|
Match
|
Document |
Document Title |
|
|
7626005 |
Inhibitors of aminoglycoside 6′-N-acetyltransferases, compositions and uses thereof
The present invention relates to novel inhibitors of aminoglycoside 6′-N-acetyltransferases, more specifically, AAC(6′)-li and AAC(6′)-ly, as well as compositions and uses thereof....
|
|
|
7514404 |
PNA-neamine conjugates and methods for producing and using the same
The present invention relates to methods and compositions pertaining to conjugates composed of a peptide nucleic acid (PNA) moiety and a neamine derivative moiety. Methods for using such conjugates...
|
|
|
7476656 |
Fluorescent affinity tag to enhance phosphoprotein detection and characterization
The invention relates to target-associative tags incorporating cysteamine as the target-associative moiety. The invention further relates to a method for producing a target-associative tag by...
|
|
|
7371733 |
Anti bacterial compounds
The invention relates to novel paranmycin compounds that have activity against gram positive and gram negative bacteria, preferably bacteria that are resistant to other antibiotics. Paranmycins are...
|
|
|
7244712 |
Aminoglycoside antibiotics and methods of using same
The present invention relates to aminoglycoside compounds having antibiotic activity. Moreover, the present invention relates to L-aminoglycoside compounds and diastereomers thereof which posses...
|
|
|
6967242 |
Antimicrobial 2-deoxystreptamine compounds
The present invention is directed to analogs of aminoglycoside compounds of the class having a glycosylated 2-deoxystreptamine (2-DOS) ring as well as their preparation and use as prophylactic or...
|
|
|
6642365 |
Anti-(retro)viral conjugates of saccharides and acetamidino or guanidino compounds
Conjugates of a saccharide and an acetamidino- or guanidino-compound, of the formula: wherein A is CH 3 or NH 2 ; X is a linear or branched C 1 -C 8 alkyl chain optionally containing hydroxy,...
|
|
|
6403777 |
Metalloligands for cleaving nucleic acids
Transition metal complexes, referred to hereinafter as “metalloligands”, that catalyze the degradation of DNA and the cleavage of RNA at select sites are provided. In one embodiment, the...
|
|
|
6120997 |
Nucleic acid binders having an hydroxyamine motif
The invention relates to the combination of hydroxyamines with nucleic acid binding motifs to generate molecules and libraries of molecules targeting specific nucleic acid sequences. In particular,...
|
|
|
4937257 |
Flavanone derivatives
New flavanone derivatives of the formula I ##STR1## wherein Ar 1 and Ar 2 are each phenyl which is unsubstituted or monosubstituted to trisubstituted by OH, alkyl, alkoxy, acylamino, halogen,...
|
|
|
4877775 |
Polymeric aminosaccharides as antihypercholesterolemic agents
Crosslinked copolymers of monomeric aminosaccharides such as aminoglycosidic antibiotics, e.g. neomycin, or of polymeric aminosaccharides, e.g., chitosan, with dialdehydes are useful...
|
|
|
4774231 |
Disaccharides formed by patterns having a glucosamine and uronic acid structure, preparation thereof and biological applications
1,4αdisaccharides of formula: ##STR1## with Z representing a nitrogenous functional group, M hydrogen or a sulphate or acetyl group, R an alkyl radical of 1 to 4 carbon atoms and A...
|
|
|
4607025 |
Disaccharides having a glucosamine and uronic acid structure, and biological applications thereof
1,4 α disaccharides of formula: ##STR1## with Z representing a nitrogenous functional group, M hydrogen or a sulphate or acetyl group, R an alkyl radical of 1 to 4 carbon atoms and A a...
|
|
|
4515942 |
Antibiotics KA-6606 XII, XIII, XV, XVI and XVII
A process for producing an antibiotic, which comprises cultivating an antibiotic KA-6606-producing strain of the genus Saccharopolyspora in a nutrient culture medium, isolating an antibiotic...
|
|
|
4503046 |
1-Nitro-aminoglycoside derivatives, pharmaceutical compositions containing them and such derivatives for use as pharmaceuticals
Hydroxymethylated aminoglycoside derivatives which are useful, in particular as anti-bacterially active antibiotics.
