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5716594 |
Biotin compounds for targetting tumors and sites of infection
Novel biotin amide analogs that are useful for targeting therapeutic and imaging agents to sites of infection and tumors in vivo are disclosed.
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5717076 |
Metal-encapsulated fullerene derivative compound of and method for making the derivative
There are provided a derivative of a metal-encapsulated fullerene having application as a functional material, superconducting material, electronics material or pharmaceutical material, and a...
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5714631 |
Conjugates possessing ortho ligating functionality
A group of functionalized amine chelants having ortho ligating functionality that form complexes with rare-earth type metal ions are disclosed. The complexes can be covalently attached to an...
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5710297 |
Metallocenes, and their use as catalysts
The present invention relates to a stereorigid metallocene compound containing, as ligands, at least two substituted or unsubstituted cyclopentadienyl groups which are bonded to one another via a...
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5708150 |
Process for preparing transition metal complexes containing disubstituted cyclopentadienyl ligands
A process for preparing transition metal complexes containing disubstituted cyclopentadienyl ligands of the general formula (1) ##STR1## in which a monomeric, monosubstituted cyclopentadiene is...
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5708101 |
Stereospecific olefin polymerization catalysts
A metallocene catalyst system for the polymerization of α-olefins to yield stereospecific polymers including syndiotactic, and isotactic polymers. The catalyst system includes a metal and a ligand...
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5705619 |
Complexes of lanthanides with heterocyclic carbenes
A complex of the formula L a Ln b X c ! n (A) n wherein Ln is an ion in the oxidation state of 2, 3 or 4 of the lanthanide elements having the atomic numbers 21, 39 and from 57 to 71 in the...
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5702683 |
Nuclear magnetic resonance contrast agents
A family of contrast agents for use in magnetic resonance imaging and a method of enhancing the contrast of magnetic resonance images of an object by incorporating a contrast agent of this...
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5696240 |
Macrocyclic complexes of yttrium, the lanthanides and the actinides having peripheral coupling functionalities
Symmetrically di-functionalized water soluble macrocyclic complexes of lanthanide, actinide and yttrium ions were obtained by metal templated, Schiff-base, cyclic condensation of: (1) a...
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5690908 |
Treated apatite particles for medical diagnostic imaging
Treated apatite particles are disclosed for enhancing medical diagnostic imaging such as magnetic resonance imaging ("MRI"), magnetic resonance spectroscopy ("MRS"), magnetic resonance spectroscopy...
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5688733 |
Catalyst and process for a ziegler polymerisation
The present invention relates to a catalyst. The catalyst contains a transition metal-imidoaryl complex which contains at least one amido group bound to the transition metal and wherein the aryl...
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5688880 |
Readily supportable metal complexes
Metal complexes useful as olefin polymerization catalysts corresponding to the formula: ##STR1## wherein: L is a delocalized, π-bonded group that is bound to M, containing up to 50 nonhydrogen...
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5681543 |
Polymer-bonded complexing agents and pharmaceutical agents containing them for MRI
Polymers comprising a ligand containing a carboxylic acid group, optionally at least one ion of an element of the atomic numbers 21-29, 42, 44 or 57-83 as well as optionally cations of inorganic...
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5679814 |
Purification of metallocenes
Metallocenes, such as silicon bridged ansa-metallocenes, are purified by heating a slurry of the metallocene at elevated temperature in an aprotic, polar solvent so as to extract impurities from...
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5674467 |
Meso-tetraphenylporphyrin complex compounds, process for their production and pharmaceutical agents containing the latter
Porphyrin complex compounds consisting of a meso-tetraphenylporphyrin ligand of general formula I ##STR1## in which R 1 , R 2 and R 3 have varying meanings, and an ion of an element of atomic...
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5665329 |
Heteroatom-bearing ligands and metal complexes thereof
Novel compounds containing a heteroatom-bearing bridge and novel complexes of these compounds with metals. The novel compounds and complexes are useful in diagnostic and therapeutic methods.
