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4946830 |
Agent and method for the prevention of metastases of malignant tumors
Agents and methods for the prevention of metastases of malignant tumors use the monosaccharides which are specific for organ cell lectins and/or glycoconjugates containing these monosaccharides,...
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4935503 |
Azidochlorination and diazidization of glycals
The invention describes a one-pot single step procedure for the azidochlorination or diazidization of glycals, including glycal elements of carbohydrates. Compounds such as...
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4935506 |
3-phenylthiosialic acid derivative, sialic acid-containing oligosaccharide derivative and process for preparing these compounds
Sialic acid derivatives and process for preparing these compounds. In these compounds, a phenylthio group is stereo-selectively incorporated at the 3-position of the sialic acid. These compounds...
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4932871 |
Rapid method for preparing chromogenic alpha-amylase substrate compounds at high preparative yields
A method for preparing chromogenic α-amylase substrate compounds at substantially high preparative yields in a relatively short period of time by the transglucosylation of a chromogenic glucoside...
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4923980 |
Process for the manufacture of a gel product
A process for the manufacture of a gel product, wherein the reducing sugar is covalently coupled to the matrix of the gel product, characterized in that the sugar, through its reducing end, is...
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4923975 |
Valiolamine derivatives and production thereof
A novel valiolamine derivative of the formula (I): ##STR1## where R stands for hydrogen or β-D-glucopyranosyl group is useful for a starting material of valiolamine which can be converted to more...
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4920099 |
Aminoglycoside steroids, a process for their preparation, their use and pharmaceutical compositions containing them
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4916136 |
Eicosatetraynoic acid amides and their application in pharmacy
Compound, characterized in that it corresponds to the formula: C 5 H 11 (C.tbd.C--CH 2 ) 4 --CH 2 CH 2 CO R (I) in which R is an amino group of structure ##STR1## in which R 1 and R 2 ,...
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4914195 |
Process for preparing N-acetylneuraminic acid derivatives
A new process for preparing halides of N-acetylneuraminic acids useful as an intermediate in preparing new N-acetylneuraminic acid derivatives having an excellent immunological activity is...
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4914085 |
Antirheumatic agent
Antirheumatic agent containing, as the active ingredient, a specific glycolipid such as difucosyl neolactonoroctasosylceramide or trifucosyl neolactonoroctaosylceramide. Said glycolipids are known...
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4912041 |
Determination of amylase
A method of assay for the presence of α-amylase in a sample employs a derivatized α-oligosaccharide which can be hydrolyzed by an enzyme mix including α-amylase to yield an electroactive...
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4912205 |
Alkyl-substituted phenylcarbamate derivative of polysaccharide
A new alkyl-substituted phenylcarbamate derivative of a polysaccharide, exclusive of cellulose, has an alkyl-substituted phenylcarbamoyl group for 80 to 100 percent of the hydroxyl groups attached...
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4906468 |
Insulin activity messengers, their antibodies, and thereof
An insulin activity messenger material and its precursor material are disclosed which have been isolated from hapatic plasma membranes that have been incubated with an enzyme known as a...
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4904644 |
Antimicrobial compound isolated from Actinomadura fulva subsp indica
A macrolactam disaccharide isolated from an antimicrobial complex 530 produced in fermentation under controlled conditions using a biologically pure culture of the microorganism Actinomadura fulva...
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4904771 |
Pseudouridine derivative
5'-Pseudouridyl-N-oleoyl carbamate represented by the formula: ##STR1## This compound is physiologically active in that it markedly enhances the actions of glucocorticoids and hence is useful as an...
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4894363 |
Derivatives of serotonin
The invention relates to new serotonin derivatives which form strong reducing agents. They can be represented by the formula: ##STR1## in which R represents a hydrogen atom or a hydroxyl group and...
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4888419 |
3'-demethoxyepipodophyllotoxin glucoside derivatives
This invention relates to novel 3'-demethoxy epipodophyllotoxin glucosides, their use as anti-tumor agents, and pharmaceutical compositions thereof.
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4883598 |
Process for isolating coagulation factors, and adsorbent material suitable therefor
This invention relates to a process and to absorbent material for isolating coagulation factors, including FVIII and vWF, from the example blood plasma and plasma products by means of liquid...
