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5571897 |
Luminescent lanthanide chelates
Lanthanide chelates which contain three heterocyclic rings covalently coupled to each other (either one 2,6-pyridylene and two five-membered unsaturated heterocyclic ring moieties or two...
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5567408 |
YIGSR peptide radiopharmaceutical applications
Peptides containing a biological-function domain which includes the sequence Tyr-Ile-Gly-Ser-Arg (YIGSR) and a medically useful metal ion-binding domain are labeled with medically useful metal ions...
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5565552 |
Method of expanded porphyrin-oligonucleotide conjugate synthesis
The invention is directed to a method of incorporating expanded porphyrins, and particularly of incorporating a sapphyrin or a texaphyrin, before, during, or after chemical synthesis of an oligomer...
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5559207 |
Texaphyrin metal complex mediated ester hydrolysis
A method of phosphate ester hydrolysis including incubating a solution of an aqueous phosphate ester with a texaphyrin metal complex. The metal is a metal cation having catalytic activity for ester...
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5556968 |
Polyazamacrocycle chelating agents with amide linkages
Macrocyclic chelating agents, optionally possessing more than one macrocyclic ring having at least two peptide linkages within the macrocyclic skeleton. The chelating agents are used for the...
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5554749 |
Functionalized macrocyclic ligands for imaging applications
The present invention provides new and structurally diverse compositions comprising compounds of the general formula: ##STR1## Wherein U is --(CH 2 ) n X or --(CH 2 ) n NR 1 (CH 2 )X; R 1 is...
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5534622 |
Rare earth cryptates, processes for their preparation, synthesis intermediates and application as fluorescent tracers
The invention relates to rare earth cryptates consisting of at least one rare earth salt complexed by a macropolycyclic compound corresponding to one of formulae I or II below, in which: the ring...
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5531978 |
Aminopolycarboxylic acids and derivatives thereof
There are provided chelating agents particularly useful for the preparation of diagnostic and therapeutic agents for magnetic resonance imaging, scintigraphy, ultrasound imaging, radiotherapy and...
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5523435 |
Process for the synthesis of monomethylmetallocenes and dimethylmetallocenes and their solutions specifically for use in the polymerization of olefins
Disclosed is a process for preparing methyltransition metal compounds in which the halide metallocene precursor to be alkylated is initially charged in a hydrocarbon desired for the subsequent...
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5508458 |
Chiral catalysts and processes for preparing the same
A novel catalyst comprising the formula: ##STR1## and which has utility in areas such as epoxidation of olefins.
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5504195 |
Rare earth compounds and their preparation
The invention provides rare earth compounds of formula (ML 3 ) x A! y where M is one or more of the rare earth metals and yttrium, L is a beta-diketone type ligand, A is a polyether or...
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5498699 |
Complexes and chelates of azithromycin with bivalent and/or trivalent metals and their use as antiulcer
The invention relates to the use of complexes and chelates resp., of antitics with bivalent and/or trivalent metals in antiulcer drugs, to new complexes and chelates resp., of antibiotics with...
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5495036 |
Metal (III) complexes containing conjugated, non-aromatic anionic II-bound groups and addition polymerization catalysts therefrom
Novel Group 4, Group 3 or Lanthanide metal complexes wherein the metal is in the +3 formal oxidation state containing a cyclic or non-cyclic, nonaromatic, anionic, dienyl ligand group bound to M...
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5494656 |
Second sphere complexes as relaxation agents for image enhancement in magnetic resonance imaging
A second sphere contrast enhancing agent for magnetic resonance imaging comprises a paramagnetic metal ion having catecholate ligands coordinated thereto and having water molecules hydrogen bonded...
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5484897 |
Organometallic complexes of lanthanides and their use in the polymerization of unsaturated monomers
Organometallic complexes of lanthanides with a well-defined stoichiometry which can be used in the stereospecific polymerization of unsaturated monomers, can be represented by the general formula: ...
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5474716 |
Process for the preparation of bridged cyclopentadienylmagnesium compounds and use thereof for preparing metallocenes
Disclosed are processes for the preparation of new bridged cyclopentadienylmagnesium compounds of the general formula Q(CpR a )(Cp'R' a ')Mg, and the use thereof for preparing bridged metallocenes.
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5475104 |
Water soluble texaphyrin metal complexes for enhancing relaxivity
The present invention involves water soluble hydroxy-substituted texaphyrins retaining lipophilicity, the synthesis of such compounds and their uses. These expanded porphyrin-like macrocycles are...
