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8828401 Cytotoxic peptides and antibody drug conjugates thereof  
The present invention is directed to cytotoxic pentapeptides, to antibody drug conjugates thereof, and to methods for using the same to treat cancer.
8828933 Mutant tat proteins and uses thereof  
Disclosed are viral proteins associated with Human Immunodeficiency Virus (HIV) infections and mutants thereof, particularly, mutant Tat proteins capable of modulating multiple steps of the HIV-1...
8828386 Method for extending pregnancy by reducing intraventricular hemorrhaging in patients exhibiting at least one symptom of preeclampsia and eclampsia  
A method lessening intraventricular hemorrhage in the fetus of a gravid human patient is provided where the patient is administered a therapeutically effective amount of digoxin antibody.
8828927 Elastin digest compositions and methods utilizing same  
The present invention provides compositions for the therapeutic and/or cosmetic treatment of Elastin comprising tissues. Therapeutic and cosmetic compositions comprising an elastin digest stimulate...
8829044 Stabilized vitamin C derivatives having a peptide molecule, preparation method thereof, and composition containing the same  
The present invention relates to a stabilized vitamin C derivative with a peptide molecule linked to vitamin C or a pharmaceutically acceptable salt thereof, a method of preparing the same, and a...
8829293 Soybean cultivar 22170671  
A soybean cultivar designated 22170671 is disclosed. The invention relates to the seeds of soybean cultivar 22170671, to the plants of soybean cultivar 22170671, to the plant parts of soybean...
8828399 Cytomegalovirus surface protein complex for use in vaccines and as a drug target  
Immunogenic compositions and prophylactic or therapeutic vaccines for use in protecting and treating against human cytomegalovirus (CMV) are disclosed. Subunit vaccines comprising a human CMV...
8828724 Method for preparing cells for engraftment  
The present invention relates to an in vitro method for preparing progenitor cells having an increased adhesivity, wherein progenitor cells are contacted with an agonist of the CD47/IAP receptor...
8828670 Method for the production of proteins and peptides  
The invention relates to a method for producing monomeric or dimeric proteins or peptides containing internal or external disulfide bonds, comprising the following steps: a) a cell-free lysate,...
8829290 Soybean cultivar 23210992  
A soybean cultivar designated 23210992 is disclosed. The invention relates to the seeds of soybean cultivar 23210992, to the plants of soybean cultivar 23210992, to the plant parts of soybean...
8822423 Affinity peptides toward infliximab  
We have disclosed affinity peptides toward infliximab. More specifically we have disclosed an affinity biomatrix where the affinity peptide is covalently attached to a biocompatible, biodegradable...
8822789 Inbred corn line BB86  
An inbred corn line, designated BB86, is disclosed. The invention relates to the seeds of inbred corn line BB86, to the plants and plant parts of inbred corn line BB86 and to methods for producing...
8822649 Anti-CLTA4, anti-GLUT2 protein for the treatment of type 1 diabetes  
The disclosure relates to a protein composed of a first polypeptide or polypeptide domain having a first specific binding activity for Cytotoxic T-lymphocyte Antigen 4 (CTLA-4) expressed on a...
8822417 Albumin variants  
Variants of a parent albumin having altered plasma half-life compared with a parent albumin are described. Fusion polypeptides and conjugates including the variant albumin are also described....
8822652 Monoclonal antibodies that bind B7H6 and uses thereof  
Disclosed are monoclonal antibodies that specifically bind to the B7 family member B7H6, including antibodies capable of inhibiting the interaction of B7H6 with NKp30. Also disclosed are anti-B7H6...
8822168 Assays for detecting small nuclear ribonucleoprotein particle assembly and survival of motor neurons activity  
The present invention includes assays and kits for detecting the assembly of an RNA binding protein-RNA complex and for detecting the activity of an RNA binding protein.
8822646 Cancer therapies and pharmaceutical compositions used therein  
The invention relates to compositions and methods to inhibit gene expression. In particular, the invention provides co-therapies comprising oligonucleotides plus other therapies to treat cancer.
