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8742094 Method for the solid phase-based production of phosphate-bridged nucleoside conjugates  
The invention relates to a method for producing phosphate-bridged nucleoside conjugates. In the method, a cyclosaligenyl nucleotide is produced first, to which a linker is added, which is used to...
8710210 Method of using N-thio compounds for oligonucleotide synthesis  
A method for synthesizing an oligonucleotide which comprises using a sulfurizing agent of general formula (I) for sulfurizing at least one phosphorus internucleotide linkage of a precursor of the...
8703923 Process for preparing fondaparinux sodium and intermediates useful in the synthesis thereof  
Processes for the synthesis of the Factor Xa anticoagulent Fondaparinux, and related compounds are described. Also described are protected pentasaccharide intermediates as well as efficient and...
8691517 Flexible carbohydrate-bearing polymer  
A sensor for the detection or measurement of a carbohydrate analyte in fluid comprises components of a competitive binding assay the readout of which is a detectable or measurable optical signal...
8680251 Triterpenoid 2-deoxy glycosides, method of preparation thereof and use thereof as medicaments  
The invention describes novel triterpenoid 2-deoxy glycosides of general formula I, wherein at least one of the substituents X1 and R2 contains a 2-deoxy glycosidic group, method of preparation...
8653049 Normuramyl glycopeptide compounds  
The invention provides a compound (which can act as an adjuvant) of Formula I or Formula (II), wherein R1 R4 R5 R6 and R7 are each independently selected from hydrogen, acetyl, hydrocarbyl, a lipid...
8614314 Saccharide structures and methods of making and using such structures  
Described are oligosaccharides having a protecting group at two, a plurality, a majority of, or each position in the oligosaccharide which is amenable to derivatization. Collections, libraries and...
8546549 Processes for the convergent synthesis of calicheamicin derivatives  
This invention describes processes for the convergent synthesis of calicheamicin derivatives, and similar analogs using bifunctional and trifunctional linker intermediates.
8541381 Process for producing enriched fractions containing up to 100% of bacopasaponins from the plant materials of bacopa species  
This invention describes a process for producing a fraction enriched with jujubogenin and psudojujubogenin lycosides from Bacopa species, wherein the total Bacopa saponin concentration is up to...
8492125 Method for dissolving cellulose and a cellulosic product obtained from a solution comprising dissolved cellulose  
The present invention relates to a method for dissolving cellulose. The method comprises—introducing cellulosic raw material,—treating the cellulosic raw material in an enzymatic treatment pro...
8470984 Process for the preparation of morpholinyl anthracycline derivatives  
The present invention provides a process for the preparation of a morpholinyl anthracycline derivative in good yields and purity, including...
8461312 Method for the production of 1,4-benzothiepin-1,1-dioxide derivatives  
The invention relates to a method for producing 1,4-benzothiepin-1,1-dioxide derivatives substituted with benzyl groups.
8436157 Method for the production of sucralose  
The present invention provides a method for producing sucralose from a feed stream including a sucrose-6-acylate in a reaction vehicle. The method includes: (i) reacting the sucrose-6-acylate with...
8436155 7,2″-dehydrate puerarin and its salts, preparation method and use thereof  
A 7,2″-dehydrate puerarin represented by formula (I) and salt derivatives thereof. The compounds are prepared from puerarin by intramolecular mitsunobu reaction. They are capable of shortening a...
8436156 Method for the production of sucralose  
The present invention provides a method for producing sucralose from a feed stream resulting from the chlorination of a sucrose-6-acylate in a reaction vehicle. The feed stream includes a...
8420790 Efficient and scalable process for the manufacture of Fondaparinux sodium  
The present invention relates to a process for the synthesis of the Factor Xa anticoagulent Fondaparinux and related compounds. The invention relates, in addition, to efficient and scalable...
8367635 Antimicrobial sucralfate paste methods and compositions  
Methods for the prevention and treatment of infection, preferably antibiotic resistant wound infection, using a paste formed by the reaction of sucralfate with an acid component are provided....