|
|
|
4468386 |
1-Deamino-1-hydroxy-aminoglycoside compounds, antibacterial compositions and method of use
Antibiotic Bu-2659 complex, containing components A, B, C, D and E, is produced by cultivation of Streptomyces hygroscopicus Strain No. J296-21, ATCC No. 39150.
|
|
|
4468512 |
1-N-Acylated and 1-N-alkylated derivatives of 4-O-substituted-2-deoxystreptamine aminoglycosides
Zinc salts are used to effect the regio-selective acylation and alkylation of the 1-amino group of 4-O-substituted-2-deoxystreptamine-containing aminoglycosides. The 1-N-substituted derivatives of...
|
|
|
4424344 |
2-N-Acylated and 2-N-alkylated derivatives of 4-O-substituted-2-deoxystreptamine aminoglycosides and process
Nickel salts are used to effect the regio-selective acylation and alkylation of the 2'-amino group of 4-O-substituted-2-deoxystreptamine containing aminoglycosides. The 2'-N-substituted derivatives...
|
|
|
4281107 |
Neamine derivatives and process for preparing the same
5,6-Dideoxyneamine, useful as an antimicrobial agent, and a process for preparing 5,6-dideoxyneamine.
|
|
|
4252970 |
6-Deoxyneamines
6-Deoxyneamine, 6-deoxy-5-epineamine, their 5-0-glycosyl derivatives, 6-deoxy-5-oxoneamine and the derivatives therefrom are useful as antibacterial agents and/or as intermediates in the synthesis...
|
|
|
4195173 |
Process for preparing pseudo-disaccharides
The invention provides pseudo-disaccharides (and their salts) and a method for their preparation. The pseudo-disaccharides are useful as intermediates for the preparation of antibiotics and are...
|
|
|
4169197 |
6-Deoxyneamines aminoglycoside compounds
6-Deoxyneamine, 6-deoxy-5-epineamine, their 5-O-glycosyl derivatives, 6-deoxy-5-oxoneamine and the derivatives therefrom are useful as antibacterial agents and/or as intermediates in the synthesis...
|
|
|
4129719 |
5,6-Epineamine and process for preparing the same
5,6-Epineamine represented by the formula (I) ##STR1## and a process for preparing 5,6-epineamine of the formula (I) above which comprises hydrolyzing the epoxy group of a compound of the formula...
|
|
|
4103082 |
Aminocyclitol derivatives and process for producing the same
Aminocyclitol derivatives, 5-deoxyneamine and 6-deoxyneamine, having antimicrobial activities against various antibiotic-resistant microorganisms, a process for producing 5-deoxyneamine and...
|
|
|
4078139 |
Process for deoxygenating secondary alcohols
The process for removing a secondary hydroxyl group from an organic compound having at least one secondary hydroxyl group and having any amino groups protected, comprises the reaction of a reactive...
|
|
|
4078138 |
3'-Epi-4'deoxykanamycin B
3',4'-α-Epoxyneamine and its related aminoglycosidic antibiotic derivatives containing 3',4'-α-epoxyneamine moiety in the molecule thereof are now provided, which may be in the form of their...
|
|
|
4065615 |
Deoxyaminoglycoside antibiotic derivatives
A new deoxystreptamine-containing aminoglycoside antibiotic derivative in which all the amino groups other than the amino group at the 1-position of the deoxystreptamine moiety are formylated is...
|
|
|
4064339 |
Antibiotic aminoglycosides, processes of preparation and pharmaceutical compositions
There are disclosed pharmaceutically-active aminoglycosides comprising 4-O-(2',6'-diamino 2',6'-didesoxy α,D-glucopyrannosyl) 6-O-(3"-amino 3",4",6"-tridesoxy α, D-xylohexopyrannosyl) 2-desoxy...
|
|
|
4060682 |
Process for the synthetic production of 3-deoxy derivative of an aminoglycosidic antibiotic
3'-Deoxy derivatives of neamine, 6'-N-alkylneamine, kanamycin B, 6'-N-alkylkanamycin B, ribostamycin, 6'-N-alkylribostamycin and paromamine may be produced by a new process comprising reducing the...
|
|
|
4048430 |
Mercaptopseudotrisaccharides
Novel pseudodisaccharide compounds which are related to neamine are prepared. These compounds have a mercapto group or a derivative thereof at position 3 or 4 of the glucose moiety of neamine. The...