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5663307 |
Hydrazone containing ligands and metal complexes thereof
Novel compounds of the formula ##STR1## where G 1 and G 2 are each independently --OH or --N(R 2 ) 2 , provided that at least one of G 1 and G 2 is --N(R 2 ) 2 , where each R 2 is...
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5658494 |
Fluorescent compounds
Novel compounds obtainable by reacting together an imido-reagent such as diphenylphosphonimido-triphenylphosphorane), or a phosphine oxide such as p-tolyldiphenylphosphine oxide, with a chelate of...
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5656254 |
Polyaza heteroatom-bearing ligands and metal complexes thereof for imaging or radiotherapy
Novel compounds containing a heteroatom-bearing bridge and novel complexes of these compounds with metals. The novel compounds and complexes are useful in diagnostic and therapeutic methods.
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5653960 |
Tetra-aza macrocycles, processes for their preparation and their use in magnetic resonance imaging
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5654423 |
Boronated metalloporphyrine and therapeutic methods
Carborane substituted porphyrin compounds complexed with a metal or transition metal have a variety of therapeutic uses. These compounds have been found, for example, selectively to inhibit viral...
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5652361 |
Macrocyclic ligands and complexes
A group of functionalized polyaminocarboxylate chelants that form complexes with rare earth-type metal ions are disclosed. The complexes, covalently attached to an antibody or antibody fragment,...
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5650133 |
Macrocyclic polyaza dichelates linked through ring nitrogens via an amide or ester functionality
This invention relates to dichelants, in particular compounds having two macrocyclic chelant groups linked by a bridge containing an ester or amide bond, especially compounds of formula Vb ##STR1##...
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5648063 |
Sterile composition comprising a chelate complex for magnetic resonance imaging
A diagnostic medium contains at least one physiologically well tolerated complex salt comprising an anion of a complexing acid and one or more central ion or ions of an element with an atomic...
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5645818 |
Diagnostic compositions comprising a complex formed by a nitrogenous macrocyclic ligand with metal ions
The invention relates to ligands having the formula (I), in which X represents a heterocyclic group, together with the process for their preparation. The invention also concerns mono- or...
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5644037 |
Method for the preparation of polyhedral particles of a rare earth ammonium double oxalate
Disclosed is a method for the preparation of particles of a rare earth ammonium double oxalate by mixing a first aqueous solution of ammonium oxalate and a second aqueous solution of a...
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5641871 |
Preparation of metallocenes in one reaction step
Metallocenes are prepared by a process in which a metal salt is reacted with at least one alkali metal and with an unsaturated, cyclic hydrocarbon in the presence of a solvent in one reaction step.
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5633353 |
Halogenated organometallic complexes and their use in the polymerization of unsaturated monomers
Organometallic complexes of lanthanides with a well-defined stoichiometry which can be used in the stereospecific polymerization of unsaturated monomers, can be represented by the general formula: ...
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5633354 |
Phosphoramidite derivatives of texaphyrins
The invention is directed to a method of incorporating expanded porphyrins, and particularly of incorporating a sapphyrin or a texaphyrin, before, during, or after chemical synthesis of an oligomer...
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5630997 |
Phosphorylated polyazamacrocyclic compounds for complexation of metal ions
The present invention relates to a new polyazamacrocyclic compound or a salt thereof and its uses as a tissue specific chelator. The compound has the formula ##STR1## where x is 2, 3 or a...
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5621127 |
Preparation of bridged half sandwich complexes
Bridged half sandwich complexes are prepared by reacting cyclopentadienides with aziridines and subsequently adding metallating agents and transition metal compounds.
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5616312 |
Thiol ligands and complexes for X-ray imaging
The present invention provides new and structurally diverse compositions comprising compounds of the general formula: ##STR1## Wherein R 1 , R 2 , R 3 , R 4 , and R 5 are the same or different and...
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5612462 |
Process for preparing bridged stereorigid metallocenes
The invention relates to a new improved process for preparing bridged stereorigid metallocenes via organomagnesium and organotin compounds.
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5602236 |
Metal-containing steroid mimics and ligands useful in the preparation thereof
Metal-containing steroid mimic complexes are provided. Compositions containing a metal ion incorporated into a steroid skeleton structure and ligands useful in the preparation of such compositions...