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4863907 |
Crosslinked glycosaminoglycans and their use
Crosslinked glycosaminoglycans or salts thereof prepared by crosslinking glycosaminoglycan or salts thereof with a polyfunctional epoxy compound wherein a crosslinking index is 0.005 or more per 1...
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4861872 |
Alkyl-phenylcarbamate derivative of polysaccharide
An alkyl-phenylcarbamate derivative of a polysaccharide has in 80 to 100 percent of hydrogen atoms of the amino and hydroxyl groups an alkylphenyl-carbamoyl group having the formula (I): ##STR1##...
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RE33000 |
Therapeutic composition and method of treating viruses
The invention provides a novel therapeutic composition comprising a pharmaceutically acceptable carrier containing a therapeutically effective amount of an ethereal monosubstitution of a...
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4845090 |
Nitroxyl compound and diagnostic media based thereon useful for enhancing NMR imaging
Diagnostic media suitable for NMR diagnoses contain compounds of Formula I ##STR1## wherein is a single bond or a double bond, X is the grouping --(CH 2 ) n -- or, if is a single bond, also...
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4839466 |
Insulin activity messengers
An insulin activity messenger material and its precursor material are disclosed which have been isolated from hapatic plasma membrane cells that have been incubated with an enzyme known as a...
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4837313 |
Polygalactosamine PF-192 and salts thereof
A natural polymer material PF-102 and salts thereof are widely available as a convenient flocculant for fine suspended matters. PF-102 can be produced by, for example, an imperfect fungus...
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4835265 |
Substituted and crosslinked glucans, process and intermediates for preparing them and use thereof
Glucans substituted by reacting oxo acids with the amino groups of a chitosan or of a polyglucosamine, reducing the imines thus formed and crosslinking the thus obtained compounds to yield gels...
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4831126 |
Antigenic polysaccharide specific to Brucella abortus and Yersinia enterocolitica serotype 0:9
The antigenic O-chain polysaccharides from Brucella abortus and Yersinia enterocolitica serotype 0:9 have similar structure, i.e. 1-2 linked 4,6-dideoxy-4-formamido-α-D-mannopyranosyl units. The...
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4814437 |
Method for preparation of sulfated polysaccharides by treating the polysaccharide with a reducing agent before sulfation
A new method for preparation of sulfated polysaccharides by means of pyridine-chlorosulfonic acid reagents. The polysaccharide is before sulfation treated with a reducing agent, e.g. sodium...
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4801581 |
Pharmaceutical composition containing para-amino-benzoic acid-N-D-xyloside as an active ingredient
Disclosed is a pharmaceutical composition containing p-aminobenzoic acid-N-D-xyloside or a pharmaceutically a acceptable salt thereof as an active ingredient.
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4801583 |
Oligosaccharides and their biological applications
The oligosaccharides of the invention contain or are constituted by a tetrasaccharide enchainment of the formula: ##STR1## in which R 1 represents an organic anion, R 2 is identical to R 1 or...
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4797477 |
Process for preparing sialic acid derivatives
The present invention relates to a new process for preparing 3-O-(sodium(5-acetamide-3,5-dideoxy-alpha-D-glycero-D-galact
o-2-noneuro pyranosyl)onate-1,2-di-O-tetradecyl-Sn-glycerol (3) consisting...
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4786725 |
Solubilized platinum (II) complexes
There are described platinum-polyhydroxylated amine compounds which exhibit anti-tumor activity in mammalian species. The products are highly soluble in aqueous solutions and they may be...
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4774327 |
N-glycolylneuraminic acid derivative
This invention provides a novel compound having the following formula: ##STR1## This compound is a useful intermediate for the preparation of N-glycolylneuraminic acid: ##STR2##
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4774326 |
Process for preparing N-glycolylneuraminic acid derivatives
This invention provides a novel process for preparing a compound represented by the formula ##STR1## In accordance with this invention, the compound is prepared by reacting a compound represented...
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4767850 |
Process for the purification of acarbose with polymers
In the purification of acarbose by contacting an acarbose-containing solution with a cation exchanger to adsorb the acarbose, eluting the ion exchanger and collecting an eluate fraction enriched in...
