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8461312 |
Method for the production of 1,4-benzothiepin-1,1-dioxide derivatives
The invention relates to a method for producing 1,4-benzothiepin-1,1-dioxide derivatives substituted with benzyl groups.
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8436157 |
Method for the production of sucralose
The present invention provides a method for producing sucralose from a feed stream including a sucrose-6-acylate in a reaction vehicle. The method includes: (i) reacting the sucrose-6-acylate with...
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8436155 |
7,2″-dehydrate puerarin and its salts, preparation method and use thereof
A 7,2″-dehydrate puerarin represented by formula (I) and salt derivatives thereof. The compounds are prepared from puerarin by intramolecular mitsunobu reaction. They are capable of shortening a...
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8436156 |
Method for the production of sucralose
The present invention provides a method for producing sucralose from a feed stream resulting from the chlorination of a sucrose-6-acylate in a reaction vehicle. The feed stream includes a...
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8420790 |
Efficient and scalable process for the manufacture of Fondaparinux sodium
The present invention relates to a process for the synthesis of the Factor Xa anticoagulent Fondaparinux and related compounds. The invention relates, in addition, to efficient and scalable...
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8367635 |
Antimicrobial sucralfate paste methods and compositions
Methods for the prevention and treatment of infection, preferably antibiotic resistant wound infection, using a paste formed by the reaction of sucralfate with an acid component are provided....
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8357787 |
Formulations and methods for solid chitosan-containing blends
Chitosan-containing blends and methods of dissolving and using chitosan are disclosed. A blend includes a solid acid or a solid agent that generates a proton in situ in the presence of water mixed...
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8357785 |
Method of aralkylation of 4′-hydroxyl group of anthracylins
A method for the aralkylation of anthracyclins by utilizing an aralkylating agent R3—CH2X (for example, BnBr) in accordance with the reaction pathway describe by the scheme shown in FIG. 1. The p...
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8357786 |
Method for preparing Gynostemma pentaphyllum extract with increasing damulin A and damulin B contents, and pharmaceutical compositions of the same for treating metabolic disease
Disclosed is an AMPK activating material used for improving and treating metabolic syndrome, in which AMPK (AMP-activated protein kinase) is a main enzyme for regulating an energy sensor and...
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8314218 |
Method of synthesizing macrolide compounds
The present invention relates to methods for synthesizing macrolide compounds which are known to have antibacterial activity, and are useful in the therapy of bacterial infections in mammals. More...
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8298436 |
Fluoroalkenyl poly[1,6]glycosides
Fire extinguishing compositions and methods of extinguishing a fire comprising compounds of formula (I) where Rf is a fluorocarbon group. The compounds and compositions described herein are useful...
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8293878 |
Methods and compounds useful for the preparation of sodium glucose co-transporter 2 inhibitors
Methods of synthesizing sodium glucose co-transporter 2 inhibitors, as well as compounds useful therein, are disclosed. Particular inhibitors are compounds of formula I.
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8288514 |
Method of preparing clarithromycin
This invention discloses a method of manufacturing clarithromycin, where an erythromycin A 9-oxime thiocyanate salt is used directly to perform an etherification reaction, and then successively...
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8273862 |
Processes for the convergent synthesis of calicheamicin derivatives
This invention describes processes for the convergent synthesis of calicheamicin derivatives, and similar analogs using bifunctional and trifunctional linker intermediates.
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8263755 |
Synthesis of compounds useful as modulators of amyloid-beta production
As described herein, the present invention provides methods for preparing compounds useful for treating or lessening the severity of a neurodegenerative disorder. The present invention also...
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8247541 |
Plant compositions enriched in dehydrosoyasaponin I (D-I) and methods of producing such compositions
There is provided a method of producing a plant composition comprising dehydrosoyasaponin I (D-I), the method comprising the steps of extracting a plant flour with a solvent capable of extracting...
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8232079 |
Oligosaccharide synthesizer
After various sugar nucleotide solutions and glycosyltransferases (or primers) have been mixed, they are introduced into a reaction tank (column) with primers (or glycosyltransferases) immobilized...