8357787 Formulations and methods for solid chitosan-containing blends  
Chitosan-containing blends and methods of dissolving and using chitosan are disclosed. A blend includes a solid acid or a solid agent that generates a proton in situ in the presence of water mixed...
8357785 Method of aralkylation of 4′-hydroxyl group of anthracylins  
A method for the aralkylation of anthracyclins by utilizing an aralkylating agent R3—CH2X (for example, BnBr) in accordance with the reaction pathway describe by the scheme shown in FIG. 1. The p...
8357786 Method for preparing Gynostemma pentaphyllum extract with increasing damulin A and damulin B contents, and pharmaceutical compositions of the same for treating metabolic disease  
Disclosed is an AMPK activating material used for improving and treating metabolic syndrome, in which AMPK (AMP-activated protein kinase) is a main enzyme for regulating an energy sensor and...
8314218 Method of synthesizing macrolide compounds  
The present invention relates to methods for synthesizing macrolide compounds which are known to have antibacterial activity, and are useful in the therapy of bacterial infections in mammals. More...
8298436 Fluoroalkenyl poly[1,6]glycosides  
Fire extinguishing compositions and methods of extinguishing a fire comprising compounds of formula (I) where Rf is a fluorocarbon group. The compounds and compositions described herein are useful...
8293878 Methods and compounds useful for the preparation of sodium glucose co-transporter 2 inhibitors  
Methods of synthesizing sodium glucose co-transporter 2 inhibitors, as well as compounds useful therein, are disclosed. Particular inhibitors are compounds of formula I.
8288514 Method of preparing clarithromycin  
This invention discloses a method of manufacturing clarithromycin, where an erythromycin A 9-oxime thiocyanate salt is used directly to perform an etherification reaction, and then successively...
8273862 Processes for the convergent synthesis of calicheamicin derivatives  
This invention describes processes for the convergent synthesis of calicheamicin derivatives, and similar analogs using bifunctional and trifunctional linker intermediates.
8263755 Synthesis of compounds useful as modulators of amyloid-beta production  
As described herein, the present invention provides methods for preparing compounds useful for treating or lessening the severity of a neurodegenerative disorder. The present invention also...
8247541 Plant compositions enriched in dehydrosoyasaponin I (D-I) and methods of producing such compositions  
There is provided a method of producing a plant composition comprising dehydrosoyasaponin I (D-I), the method comprising the steps of extracting a plant flour with a solvent capable of extracting...
8232079 Oligosaccharide synthesizer  
After various sugar nucleotide solutions and glycosyltransferases (or primers) have been mixed, they are introduced into a reaction tank (column) with primers (or glycosyltransferases) immobilized...
8212013 Process for producing 1,2-trans-glycoside compound  
In preparing a glycoside compound from (a) a furanose compound or pyranose compound, and (b) an alcohol compound, a process for preparing a glycoside compound in which glycosidic bond locates...
8163891 Process for the preparation of poly(alkoxylated) oligonucleotides  
A process for the preparation of a poly(alkoxylated) oligonucleotide is provided. The process comprises reacting an oligonucleotide which has been purified by ultrafiltration with a poly(alkoxide)...
8148505 Method of α-selective glycosylation  
An α-selective glycosylation process of a glycosylation reaction between a sugar structure of hexose or an aldose having a chain with six or more carbon atoms in the molecule, which is a ...
8124575 Polymeric surfactants based upon alkyl polyglycosides and sugars  
The present invention relates to a series of polyglycoside derivatives that are (a) polymeric (that is cross linked with hydroxypropyl linkages) and (b) contain additional functional groups...
8119781 Luminescent metal ion complexes  
The present invention provides luminescent metal ion complexes for use in a wide range of biological and chemical studies. The luminescent metal ion complexes of the invention comprise a metal ion...
8114987 Preparation method of 2-deoxy-L-ribose  
A method of preparing 2-deoxy-L-ribose represented by the following formula I is disclosed. The preparation method includes the steps of: treating L-arabinose with an alcohol solvent in the...
