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8951974 Self-assembling peptide and peptide gel with high strength  
Provide are a peptide gel with practically sufficient mechanical strength and a self-assembling peptide capable of forming the peptide gel. The self-assembling peptide is formed of the following...
8951801 Method for making IPS cells  
Reprogramming substances capable of substituting for Klf4, selected from the group consisting of members of the IRX family (e.g., IRX6), members of the GLIS family (e.g., GLIS1), members of the PTX...
8951967 Recombinant FSH including alpha 2,3- and alpha 2,6-sailylation  
The present disclosure describes recombinant follicle stimulating hormone (FSH) and methods for the production thereof. The recombinant FSH can include α2,3, α2,6, and, optionally, α2,8 si...
8952226 Tomato line CHI 18-2101  
The invention provides seed and plants of tomato line CHI 18-2101. The invention thus relates to the plants, seeds and tissue cultures of such plants, and to methods for producing a tomato plant...
8951751 Polypeptides with xylanase activity  
Polypeptides with xylanase activity modified to increase bran solubilization and/or xylanase activity. The modification comprises at least an amino acid modification i position 110 and may have...
8952137 Method for producing high-purity soluble thrombomodulin  
A method is provided for producing soluble thrombomodulin substantially not containing a denatured product of the soluble thrombomodulin that is generated under acidic conditions, which comprises:...
8952127 Peptoids useful for catalyzing the mineralization of calcium carbonate  
The present invention provides for a bio-mimetic polymer capable of catalyzing CO2 into a carbonate.
8952130 Designer ligands of TGF-β superfamily  
The present disclosure relates to chimeric polypeptide having TGF-beta activity, nucleic acids encoding the polypeptides, and host cells for producing the polypeptides.
8951526 Antibody against mucin 1 (MUC1) protein and use of same  
The present invention provides means and a method assuring the effectiveness of early diagnosis of cancers including gastric cancers. Specifically, the present invention provides an antibody, which...
8952136 Antibodies to human programmed death receptor PD-1  
Antibodies which block binding of hPD-1 to hPD-L1 or hPD-L2 and their variable region sequences are disclosed. A method of increasing the activity (or reducing downmodulation) of an immune cell...
8951754 Methods and materials for making simvastatin and related compounds  
The invention disclosed herein relates to methods and materials for producing simvastatin and related compounds such as huvastatin.
8952227 Tomato line PSQ-9Z08005  
The invention provides seed and plants of tomato line PSQ-9Z08005. The invention thus relates to the plants, seeds and tissue cultures of tomato line PSQ-9Z08005, and to methods for producing a...
8945565 Methods of treating inflammatory or thrombotic conditions with anti-P-selectin antibodies  
Antibodies are disclosed which bind specifically to P-selectin and which block the binding of PSGL-1 to P-selectin. These anti-P-selectin antibodies may also cause dissociation of preformed...
8946155 Long-acting polypeptides and methods of producing and administering same  
A polypeptide and polynucleotides comprising at least two carboxy-terminal peptides (CTP) of chorionic gonadotrophin attached to a non-human peptide-of-interest are disclosed. Pharmaceutical...
8946396 Agglomerated particulate lignosulfonate  
An agglomerated particulate lignosulfonate material may be made by introducing or forming lignosulfonate microparticles in a fluidized bed agglomerator, and introducing sufficient heated gas and...
8946164 Bioactive peptide  
The present invention provides a pharmaceutical or a food that comprises, as an active ingredient, at least one peptide selected from the group consisting of Val-Tyr-Leu-Pro-Arg (SEQ ID NO:1),...
8945589 Immunogenic compositions for Streptococcus agalactiae  
This application relates to Group B Streptococcus (“GBS”) vaccines comprising combinations of GBS polypeptide antigens where the polypeptides contribute to the immunological response in a rec...
8945559 Stabilized formulations containing anti-interleukin-4 receptor (IL-4R) antibodies  
The present invention provides pharmaceutical formulations comprising a human antibody that specifically binds to human interleukin-4 receptor (hIL-4R). The formulations may contain, in addition to...
8946386 Proteins expressed in NK cells  
Purified immunocytes were analyzed for expression frequencies, and the NKIR gene expressed specifically in natural killer (NK) cells was successfully identified. The NKIR gene encodes a receptor....
8945528 Use of interleukin-22 in treating viral hepatitis  
This invention relates to a use of IL-22 in the treatment of viral hepatitis. As illustrated in the examples of this invention, IL-22 can significantly reduce liver damage caused by hepatitis...
8946392 Gemcitabine immunoassay  
The present invention comprises novel conjugates and immunogens derived from gemcitabine and unique antibodies generated by using gemcitabine linked immunogens, which conjugates immunogens and...
8945553 Bispecific antibodies to IL-23 and IL-17A/F  
The present invention relates to antagonizing the activity of IL-17A, IL-17F and IL-23 using bispecific antibodies that comprise a binding entity that is cross-reactive for IL-17A and IL-17F and a...
8945872 Methods of purifying human recombinant growth and differentiation factor-5 (rhGDF-5) protein  
Expression vector systems are provided for increased production of a recombinant GDF-5 (rhGDF-5) protein. Also provided are transformed host cells that were engineered to produce and express high...
8946161 Method of treatment using stable liquid formulation of G-CSF  
Provided are pharmaceutical liquid formulations of G-CSF, which are stable over a long time period and substantially free of excipients, as well as ready-to-use syringes containing such...
8945562 Anti-complement C1s antibodies  
The present disclosure provides antibodies that bind complement C1s protein; and nucleic acid molecules that encode such antibodies. The present disclosure also provides compositions comprising...