8822188 Use of enzymes having silicase activity  
The present disclosure relates to the use of polypeptides having silicase activity for the modification or synthesis of silica, silicones and other silicium (IV) compounds. The present invention...
8822650 Method for the mass production of immunoglobulin constant region  
Disclosed are a recombinant expression vector comprising a nucleotide sequence encoding an E. coli-derived signal sequence and a nucleotide sequence encoding an immunoglobulin constant region, and...
8822442 Somatostatin-dopamine chimeric analogs  
The invention features somatostatin-dopamine chimeric analogs and methods relating to their therapeutic use for the treatment of neoplasia, acromegaly, and other conditions.
8822637 Somatostatin analogues  
The invention provides cyclo[{4-(NH2—C2H4—NH—CO—O-)Pro}-Phg-DTrp-Lys-Tyr(4- Benzyl)-Phe], optionally in protected form, or a pharmaceutically acceptable salt or complex thereof, which has interes...
8822655 Pre-filtration adjustment of buffer solutes  
Herein is reported a tangential flow filtration method with a pre-filtration solute concentration adjustment in order to ensure a defined concentration of the components of the solution after...
8822643 Process for the preparation of a virus-inactivated FV concentrate starting from human plasma, scalable to industrial level  
The present invention provides a process for purifying FV starting from human plasma or a fractionation intermediate thereof, that is simple, scalable to the industrial level and relatively...
8821874 KLK-13 antibody inhibitor for treating dry eye  
Disclosed herein is a method of treating dry eye with a KLK-13 antibody.
8821877 Methods for inhibiting HIV-1 replication involving the administration of an anti-CCR5 receptor monoclonal antibody and small molecule CCR5 receptor antagonist  
This method provides a method for reducing HIV-1 viral load in an HIV-1-infected human subject which comprises administering to the subject at a predefined interval effective HIV-1 viral...
8821851 Inflammation-inhibitory serum factors and uses thereof  
Disclosed are methods of purifying compounds that reduce or prevent an inflammatory response in a mammal, use of such compounds in treating a mammal having or being at risk of developing...
8821880 Methods and agents for the diagnosis and treatment of hepatocellular carcinoma  
The present invention relates to methods of diagnosing, and methods of treating, hepatocellular carcinoma in a subject. The invention also relates to polypeptide antagonists of PLVAP proteins,...
8821869 Treatment methods using c-Met antibodies  
The present invention relates to antibodies including human antibodies and antigen-binding portions thereof that specifically bind to c-Met, preferably human c-Met, and that function to inhibit...
8822764 Soybean variety A1026201  
The invention relates to the soybean variety designated A1026201. Provided by the invention are the seeds, plants and derivatives of the soybean variety A1026201. Also provided by the invention are...
8821955 Protein concentrates and isolates, and processes for the production thereof  
Protein concentrates and protein isolates, in addition to processes for the production of protein concentrates and protein isolates, are disclosed. In particular, the disclosure relates to the...
8822648 Antibody derivatives  
An anti-CEA scFv having an uncleaved Pel B leader sequence is surprisingly stable and is highly specific for CEA and CEACAM1.
8821883 Method of treating B cell cancers by administering truncated BAFF receptors  
The disclosure provides a non-naturally occurring BAFF-R glycoprotein having a deletion in the extracellular domain which results in an altered O-linked glycosylation pattern. The disclosure also...
8822656 Manufacture of factor H (FH) and FH-derivatives from plasma  
The present invention provides compositions and pharmaceutical formulations of Factor H derived from plasma. Also provided are methods for the manufacture of the Factor H compositions and...
8821872 Identification and characterization of a specific CCK-C receptor antibody for human pancreatic cancer and its use for early detection and staging of pancreatic cancer  
Human pancreatic cancer cells possess a distinct plasma membrane CCK receptor variant that can be differentiated from the classic CCK-B receptor with selective monoclonal antibodies. Use of this...
