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7378519 |
Adduct of topiramate and tramadol hydrochloride and uses thereof
Processes for isolation and purification of enantiomerically enriched compositions comprising tramadol and topiramate, and also for the subsequent isolation of 1S,2S-tramadol hydrochloride, are...
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7345166 |
Water soluble biodegradable polymeric photocatalysts
Novel antenna polymers characterized by a polymeric background of a biodegradable water soluble polymer and chromophores chemically bonded to the polymeric background have been found to be useful...
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7345117 |
Sulphated hyaluronic acid and sulphated derivatives thereof covalently bound to polyurethanes, and the process for their preparation
The present invention relates to the synthesis of a haemocompatible polymer, consisting of a polyurethane bound covalently to sulphated hyaluronic acid. These sulfated derivatives have...
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7244830 |
Glycopolymers and free radical polymerization methods
A glycopolymer composition is provided comprising glycopolymer molecules having a polymer backbone; a first pendent unit comprising a linking group connected to said polymer backbone and a...
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7189843 |
Production of carrageenan and carrageenan products
The methods of the present invention prepare carrageenan products from processed seaweed material having a solids content of less than 25% by weight solids, using shear stress treatment. The...
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7115586 |
Non-inclusion cyclodextrin complexes
The invention provides a number of methods for enhancing the aqueous solubility of an active ingredient which is insoluble or sparingly soluble in water. In one preferred embodiment, solubilization...
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7087709 |
Polymers for delivering nitric oxide in vivo
Disclosed are novel polymers derivatized with at least one —NO x group per 1200 atomic mass unit of the polymer. X is one or two. In one embodiment, the polymer is an S-nitrosylated polymer and...
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7087571 |
Alkyl polyglycoside derived sulfosuccinates
The invention relates to a series of polyglycoside derivatives that contain water-soluble sulfosuccinate groups introduced into the molecule by reaction with the hydroxyl groups present in the...
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7084132 |
Artemisinins with improved stability and bioavailability for therapeutic drug development and application
A stable form of artemisinin wherein an artelinic acid or artesunic acid is complexed with cyclodextrin analogs, preferably, β-cyclodextrin. The complexed cyclodextrin artemisinin formulation...
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7074919 |
Use of amphoteric polysaccharide for treating textile fiber articles
The invention concerns the use, in a composition for treating textile fiber articles in aqueous or moist medium, of an amphoteric polysaccharide, whereof the native skeleton is a polysaccharide...
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7060685 |
Compounds and methods for inhibiting selectin-mediated function
Compounds and methods are provided for modulating in vitro and in vivo processes mediated by selectin binding. More specifically, selectin modulators and their use are described, wherein the...
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7030237 |
Method and equipment for continuous and selective inclusion separation
In a reaction system having at least two liquid-liquid interfaces between an organic phase of raw material containing a compound(s) to be separated and an aqueous phase of an aqueous solution of...
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7022682 |
Method for the treatment of diabetes
The present invention provides for a method for treatment and prevention of Type II Diabetes Mellitus and its complications comprising the step of administering to a patient a...
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7001893 |
Inclusion complex of Rifampicin, an anti-tubercular drug, with β-cyclodextrin or 2-hydroxypropyl β-cyclodextrin and a process thereof
The present invention relates to an inclusion complex of Rifampicin and cyclodextrin (CD) that can be used as an anti-tubercular drug. The present invention also relates to a process for...
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6984732 |
High-intensity sweetener composition and delivery of same
A composition for sweetening ingestable solids or liquids. The composition is compressed and comprises less than about 7.5 weight-% sucralose and one or more diluents. The composition is compressed...
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6951934 |
Method for preparing functionalized β-(1,3)-glucan derivatives
The present invention relates to a novel method of chemically preparing functionalized derivatives of β-(1,3)-glucans, enabling obtaining oligosaccharides which are free or which comprise specific...
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6951846 |
Artemisinins with improved stability and bioavailability for therapeutic drug development and application
A stable form of artemisinin wherein an artelinic acid or artesunic acid is complexed with cyclodextrin analogs, preferably, β-cyclodextrin. The complexed cyclodextrin artemisinin formulation...