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5468465 |
Treated apatite particles for x-ray diagnostic imaging
Treated apatite particles are disclosed for enhancing medical diagnostic imaging such as magnetic resonance imaging ("MRI"), magnetic resonance spectroscopy ("MRS"), magnetic resonance spectroscopy...
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5462725 |
2-pyridylmethylenepolyazamacrocyclophosphonic acids, complexes and derivatives thereof, for use as contrast agents
2-Pyridylmethylenepolyazamacrocyclophosphonic acid compounds and their derivatives are disclosed which may form inert complexes with Gd, Mn or Fe ions. The overall charge of the complex can be...
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5463099 |
Extractant for selectively extracting strontium from aqueous solution containing the same
An extractant for selectively extracting strontium from an aqueous solution containing the same, which comprises a 1,2-benzenebis(1,4-dioxanonyl-6,8-dionato)metal complex of the following...
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5457184 |
Rare earth macrocyclic complexes and use thereof for reduction of disturbances in an assay using fluorescence
The invention relates to macrocyclic rare earth complexes which consist of at least one rare earth salt complexed by a macrocyclic compound of formula (I): ##STR1## in which: the bivalent radicals...
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5457186 |
Luminescent lanthanide chelates with decreased non-radiative energy loss
A method of conducting assays for analytes, usually from biological samples, utilizing bioaffinity reagents linked to luminescent lanthanide chelates, which are synthesized so that the...
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5457183 |
Hydroxylated texaphyrins
A method of using texaphyrins as radiosensitizers. Advantageous properties of texaphyrins for use as a radiosensitizer include i) a low redox potential which allows radiation induced solvated...
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5455333 |
Preparation of metallocenes
Metallocenes which are useful as olefin polymerization catalysts are prepared by reacting a compound of a metal of the group 4 to 10, lanthanide or actinide series of the Periodic Table of the...
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5453494 |
Metal complex source reagents for MOCVD
Metal organic chemical vapor deposition (MOCVD) source reagents useful for formation of metal-containing films, such as thin film copper oxide high temperature superconductor (HTSC) materials. The...
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5451576 |
Tumor imaging and treatment by water soluble texaphyrin metal complexes
The present invention involves water soluble hydroxy-substituted texaphyrins retaining lipophilicity, the synthesis of such compounds and their uses. These expanded porphyrin-like macrocycles are...
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5439668 |
Heterocyclic chelating agents
Heterocyclic chelating agents and salts thereof of formula I: ##STR1## wherein X represents a bond, O or S, or a group CHR 1 or NR 3 , each R 1 represents H, a group OR 3 or NR 3 R 3 , or an...
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5428154 |
Complexes of functionalized tetraazacyclododecane chelates with bismuth, lead, ytriium, actinium, or lanthanide metal ions
The invention is a chelate of formula I: ##STR1## wherein R 1 -4 is --CH 2 COOH; n is 1 to 5; X is a member selected from the group consisting of --NO 2 , --NH 2 , --NCS, ...
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5424057 |
Polyethylene glycol carbamates
Compounds of the formula ##STR1## in which R is alkyl having up to 4 carbon atoms, n has an average value of at least 9, X is a radical of the formula --C(O)--(NH--SO 2 ) m -- in which m is 0...
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5417959 |
Functionalized aza-crytand ligands for diagnostic imaging applications
The present invention provides new and structurally diverse compositions comprising compounds of the general formula: ##STR1## Wherein V is CR 1 or N; W is CR 2 or N; R 1 and R 2 may be the...
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5409689 |
MRI image enhancement using complexes of paramagnetic cations and amine ligands containing a mixture of phosphonate and non-phosphonate pendant arms
Ligands with three or more nitrogen atoms incorporated into a linear or cyclic backbone structure, with the nitrogen atoms substituted with a combination of phosphonate groups and nonphosphonate...
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5405601 |
Functionalized tripodal ligands for imaging applications
The present invention provides new and structurally diverse compositions for diagnostic imaging comprising compounds of the general formula: ##STR1## wherein A is N or CR 1 , R 1 is hydrogen, C 1 ...
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5385893 |
Tricyclopolyazamacrocyclophosphonic acids, complexes and derivatives thereof, for use as contrast agents
Tri- and tetra-cyclopolyazamacrocyclophosphonic acid compounds and their derivatives are disclosed which may form inert complexes with Gd, Mn or Fe ions. The overall charge of the complex can be...
