|
Match
|
Document |
Document Title |
|
|
7615652 |
Two-stage dehydration of sugars
The invention includes methods for producing dianhydrosugar alcohol by providing an acid catalyst within a reactor and passing a starting material through the reactor at a first temperature. At...
|
|
|
7605241 |
Synthesis of inhibitors of p90Rsk
The synthesis of the naturally occurring kaempferol glycoside SLO1O1-1, as well as analogs thereof, has been accomplished, as has its biochemical evaluation. SLO1O1-1 exhibits selective and potent...
|
|
|
7572898 |
Process of making an alpha-anomer enriched 2-deoxy-2,2-difluoro-D-ribofuranosyl sulfonate and use thereof for making a beta nucleoside
A process of preparing an alpha-anomer enriched 2-deoxy-2,2-difluoro-D-ribofunanosyl sulfonate, which is useful as an intermediate in the preparation of a beta nucleoside, such as gemcitabine, an...
|
|
|
7569686 |
Compounds and methods for synthesis of bicyclic nucleic acid analogs
The present invention provides compounds and methods of using them for preparing bicyclic nucleosides. The bicyclic nucleosides are useful for preparing chemically modified oligomeric compounds....
|
|
|
7538092 |
Pharmaceutically active oligosaccharide conjugates
The present invention relates to pharmaceutically active oligosaccharide conjugates having the formula: (X—Y m ) n —S, wherein component X is a pharmaceutically active compound, Y is a...
|
|
|
7524822 |
Crystalline form of 1′-(1-methylethyl)-4′-[(2-fluoro-4-methoxyphenyl)methyl]-5′-methyl-1H-pyrazol-3′-O-β-D-glucopyranoside, a method for its preparation and the use thereof for preparing medicaments
The invention relates to a crystalline form of 1′-(1-methylethyl)-4′-[(2-fluoro-4-methoxyphenyl)methyl]
-5′-methyl-1H-pyrazol-3′-O-β-D-glucopyranoside, to a method for the preparation...
|
|
|
7514541 |
Process for the production of multiple cross-linked hyaluronic acid derivatives
The present invention relates to a process for the production of cross-linked hyaluronic acid (HA) derivatives, in particular multiple, e.g. double cross-linked hyaluronic acid derivatives. The...
|
|
|
7510657 |
Method of preparing affinity ligands
The present invention is a method of preparing affinity ligands, which method comprises to provide a cyclic scaffold comprising a thiol group, a carbonyl group and an amine group; to derivatize the...
|
|
|
7470671 |
Thioxylose compounds, preparation method thereof, pharmaceutical compositions containing same and use thereof in therapeutics
The invention relates to novel 5-thioxylose compounds, preferably derivatives of the 5-thioxylopyranose type, to the method for their preparation and to their use as active principles of drugs...
|
|
|
7439352 |
Process for the production of anhydrosugar alcohols
A process is provided for the preparation of anhydrosugar alcohols. The process involves heating a sugar alcohol or a monoanhydrosugar alcohol starting material in the presence of an acid catalyst,...
|
|
|
7439344 |
Selective O-acylation of nucleosides
The present invention relates to a one-step process for the selective O-acylation of the hydroxy groups of a nucleoside under basic conditions utilizing DMAP and a carboxylic acid anhydride in...
|
|
|
7435816 |
Synthesis of solanum glycosides
The present invention relates to the chemical synthesis of solanum glycosides, in particular to the synthesis of solasonine as well as to novel β-monosaccharide intermediate compounds, of Formula...
|
|
|
7432368 |
Photolabile protecting groups
The present invention relates to novel nucleoside derivatives of general formula (I)
wherein R 1 =H, halogen, NO 2 , CN, OCH 3 , an alkyl, alkoxy or alkoxyalkyl residue having 1 to 4 C atoms,...
|
|
|
7396925 |
Volatilizable solid phase supports for compound synthesis
A solid phase synthetic method is disclosed in which the usual solid phase synthetic steps are carried out and the spent solid phase support is reacted to form a volatilizable compound upon...
|
|
|
7375090 |
Glucopyranosyloxy-pyrazoles, pharmaceutical compositions containing these compounds, the use thereof and processed for the preparation thereof
The present invention relates to glucopyranosyloxy-pyrazoles of general formula
wherein
R 1 to R 6 and R 7a , R 7b , R 7c are defined as in claim 1 , the tautomers, the stereoisomers, the...
|
|
|
7365055 |
Derivatives of morphine-6-glucuronide, pharmaceutical compositions containing them, their preparation method and their uses
The invention relates to novel derivatives of morphine-6-glucuronide, the preparation method thereof and the uses of same in therapy, for example, as analgesics.
