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7375090 |
Glucopyranosyloxy-pyrazoles, pharmaceutical compositions containing these compounds, the use thereof and processed for the preparation thereof
The present invention relates to glucopyranosyloxy-pyrazoles of general formula
wherein
R 1 to R 6 and R 7a , R 7b , R 7c are defined as in claim 1 , the tautomers, the stereoisomers, the...
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7365055 |
Derivatives of morphine-6-glucuronide, pharmaceutical compositions containing them, their preparation method and their uses
The invention relates to novel derivatives of morphine-6-glucuronide, the preparation method thereof and the uses of same in therapy, for example, as analgesics.
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7361745 |
Process for the preparation of 1-chloro-3,5-di-o-acyl-2-deoxy-l-ribofuranoside derivatives
Herein described is a process for the preparation of 1-chloro-3,5-di-O-acyl-2-de-oxy-L-ribofuranoside derivatives of general formula (I) useful as intermediates in processes for preparing...
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7361744 |
Oligosaccharide derivative
Compounds having the formula (I):
wherein A represents a group such as a cyclic group, R 1 and R 2 represent groups such as alkyl groups or hydroxymethyl groups, and n represents 1 or 2, or...
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7351809 |
Glycerol carbonate glycoside
A process is provided for the selective and convenient production of a glycerol glycoside, which has been glycosidated at the 1-hydroxyl group of glycerol and is useful as a glyceroglycolipid...
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7335627 |
Polymeric alkylpolyglycoside carboxylates
The products of the invention are polymers of carboxylated alkylpolyglycosides. The products are very mild surfactants that are useful in personal care applications.
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RE40040 |
Process of use in converting the 4″(S)-OH functional group of the cladinose unit of an azamacrolide to 4″(R)-NH2
The subject-matter of the invention is a process for the stereoselective preparation of a compound of general formula I
by stereoselective displacement by a nitrogenous nucleophilic compound...
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7282150 |
Method of extracting and method of purifying an effective substance
A method for extracting a hydrophobic group-containing water-soluble organic compound, comprising the step of bringing an aqueous solution containing the hydrophobic group-containing water-soluble...
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7241875 |
Method for the production of surface active agent mixtures
An aqueous surfactant mixture comprised of an alkyl and/or alkenyl oligoglycoside ether carboxylic acid is made by a process comprising reacting in an aqueous solution an alkyl and/or alkenyl...
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7235646 |
Process for the preparation of azithromycin monohydrate isopropanol clathrate
The present invention relates to an improved, cost effective and easy process for the preparation of azithromycin monohydrate isopropanol clathrate. The process provides a one-step method of...
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7211663 |
Synthesis of oligosaccharides, reagents and methods related thereto
One aspect of the present invention relates to differentially protected glycosyl phosphates. Another aspect of the present invention relates to the preparation of glycosyl phosphates from glycal...
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7205395 |
Process of preparing azithromycin and crystalline 9-deoxo-9a-aza-9a-homoerythromycin A hydrate used therein
Azithromycin is prepared in a high yield by a simple process using a crystalline 9-deoxo-9a-aza-9a-homoerythromycin A hydrate.
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7205394 |
Clathrate of azithromycin hydrate with 1,2-propyleneglycol, method for the manufacture thereof and pharmaceutical composition comprising same
A clathrate of azithromycin hydrate with 1,2-propyleneglycol is much less hygroscopic than azithromycin hydrate or crystals known in the art, therefore, it can be useful for the preparation of a...
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RE39560 |
Erythromycin A derivatives and method for preparing same
Erythromycin A derivatives represented by the general formula
wherein R 1 is a 2-alkenyl group having 3 to 15 carbon atoms, an arylmethyl group, or an arylmethyl group substituted by 1 to 3...
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7196179 |
Method for manufacturing calcium gluconolcatate compositions, processes and uses
A method to manufacture calcium gluconolactate as a single molecule, compositions formed thereby, and uses therefor are disclosed and described. In one embodiment, a method of manufacturing calcium...
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RE39531 |
9-hydrazone and 9-azine erythromycin derivatives and a process for making the same
Disclosed are 9-hydrazone erythromycin and 9-azine erythromycin derivatives and the processes for making the same. The compounds are useful intermediates for conversion into 6-O-alkyl erythromycin....
