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5639824 |
Separating agent containing a support and a cyclodextrin derivative
Chemically bonded bodies comprising a support and a cyclic oligosaccharide derivative, at least one of the 2-, 3- and 6-position hydroxyl groups of which is chemically bonded to the support through...
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5639734 |
Disaccharide inflammation inhibitors and uses thereof
The present invention provides a composition of matter comprising a biosynthetic anti-inflammatory oligosaccharide, comprising the structure of: sugar - sugar - X - R; wherein said sugar is...
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5639732 |
Phosphorous-containing cysteine and serine protease inhibitors
The present invention is directed to novel phosphorous-containing inhibitors of cysteine or serine proteases. Methods for the use of the protease inhibitors are also described.
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5637569 |
Ganglioside analogs
Ganglioside lactam analogue derivatives of general formula (I) in which A is a sialic acid residue of formula (II) which is bound via the dashed line in the 2-position; and in which Z 1 is --OH or...
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5637681 |
Aminosaccharide biguanides
Novel aminosaccharide biguanides are prepared by either reacting a aminosaccharide with a mono- or multi-functional cyanoguanidine or by reacting a monocyano-guanidine of an aminosaccharide with a...
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5635609 |
Particles prepared by transacylation reaction between an esterified polysaccharide and a polyamine, methods of preparation therefor and compositions containing same
Particles, preparation methods therefor, and compositions containing same. The particles include at least one esterified polysaccharide and at least one polyamine, as well as at least one gellable...
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5631374 |
Reagents for detection of primary amines
The present invention is directed to derivatives of aroyl-2-quinoline-carboxaldehyde and their use in detection and quantification of minute amounts of primary amines.
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5627273 |
Method for preparing hydrophobically-terminated polysaccharide polymers and detergent compositions comprising the polysaccharide polymers
The present invention is directed to methods of preparing hydrophobically-terminated polysaccharide polymers. The methods utilized to prepare the hydrophobically-terminated polysaccharide polymers...
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5624906 |
Oral hygiene compositions comprising heteroatom containing alkyl aldonamide compounds
The present invention is related to new oral hygiene compositions that have improved foam, viscosity, clarity and good taste due to the inclusion of a new type of alkyl aldonamide compound,...
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5623049 |
Nucleic acid-binding oligomers possessing N-branching for therapy and diagnostics
The invention relates to nucleic acid-binding oligomers possessing N-branching of the general formula (I), ##STR1## and their monomers, where the individual radicals have the meaning given in the...
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5622945 |
Rubyrin macrocycles
The present invention is directed to the synthesis and use of novel macrocyclic compounds, based upon a new class of expanded porphyrins, termed rubyrins. Disclosed herein is the structure and...
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5620902 |
Sialic acid glycosides, antigens, immunoadsorbents, and methods for their preparation
The stereochemistry of sialylation of an acceptor saccharide to obtain an α (2-3) or α (2-6) linkage is controlled to favor the α anomer by use of an aromatic ester of the sialyl reagent. The...
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5621088 |
Process for derivatizing polyglucosamines
Processes for the preparation of polyglucosamine derivatives, e.g., hydroxypropyl chitosan and carboxymethyl chitosan, are disclosed. The polyglucosamine derivatives can be prepared in a covalently...
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5616568 |
Functionalized derivatives of hyaluronic acid
Hyaluronate functionalized with dihydrazide is provided and may be cross-linked. A method for producing hyaluronate functionalized with dihydrazide includes mixing hyaluronate and dihydrazide in...
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5614616 |
Process for the production of polysaccharides
Polysaccharides corresponding to formula (I) ##STR1## in which S is a recurrent monosaccharide unit and B is a group of formula (Ia) attached to the monosaccharide unit S by an O atom ##STR2##...
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5604206 |
Complexes containing S(+) phenyl alkane acids and amino sugars
New complexes of S(+)-ibuprofen and amino sugars are described. These complexes are particularly suitable for the treatment of inflammations and pains.
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5601799 |
Partially delipidated D25 polysaccaride composition for imaging and diagnosis
The present invention relates to a D 25 polysaccharide compound whose lipid has been partially removed and to its derivatives, wherein at least 85% by weight, preferably 90% of the compound, exists...