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8212013 |
Process for producing 1,2-trans-glycoside compound
In preparing a glycoside compound from (a) a furanose compound or pyranose compound, and (b) an alcohol compound, a process for preparing a glycoside compound in which glycosidic bond locates...
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8163891 |
Process for the preparation of poly(alkoxylated) oligonucleotides
A process for the preparation of a poly(alkoxylated) oligonucleotide is provided. The process comprises reacting an oligonucleotide which has been purified by ultrafiltration with a poly(alkoxide)...
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8148505 |
Method of α-selective glycosylation
An α-selective glycosylation process of a glycosylation reaction between a sugar structure of hexose or an aldose having a chain with six or more carbon atoms in the molecule, which is a ...
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8124575 |
Polymeric surfactants based upon alkyl polyglycosides and sugars
The present invention relates to a series of polyglycoside derivatives that are (a) polymeric (that is cross linked with hydroxypropyl linkages) and (b) contain additional functional groups...
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8119781 |
Luminescent metal ion complexes
The present invention provides luminescent metal ion complexes for use in a wide range of biological and chemical studies. The luminescent metal ion complexes of the invention comprise a metal ion...
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8114987 |
Preparation method of 2-deoxy-L-ribose
A method of preparing 2-deoxy-L-ribose represented by the following formula I is disclosed. The preparation method includes the steps of: treating L-arabinose with an alcohol solvent in the...
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8110380 |
Starch-based biodegradable material composition
A starch-based biodegradable material composition includes: an enzyme-hydrolyzed starch; and a biodegradable polyester selected from at least one of an aliphatic polyester of polybutylene succinate...
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8110667 |
Method for conversion of carbohydrate polymers to value-added chemical products
Methods are described for conversion of carbohydrate polymers in ionic liquids, including cellulose, that yield value-added chemicals including, e.g., glucose and 5-hydroxylmethylfurfural (HMF) at...
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8080641 |
Process for the production of multiple cross-linked hyaluronic acid derivatives
The present invention relates to a process for the production of cross-linked hyaluronic acid (HA) derivatives, in particular multiple, e.g. double cross-linked hyaluronic acid derivatives. The...
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8071755 |
Nucleotide analogs
The invention provides for nucleotide analogs and methods of using the same, e.g., for sequencing nucleic acids.
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8067625 |
Fluorosurfactants
The present invention relates to fatty acid esters of polyols or sulfonated fatty acid esters or sulfonated fatty acid amides containing at least one group Y, where Y stands for...
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8044194 |
Cyclic carbonyl monomers functionalized with carbohydrates, polymers derived therefrom, and methods of preparation thereof
A cyclic carbonyl monomer has the formula (7): wherein at least one W′ or Wa group comprises a protected glycoside; each Z independently represents O, S, NH or NW″; n is an integer from 0 to 6 whe...
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8026347 |
Methods and compounds useful for the preparation of sodium glucose co-transporter 2 inhibitors
Methods of synthesizing sodium glucose co-transporter 2 inhibitors, as well as compounds useful therein, are disclosed. Particular inhibitors are compounds of formula I:
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8003615 |
Stable vitamin B6 derivative
A compound represented by the following general formula (I) or a salt thereof: wherein R1 represents a glycosyl group, a phosphate group, or a cyclic phosphate group bound to R2; R2 represents...
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7998937 |
Flavonoid compound having an antiviral activity
The present invention relates to a flavonoid compound having an antiviral activity, more particularly to a flavonoid compound obtained by extracting Houttuynia cordata with methanol and...
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7943750 |
Process for obtaining pure monosialoganglioside GM1 for medical use
A process for preparing pure monosialoganglioside GM1 in the form of its sodium salt. There is provided a process for the isolation and purification of monosialoganglioside GM1 comprising (a)...
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7935672 |
Derivatives of genkwanin and sakuranetin, cosmetic and therapeutic use thereof and preparation method of same
The invention relates to: (i) the use of osyl derivatives of genkwanin and sakuranetin having formula (I) in (a) cosmetics or dermatology and (b) therapeutics; (ii) the use of novel derivatives...