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4762824 |
Compositions and methods useful for uropathogenic bacterial identification or diagnosis and inhibition of adherence of uropathogenic bacteria to cells having a structural element similar to that of the active principle of the invention
Compositions and methods useful for identification or diagnostic use, or inhibition of adherence of uropathogenic bacteria to cells, all in connection with uropathogenic bacterial infections,...
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4737488 |
Immune system-stimulating N-glycosylated ureas and carbamates
Compounds of the formula ##STR1## wherein R 1 is hydrogen, an optionally substituted aromatic hydrocarbon radical, an aralkyl radical or an optionally substituted aliphatic hydrocarbon radical...
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4736024 |
Process for preparing salt of hyaluronic acid with a pharmaceutically active substance
Pharmaceutical preparations for topical administration containing a pharmacologically active substance together with hyaluronic acid or a molecular weight fraction thereof. The hyaluronic acid may...
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4736022 |
Isolation of unreduced oligosaccharides
A preparative scale method for the isolation of unreduced oligosaccharides of glycoproteins and glycohormone having a N-linked oligosaccharide structure is disclosed. The method employs...
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4732976 |
3,3-neotrehalosadiamine antibiotic and producing it with novel microorganism
3,3'-Neotrehalosadiamine antibiotic is prepared by fermentation of B. pumilus K169-B91 (ATCC No. 53206) in a nutrient medium preferably comprising soybean meal, corn starch, calcium carbonate and...
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4720543 |
1a-7-substituted derivatives of mitomycin and uses thereof
This invention discloses 1a- and 7-substituted derivatives of mitosanes containing thiocarbamoyl and glycosyl residues. The compounds possess antibacterial and antitumor activity, with a...
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4719289 |
Glycopeptides, process for their preparation and their use
Compounds of the general formula I, II or III R 1 --A 1 --T--NH--R 2 --COR 3 I R 1 --A 1 --T--A 2 --NH--R 2 --COR 3 II R 1 --A 1 --T--A 2 --A 3 --T--A 4 --NH--R 2 ...
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4719202 |
Disaccharide and trisaccharide derivatives of the "Lipid A" type
The present invention is dealing with certain disaccharide or trisaccharide derivatives of the lipid A type, which have interesting immuno-modulating, more particularly immuno-stimulating properties.
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4716222 |
Substrates for hydrolases
Chromogenic substrates of the formula A--O--B are described, in which A represents the radical in the ion A--O - of a compound A--OH, whose absorbance is measured photometrically after hydrolysis...
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4707471 |
Water-soluble aminated β-1,3-bound D-glucan and composition containing same
Water-soluble aminated β-1,3-bound D-glucan and macrophage-stimulating composition containing as an active constituent such glucan.
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4705850 |
C-glycosidic adriamycin analogs
Disclosed herein is a new procedure for preparing the C.1-2,4-pentadienyl derivatives of 2-deoxyhexopyranoses, as well as a new procedure for allylation of daunosamine. These methods are...
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4703115 |
Platinum complexes of diamino-dideoxy sugars and di- or tricarboxylic acids
Platinum complexes and Di- or Tricarboxylic acids which is then reacted with the appropriate di- or tricarboxylic acid in aqueous medium.
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4698331 |
2,3-diamino-2,3-didesoxyhexose derivatives and their use
Compounds of formula I ##STR1## wherein R 2 and R 3 are the same or different and each represent unsubstituted or substituted acyl, and (a) R 1 represents lower alkyl, aralkyl or the...
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4696980 |
Sulfone activated thioether adsorbents for the separation of proteins and the like
The adsorbent consists of a solid phase, completely or partially penetrated by or surface-coated with a hydrophilic molecular polymer netting to which has been bound substituents or cross bridges...
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4697006 |
Modified oligosaccharides used as substrate for measuring α-amylase activity
A modified oligosaccharide having at most 7 glucose units and having a substituent selected from the group consisting of 2-aminopyridyl, 3-aminopyridyl, anilino, methylanilino, hydroxyanilino,...
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4690918 |
Use of trichostatin compounds for treating tumor cells
A method for inducing the differentiation of tumor cells in human or animal, which comprises administering an effective amount of trichostatin A and/or trichostatin C to the human or animal.
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