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7157432 |
Tetraphenylbacteriochlorin derivatives and compositions containing the same
Provided is a tetraphenylbacteriochlorin derivative represented by the formula (I):
[wherein R 1 , R 2 , R 3 and R 4 , independently from each other, are a residue of a monosaccharide...
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7148223 |
4′-thio-L-xylo furanosyl nucleosides, precursors thereof, preparation and use thereof
Compounds represented by the formula 1:
A is selected from the group consisting of
wherein each R individually is H or acyl, Y is X, N 3 , NH 2 , monoalkylamino, or dialkylamino; Z is...
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RE39383 |
Process for 6-O-alkylation of erythromycin derivatives
A procedure for preparing 6-O-alkyl erythromycin compounds having the formula:
wherein R 1 is a loweralkyl group, R 2 and R 3 an independently hydrogen or a hydroxy-protecting group, except...
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7109182 |
Synthetic oligomannosides, preparation and uses thereof
A pharmaceutical composition including a therapeutically effective amount of at least one oligomannoside produced by chemical synthesis which is homologous to a wall oligomannoside of an infectious...
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7071314 |
Arylation method for the functionalization of O-allyl erythromycin derivatives
An efficient arylation technique for use in the synthesis of erythromycin derivatives, involving a modified Heck reaction which employs less than six mole percent of palladium catalyst and no...
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7049417 |
6,11-4-Carbon bridged ketolides
Novel 6,11-4-carbon bridged ketolides, pharmaceutically-acceptable compositions comprising a therapeutically effective amount of a compound of the invention in combination with a...
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7045506 |
Personal care applications of surfactants based upon alkyl p lyglycosides
The invention relates to a series of polyglycoside derivatives that contain water-soluble groups introduced into the molecule by reaction with the hydroxyl groups present in the starting...
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7038039 |
Process for selectively producing 1-phosphorylated sugar derivative anomer and process for producing nucleoside
A desired isomer is selectively prepared by phosphorolyzing and isomerizing an anomer mixture of a 1-phosphorylated saccharide derivative while crystallizing one of the isomers to displace the...
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7022679 |
Processes for the preparation of 6-11 bicyclic erythromycin derivatives
The present invention relates to processes and intermediates for the preparation of 6–11 bicyclic erythromycin derivatives. In particular, the present invention relates to processes and...
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7019131 |
Programmable one-pot oligosaccharide synthesis
The reactivity of a number of p-methylphenyl thioglycoside (STol) donors which are either fully protected or have one hydroxyl group exposed has been quantitatively determined by HPLC in...
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7001994 |
Methods for introducing mannose 6-phosphate and other oligosaccharides onto glycoproteins
Methods to introduce highly phosphorylated mannopyranosyl oligosaccharide derivatives containing mannose 6-phosphate (M6P), or other oligosaccharides bearing other terminal hexoses, to carbonyl...
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6960654 |
Method of forming glycosidic bonds from thioglycosides using an N,N-dialkylsulfinamide
A method of forming a glycosidic bond utilizing an activated thioglycoside is disclosed. The thioglycoside is activated by an N,N-dialkylsulfinamide and trifluoromethanesulfonic anhydride. The...
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6958314 |
Alkylated alkyl polyglucoside non-ionic surfactants
A petro-chemical free nonionic surfactant is prepared by the alkylation of an alkyl polyglucoside (APG). Under suitable alkylation reaction conditions, the surfactants are preferably prepared by...
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6953850 |
Protecting groups for carbohydrate synthesis
The invention provides collections of orthogonally-protected monosaccharides as universal building blocks for the synthesis of glycoconjugates of non-carbohydrate molecules, neo-glycoconjugates and...
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6949524 |
Polysaccharide conjugates of biomolecules
Compounds that are modified polysaccharides having pendant aldehyde functionalities are disclosed. Each of the aldehyde functionalities is attached through a linker to a position corresponding to a...
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6949519 |
Macrolide solvates
Azithromycin in the form of a monohydrate comprising from 4.0% to 6.5% of water, a process for its preparation and its use in pharmaceutical compositions.
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6936710 |
Process for oxidizing primary alcohols
Primary hydroxyl groups in a substrate having both primary and secondary hydroxyl groups can be selectively oxidized to carbaldehyde and/or carboxyl groups by contacting the substrate with a cyclic...