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7888487 |
Pyrazole derivative, medicinal composition containing the same, medicinal use thereof and intermediate in producing the same
Pyrazole derivatives represented by the general formula: wherein R1 represents H, an optionally substituted C1-6 alkyl group etc.; one of Q and T represents a group selected from the following...
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7883873 |
Saccharide composition synthesizer
The present invention provides a sugar chain synthesizer capable of continuously reacting sugar chains when a plurality of sugar chains are successively reacted. The sugar chain synthesizer of the...
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7875708 |
Sialic acid derivatives
An amine or hydrazide derivative of a sialic acid unit, e.g. in a polysaccharide, is reacted with a bifunctional reagent at least one of the functionalities of which is an ester of N-hydroxy...
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7858761 |
1-α-halo-2,2-difluoro-2-deoxy-D-ribofuranose derivatives and process for the preparation thereof
1-α-halo-2,2-difluoro-2-deoxy-D-ribofuranose derivative of formula (I) having the 3-hydroxy group protected with a biphenylcarbonyl group is a solid which can be easily purified by a simple ...
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7829697 |
Mutant bacterial strains of the genus Sphingomonas deficient in production of polyhydroxybutyrate and a process of clarification of sphingans and compositions thereof
The invention relates to mutant strains of the genus Sphingomonas which have a mutation in at least one gene encoding a protein involved in polyhydroxybutyrate (“PHB”) synthesis that allows the mut...
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7820810 |
Process for the synthesis of 2′-O-substituted purine nulceosides
The present invention provides an improved process for the synthesis of 2′-O-substituted purine nucleosides. The process includes anhydro or thioanhydro ring opening of a selected 8...
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7795423 |
Polynucleotide labeling reagent
The present invention provides a new labeling reagent for preparing modified oligonucleotides and processes for their production wherein these oligonucleotides contain at least once the structure...
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7772381 |
Efficient method to synthesize benzyl group-protected alpha-pentagalloylglucose (α-PGG) and its analogues
A method to synthesize benzyl group protected alpha-pentagalloylglucose (α-PGG) and related compounds. The method comprises the steps of: suspending a highly reactive acylation agent and an ...
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7767798 |
Loganin analogues and a process for the preparation thereof
The present invention provides novel loganin analogues and a process for the preparation thereof. The present invention further provides the use of Iridoid glycoside loganin isolated from the fruit...
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7754864 |
Tyrosinase activity controlling agent, process for producing the same and external preparation containing the same
Disclosed is a tyrosinase activity controlling agent comprising, as an active ingredient, a compound that has tyrosinase inhibiting or promoting activity, an external preparation comprising the...
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7728156 |
Method of performing sugar dehydration and catalyst treatment
The invention includes a method of treating a solid acid catalyst. After exposing the catalyst to a mixture containing a sugar alcohol, the catalyst is washed with an organic solvent and is then...
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7723528 |
Sulfur transfer reagents for oligonucleotide synthesis
The use of N-formamidino-5-amino-3H-1,2,4-dithiazole-3-thiones as novel, efficient sulfur-transfer reagents is disclosed. The sulfur transfer from these reagents to compounds containing P(III)...
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7683161 |
Selective reduction of spinosyn factors Et-J and Et-L to spinetoram
Spinetoram is selectively produced in excellent yields by hydrogenating a mixture of 3′-O-ethyl spinosyn J and 3′-O-ethyl spinosyn L in a water miscible organic solvent using hydrogen gas and a het...
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7671191 |
Methods for preparing 2-alkynyladenosine derivatives
Disclosed are methods for preparing 2-alkynyladenosine derivatives of formula A: or a stereoisomer, pharmaceutically acceptable salt, hydrate, solvate, acid salt hydrate or isomorphic crystalline...
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7649099 |
Method of forming a dianhydrosugar alcohol
The invention includes methods of producing dianhydrosugars. A polyol is reacted in the presence of a first catalyst to form a monocyclic sugar. The monocyclic sugar is transferred to a second...
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7635762 |
Luminescent metal ion complexes
The present invention provides luminescent metal ion complexes for use in a wide range of biological and chemical studies. The luminescent metal ion complexes of the invention comprise a metal ion...
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