|
|
|
4024332 |
Aminoglycoside antibiotics and intermediates therefor
Certain novel derivatives of naturally-occurring aminoglycoside antibiotics such as neamine, kanamycins A and B, 3',4'-dideoxykanamycin B, 3',4'-dideoxy-4,5-dehydrokanamycin B, tobramycin and the...
|
|
|
4020269 |
Epiminodeaminodeoxyaminoglycoside antibiotics and intermediates
Deoxyaminoglycoside antibiotics are prepared in a high yield from phosphorylated aminoglycosides by reacting a phosphorylated aminoglycoside (a) with a silylating agent, or (b) successively with...
|
|
|
4008362 |
1-N-((S)-α-substituted-ω-aminoacyl)-neamine or -ribostamycin and the production thereof
An 1-N-((S)-α-substituted-ω-aminoacyl)-neamine or -ribostamycin of the formula ##STR1## wherein R is a hydrogen atom or β-D-ribofuranosyl group of the formula ##STR2## and R 3 is hydroxyl,...
|
|
|
3996205 |
Aminoglycoside antibiotics and intermediates
6-0- AND 3'-0-D-glycosyl analogs of neamine, 6-0- and 3'-0-D-glycosyl ortho esters of neamine, novel aminoglycoside antibiotics, and novel intermediates are prepared by a new chemical process. The...
|
|
|
3965089 |
Process for the production of a cyclic ureido-derivative of a deoxystreptamine-containing antibiotic and products thereof
A new cyclic ureido-derivative of a deoxystreptamine-containing antibiotic represented by the general formula: ##SPC1## Wherein R a , R b and R c stand for the residues present in the molecule of...
|
|
|
3963695 |
Tetradeoxyneamine and derivatives thereof
Novel deoxy derivatives of neamine are prepared and disclosed as antibacterial agents.
|
|
|
3960838 |
Mercaptopseudodisaccharides
Novel pseudodisaccharide compounds which are related to neamine are prepared. These compounds have a mercapto group or a derivative thereof at position 3 or 4 of the glucose moiety of neamine. The...
|
|
|
3948882 |
Process for the production of a 1-N((S)-α-hydroxy-ω-aminoacyl)-3',4'-dideoxyneamine or -3',4'- d
Process of producing a 1-N-((S)-α-hydroxy-ω-aminoacyl)-3',4'-dideoxyneamine or -3',4'-dideoxyribostamycin, a useful semi-synthetic antibiotic in which the corresponding...
|
|
|
3929762 |
3'-Deoxy derivatives of neamine and its related aminoglycosidic antibiotics, and the production thereof
The 3'-hydroxyl group of neamine and related aminoglycosidic antibiotics is preferentially sulfonylated with an alkylsulfonyl halide, arylsulfonyl halide or benzylsulfonyl halide and the resultant...
|
|
|
3925353 |
4-0-(6-Alkylamino-6-deoxy-alpha-D-hexopyranosyl)-deoxystreptamine derivatives and the production thereof
6'-N-alkyl derivatives of kanamycin, 3',4'-dideoxykanamycin B, 3',4'-dideoxyneamine and 3', 4'-dideoxyvistamycin, typically represented by 6'-N-methylkanamycin, 6'-N-methyl-3',4'-dideoxykanamycin B...
|
|
|
3925354 |
Process for the production of an 1-n-(s)-alpha- substituted-w-aminoacyl) derivative of neamine, 3', 4'-dideoxyneamine, ribostamycin or 3',4'-dideoxyribostamycin
A new process of synthetizing an 1-N-[(S)-α-substituted-ω-aminoacyl] derivatives of aminoglycosidic antibiotic, including known compounds such as butirosin B as well as new compounds such as the...
|
|
|
3893997 |
Pseudodisaccharide intermediates
Epoxides of pseudodisaccharides such as neamine, paromamine and the like are prepared. These compounds are useful intermediates to prepare other pseudodisaccharides which have antibacterial activity.
|
|
|
3350387 |
Poly-nu-alkylated neomycins, kanamycins and paromomycins
|
|
|
3296246 |
Derivatives of antibiotics having a basic reaction and process for preparation
|
|
|
3282783 |
Method for causing hypocholesterolemic activity in animals with poly-n-lower alkyl derivatives of polyamino antibiotics
|
|
|
3239501 |
Antibiotic amine addition compounds
|
|
|
3743634 |
Title is not available
|