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5922860 |
Antitumor indolopyrrolocarbazole derivatives
This invention relates to compounds of the general formula ##STR1## or pharmaceutically salts thereof, wherein R 1 and R 2 each represent an OH group, R 1 is located at the 1- or 2-position, R 2...
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5905071 |
Glycosylamides of 2-aminoacylamino-2-deoxy sugars
The present invention relates to (2-aminoacylamino-2-deoxy-glycosyl)-amides, which are substituted on the nitrogen atom of the amino acid, of the general formula (I) ##STR1## in which the...
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5902801 |
Glucosamine sulfate metal chloride compositions and process of preparing same
Glucosamine compositions comprising the compounds glucosamine sulfate metal chloride, wherein the metal, i.e. the cation, is lithium, sodium, magnesium, zinc or manganese. The compounds have purity...
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5883079 |
Method for inhibiting H. pylori infection in mammalian tissue
A method for treating and/or inhibiting gastric and duodenal ulcers, comprising administering a pharmaceutical composition comprising an oligosaccharide of Formula I ...
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5882902 |
Amino acid conjugate
Method for synthesis of GalNAcα-serine or GalNAcα-threonine containing compounds, including at least one reaction where an α-saccharide or α-glycoside of GalNAca is used as gylcosyl donor and a...
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5880100 |
Method for inhibiting binding of human lens cells
The present invention provide a method of inhibiting an irregular binding of human cells caused by specific adhesion of Lewis x glycolipids by administering any of an oligosaccharide having a...
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5877158 |
Pro-prodrugs, their production and use
Substrate-spacer-prodrug compounds (pro-prodrugs) suited for site specific delivery of drugs, a process of preparing them and their use are described.
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5872111 |
Compositions comprising glycosylamide surfactants
The present invention relates to novel detergent and/or personal wash compositions comprising glycosylamide surfactants.
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5864024 |
Synthetic glycoamines and methods for their use that affect cell adhesion, inhibit cancer cell metastasis, and induce apoptosis
A class of molecules and methods that alter cell adhesion, inhibit cancer metastasis, and induce apoptosis. A method according to the present invention comprises bringing cells into contact with...
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5856299 |
Highly reactive esters of carboxy polysaccharides and carboxy polysaccharides derived therefrom
Provided are active esters of carboxy polysaccharides and semisynthetic derivatives of carboxy polysaccharides, wherein all or part of the carboxy groups thereof are esterified with an aromatic...
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5856453 |
Glycophospholipid
The present invention relates to glycophospholipids represented by the general formula I!: ##STR1## The glycophospholipid of the present invention can be obtained by extracting lipid fraction of...
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5849716 |
Sphingoglycolipids, their preparation, and therapeutic methods of use
The present invention relates to a sphingoglycolipid represented by the following formula (I) which is effective at a small dose and has an anti-tumor activity and an immunostimulating effect with...
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5847110 |
Method of reducing a schiff base
The invention relates to methods of reducing Schiff bases and making chelator conjugates by treating with borane-pyridine complex.
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5837695 |
Fluorescent chlamydia antigen substrate
The present invention relates to a unique fluorescently labeled Chlamydial antigen. This fluorescently labeled Chlamydial antigen is useful in immunoassay-type formatted systems for the detection...
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5811532 |
Covalently bound, polysaccharide-based chiral stationary phases
There are described stable, non-leaching chiral stationary phases in which a chiral polysaccharide or polysaccharide derivative is covalently bound through a spacer to the surface hydroxyl groups...
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5811405 |
Multiply fucosylated dicarboxylic acids possessing antiadhesive properties
The invention relates to multiply fucosylated dicarboxylic acid derivatives possessing antiadhesive properties, to a process for preparing them, to their use, and to pharmaceuticals and diagnostic...
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5807847 |
Nitrate esters
Aliphatic Nitrate esters having a sulfur or phosphorus atom β or γ to a nitrate group having efficacy as vasodilators are described. Preferred nitrate esters may be synthesized by nitration of a...
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5808018 |
Fluorine containing sialyl Lewis X derivatives and synthetic intermediates thereof
A sialyl Lewis X derivative represented by the general formula: ##STR1## in which a hydroxyl group at the 2 position of fucose is replaced with a fluorine atom, and a synthetic intermediate...
