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8822180 Method of synthesizing a suppressor tRNA, DNA construct and use thereof for producing a non-natural amino acid-incorporated protein  
There are provided a DNA construct comprising a suppressor tRNA gene of a non-eukaryote containing no internal promoter functioning in a eukaryotic cell, and a eukaryotic or bacteriophage promoter...
8822412 Charged nutritive proteins and methods  
Charged nutritive proteins are provided. In some embodiments the nutritive proteins an aqueous solubility of at least 12.5 g/L at pH 7. In some embodiments the nutritive proteins an aqueous...
8822178 Sweetener preparations and methods of use  
The present disclosure relates to codon-optimized brazzein coding sequences and the expression of brazzein and variants thereof using yeast expression systems. The disclosure also relates to...
8822651 Human rhinovirus (HRV) antibodies  
The invention provides isolated fully human monoclonal anti-HRV antibodies, as well as method of making and using these antibodies. Anti-HRV antibodies of the invention prevent or treat subjects...
8822647 Method and compositions using a chimeric antigen receptor for enhanced anti-tumor effector functioning of T cells  
Integration of costimulatory signaling domains within a tumor targeting chimeric antigen receptor (CAR), such as the IL13Rα2 specific IL13-zetakine (IL13ζ), enhances T cell-mediated responses a...
8822761 Genes for enhancing nitrogen utilization efficiency in crop plants  
The invention provides isolated NUE (nitrogen utilization efficiency) nucleic acids and their encoded proteins. The present invention provides methods and compositions relating to altering nitrogen...
8822406 Tumor activated prodrugs  
The instant invention provides compositions comprising a prodrug, the prodrug comprising a therapeutically active drug; and a peptide selected from the group consisting of the sequences:...
8822644 Method of treating cancer comprising a VEGF-B antagonist  
The present invention relates generally to the field of cancer therapy and prophylaxis. More particularly, the present invention provides growth factor antagonists which inhibit the growth of...
8821856 Method of targeted gene delivery using viral vectors  
Methods and compositions are provided for delivering a polynucleotide encoding a gene of interest to a target cell using a virus. The virus envelope comprises a cell-specific binding determinant...
8821868 Anti-pancreatic cancer antibodies  
Described herein are compositions and methods of use of anti-pancreatic cancer antibodies or fragments thereof, such as murine, chimeric, humanized or human PAM4 antibodies. The subject antibodies...
8821871 Anticoagulant antidotes comprising antibodies that bind dabigatran and/or related compounds and methods of use thereof  
The present invention relates to antibody molecules against anticoagulants, in particular dabigatran, and their use as antidotes of such anticoagulants.
8822645 Prostaglandin E2 dual variable domain immunoglobulins and uses thereof  
The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.
8822162 Cyanochrome fluorophores  
Genetically-engineered cyanochrome fluorophore molecules (fluorophores) with increased fluorescence and with absorbing fluorescence in the blue and green (blue/green) portion of the light spectrum...
8822788 Maize variety hybrid X13B640  
A novel maize variety designated X13B640 and seed, plants and plant parts thereof, produced by crossing Pioneer Hi-Bred International, Inc. proprietary inbred maize varieties. Methods for producing...
8822639 Transferrin fusion protein libraries  
Fusion proteins comprising a transferrin moiety and integrin binding domain and peptide libraries thereof are disclosed. The present invention includes a method of screening transferrin and...
8821885 Immunogenic compositions and methods  
The invention is directed to immunogenic compositions, and methods for their use in the formulation and administration of therapeutic and prophylactic pharmaceutical agents. In particular, the...
8821895 Streptococcus pyogenes antigens and corresponding DNA fragments  
The present invention relates to antigens, more particularly antigenS of Streptococcus pyogenes (also called group A Streptococcus (GAS)) bacterial pathogen which are useful as vaccine component...
8822892 Combined metal PTC rapid electric heater  
A combined metal PTC rapid electric heater for use in the electric heating field composes at least one electric heating device. The electric heating device composes a metal PTC tube which is...
8822420 Peptides and aptamers thereof as specific modulators of mutant p53 function  
In the present application isolated peptides and aptamers thereof able to interact with structural and conformational p53 mutants within the region of the wild-type p53 DNA binding core domain...
8822636 Peptides for activation and inhibition of δPKC  
Peptides able to inhibit or activate the translocation or function of δPKC are identified. Administration of the peptides for protection or enhancement of cell damage due to ischemia is described. ...
8822638 Procoagulant peptides  
A peptide or peptide derivative comprising: (i) WDLYFEIVW;(SEQ ID NO: 1) or (ii) a variant amino acid sequence comprising one, two, three or four L-amino acid substitutions in WDLYFEIVW (SEQ ID NO:...
8821894 Compositions and methods related to protein A (SpA) variants  
The present invention concerns methods and compositions for treating or preventing a bacterial infection, particularly infection by a Staphylococcus bacterium. The invention provides methods and...
8822762 Bacillus thuringiensis gene with lepidopteran activity  
The invention provides nucleic acids, and variants and fragments thereof, obtained from strains of Bacillus thuringiensis encoding polypeptides having pesticidal activity against insect pests,...
8822657 Recovery of lignin and water soluble sugars from plant materials  
In one aspect, a process for treating woody plant material is provided, the process involving contacting the plant material with a continuous flow of an aqueous ethanol solution at elevated...
8822422 Antitumor agent  
An antitumor agent containing, in combination, at least one kind of antitumor agent selected from the group consisting of an antitumor agent that forms a cross-link with DNA and shows an antitumor...