8822409 Compositions and uses thereof for the treatment of acute respiratory distress syndrome (ARDS) and clinical disorders associated with therewith  
Polypeptides are identified through an assay based on inhibiting AP-I signalling activity and others to treat acute respiratory distress syndrome (ARDS) and clinical disorders associated with the...
8822163 Method for measuring β-glucan, and β-glucan-binding protein for use in the method  
Disclosed are a method for measuring βG comprising the steps of bringing a sample into contact with a βG-binding protein 1 and a βG-binding protein 2, each comprising an amino acid sequence wh...
8822654 Mutated antithrombins, a process for preparing the same and their use as drugs  
The present invention relates to the use of a composition including of at least a mutated antithrombin having an anticoagulant activity substantially reduced with respect to the anticoagulant...
8822408 Cell growth-promoting peptide and use thereof  
The pharmaceutical composition includes at least one pharmaceutically acceptable carrier, and an active ingredient including an artificially synthesized peptide includes: (A) an amino acid sequence...
8822642 Dimeric fusion proteins and related compositions and methods  
Compositions and methods relating to soluble dimeric proteins are disclosed. The dimeric proteins comprise first and second polypeptide fusions linked via a dimerizing domain, each polypeptide...
8822160 Molecular adaptors  
The invention relates to transmembrane protein pore for use in detecting a analyte in a sample. The pore comprises a molecular adaptor that facilitates an interaction between the pore and the...
8821850 Protein-polymer-drug conjugates  
A drug conjugate is provided herein. The conjugate comprises a protein based recognition-molecule (PBRM) and a polymeric carrier substituted with one or more -LD-D, the protein based...
8822182 Chimeric antigen-specific T cell-activating polypeptides  
The invention provides an immunogenic or antigenic polypeptide containing a translocation domain, a peptide epitope, at least one biologically active agent, and cleavage sites. These polypeptides...
8821879 Anti-botulism antibody coformulations  
This invention relates to stable formulations of multiple antibodies comprising a plurality of anti-botulism antibodies and an effective amount of a succinate buffer, an effective amount of...
8822413 Bifunctional hormone having alpha-MSH activity and natriuretic peptide activity and uses thereof  
A bifunctional hormone exhibiting an alpha-MSH activity and a natriuretic peptide activity is described. The bifunctional hormone comprises for example a first domain having alpha-MSH related...
8822180 Method of synthesizing a suppressor tRNA, DNA construct and use thereof for producing a non-natural amino acid-incorporated protein  
There are provided a DNA construct comprising a suppressor tRNA gene of a non-eukaryote containing no internal promoter functioning in a eukaryotic cell, and a eukaryotic or bacteriophage promoter...
8822412 Charged nutritive proteins and methods  
Charged nutritive proteins are provided. In some embodiments the nutritive proteins an aqueous solubility of at least 12.5 g/L at pH 7. In some embodiments the nutritive proteins an aqueous...
8822178 Sweetener preparations and methods of use  
The present disclosure relates to codon-optimized brazzein coding sequences and the expression of brazzein and variants thereof using yeast expression systems. The disclosure also relates to...
8822651 Human rhinovirus (HRV) antibodies  
The invention provides isolated fully human monoclonal anti-HRV antibodies, as well as method of making and using these antibodies. Anti-HRV antibodies of the invention prevent or treat subjects...
8822647 Method and compositions using a chimeric antigen receptor for enhanced anti-tumor effector functioning of T cells  
Integration of costimulatory signaling domains within a tumor targeting chimeric antigen receptor (CAR), such as the IL13Rα2 specific IL13-zetakine (IL13ζ), enhances T cell-mediated responses a...
8822761 Genes for enhancing nitrogen utilization efficiency in crop plants  
The invention provides isolated NUE (nitrogen utilization efficiency) nucleic acids and their encoded proteins. The present invention provides methods and compositions relating to altering nitrogen...