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6936591 |
Amorphous 9-deoxo-9a-aza-9a-methyl-9a-homoerythromycin A, process for preparing the same, and uses thereof
Substantially pure amorphous 9-deoxo-9a-aza-9a-methyl-9a-homoerythromycin A. In addition, this disclosure is directed to a process for the preparation thereof from crude...
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6936588 |
Method of production of an isomaltulose-containing enteral nutrient
The present invention relates to a method for the production and use of enteral nutrients, particularly an enteral solution, wherein this method is distinguished by a particularly gentle...
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6927211 |
Method for reducing toxicity of combined chemotherapies
Compositions and methods are provided for use in the treatment of cancer.
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6921841 |
Process for the synthesis of optically active anthracyclines
It is described a process for the synthesis of optically active anthracyclines by the fact that the key intermediate (R)2-acetyl-2-hydroxy-1,2,3,4-tetrahydronaphtalene...
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6916920 |
Process for producing hydrazinomonosaccharide derivatives and use thereof
A process for producing hydrazinomonosaccharide derivatives and use of hydrazines in determining the structures of aldose and ketose monosaccharides located at the reducing ends of saccharides.
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6916792 |
Process for preparing erythromycin compound
The present invention is to provide a process for producing a 2′-O-acetyl-4″-formyl-8,9-anhydroerythromycin A 6,9-hemiketal compound 4, and it provide a process for producing an erythromycin...
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6914061 |
4′-thio-L-xylofuranosyl nucleosides, precursors thereof, preparation and use thereof
Compounds represented by the formula 1:
A is selected from the group consisting of
wherein each R individually is H or acyl, Y is X, N 3 , NH 2 , monoalkylamino, or dialkylamino; Z...
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6906184 |
Process for antiparasitic agent
An improved process for the preparation of the antiparasitic compound 25-cyclohexyl-22,23-dihydro-5-hydroxyiminoavermectin B1 monosaccharide from doramectine and intermediates therefor and...
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6906039 |
Process for preparation of erythromycin compounds
The present invention is to provide a process for producing a 2′-O-acetyl-4″-O-formyl-8,9-anhydroerythromycin A 6,9-hemiketal compound 4 , and it provide a process for producing an...
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6900296 |
Cost effective method for selective methylation of erythromycin A derivatives
The invention relates to a cost effective and industrially advantageous process for the selective methylation of a hydroxy group at the 6 position of erythromycin A derivative which comprised...
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6900295 |
Polymeric compound comprising glycopolymer and a method for decomposing the same
The present invention is an enzyme-decomposable polymer compound having recyclable decomposition products. The polymeric compound is a glycopolymer of a saccharide having only glucopyranose rings...
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6897299 |
Process for producing erythromycin derivative
A method for preparing a fumarate salt of a compound represented by Formula (II):
(wherein R 1 represents a hydrogen atom or a lower alkyl group, and R 2 represents a lower alkyl group),...
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6881549 |
Method for introduction of reporter groups into bacterial lipopolysaccharide-derived carbohydrates and the subsequent coupling of such derivatives onto solid surfaces
The present invention provides a method for immobilizing a polysaccharide (PS) to a solid surface, said polysaccharide having a keto-carboxy group (—C(═O)—COOH) or a ketal or hemiketal group...
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6875861 |
Process for producing nitrosonium ions
A process for producing nitrosonium ions is described, in which a nitroxyl compound such as TEMPO is oxidized using an oxidizing agent in the presence of a complex of a transition metal such as Mn,...
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6872707 |
Halo derivatives of 9-deoxo-9a-aza-homerythromycin A
The invention relates to halo derivatives of 9a-N-(N′-arylcarbamoyl)- and 9a-N-(N′-arylthiocarbamoyl)-9-deoxo-9a-aza-9a-homoerythrom
ycin A of the general formula (I)
wherein R has the...
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6867296 |
Recovery and purification of anhydro sugar alcohols from a vapor stream
This invention concerns a process for recovering and purifying dianhydro sugar alcohols from a vapor stream comprising dianhydro sugar alcohols, such as isosorbide, and water vapor.
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6861512 |
Separation of olefinic isomers
The geometric isomers of olefins and olefinic compounds are separated by means of liquid chromatography using a stationary phase comprising an organosilane with a pendant aliphatic functional group...
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