phosphate triester having the phosphate group cis to the adjacent C-2 substituent is disclosed.
5278301 Route to glycals in the allal and gulal series  
Axial anomeric sulfoxides generated via thiophenol Ferrier rearrangement of glucal and galactal derivatives are used to synthesize glycals of the gulal and allal series. An application of the...
5268364 Method for inhibiting selectin-dependent adhesion of leukocytes and platelets by O-glycosylation modification  
O-glycosylation and O-glycosylation extension inhibitors influence selectin-dependent interactions between cells and between cells and platelets.
5264431 Polycyclic conjugates  
Staurosporin derivatives of the formula I are described, ##STR1## in which R 1 is hydrogen, hydroxyl, lower alkoxy or oxo and R 2 is a radical of the formula II ##STR2## in which the...
5260428 Agent for the detection of substances with hydrolase activity  
A process for the detection of substances with hydrolase activity in a sample by mixing the sample with a hydrolase substrate and an oxidising agent, and the evaluating the resultant colour...
5254540 Saccharide copolymers having antibacterial activity  
Saccharide copolymers having antibacterial activity obtained by copolymerization of an oligosaccharide or polysaccharide with a nitrogen containing vinyl derivative, quaternarization of the...
5234914 Methods of treating hemorrhoids and anorecial disease  
A method of treating hemorrhoids and anorectal disease which includes applying to the hemorrhoids and anorectal tissues an effective amount of a composition including a pharmaceutically acceptable...
5227479 Process for the preparation of nojirimycin and related compounds  
The present invention relates to an efficient new route for the preparation of (+)-nojirimycin and (+)-1-deoxynojirimycin which involves the stereoselective reductive amination of...
5227481 Cationic polysaccharides and reagents for their preparation  
Cationic polysaccharide derivatives are prepared by reacting a polysaccharide with a polycationic reagent having one polysaccharide reactive group and at least two cationic groups. Suitable...
5225529 Synthetic amphiphilic glycoconjugates for neurological use  
Chemically and sterically pure synthetic amphiphilic glycoconjugates for neurological use of the formula (I): ##STR1## in which: the saccharide ring represents a monosaccharide such as glucose,...
5220002 Deacetylcolchicine derivatives  
Deacetylcolchicine derivatives represented by the formula ##STR1## wherein R denotes a residue obtained by removing COOH from a C 3 -C 7 sugar carboxylic acid, and a hydroxyl group present in the...
5217961 Condensed quinoline system N-glycosides  
The present invention provides condensed quinoline compounds represented by the following general formula (I): ##STR1## in which Z is NH, X is hydrogen, L is lower alkoxy, M is NHQ, Q is --SO 2 CH...
5218097 Process for the preparation of protected mono-sugar and oligo-sugar halides  
The reaction of protected monosaccharides or oligosaccharides or protected monosaccharide and oligosaccharide derivatives containing an anomeric hydroxyl group with secondary α-haloenamines...
5216145 Asymmetric synthesis of 3-substituted furanoside compounds  
Novel processes, intermediates and reagents for the preparation of 3-substituted furanose or furanoside compounds of Formula I: ##STR1## wherein M is hydrogen or alkyl (C 1 -C 3 ), A is halogen or...
5208326 8-hydroxy-2H-dibenz(b,f)azepin-2-one dyes  
Disclosed are 8-Hydroxy-2H-dibenz[b,f]azepin-2-one dyes, chromogenic enzyme substrates made from them and methods for preparing the same.
5206318 Styrene derivatives having N-acetylchito-oligosaccharide chains and method for the same  
A styrene derivative carrying N-acethylchito-oligosaccharide chains, a polystyrene derivative carrying N-acetylchito-oligosaccharide chains on the side chains as well as a method for preparing...
5192540 Haemophilus influenzae type b oxidized polysaccharide-outer membrane protein conjugate vaccine  
Immunogenic conjugates of a 38,000 daltons or 40,000 daltons outer membrane protein of H. influenzae type b and oxidized polyribosyl-ribitol-phosphate polysaccharide fragments of H. influenzae type...
5192661 Multicomponent kit containing an antibody to a synthetic antigen of sialic acid  
A compound X-Y wherein X comprises sialic acid, a sialic acid derivative or and oligosaccharide terminating in a sialic acid or sialic acid derivative if multibranched at the end of at least the...
Matches 351 - 400 out of 639 < 1 2 3 4 5 6 7 8 9 10 11 12 13 >