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5795749 |
Use of 2-deoxyribose-5-phosphate aldolase to prepare 2-deoxyfucose, analogues and derivatives
Processes using 2-deoxyribose-5-phosphate aldolase (DERA) are described for the preparation of 2-deoxyfucose and related compounds. In one embodiment, DERA is used to catalyze the condensation of...
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5792842 |
Ganglioside GM3 derivative having fluorine atom at 9-position of sialic acid and intermediates therefor
A ganglioside GM3 derivative having a fluorine atom at the 9-position of sialic acid represented by the formula: ##STR1## wherein R is an aliphatic lower acyl group, R 1 is a hydrogen atom or a...
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5786461 |
Peptide nucleic acids having amino acid side chains
A novel class of compounds, known as peptide nucleic acids, bind complementary DNA and RNA strands more strongly than the corresponding DNA or RNA strands, and exhibit increased sequence...
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5780606 |
Neisseria meningitidis capsular polysaccharide conjugates
Capsular polysaccharides containing multiple sialic acid residues, particularly the Group B polysaccharide of Neisseria meningitidis, are modified by chemical reaction to randomly introduce pendant...
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5780442 |
Orthosomycins from micromonospora carbonacae
Orthosomycins have been isolated from the fermentation broth of the microorganism Micromonospora Carbonacea var Africana designated SCC 2146. These compounds are antibacterial agents. Compositions...
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5763413 |
Lewis-associated compound, process for producing the same, and anti-inflammatory
A Lewis-associated compound, represented by general formula (I), a process for producing the same, and an anti-inflammatory, wherein R 1 and R 3 represent each hydrogen, m SO 3 H or CH 2 COOH;...
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5760199 |
Polysaccharide acid amide comprising fatty alkyl group in amide
Polysaccharide acid amide compositions are disclosed which contains one extra carbon atom as compared to the polysaccharide and which comprises an acid amide of the formula --C(O)N(R)(R') where R...
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5753630 |
Method for treating and inhibiting gastric and duodenal ulcers
A method for treating and/or inhibiting gastric and duodenal ulcers, comprising administering a pharmaceutical composition comprising an oligosaccharide of Formula I ...
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5753631 |
Intercellular adhesion mediators
The present invention is directed towards compositions and methods for reducing or controlling inflammation and for treating inflammatory disease processes and other pathological conditions...
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5744596 |
Nucleoside analogues and synthetic intermediates
The present invention relates to highly diastereoselective processes for production of cis-nucleosides and nucleoside analogues and derivatives in high optical purity and intermediates useful in...
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5741897 |
Process for preparing an N-substitued aldonamide
The present invention generally relates to a process for preparing an N-substituted aldonamide by reacting an aldonic acid in a polar organic solvent with an amine of the formula HNR 1 (X--NR 1...
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5739304 |
Process for the preparation of water-soluble aminoalkyl derivatives of polysaccharides
Water-soluble polysaccharides which contain a) substituents selected from the group consisting of alkyl, hydroxyalkyl, carboxyalkyl and sulfoalkyl, b) N,N-disubstituted aminoalkyl groups, are...
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5733892 |
Metastasis inhibitor composition comprising a phospholipid-linked glycosaminoglycan and method for inhibiting metastasis employing the same
This invention relates to compounds prepared by linking glycosaminoglycan to phospholipid or lipid, which are expected to exert a pharmacological effect for inhibiting metastasis because of their...
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5723504 |
Amadori reaction compounds and products, process for their manufacture, and their use as cytokine inducers
Novel Amadori reaction compounds have the formula R 1 --NH--R 2 , wherein R 1 comprises the D-form of a 1-amino-1-deoxy-2-ketose radical derived from a sugar radical selected from the group of...
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5721357 |
Preparation of sulfated polysaccharides for treatment or prevention of thromboses
The invention relates to new mixtures of sulfated oligosaccharides having the general structure of heparin constitutive oligosaccharides, having an average molecular mass of 6±0.6 kD, a...