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5599915 |
Sialyl Lewis X mimetics
Sialyl Lewis x mimetic compounds are disclosed that are free of sialyl groups and glycosidically-linked fucosyl groups. These compounds exhibit about the same inhibition of selectin-medicated...
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5599914 |
Glycosphingolipids with a group capable of coupling in the sphingoid portion, the preparation and use thereof
The invention relates to the chemical modification of the sphingoid portions of glycosphingolipids. It has been possible by a series of reactions to introduce an amino group in the position of the...
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5597811 |
Oxirane carboxylic acid derivatives of polyglucosamines
Polyglucosamine derivatives, e.g., chitosan, substituted with oxirane carboxylic acids, e.g., epoxysuccinic acid, are disclosed. The polyglucosamine derivatives can be prepared in a covalently...
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5597573 |
Lipid-A analogs: new monosaccharide and disaccharide intermediates for eliciting therapeutic antibodies and for antitumor and antiviral activities
The present invention relates to novel amidine components of formula (II): ##STR1## A method for eliciting antibodies in an animal which bind to Lipid A or LPS comprising administering to the...
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5593969 |
Lipid-A analogs: monosaccharide and dissaccharide compounds for inhibiting binding of lipid A receptors to lipid A receptors
A compound of the formula: ##STR1## wherein: each of R 1 , R 1 ', R 2 and R 2 ' independent of each other is a substituted or unsubstituted, branched or linear C 1 -12 alkyl, alkene or alkyne...
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5585473 |
Compounds and methods for monosaccharide analysis
Compounds and methods are provided for use in monosaccharide analysis. The present invention discloses hydrazino monosaccharide derivatives. Methods for preparing and using hydrazino monosaccharide...
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5580553 |
Cosmetic composition containing alkenylsuccinic acid ester of saccharide
There is disclosed a cosmetic composition containing as an essential ingredient an alkenylsuccinic acid half ester of a saccharide which can be obtained by reacting the sugar with an...
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5576426 |
Aldolase catalyzed stereoselective synthesis of arabinohexulose, xyloheptulose, threohexulose and xylohexulose
The present invention relates to aldolase catalyzed stereo-selective synthesis of sugars and compositions of matter comprising arabinohexulose, xyloheptulose, threohexulose, and xylohexulose.
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5567683 |
Substituted lactose and lactosamine derivatives as cell adhesion inhibitors
Simple lactose or lactosamine related compounds which behave as ligands for the ELAM-1 and related receptors are described. These compounds are useful in the treatment of conditions characterized...
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5563250 |
Cleavable conjugates for the delivery and release of agents in native form
The present invention provides cleavable conjugates whose linkers contain a labile bond that is cleavable under a variety of mild conditions, including weakly acidic. Since the agent may be bonded...
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5563252 |
Polymerizable saccharide monomers which contain a single, polymerizable, α-methyl styryl moiety
Polymerizable, saccharide-derived monomers are prepared in processes which utilize water as the reaction solvent and which preferably do not utilize a cosolvent. The saccharide monomers are...
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5552387 |
Polycyclic ether antibiotics
An antibiotic of the formula ##STR1## wherein R is hydrogen or a pharmaceutically acceptable cation and Me is methyl.
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5543506 |
Polysaccharide derivative and separating agent
The present invention provides a novel polysaccharide derivative in which part or all of the hydroxyl groups or the amino groups contained in a polysaccharide are replaced by two or more kinds of...
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5539090 |
Release and isolation of N-glycans and O-glycans
N- and O-glycans are released from a glycoconjugate with a substantially anhydrous hydrazine reagent, the glycoconjugate being substantially salt-free and substantially anhydrous. Released N- and...
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5529986 |
Conjugate, its preparation and use and a substrate prepared with the conjugate
The present invention relates to a water-soluble conjugate having antithrombin-binding activity comprising a substantially straight-chained organic polymer backbone having at least 30 molecules of...
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5527675 |
Method for degradation and sequencing of polymers which sequentially eliminate terminal residues
A method and apparatus for sequentially degrading at least a portion of a polymer of backbone repeating units, the polymer having a terminal repeating unit comprised of a nucleophile and a backbone...