8945550 Antibodies and methods for making and using them  
The invention provides antibodies, including chimeric human antibodies, recombinant antibodies, synthetic anti-bodies, and the nucleic acids encoding them, and methods for making and using these...
8945568 Pneumococcal Serotype 6D  
Disclosed is a new and emerging serotype of Streptococcus pneumoniae designated serotype 6D, and assays and monoclonal antibodies useful in identifying same. Also disclosed is a novel pneumococcal...
8946156 Albumin Fusion Proteins  
The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins are also encompassed by the invention, as are vectors containing these nucleic...
8945548 Anti-IL12Rbeta1 antibodies and their use in treating autoimmune and inflammatory disorders  
The present invention relates to antibodies that specifically bind to IL12Rβ1, the non-signal transducing chain of both the heterodimeric IL12 and IL23 receptors. The invention more specifically ...
8946389 Compositions and methods for multiplex biomarker profiling  
Provided herein are compositions and methods for identifying or quantitating one or more analytes in sample. The composition can comprise an affinity molecule reversibly conjugated to a label...
8945571 Targeted immunoconjugates  
The present invention relates to immunoconjugates. In particular embodiments, the present invention relates to immunoconjugates comprising at least one single-chain effector moiety and two or more...
8946388 Monoclonal antibodies for treatment of cancer  
The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing GT468, including tumor-related diseases such as breast...
8946149 Use of exendin and analogs thereof to delay or prevent cardiac remodeling  
The present invention relates generally to the novel use of cardioprotective incretin compounds (CICs) such as GLP-1 and exendin and agonists thereof, including analogs and derivatives to prevent,...
8945561 Receptor modulators  
Method of identifying a modulator of CD28 comprising comparing a structural model of a candidate modulator with a structural model of CD28 to thereby determine whether the modulator will bind to...
8945873 Polynucleotides encoding Notch receptor antibodies  
The present invention relates to Notch-binding agents and Notch antagonists and methods of using the agents and/or antagonists for treating diseases such as cancer. The present invention provides...
8945512 Adducts between magnetic resonance shift reagents and substrates containing exchangeable protons for “cest” applications  
Disclosed are CEST paramagnetic agents comprising a substrate (SH) containing mobile protons bonded to a paramagnetic chelate (SR) containing a metal selected from iron (11) (high-spin...
8946390 Cancer-associated antigen  
The present invention provides a novel cancer-associated antigen that can be used in the treatment and diagnosis of cancer. Further, the invention provides amino acid and nucleic acid sequence of...
8945569 Jagged-binding agents and uses thereof  
Antibodies that specifically bind to an extracellular domain of human Jagged 1 or human Jagged2 and modulate Jagged activity, and methods of using said antibodies to inhibit tumor growth are...
8945547 Notch1 receptor antibodies and methods of treatment  
The present invention relates to compositions and methods for characterizing, diagnosing, and treating cancer. In particular the invention provides the means and methods for the diagnosis,...
8945583 GLUT-1 as a receptor for HTLV envelopes and its uses  
The invention relates to the use of the ubiquitous vertebrate glucose transporter GLUT1, or of fragments or sequences derived thereof, for the in vitro diagnosis of cancers, when used as a tumor...
8945552 Bispecific, bivalent anti-VEGF/anti-ANG-2 antibodies  
The present invention relates to bispecific, bivalent antibodies against human vascular endothelial growth factor (VEGF/VEGF-A) and against human angiopoietin-2 (ANG-2), methods for their...
8946154 Peptide ligands of somatostatin receptors  
Peptide derivatives, their stereoisomers, mixtures thereof and/or their pharmaceutically acceptable salts, a method of obtaining them, pharmaceutical compositions containing them and the use...
8945868 Methods and compositions for modification of a HLA locus  
Disclosed herein are methods and compositions for modulating the expression of a HLA locus or for selectively deleting or manipulating a HLA locus or HLA regulator.
8946393 Methods for diagnosing lyme disease  
A method for diagnosing Lyme disease status in a mammal is provided. The method entails, in a biological sample obtained or derived from a mammal, determining antibodies to Borrelia burgdorferi (B....
8945570 Nucleic acid and corresponding protein named 158P1D7 useful in the treatment and detection of bladder and other cancers  
The invention described herein relates to novel nucleic acid sequences and their encoded proteins, referred to as 158P1D7 and variants thereof, and to diagnostic and therapeutic methods and...
8945574 Hypoallergenic variants of the major allergen from Betula verrucosa pollen  
The invention provides hypoallergenic variants of Bet v 1 major allergen from Betula verrucosa plant pollen and the use thereof for the preventive or therapeutic treatment of allergic diseases.
8946525 Plants and seeds of hybrid corn variety CH164731  
According to the invention, there is provided seed and plants of the hybrid corn variety designated CH164731. The invention thus relates to the plants, seeds and tissue cultures of the variety...
8946391 Construction of a multivalent scFv through alkyne-azide 1,3-dipolar cycloaddition  
The present invention provides for a practical, universal and efficient method to ligate two large macromolecules (e.g., proteins) using the alkyne-azide 1,3-dipolar cycloaddition reaction to...
8945897 Materials and methods for conjugating a water soluble fatty acid derivative to a protein  
The invention relates to materials and methods of conjugating a water soluble fatty acid derivative to a therapeutic protein comprising contacting the therapeutic protein with an activated water...
8946524 Tomato line FDS 15-2118  
The invention provides seed and plants of tomato line FDS 15-2118. The invention thus relates to the plants, seeds and tissue cultures of tomato line FDS 15-2118, and to methods for producing a...