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5602267 |
Organometallic catalysts for epoxidizing prochiral olefins and a new class of amid-salicylidene ligands
Asymmetric synthesis using a novel catalyst comprising the formula: ##STR1## and which has utility in areas such as epoxidation of olefins.
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5595724 |
Treated calcium/oxyanion-containing particles for medical diagnostic imaging
Treated calcium/oxyanion-containing particles are disclosed for enhancing medical diagnostic imaging such as magnetic resonance imaging ("MRI"), magnetic resonance spectroscopy ("MRS"), magnetic...
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5594080 |
Thermoplastic elastomeric olefin polymers, method of production and catalysts therefor
This invention is directed to novel catalysts the structure and activity of which can be controlled to produce a wide range of alpha olefin polymers and co-polymers, and preferably for the...
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5593659 |
MRI image enchancement of bone and related tissue using complexes of paramagnetic cations and polyphosphonate ligands
Polyphosphonate ligands containing three or more phosphonate groups, combined with paramagnetic metal cations and administered in the form of pharmacologically acceptable salts, are useful as MRI...
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5593656 |
Metal-binding targeted polypeptide constructs
This invention relates to the preparation and use of novel open-chain or cyclic polypeptide constructs in which two or more polypeptide chains, in an open-chain construct, or one or more chains, in...
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5594136 |
Texaphyrin solid supports and devices
The present invention provides various novel matrix-supported texaphyrins in which a polymeric or solid matrix is covalently modified by the addition of one or more texaphyrins or texaphyrin...
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5591422 |
Texaphyrin complexes having improved functionalization
Texaphyrin metal complexes having improved functionalization include the addition of electron-donating groups to positions 2, 7, 12, 15, 18 and/or 21 and/or the addition of electron-withdrawing...
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5589595 |
Process for tetraazacycloalkane preparation
The present invention provides a synthetic route for tetraazacycloalkane preparation which facilitates heteropoly-N-alkylation of the macrocyclic product, and is thereby beneficial for the...
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5587371 |
Texaphyrin-oligonucleotide conjugates
Texaphyrins are provided for use as radiation sensitizers. Advantageous properties of texaphyrins for use as a radiation sensitizer include: i) a low redox potential which allows radiation-induced...
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5587463 |
Texaphyrin macrocycles and metal complexes thereof
The present invention involves a novel tripyrrole dimethine-derived "expanded porphyrin" (texaphyrin), the synthesis of such compounds, their analogs or derivatives and their uses. These expanded...
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5587394 |
Production and use of diels alder adducts of vinyl porphyrins, of metal complexes thereof, and of compositions containing such adducts and complexes
Families of Diels Alder adducts and of metal complexes of Diels Alder adducts, which are useful as particularly active compounds for use in photodynamic therapy, are disclosed. The Diels Alder...
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5583219 |
Macrocyclic chelating agent
A novel bifunctional macrocyclic chelating agent useful for attaching metal ions to proteins, polypeptides and other polymers. These reagents are unique in their ability to bind a variety of metal...
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5583206 |
Chelating polymers
In accordance with this invention, there is provided a polymer comprising units comprising the residue of a chelating agent linked to a poly(alkylene oxide) moiety, and a method for the preparation...
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5580543 |
Method of magnetic resonance image enhancement
Texaphyrins are provided for use as radiation sensitizers. Advantageous properties of texaphyrins for use as a radiation sensitizer include: i) a low redox potential which allows radiation-induced...
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5578286 |
Two powder synthesis of hydrotalcite-like compounds with divalent or polyvalent organic anions
There is provided a method for making a divalent or polyvalent organic anion-intercalated hydrotalcite-like materials by first reacting a magnesium-containing powder and a transition alumina powder...
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5573752 |
Aromatic amide compounds and metal chelates thereof
Novel aromatic amide compounds comprising a ligand nucleus containing at least one aminocarboxylate, aminophosphonate and/or aminohydroxamate chelating group, substituted with a substituted...
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