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7626005 |
Inhibitors of aminoglycoside 6′-N-acetyltransferases, compositions and uses thereof
The present invention relates to novel inhibitors of aminoglycoside 6′-N-acetyltransferases, more specifically, AAC(6′)-li and AAC(6′)-ly, as well as compositions and uses thereof....
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7605240 |
Methods of treating diarrhea and bloating caused by small intestinal bacterial overgrowth
Disclosed is a method of diagnosing irritable bowel syndrome, fibromyalgia, chronic fatigue syndrome, depression, attention deficit/hyperactivity disorder, autoimmune diseases, such as multiple...
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7592023 |
Transplant media
The present invention relates to media containing purified antimicrobial polypeptides, such as defensins, and/or cell surface receptor binding proteins. The media may also contain buffers,...
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7482439 |
Caprazene as novel compound and derivatives thereof, and caprazol as novel compound and derivatives thereof
Caprazene and caprazol could be synthesized by hydrolysis of a caprazamycin. There could be synthesized a caprazene-1′″-amide derivative of the formula (II)
and a caprazene-1′″-ester...
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7449181 |
Remedies for cancer
A medicament for treating cancer for use in combination therapy with an anti-HER2 antibody, which comprises amrubicin or a pharmaceutically acceptable salt thereof as an active ingredient.
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7417129 |
Combinatorial libraries of monosaccharides
A monosaccharide compound of formula I as shown in the specification. Processes for the preparation of the compound of formula I and methods of screening for antibacterial or antibiotic compounds...
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7407654 |
Antibiotics GE 81112 factors A,B,B1, pharmaceutically acceptable salts and compositions, and use thereof
The invention relates to an antibiotic substances of microbial origin, arbitrarily denominated antibiotic GE 81112 factor A, factor B1 and factor B, which is produced by fermentation of ...
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7375088 |
Polyene polyketides, processes for their production and their use as a pharmaceutical
This invention relates to a new class of polyene polyketides, their pharmaceutically acceptable salts and derivatives, and to methods for obtaining the compounds. One method of obtaining these...
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7371733 |
Anti bacterial compounds
The invention relates to novel paranmycin compounds that have activity against gram positive and gram negative bacteria, preferably bacteria that are resistant to other antibiotics. Paranmycins are...
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7368431 |
Polypeptide, the conjugate thereof with doxorubicine and a pharmaceutical composition based thereon
The inventive polypeptide is embodied in the form of a similar fragment of the epidermal growth factor of aminoacid ranging from 21 to 31 and capable of efficiently binding with the receptor of the...
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7358232 |
Method for the antibiotic coating of bodies with interconnecting microcavities as well as coated bodies and their usage
The invention relates to a method for the antibiotic coating of bodies with interconnecting microcavities as well as bodies coated this way and their usage. The invented method is characterized in...
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7259141 |
Vancomycin analogs and methods thereof
The present invention provides vancomycin analogs and methods related to synthesis of these analogs via chemoenzymatic techniques. In a preferred embodiment, the vancomycin analogs have a...
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7244712 |
Aminoglycoside antibiotics and methods of using same
The present invention relates to aminoglycoside compounds having antibiotic activity. Moreover, the present invention relates to L-aminoglycoside compounds and diastereomers thereof which posses...
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7241595 |
Glycosyl-etoposide prodrugs, a process for preparation thereof and the use thereof in combination with functionalized tumor-specific enzyme conjugates
The present invention relates to glycosyl-etoposide prodrugs, a process for the preparation thereof and the use thereof in combination with functionalized tumor-specific enzyme conjugates for...
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7220727 |
Aminoglycosides as antibiotics
The present invention provides aminoglycosides and pharmaceutical compositions that include the aminoglycosides. The aminogylcosides are useful to treat or prevent infectious diseases (e.g.,...
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7166270 |
Methods of screening compounds useful for prevention of infection or pathogenicity
Screening procedures are disclosed for identifying compounds useful for inhibiting infection or pathogenicity. Methods are also disclosed for identifying pathogenic virulence factors.
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7030093 |
Antibiotic coating for porous bodies and method for its production as well as its use
The invention describes an antibiotic coating for porous bodies and its use. Into the porous system of non-metallic porous bodies and of metallic porous bodies, a coating made of at least one...
