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9102708 Methods for the synthesis of dicarba bridges in organic compounds  
The present invention relates to methods for forming dicarba bridges in organic compounds. This involves the use of a pair of complementary metathesisable groups on the organic compound, and...
9062113 Antibodies directed to the deletion mutants of epidermal growth factor receptor and uses thereof  
The present invention relates to novel antibodies, particularly antibodies directed against deletion mutants of epidermal growth factor receptor and particularly to the type III deletion mutant,...
9040020 Muteins of hNGAL and related proteins with affinity for a given target  
The present invention relates to novel muteins derived from human lipocalin 2 (hNGAL) and related proteins that bind a given non-natural ligand with detectable affinity. The invention also related...
9040667 Antibody cocktail  
The present invention relates to a composition comprising at least three primary antibodies or fragments thereof, wherein the at least three antibodies or fragments thereof binds specifically to...
9040664 Materials and methods for preparing protein-polymer conjugates  
The invention is directed to a single-step method for rapidly and efficiently preparing protein-polymer conjugates, including an insulin-polymer conjugate. According to the method of the present...
9040672 Devices and methods for reducing matrix effects  
Devices and methods are provided for reducing matrix effects in protein precipitated bioanalytical samples comprising: a support, and a sorbent associated with the support capable of binding...
9040671 Methods for cancer management targeting Co-029  
The present disclosure relates to a Co-029 inhibitor for inhibiting the migration of cancer cells which express Co-029. The disclosure relates to a Co-029 inhibitor for the treatment of cancer...
9040043 Monoclonal antibodies against GMF-B antigens, and uses therefor  
The disclosure relates to anti-glial maturation factor beta (“GMF-B”) monoclonal antibodies (mAbs) and fragments thereof, as well as hybridoma lines that secrete antibodies or fragments....
9040055 Conjugation of streptococcal capsular saccharides  
Three conjugation methods for use with the capsular saccharide of Streptococcus agalactiae. In the first method, reductive animation of oxidized sialic acid residue side chains is used, but the...
9040668 Anti-serum albumin binding variants  
The invention relates to improved variants of the anti-serum albumin immunoglobulin single variable domain DOM7h-11, as well as ligands and drug conjugates comprising such variants, compositions,...
9040048 Antibody molecules having specificity for human OX40  
The invention relates to antibody molecules having specificity for antigenic determinants of human OX40, therapeutic uses of the antibody molecules and methods for producing said antibody molecules.
9039994 Biomarkers for myocardial ischemia  
This invention relates, e.g., to a method for determining if a subject has myocardial ischemia, comprising (a) providing a blood sample obtained from a subject suspected of having myocardial...
9040661 Support for affinity chromatography and method for isolating immunoglobulin  
Provided are a support for affinity chromatography which has excellent alkali resistance, and a method for isolating immunoglobulin. A support for affinity chromatography, containing an...
9040054 Hypoallergenic molecules  
The present invention relates to a hypoallergenic molecule consisting of Bet v Ia or an allergen having at least 40% identity to Bet v Ia comprising mutations of at least four amino acid residues...
9040663 Melanocortin receptor-specific peptides  
The invention relates to melanocortin receptor-specific cyclic peptides of Formula (I) or a pharmaceutically acceptable salt thereof, where R1, R2, R3, R4a, R4b, R4c, R5, x and y are as defined in...
9040251 Biomolecule fixing board and method of manufacturing the same  
This invention provides a biomolecule modifying substrate comprising biomolecules selectively fixed to given regions thereon. The biomolecule modifying substrate comprises: a substrate at least...
9040665 Controlled cross-linking processing of proteins  
A method of forming a cross-linked protein structures includes preparing a solution of protein dissolved in a benign solvent and forming an intermediate protein structure from the solution. The...
9040250 Binding interaction of proanthocyanidins with bacteria and bacterial components  
A composition having proanthocyanidin compounds having an average degree of polymerization of at least about 6. A method of administering to an immunosuppressed patient or a patient diagnosed with...
9040666 Single-domain antigen-binding proteins that bind mammalian IgG  
The present application relates to antigen-binding proteins that are capable of binding to mammalian IgG. The frame-work regions of the antigen-binding proteins of the application preferably...
9040310 Antibody-nanoparticle conjugates and methods for making and using such conjugates  
Disclosed herein are antibody-nanoparticle conjugates that include two or more nanoparticles (such as gold, palladium, platinum, silver, copper, nickel, cobalt, iridium, or an alloy of two or more...
9040660 Long-acting gastrin derivatives  
The present invention relates to gastrin derivatives comprising gastrin or an analogue or fragment thereof and a derivatisation group and therapeutic use thereof.
9040662 Methods and compositions comprising a C-terminal Bax peptide  
In an aspect, the invention relates to compositions and methods for permeabilizing membranes of cells. In an aspect, the invention relates to compositions and methods for killing cells. In an...
9040487 Cyclosporine emulsion  
The present invention relates to a cyclosporine emulsion containing: i) a cyclosporine ii) a natural oil (long chain triglyceride) iii) a phosphatidylcholine, iv) glycerol, v) a pharmaceutically...
9040669 HLA-restricted, peptide-specific antigen binding proteins  
Antigen binding proteins with T cell receptor-like paratopes, that is, with an antigen binding region specific for an human leukocyte antigen-A2 restricted peptide are disclosed. The antigen...
9040670 Monoclonal thyroid stimulating or blocking antibodies, peptide sequences corresponding to their variable regions, and their uses in diagnostic, preventive and therapeutic medicine  
Monoclonal antibodies (mAbs) having thyroid stimulating activity (TSAb), especially full or considerably agonistic activity, or thyroid blocking activity (TBAb), which are obtainable by genetic...