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6943248 |
Crystalline form of sucralose, and method for producing it
A crystalline form of sucralose, and a method of making it. The method involves continuously crystallizing sucralose from an aqueous solution by a process providing continuous removal and...
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6927209 |
5-thio-β-D-xylopryanoside derivatives, preparation, method, pharmaceutical compositions containing them and their therapeutic use
The present invention relates to novel compounds of formula (I):
in which:
R 1 , R 2 and R 3 , which are identical or different, are each independently:
a (C 1 -C 6 )alkyl group, a...
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6891035 |
Process for bulk autoclaving
Process for bulk autoclaving of polysaccharides, wherein the process includes: a) dissolving the polysaccharides in an aqueous solution and mixing until a homogeneous solution is obtained; b)...
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6875840 |
Polymers for delivering nitric oxide in vivo
Disclosed are novel polymers derivatized with at least one —NO x group per 1200 atomic mass unit of the polymer. X is one or two. In one embodiment, the polymer is an S-nitrosylated polymer and...
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6844329 |
Polysaccharides with antithrombotic activity comprising at least a covalent bond with biotin or a biotin derivative
The present invention relates to novel synthetic polysaccharides with antithrombotic activity exhibiting at least one covalent bond with biotin or a biotin derivative and to a process employing...
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6828334 |
Fenofibrate-cyclodextrin inclusion complexes and their pharmaceutical composition
The present invention relates to pharmaceutical compositions containing fenofibrate in the form of an inclusion complex with cyclodextrin, having high dissolution profile and in vivo enhanced...
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6812223 |
Crystalline glucosamine sulfate metal salts and processes for preparing the same
The present invention relates to novel crystalline glucosamine sulphate metal salts for use in the treatment of acute and chronic forms of rheumatic and arthritic diseases and of all the...
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6809198 |
Sucralose composition and process for its preparation
The present invention provides an improved form of sucralose and a process for making it.
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6720419 |
Sulfated fucan oligosaccharide
A smaller molecule obtainable by allowing a sulfated fucan-digesting enzyme which digests a novel sulfated polysaccharide derived from an alga belonging to Laminariales to act on a sulfated fucan,...
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6673891 |
Polymers for delivering nitric oxide in vivo
Disclosed are novel polymers derivatized with at least one —SNO group per 1200 atomic mass unit of the polymer. In one embodiment, the S-nitrosylated polymer has stabilized —S-nitrosyl groups....
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6670338 |
Pentasaccharides processes for their preparation and pharmaceutical compositions containing them
Pentasaccharides in acidic form and their pharmaceutically acceptable salts, the anionic form thereof having the formula: wherein: R represents hydrogen or an —SO 3 − , (C 1 -C 3 )alkyl or...
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6660722 |
Therapeutical treatments
Therapeutical method comprising administration to a patient of an effective amount of especially soluble laminarin for the treatment of tumors and more generally of cancers of the group comprising...
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6656922 |
Oral delivery of macromolecules
Polysaccharides, which are widely used as an anticoagulation drugs, especially heparin, are clinically administered only by intravenous or subcutaneous injection because of their strong...
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6642366 |
Process for making morphine-6-glucuronide and its analogues using haloglucuronate ester intermediates
A process for manufacturing morphine-6-glucuronide and related compounds of the general structure of Formula 1: wherein optionally substituted morphine is conjugated with an optionally...
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6638916 |
Use of sulfated oligosaccharides as inhibitors of cardiovascular disease
A method for the inhibition of vascular smooth muscle cell hyperplasia in a human or other warm-blooded animal patient in need of such treatment, comprises administration to the patient of an...
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6627751 |
Hydrophobically modified anionic cellulose ethers
A hydrophobically modified anionic cellulose ether obtainable by a process comprising reacting an alkali metal cellulose with at least three alkylating reagents A, B, and C. Reagent A is selected...
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6627744 |
Synthesis of glycodendrimer reagents
The present invention relates to a chemically modified mutant protein including a cysteine residue substituted for a residue other than cysteine n a precursor protein, the substituted cysteine...