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6967242 |
Antimicrobial 2-deoxystreptamine compounds
The present invention is directed to analogs of aminoglycoside compounds of the class having a glycosylated 2-deoxystreptamine (2-DOS) ring as well as their preparation and use as prophylactic or...
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6867230 |
Hygromycin A derivatives
This invention relates to compounds of the formula
and to pharmaceutically acceptable salts, prodrugs and solvates thereof, wherein R 1 , R 2 , R 3 and R 10 are as defined herein. The...
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6858589 |
Methods of and compositions for potentiating the action of agents active on cell wall sites of the susceptible bacteria
The invention provides a method of potentiating the activity of antibacterial agents that act on bacterial cell walls, comprising the step of administering to a subject an antibacterial agent and...
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6841661 |
Glycopeptide antibacterial compounds, compositions containing same and methods of using same
The present invention relates to vancomycin analogs in which the vancosamine residue is substituted with a lipid-like substituent that includes a first aryl moiety and a second aryl moiety joined...
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6812331 |
Aromatic derivatives substituted by a ribose, their preparation process and their use as medicaments
A subject of the invention is the compounds of formula (I): R 1 ═H, OH, alkyl, alkenyl or alkynyl optionally substituted or alkoxy, R 2 ═H, Hal, R 3 ═H, alkyl, Hal, Rg and Rh: H, alkyl,...
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6756489 |
Substituted tetrahydropyrane derivatives, method for producing same, their use as medicine or diagnostic agent, as well as medicine containing same
Substituted tetrahydropyran derivatives, processes for their preparation, their use as a pharmaceutical or diagnostic, and pharmaceutical comprising them. The invention relates to compounds of the...
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6709679 |
Antineoplastic conjugates of transferin, albumin and polyethylene glycol
Conjugates of transferrin, albumin and polyethylence glycol consisting of native or thiolated transferrin or albumin or of polyethylene glycol (MW between approximately 5,000 and 20,0000) with at...
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6699836 |
Vancomycin analogs
Compounds that are vancomycin analogs bearing terminal carboxyl group modifications as well as modifications to the vancosamine nitrogen and, optionally, modifications to the C6 position of the...
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6693085 |
Macrolide compound JK
Compound JK represented by the general formula (1): wherein R is H or —CH 3 ; or a pharmaceutically acceptable salt thereof. Compound JK has an excellent antimicrobial activity even against...
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6562792 |
Hygromycin derivatives
The present invention relates to compounds of the formula 1 and to pharmaceutically acceptable salts, prodrugs and solvates thereof, wherein X, Y, V, W 1 , W 2 , Z 1 and Z 2 are as defined...
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6548536 |
Agent for inducing apoptosis
Agents for inducing apoptosis comprising a tetrocarcin derivative represented by the following formula (I) or a salt thereof as an active ingredient ( ---- represents a single bond or a double...
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6528491 |
Pyranoside derivatives
The present invention relates to new pyranoside derivatives of general formula I, processes for preparing them as well as their use as medicaments:
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6515115 |
Membrane filtration
The invention relates to a process for isolating a desired water-soluble product from a fermentation broth wherein the broth is circulated along a ceramic membrane, and wherein a trans-membrane...
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6500936 |
Pluraflavins and derivatives thereof, process for their preparation and use thereof
The invention relates to a compound of formula (I) wherein R 1 is a sugar; R 2 is —CH 2 —O—(R 7 )m, R 7 representing a sugar, or is —COOH; R 3 is an epoxide-comprising group, or is C...
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6492342 |
Hygromycin A prodrugs
This invention relates to compounds of the formula and to pharmaceutically acceptable salts and solvates thereof, wherein a, b, X, Y, Z, R 1 , R 2 , and R 3 are as defined herein. The compounds...
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6406880 |
Betaines as adjuvants to susceptibility testing and antimicrobial therapy
The present invention is related to methods and compositions for susceptibility testing of bacteria containing mycolic acid structures using betaine-like detergents, and inducing the susceptibility...
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6403777 |
Metalloligands for cleaving nucleic acids
Transition metal complexes, referred to hereinafter as “metalloligands”, that catalyze the degradation of DNA and the cleavage of RNA at select sites are provided. In one embodiment, the...