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5719020 |
4,7-dialkoxy N-acetylneuraminic acid derivatives and methods for detection of influenza type A and B viruses in clinical specimens
Chromogenic and fluorogenic 4,7-dialkoxy-N-acetylneuraminic acid substrates of the general formula ##STR1## are provided wherein R 1 and R 2 are alkyl groups containing 1 to 4 carbon atoms and R...
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5700917 |
Aldehyde cationic derivatives of galactose containing polysaccharides used as paper strength additives
Aldehyde cationic derivatives of galactose containing polysaccharides which are obtained by oxidizing galactose containing polysaccharides with the enzyme galactose oxidase. The enzyme oxidized...
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5700918 |
Moranoline derivative
The present invention has for its object to provide a trisaccharide Lewis sugar-chain epitope derivative of the following structural formula, which is of value as a medicine and has a novel...
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5691423 |
Polysaccharide-bound nitric oxide-nucleophile adducts
A polymeric composition capable of releasing nitric oxide comprises a polysaccharide including a nitric oxide-releasing N 2 O 2 - functional group bound to the polymer; pharmaceutical...
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5686439 |
Chelate complexes and processes for their preparation
Phthalocyanine-chelate complexes of formula I ##STR1## are described which contain as central atom M aluminium, gallium, indium, tin, ruthenium or preferably germanium and in which the remaining...
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5681947 |
Oligonucleotides having universal nucleoside spacers
Oligonucleotides having at least ten nucleosides, at least two of which are selected from the group consisting of A, T, C and G, and at least one nucleoside being a universal nucleoside of the...
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5677285 |
Derivatives of neuraminic acid
Provided are new derivatives of neuraminic acid of formula (I), where Ac represents an acyl residue of an aliphatic, araliphatic, aromatic, alicyclic, or heterocyclic carboxylic acid, including...
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5665574 |
Method for preparing N-acetylneuraminic acid
A method for preparing N-acetylneuraminic acid characterized in reacting N-acetylglucosamine with pyruvic acid in an alkaline condition by the action of N-acetylneuraminic acid lyase.
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5665876 |
3-(aminoacyl-amino)-saccharides and processes for their preparation
The invention pertains to 3-(aminoacyl-amino)-saccharides of the general formula (I), ##STR1## wherein R' is selected from the group consisting of hydrogen, a carboxyl group, a phenyl group and an...
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5663311 |
Polysaccharide derivative and separation agent
The present invention provides a novel polysaccharide derivative in which part or the whole of the hydroxyl groups or the amino groups contained in a polysaccharide are displaced by two or more...
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5654282 |
Selectin binding glycopeptides
Glyco-amino acids and glycopeptides having three-dimensionally stable configurations are described. These glyco-amino acids and glycopeptides have glycoside functional groups, such as fucose and...
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5652335 |
Physiologically active substance well capable of permeating biomembrane
A physiologically active substance well capable of permeating biomembrane according to the present invention is represented by: ##STR1## where R represents a residue of a physiologically active...
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5648343 |
Method for treating LPS-mediated disorders
A purified lipid A from Rhizobium leguminosarum biovar phaseoli CE3, as well as analogs and derivatives of the purified lipid A are provided. Compositions containing heterogenous mixtures of lipid...
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5644049 |
Biomaterial comprising hyaluronic acid and derivatives thereof in interpenetrating polymer networks (IPN)
Provided is a biomaterial comprising an interpenetrating polymer network (IPN), wherein one of the polymer components is an acidic polysaccharide or a semi-synthetic derivative thereof. The...
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5643884 |
Lupane triterpenoid derivatives
This invention relates generally to the field of medicinal chemistry, and more specifically to derivatives of a subclass of triterpenoid acids that have multi-medicament properties, that is...
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5643780 |
Compositions and methods for modulating RNA activity through modification of the 5' cap structure of RNA
Methods for regulating gene expression in biological experimental systems via modification or removal of the 5' cap structure of targeted ribonucleic acids are disclosed. Modification or removal of...
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5641764 |
Halogenated DNA ligand radiosensitizers for cancer therapy
A radiosensitizer for use in radiotherapy comprises a halogenated DNA ligand. The susceptibility of DNA to radiation damage is enhanced by causing or allowing the halogenated DNA ligand to bind to...
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