|
|
|
7361744 |
Oligosaccharide derivative
Compounds having the formula (I):
wherein A represents a group such as a cyclic group, R 1 and R 2 represent groups such as alkyl groups or hydroxymethyl groups, and n represents 1 or 2, or...
|
|
|
7361745 |
Process for the preparation of 1-chloro-3,5-di-o-acyl-2-deoxy-l-ribofuranoside derivatives
Herein described is a process for the preparation of 1-chloro-3,5-di-O-acyl-2-de-oxy-L-ribofuranoside derivatives of general formula (I) useful as intermediates in processes for preparing...
|
|
|
7351809 |
Glycerol carbonate glycoside
A process is provided for the selective and convenient production of a glycerol glycoside, which has been glycosidated at the 1-hydroxyl group of glycerol and is useful as a glyceroglycolipid...
|
|
|
7335627 |
Polymeric alkylpolyglycoside carboxylates
The products of the invention are polymers of carboxylated alkylpolyglycosides. The products are very mild surfactants that are useful in personal care applications.
|
|
|
RE40040 |
Process of use in converting the 4″(S)-OH functional group of the cladinose unit of an azamacrolide to 4″(R)-NH2
The subject-matter of the invention is a process for the stereoselective preparation of a compound of general formula I
by stereoselective displacement by a nitrogenous nucleophilic compound...
|
|
|
7282150 |
Method of extracting and method of purifying an effective substance
A method for extracting a hydrophobic group-containing water-soluble organic compound, comprising the step of bringing an aqueous solution containing the hydrophobic group-containing water-soluble...
|
|
|
7241875 |
Method for the production of surface active agent mixtures
An aqueous surfactant mixture comprised of an alkyl and/or alkenyl oligoglycoside ether carboxylic acid is made by a process comprising reacting in an aqueous solution an alkyl and/or alkenyl...
|
|
|
7235646 |
Process for the preparation of azithromycin monohydrate isopropanol clathrate
The present invention relates to an improved, cost effective and easy process for the preparation of azithromycin monohydrate isopropanol clathrate. The process provides a one-step method of...
|
|
|
7211663 |
Synthesis of oligosaccharides, reagents and methods related thereto
One aspect of the present invention relates to differentially protected glycosyl phosphates. Another aspect of the present invention relates to the preparation of glycosyl phosphates from glycal...
|
|
|
7205395 |
Process of preparing azithromycin and crystalline 9-deoxo-9a-aza-9a-homoerythromycin A hydrate used therein
Azithromycin is prepared in a high yield by a simple process using a crystalline 9-deoxo-9a-aza-9a-homoerythromycin A hydrate.
|
|
|
7205394 |
Clathrate of azithromycin hydrate with 1,2-propyleneglycol, method for the manufacture thereof and pharmaceutical composition comprising same
A clathrate of azithromycin hydrate with 1,2-propyleneglycol is much less hygroscopic than azithromycin hydrate or crystals known in the art, therefore, it can be useful for the preparation of a...
|
|
|
RE39560 |
Erythromycin A derivatives and method for preparing same
Erythromycin A derivatives represented by the general formula
wherein R 1 is a 2-alkenyl group having 3 to 15 carbon atoms, an arylmethyl group, or an arylmethyl group substituted by 1 to 3...
|
|
|
RE39531 |
9-hydrazone and 9-azine erythromycin derivatives and a process for making the same
Disclosed are 9-hydrazone erythromycin and 9-azine erythromycin derivatives and the processes for making the same. The compounds are useful intermediates for conversion into 6-O-alkyl erythromycin....
|
|
|
7196179 |
Method for manufacturing calcium gluconolcatate compositions, processes and uses
A method to manufacture calcium gluconolactate as a single molecule, compositions formed thereby, and uses therefor are disclosed and described. In one embodiment, a method of manufacturing calcium...
|
|
|
7157432 |
Tetraphenylbacteriochlorin derivatives and compositions containing the same
Provided is a tetraphenylbacteriochlorin derivative represented by the formula (I):
[wherein R 1 , R 2 , R 3 and R 4 , independently from each other, are a residue of a monosaccharide...
|
|
|
7148223 |
4′-thio-L-xylo furanosyl nucleosides, precursors thereof, preparation and use thereof
Compounds represented by the formula 1:
A is selected from the group consisting of
wherein each R individually is H or acyl, Y is X, N 3 , NH 2 , monoalkylamino, or dialkylamino; Z is...