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6399583 |
Hybrid anthracyclines from genetically engineered streptomyces galilaeus strains, process for production and uses thereof
The present invention relates to novel hybrid anthracyclines generated by cloning of fused genes in a mutated Streptomyces galilaeus strain DSM 11638. Said strain was obtained by mutagenization...
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6391851 |
Hydrochlorides of vancomycin antibiotics and process for producing the same
Process for producing a hydrochloride of a vancomycin antibiotic, comprising subjecting an aqueous solution of a hydrochloride of a vancomycin antibiotic to a primary freezing at from −1° C. to...
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6350733 |
Aromatic derivatives substituted by a ribose, their method of preparation and application as medicine
A subject of the invention is the compounds of formula (I): R 1 =H, OH, alkyl, alkenyl or alkynyl optionally substituted or alkoxy, R 2 =H, Hal, R 3 =H, alkyl, Hal, Rg and Rh: H, alkyl, aryl...
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6242424 |
Moenomycin and its derivatives for the production of pharmaceuticals, and pharmaceuticals containing moenomycin or its derivatives
Moenomycin and its derivatives are suitable for the production of pharmaceuticals for the treatment of gastric ulcers and for the control of Helicobacter pylori.
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6143726 |
Complexes of N'-dimethylaminoacetylpartricin A dimethylaminoethylamide, or the salts thereof, and cholesterol 3-sulphate
A complex containing N'-dimethylaminoacetylpartricin A dimethylaminoethylamide, as a salt or as the free base, and cholesterol 3-sulphate, in a molar ratio between 1:0.5 and 1:10, respectively.
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6140306 |
Method of treating gram-negative bacterial infection by administration of bactericidal/permeability-increasing (BPI) protein product and antibiotic
The present invention relates to methods and compositions for treating gram-negative bacterial infections, using BPI protein products. Co-treatment, or concurrent administration, of BPI protein...
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6077830 |
Bismuth salts of antibiotics of the moenomycin group, processes for their preparation, their use and pharmaceuticals comprising such salts
The present invention relates to bismuth salts of antibiotics of the moenomycin group, processes for their preparation, their use and pharmaceuticals comprising such salts. The salts according to...
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6051395 |
Method and compound for detecting low levels of microorganisms
A method and compound for detecting low levels of microorganisms in biological samples is disclosed. In the method, an antibiotic is conjugated to a detectable label. This antibiotic/label...
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6013647 |
Benzoxazinedione derivatives, method of producing them and uses thereof
This invention relates to new benzoxazinedione derivatives corresponding to the formula I: ##STR1## wherein R 1 =H or carboxyalkyl, R 2 =H, alkyl or phenyl, and R 3 represents different acid...
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6001981 |
Synthetic modification of Spinosyn compounds
The compounds of the present invention are prepared directly or indirectly by modifying the compounds that are naturally produced from Saccharopolyspora spinosa. The compounds of the invention have...
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5986089 |
Process for the preparation of moenomycin A
Moenomycin A can be prepared by fermentation of a moenomycin-producing microorganism and subsequent separation of moenomycin A from the other components of the culture filtrate by chromatography,...
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5965445 |
Polycyclic ether antibiotic having anthelmintic, anticoccidial and growth promotant activity
An acidic polycyclic ether antibiotic, having structure established by X-ray crystallography, is formed by fermentation of a novel microorganism, Streptomyces sp. ATCC 55028. This novel antibiotic...
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5939399 |
Polyene antibiotics, 3874 H1 to H6, processes for their preparation and use
Novel polyene antibiotics, 3874 H1 to H6, processes for their preparation and use which are suitable for treating fungal diseases, trichomonad diseases, and for treating diseases associated with an...
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5891727 |
Acidic polycyclic ether useful as an anticoccidial agent and as a growth promotant
An acidic polycyclic ether antibiotic, having structure established by X-ray crystallography, is formed by fermentation of a novel microorganism, Actinomadura sp. ATCC 53676. This novel antibiotic...
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5877157 |
Modified kojibioside analogues
Disclosed are novel analogues of kojibiose and pharmaceutical compositions comprising such analogues.
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5843908 |
Pradimicins l and fl, and derivatives thereof
The present invention relates to novel antifungal antibiotics herein designated as pradimicin L and pradimicin FL, and derivatives thereof. Pradimicins L and FL are produced by Actinomadura...
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