9040042 Optimized antibodies that target HM1.24  
The present disclosure describes antibodies that target HM1.24. In various aspects, the antibodies have specific CDR, variable, or full length sequences, have modifications with the parent...
9040478 Derivatisation of granulocyte colony-stimulating factor  
The present invention relates to a compound which is a polysaccharide derivative of GCSF, or of a GCSF like protein, wherein the polysaccharide is anionic and comprises between 2 and 200...
9040481 Methods for treating steatotic disease  
Methods for treating fatty liver disease, e.g., hepatic steatosis, using peptide fragments of the C-terminal end of glucagon-like peptide-1 (GLP-1), e.g., GLP-1(28-36).
9035027 Dual variable domain immunoglobulins and uses thereof  
The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.
9034339 Nucleic acid and amino acid sequences, and vaccine for the control of ectoparasite infestations in fish  
The present invention is related with the isolation and cloning of a new gene, the production of the protein encoded by this gene by using recombinant systems, and the use of this antigen in a...
9035020 Insulins with an acyl moiety comprising repeating units of alkylene glycol containing amino acids  
Acylated insulins wherein an acyl moiety is attached to the parent insulin and wherein the acyl moiety comprises repeating units of alkylene glycol containing amino acids and wherein there is only...
9035022 Cyclic CRF antagonist peptides  
Cyclic CRF antagonist peptides having improved properties of “drugability”. The peptides are 33 residues in length with a lactam bond between the residues in position 22 and 25; however, they may...
9034822 Methods of using antibodies during anticoagulant therapy of dabigatran and/or related compounds  
The present invention relates to antibody molecules against anticoagulants, in particular dabigatran, and their use as antidotes of such anticoagulants.
9035025 Molecularly imprinted surfaces using surface-bound peptides  
A method of producing a molecularly-imprinted material comprises synthesizing a peptide, oligosaccharide or oligonucleotide on a disposable surface modified support to produce a support...
9034345 GNA1870-based vesicle vaccines for broad spectrum protection against diseases caused by Neisseria meningitidis  
The present invention generally provides methods and compositions for eliciting an immune response against Neisseria spp. bacteria in a subject, particularly against a Neisseria meningitidis...
9034608 Polypeptides with permease activity  
The invention relates to a polypeptide having a mutation at one or more position corresponding to T219 of SEQ ID NO: 55, wherein the polypeptide has at least 50% sequence identity with SEQ ID NO:...
9035021 Somatostatin analogues  
The invention provides cyclo[{4-(NH2—C2H4—NH—CO—O—)Pro}-Phg-DTrp-Lys-Tyr(4-Benzyl)- Phe], optionally in protected form, or a pharmaceutically acceptable salt or complex thereof, which has...
9034818 Pharmaceutical formulations comprising an insulin derivative  
The invention concerns a soluble pharmaceutical formulation comprising an insulin derivative wherein the formulation further comprises more than 4 zinc atoms per 6 molecules of the insulin...
9035026 Anti-CD16 binding molecules  
The present invention relates to binding molecules that specifically bind to the human Fc gamma receptor expressed on the surface of natural killer (NK) cells and macrophages (i.e. FcγRIIIA), and...
9035031 Method for providing a β-lactoglobulin product and an α-enriched whey protein isolate  
The present invention relates to isolation of whey proteins and the preparation of a whey product and a whey isolate. In particular the present invention relates to the isolation of a...
9034318 Chemically modified cystathionine beta-synthase enzyme for treatment of homocystinuria  
The invention provides reagents and methods for enzyme replacement therapy using chemically modified species of human cystathionine β-synthase (CBS) to treat homocystinuria and other related...
9035023 Bombesin analog peptide antagonist conjugates  
To provide a diagnostic and therapeutic medicament, a bombesin analog peptide antagonist conjugate is provided which has general Formula (I), wherein A is a metal chelator comprising at least one...
9034655 Highly water-soluble, cationic luminescent labels  
Luminescent labels based on aromatic and heterocyclic compounds, including reactive intermediates used to synthesize these compounds, and methods of synthesizing and using these reporter...
9034324 Anti-BCMA antibodies  
This invention provides antibodies that recognize the B Cell Maturation Antigen (BCMA) and that bind naïve B cells, plasma cells, and/or memory B cells. The invention further provides methods for...
9034338 Nucleic acid and amino acid sequences, and vaccine for the control of ectoparasite infestations in fish  
The present invention is related with the isolation and cloning of a new gene, the production of the protein encoded by this gene by using recombinant systems, and the use of this antigen in a...
9034798 Capture compounds, collections thereof and methods for analyzing the proteome and complex compositions  
Capture compounds and collections thereof and methods using the compounds for the analysis of biomolecules are provided. In particular, collections, compounds and methods are provided for...
9034585 Diabetes-related biomarkers and methods of use thereof  
The invention describes biomarkers which can be used to predict the likelihood that an individual will develop Diabetes. The biomarkers can also be used to screen large groups in order to identify...
9034341 Control of RAGE fusion protein glycosylation and RAGE fusion protein compositions  
The invention relates to methods for controlling the glycosylation of a RAGE fusion protein. The invention also relates to compositions comprising an amount of a RAGE fusion protein where at least...
9035030 Human antibodies that bind the P40 subunit of human IL-12 and methods for using the same  
Human antibodies, preferably recombinant human antibodies, that specifically bind to human interleukin-12 (hIL-12) are disclosed. Preferred antibodies have high affinity for hIL-12 and neutralize...
9035024 Compounds that inhibit Hsp90 protein-protein interactions with IAP proteins  
Disclosed herein are compounds that inhibit Hsp90 interactions with IAP proteins, such as Survivin, XIAP, cIAP1, or cIAP2, and methods for identifying and using such compounds.