8821917 Biopolymeric membranes  
This invention relates to a sheet membrane for repairing a damaged tissue. The membrane includes an isotropic layer of cross-linked biopolymeric fibers in which the fibers are 10 to 1,000 cm in...
8821867 4-1BB binding molecules  
The present disclosure provides isolated binding molecules that bind to human 4-1BB, nucleic acid molecules encoding an amino acid sequence of the binding molecules, vectors comprising the nucleic...
8821863 Humanized anti-α 9 integrin antibodies and the uses thereof  
The present invention provides humanized antibodies that immunospecifically recognize human α9 integrin. Some of these antibodies inhibit the biological functions of the α9 integrin, thereby e...
8822653 Plasma kallikrein binding proteins  
Plasma kallikrein binding proteins and methods of using such proteins are described.
8822640 Tetrameric streptavidin mutein with reversible biotin binding capability  
The present invention relates to a new streptavidin muteins. This mutein is The muteins are capable of oligomerization to form tetramers, with relatively strong subunit interactions, dissociation...
8821857 Human placental collagen compositions and methods of making and using the same  
The present invention provides compositions comprising human placental telopeptide collagen, methods of preparing the compositions, methods of their use and kits comprising the compositions. The...
8822641 Method for detecting and removing endotoxin  
The present invention relates to bacteriophage tail proteins and the derivatives and fragments thereof that are capable of binding endotoxins in the absence of bivalent positive ions, especially...
8815808 Modulation of activity of neurotrophins  
The present invention relates to methods for modulating the activity of one or more neurotrophins, such as neural growth factor (NGF), brain derived neurotrophic factor (BDNF), neurotrophin-3...
8818734 Peptide ligands for sperm DNA fragmentation assay  
This invention comprises peptides, methods and a kit for identifying DNA fragmentation in non-viable sperm. Specific peptide sequences are claimed that bind to ssDNA and fragmented DNA.
8815544 Production of galactosylated glycoproteins in lower eukaryotes  
The present invention provides a novel lower eukaryotic host cell producing human-like glycoproteins characterized as having a terminal β-galactose residue and essentially lacking fucose and ...
8815793 Polymeric compositions and related methods of use  
Adhesive polymeric compositions which can comprise dihydroxyphenyl moieties and derivatives thereof, and related methods of use.
8816052 Mutant apoprotein of photoprotein with low calcium sensitivity  
Calcium-binding photoproteins showing the luminescence pattern with a slow decay of are desired. The invention provides a mutant apoprotein comprising an amino acid sequence wherein the 23rd to...
8815814 Cosmetic composition containing oligopeptides  
The invention is directed to the cosmetic use of tetrapeptides according to formula (I) R1-Val-Leu-Leu-Lys-R2 (I) wherein R1 is linked to the NH2-terminal group of the peptide and is chosen from...
8816047 Compositions and methods of using proislet peptides and analogs thereof  
Embodiments relate to proislet peptides, preferably HIP, that exhibit increased stability and efficacy, and methods of using the same to treating a pathology associated with impaired pancreatic...
8816054 Compositions and methods for enhancing coagulation Factor VIII function  
Factor VIII variants and methods of use thereof are disclosed.
8816163 Soybean variety D2011911  
The invention relates to the soybean variety designated D2011911. Provided by the invention are the seeds, plants and derivatives of the soybean variety D2011911. Also provided by the invention are...
8815551 Production of biofuel and protein from a raw material  
The present invention relates to a method for providing an isolated biofuel and a purified protein product from a raw material suitable for the production of the biofuel or a derivative of said raw...
8815250 Clotting factor-Fc chimeric proteins to treat hemophilia  
The invention relates to a chimeric protein comprising at least one clotting factor and at least a portion of an immunoglobulin constant region. The invention relates to a method of treating a...
8816162 Soybean variety A1026213  
The invention relates to the soybean variety designated A1026213. Provided by the invention are the seeds, plants and derivatives of the soybean variety A1026213. Also provided by the invention are...
8815794 Treatment of amyloidoses using myelin basic protein and fragments thereof  
In its various embodiments, the invention provides myelin basic proteins and fragments of that interfere with the fibril lization of peptides implicated in the amyloidoses, especially the...
8816053 Methods for treating viral infection using IL-28 and IL-29 cysteine mutants  
IL-28A, IL-28B, IL-29, and certain mutants thereof have been shown to have antiviral activity on a spectrum of viral species. Of particular interest is the antiviral activity demonstrated on...
8815580 Cells producing glycoproteins having altered glycosylation patterns and method and use thereof  
The present application relates to the field of glyco-engineering, more specifically to eukaryotic cells wherein both an endoglucosaminidase and a glycoprotein are present. These cells can be used...
8815266 Peptide derivatives useful in the treatment, care or cleansing of the skin, mucosae, scalp or nails  
The invention relates to peptide derivatives of general formula (I): R1-AA1-AA2-R3-AA4-R2 (I) their stereoisomers, mixtures thereof, and their cosmetically or pharmaceutically acceptable salts, a...
8815807 Peptides and peptide compositions having osteoinductive activity  
Compositions and kits are provided having a peptide having an amino acid sequence that binds to eukaryotic cells and effects differentiation and support growth of the cells. Peptide-scaffold...
8815256 Induction of tumor immunity by variants of folate binding protein  
The present invention is directed to variants of antigens comprising folate binding protein epitopes as a composition associated with providing immunity against a tumor in an individual. The...