|
|
|
RE39383 |
Process for 6-O-alkylation of erythromycin derivatives
A procedure for preparing 6-O-alkyl erythromycin compounds having the formula:
wherein R 1 is a loweralkyl group, R 2 and R 3 an independently hydrogen or a hydroxy-protecting group, except...
|
|
|
7109182 |
Synthetic oligomannosides, preparation and uses thereof
A pharmaceutical composition including a therapeutically effective amount of at least one oligomannoside produced by chemical synthesis which is homologous to a wall oligomannoside of an infectious...
|
|
|
7071314 |
Arylation method for the functionalization of O-allyl erythromycin derivatives
An efficient arylation technique for use in the synthesis of erythromycin derivatives, involving a modified Heck reaction which employs less than six mole percent of palladium catalyst and no...
|
|
|
7049417 |
6,11-4-Carbon bridged ketolides
Novel 6,11-4-carbon bridged ketolides, pharmaceutically-acceptable compositions comprising a therapeutically effective amount of a compound of the invention in combination with a...
|
|
|
7045506 |
Personal care applications of surfactants based upon alkyl p lyglycosides
The invention relates to a series of polyglycoside derivatives that contain water-soluble groups introduced into the molecule by reaction with the hydroxyl groups present in the starting...
|
|
|
7038039 |
Process for selectively producing 1-phosphorylated sugar derivative anomer and process for producing nucleoside
A desired isomer is selectively prepared by phosphorolyzing and isomerizing an anomer mixture of a 1-phosphorylated saccharide derivative while crystallizing one of the isomers to displace the...
|
|
|
7022679 |
Processes for the preparation of 6-11 bicyclic erythromycin derivatives
The present invention relates to processes and intermediates for the preparation of 6–11 bicyclic erythromycin derivatives. In particular, the present invention relates to processes and...
|
|
|
7019131 |
Programmable one-pot oligosaccharide synthesis
The reactivity of a number of p-methylphenyl thioglycoside (STol) donors which are either fully protected or have one hydroxyl group exposed has been quantitatively determined by HPLC in...
|
|
|
7001994 |
Methods for introducing mannose 6-phosphate and other oligosaccharides onto glycoproteins
Methods to introduce highly phosphorylated mannopyranosyl oligosaccharide derivatives containing mannose 6-phosphate (M6P), or other oligosaccharides bearing other terminal hexoses, to carbonyl...
|
|
|
6960654 |
Method of forming glycosidic bonds from thioglycosides using an N,N-dialkylsulfinamide
A method of forming a glycosidic bond utilizing an activated thioglycoside is disclosed. The thioglycoside is activated by an N,N-dialkylsulfinamide and trifluoromethanesulfonic anhydride. The...
|
|
|
6958314 |
Alkylated alkyl polyglucoside non-ionic surfactants
A petro-chemical free nonionic surfactant is prepared by the alkylation of an alkyl polyglucoside (APG). Under suitable alkylation reaction conditions, the surfactants are preferably prepared by...
|
|
|
6953850 |
Protecting groups for carbohydrate synthesis
The invention provides collections of orthogonally-protected monosaccharides as universal building blocks for the synthesis of glycoconjugates of non-carbohydrate molecules, neo-glycoconjugates and...
|
|
|
6949524 |
Polysaccharide conjugates of biomolecules
Compounds that are modified polysaccharides having pendant aldehyde functionalities are disclosed. Each of the aldehyde functionalities is attached through a linker to a position corresponding to a...
|
|
|
6949519 |
Macrolide solvates
Azithromycin in the form of a monohydrate comprising from 4.0% to 6.5% of water, a process for its preparation and its use in pharmaceutical compositions.
|
|
|
6936591 |
Amorphous 9-deoxo-9a-aza-9a-methyl-9a-homoerythromycin A, process for preparing the same, and uses thereof
Substantially pure amorphous 9-deoxo-9a-aza-9a-methyl-9a-homoerythromycin A. In addition, this disclosure is directed to a process for the preparation thereof from crude...
|
|
|
6936588 |
Method of production of an isomaltulose-containing enteral nutrient
The present invention relates to a method for the production and use of enteral nutrients, particularly an enteral solution, wherein this method is distinguished by a particularly gentle...
|
|
|
6936710 |
Process for oxidizing primary alcohols
Primary hydroxyl groups in a substrate having both primary and secondary hydroxyl groups can be selectively oxidized to carbaldehyde and/or carboxyl groups by contacting the substrate with a cyclic...
|
|
|
6927211 |
Method for reducing toxicity of combined chemotherapies
Compositions and methods are provided for use in the treatment of cancer.
|