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5380515 |
MRI image enhancement of bone and related tissue using complexes of paramagnetic cations and polyphosphonated ligands
Polyphosphonate ligands containing three or more phosphonate groups, combined with paramagnetic metal cations and administered in the form of pharmacologically acceptable salts, are useful as MRI...
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5374416 |
Nitrogenous macrocyclic ligands, polymetallic complexes and diagnostic and therapeutic composition
The invention relates to ligands of formula ##STR1## in which B represents an ##STR2## W representing the ##STR3## group, in which groups X and Z represent a heterocycle. The invention also relates...
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5371199 |
Substituted porphyrins, porphyrin-containing polymers, and synthetic methods therefor
Porphyrins substituted with, for example, vinyl and acetylene groups are provided, along with polymers containing the same. In preferred embodiments, the substituted porphyrins are prepared by...
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5368840 |
Natural polymers as contrast media for magnetic resonance imaging
Novel contrast media for use in magnetic resonance imaging are described. Such contrast media are comprised of biocompatible polymers either alone or in admixture with one or more contrast agents...
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5364953 |
High relaxivity, paramagnetic, metal clusters for magnetic resonance imaging
The present invention relates to novel compounds for use as imaging agents. In particular, the present invention relates to paramagnetic metal clusters having oxygen and/or nitrogen containing...
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5364613 |
Polychelants containing macrocyclic chelant moieties
There are provided polychelants and their metal chelates which are useful in diagnostic imaging and in radiotherapy and which comprise a plurality of macrocyclic chelant moieties, e.g, DOTA...
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5362476 |
Alkyl phosphonate polyazamacrocyclic cheates for MRI
The present invention relates to a new polyazamacrocyclic compound or a salt thereof and its uses as a tissue specific chelator. The compound has the formula ##STR1## where x is 2, 3 or a...
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5362475 |
Gadolinium chelates for magnetic resonance imaging
A diagnostic medium contains at least one physiologically well tolerated complex salt comprising an anion of a complexing acid and one or more Gadolinium ions and, optionally, one or more...
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5344640 |
Preparation of apatite particles for medical diagnostic imaging
Treated apatite particles are disclosed for enhancing medical diagnostic imaging such as magnetic resonance imaging ("MRI"), magnetic resonance spectroscopy ("MRS"), magnetic resonance spectroscopy...
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5344948 |
Single-source molecular organic chemical vapor deposition agents and use
Neutral single-source molecular organic precursors containing tetradentate tripodal chelating ligands are provided that are useful for the preparation of films using chemical vapor deposition....
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5336795 |
Process for the preparation of transition metal complexes having monosubstituted cyclopentadienyl ligands
Disclosed is a process for the preparation of transition metal complexes having monosubstituted cyclopentadienyl ligands of the general formula: ##STR1## in which monomeric cyclopentadiene is...
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5328992 |
Metal complexes of polyethylene glycol carbamate derivatives of desferrioxamine B
Compounds of the formula ##STR1## in which R is alkyl having up to 4 carbon atoms, n has an average value of at least 9, X is a radical of the formula --C(O)--(NH--SO 2 ) m -- in which m is 0...
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5324825 |
Terpyridine derivatives
The invention pertains to terpyridine compounds having structure (I). These compounds form fluorescent lanthanide chelates with the appropriate metal ions. The fluorescent metal chelates are useful...
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5322681 |
Chelating compounds
The invention provides novel condensed macrocyclic chelants of formula [X(CR 2 R 3 ) n ] m , (wherein each X independently represents an oxygen or sulphur atom or a group of formula NH, N(CR 2 R...
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5322934 |
Purification of a crude MRI agent using continuous deionization
The use of continuous deionization as an alternative or substitute method for the purification of a crude magnetic resonate.
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5314680 |
Polyazamacrocycles for magnetic resonance imaging
Novel magnetic resonance imaging agents comprise complexes of paramagnetic ions with hydrazide derivatives of polyaminocarboxylic acid chelating agents. These novel imaging agents are characterized...
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5286848 |
Lanthanide cryptate of trisphenanthroline
A photoactive lanthanide complex of 2,2',2",9,9',9"-bis[nitrilotri(methylene)]tris(1,10-phenanth
roline) and its functional derivative capable of bonding with substrate such as polymer and protein...
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