8110380 Starch-based biodegradable material composition  
A starch-based biodegradable material composition includes: an enzyme-hydrolyzed starch; and a biodegradable polyester selected from at least one of an aliphatic polyester of polybutylene succinate...
8110667 Method for conversion of carbohydrate polymers to value-added chemical products  
Methods are described for conversion of carbohydrate polymers in ionic liquids, including cellulose, that yield value-added chemicals including, e.g., glucose and 5-hydroxylmethylfurfural (HMF) at...
8080641 Process for the production of multiple cross-linked hyaluronic acid derivatives  
The present invention relates to a process for the production of cross-linked hyaluronic acid (HA) derivatives, in particular multiple, e.g. double cross-linked hyaluronic acid derivatives. The...
8071755 Nucleotide analogs  
The invention provides for nucleotide analogs and methods of using the same, e.g., for sequencing nucleic acids.
8067625 Fluorosurfactants  
The present invention relates to fatty acid esters of polyols or sulfonated fatty acid esters or sulfonated fatty acid amides containing at least one group Y, where Y stands for...
8044194 Cyclic carbonyl monomers functionalized with carbohydrates, polymers derived therefrom, and methods of preparation thereof  
A cyclic carbonyl monomer has the formula (7): wherein at least one W′ or Wa group comprises a protected glycoside; each Z independently represents O, S, NH or NW″; n is an integer from 0 to 6 whe...
8026347 Methods and compounds useful for the preparation of sodium glucose co-transporter 2 inhibitors  
Methods of synthesizing sodium glucose co-transporter 2 inhibitors, as well as compounds useful therein, are disclosed. Particular inhibitors are compounds of formula I:
8003615 Stable vitamin B6 derivative  
A compound represented by the following general formula (I) or a salt thereof: wherein R1 represents a glycosyl group, a phosphate group, or a cyclic phosphate group bound to R2; R2 represents...
7998937 Flavonoid compound having an antiviral activity  
The present invention relates to a flavonoid compound having an antiviral activity, more particularly to a flavonoid compound obtained by extracting Houttuynia cordata with methanol and...
7943750 Process for obtaining pure monosialoganglioside GM1 for medical use  
A process for preparing pure monosialoganglioside GM1 in the form of its sodium salt. There is provided a process for the isolation and purification of monosialoganglioside GM1 comprising (a)...
7935672 Derivatives of genkwanin and sakuranetin, cosmetic and therapeutic use thereof and preparation method of same  
The invention relates to: (i) the use of osyl derivatives of genkwanin and sakuranetin having formula (I) in (a) cosmetics or dermatology and (b) therapeutics; (ii) the use of novel derivatives...
7888487 Pyrazole derivative, medicinal composition containing the same, medicinal use thereof and intermediate in producing the same  
Pyrazole derivatives represented by the general formula: wherein R1 represents H, an optionally substituted C1-6 alkyl group etc.; one of Q and T represents a group selected from the following...
7883873 Saccharide composition synthesizer  
The present invention provides a sugar chain synthesizer capable of continuously reacting sugar chains when a plurality of sugar chains are successively reacted. The sugar chain synthesizer of the...
7875708 Sialic acid derivatives  
An amine or hydrazide derivative of a sialic acid unit, e.g. in a polysaccharide, is reacted with a bifunctional reagent at least one of the functionalities of which is an ester of N-hydroxy...
7858761 1-α-halo-2,2-difluoro-2-deoxy-D-ribofuranose derivatives and process for the preparation thereof  
1-α-halo-2,2-difluoro-2-deoxy-D-ribofuranose derivative of formula (I) having the 3-hydroxy group protected with a biphenylcarbonyl group is a solid which can be easily purified by a simple ...
7829697 Mutant bacterial strains of the genus Sphingomonas deficient in production of polyhydroxybutyrate and a process of clarification of sphingans and compositions thereof  
The invention relates to mutant strains of the genus Sphingomonas which have a mutation in at least one gene encoding a protein involved in polyhydroxybutyrate (“PHB”) synthesis that allows the mut...