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5525710 |
Highly porous chitosan bodies
There is provided a crosslinked, highly porous chitosan body, wherein the porous body is characterized in that it has an open-celled 3-dimensional lattice structure, a density of less than about...
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5523212 |
Aryl N-alkylacridanthiocarboxylate derivatives useful for chemiluminescent detection
Aryl N-alkylacridanthiocarboxylate compounds which produce chemiluminescence. The compounds produce light with peroxide and peroxidase. The compounds are used as a substrate in assays for various...
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5521294 |
2,2-difluoro-3-carbamoyl ribose sulfonate compounds and process for the preparation of beta nucleosides
This invention provides novel 1-alkylsulfonyl-2,2-difluoro-3-carbamoyl ribose intermediates and intermediate nucleosides derived therefrom. The compounds are particularly useful in the preparation...
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5514547 |
Molecular genetic identification using probes that recognize polymorphic loci
Polynucleotide sequences and cloned DNA fragments useful for visualizing DNA polymorphism and other genetic analyses are disclosed herein. Specifically, polynucleotide probes and methods are...
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5508268 |
Parenteral elsamitrucin formulations
Stable parenteral antitumor formulations contain elsamitrucin salt, a stabilizer and a buffer. The formations are optionally stored in sealed containers under air or nitrogen headspace.
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5498707 |
Hydrogen sulfide converter
A composition adapted to convert hydrogen sulfide and organic sulfides to nontoxic polymers. The compositions comprise amine resin solutions made by reacting sterically hindered amines such as...
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5498604 |
Lewis-type sugar chain derivative
The object of the present invention is to provide a new SLe-type sugar chain derivative represented by the following formula (I), which is useful as a pharmaceutical and which contains moranoline:...
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5496937 |
Polysaccharide substances, process for producing them and use of them
A polysaccharide substance having the following formula is provided: ##STR1## Also provided is a method of producing the polysaccharide substance in which an oligosaccharide having a degree of...
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5496930 |
Unsaturatd sugar compounds
A process for highly regioselective esterification and ester cleavage on unsaturated sugar compounds with the aid of lipases and esterases, and products which can be prepared by this process....
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5491072 |
N-alkylacridan carboxyl derivatives useful for chemiluminescent detection
N-alkylacridan carboxylic acid derivative compounds (I) are used to generate chemiluminescence by the action of a peroxidase enzyme and an oxidant. The compounds I are useful in assays of all types.
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5489578 |
Sulfated ligands for l-selectin and methods of treating inflammation
Sulfated oligosaccharides which bind to L-selectin receptors and act as agonists are formulated into pharmaceutical formulations and administered by injection to treat inflammation. Compounds which...
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5476671 |
Synthetic ceramides and their use in cosmetic compostions
A novel pseudoceramide which has improved dispersibility in aqueous solutions and which can be produced by an economical manufacturing process. The process for producing new pseudoceramides and...
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5472860 |
Method for preparing N-acetylneuraminic acid by N-acetylneuraminic acid lysase at a pH of 10-12
A method for preparing N-acetylneuraminic acid characterized in reacting N-acetylglucosamine with pyruvic acid at an alkaline pH in the presence of N-acetylneuraminic acid lyase.
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5472582 |
Analysis of carbohydrates using 2-aminoacridone
The present invention provides for the use of the fluorescent label 2-aminoacridone for use in separating carbohydrate mixtures and analyzing the structure of carbohydrates. Carbohydrates for...
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5472951 |
Stabilizer for phospholipid vesicles
An oligosaccharide lipid is provided which has 2 to 20 saccharide units, and has a hydrophobic group linked by an ether linkage to an anomer carbon on a reducing end group. A stabilizer for a...
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5473059 |
Modified hydrophobic cationic thickening compositions
Water soluble quaternary ammonium ethers of polysaccharides or polyols wherein the quaternary ammonium ether substituents correspond to the formula ##STR1## wherein R 1 is a monohydroxylated or...
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5470965 |
Complexable heterogenous oligosaccharides and alpha-hydosanes having therapeutical activity, process for their preparation and related pharmaceutical compositions
Complexable heterogeneous oligosaccharides and pure alpha-hydosanes, namely not contaminated from other macromolecules (mucopolysaccharides, proteins, nucleic acids, etc.) of a defined molecular...
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