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6589943 |
Formulation of amphiphilic heparin derivatives for enhancing mucosal absorption
Formulations for enhanced mucosal absorption of heparin are disclosed. In one embodiment, a powdered heparin composition is made by dissolving an amphiphilic heparin derivative including heparin...
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6528497 |
Synthetic polysaccharides, their method of production and pharmaceutical compositions containing same
Novel synthetic polysaccharides for use in the treatment of pathologies associated with a coagulation dysfunction.
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6495678 |
Immunosuppressant containing glucopyranose derivative as active ingredient
An immunosuppressant comprising Glucopyranose derivatives of the formula (I): wherein R is H, OH etc; G is —CH 2 CH(R 1 —R 2 )(R 3 —R 4 ), in which R 1 is a single bond, OCO-alkyl; R 2 ,...
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6462215 |
Sulfonation, sulfation, and sulfamation
A process that can be used for sulfonating, sulfating, or sulfamating an organic compound is disclosed. The process can comprise, consist essentially of, or consist of, contacting the organic...
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6462191 |
Synthesis of 2-deoxy-2-fluoro-arabinose derivatives
A process for deoxofluorinating a C 2 -hydroxyl group of a furanose, includes: (a) mixing the furanose and a deoxofluorinating agent in a solvent to form a reaction mixture, and (b) heating the...
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6407072 |
Lysoganglioside derivatives
Novel N-acyl-lysogangliosides obtained from gangliosides by deacyation of the ceramide group, wherein the acyl group is derived from an aliphatic acid having from 2 to 24 carbon atoms, substituted...
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6403759 |
Polymers for delivering nitric oxide in vivo
Disclosed are novel polymers derivatized with at least one —SNO group per 1200 atomic mass unit of the polymer. In one embodiment, the S-nitrosylated polymer has stabilized-S-nitrosyl groups. In...
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6391862 |
Chiral resolving agents for enantioseparations
A cyclodextrin composition of substantially pure, sulfated-cyclodextrin derivatives particularly suitable as chiral resolving agents for enantioseparation by electrophoresis. The cyclodextrin...
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6388060 |
Process for the sulfation of uronic acid-containing polysaccharides
This present invention provides methods of sulfating uronic acid-containing polysaccharides. High levels of sulfation can be obtained using the methods of the present invention.
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6355784 |
Methods and compositions for the manufacture of halogenated anthracyclines with increased antitumor activity, other anthracyclines, halogenated sugars, and glycosyl donors
The present invention discloses new and novel halogenated anthracyclines linked through the saccharide portions. These congeners show high activity in vitro against several tumor cell lines. In...
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6288043 |
Injectable hyaluronate-sulfated polysaccharide conjugates
An injectable composition is provided for promoting bone and/or cartilage growth comprising hyaluronic acid cross-linked to sulfated polysaccharide through linking groups. The linking groups are...
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6245753 |
Amphiphilic polysaccharide derivatives
Polysaccharides, which are widely used as an anticoagulation drugs, especially heparin, are clinically administered only by intravenous or subcutaneous injection because of their strong...
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6232434 |
Polymers for delivering nitric oxide in vivo
Disclosed are novel polymers derivatized with at least one --SNO group per 1200 atomic mass unit of the polymer. In one embodiment, the S-nitrosylated polymer has stabilized --S-nitrosyl groups. In...
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6229008 |
α-D-pentofuranosides, and a process for preparing the same
α-D-pentofuranoside derivatives have the general formula (D), in which R stands for (C 1 -C 4 )alkyl that is non-substituted or substituted one or several times by halogen, (C 1 -C 4 )alkyl, (C...
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6228998 |
Amino spacered glycosaminoglycan derivatives and their use in copolymerization with acrylamide
A glycosaminoglycan derivative is disclosed wherein a first amino group of a spacer compound (NH 2 --Y--NH 2 ) is bonded to an aldehyde formed by reducing and partially oxidizing a reducing end...
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6225450 |
DNA sequencing by mass spectrometry
The invention describes a new method to sequence DNA. The improvements over the existing DNA sequencing technologies are high speed, high throughput, no electrophoresis and gel reading artifacts...
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