Sign up


Match Document Document Title
8900816 Assay for anti-EGFRvIII antibodies  
Detection of human antibodies directed against the tumor-specific protein Epidermal Growth Factor Receptor variant Class III (EGFRvIII) provide information on tumor burden and vaccine response. The...
8900578 Anti-IL-TIF antibodies  
The present invention relates to blocking the activity of IL-TIF polypeptide molecules. IL-TIF is a cytokine involved in inflammatory processes and human disease. The present invention includes...
8900826 Glycoprotein synthesis and remodeling by enzymatic transglycosylation  
A chemoenzymatic method for the preparation of a homogeneous glycoprotein or glycopeptide, including (a) providing an acceptor selected from the group consisting of GlcNAc-protein and...
8900817 Progastrin and liver pathologies  
Progastrin levels are determined to diagnose one or more liver pathologies.
8900824 High-affinity monoclonal antibodies for botulinum toxin type B  
High affinity antibodies for binding epitopes of BoNT/B and hybridomas that produce such antibodies are described. The antibodies may be used in a kit for detecting BoNT/B in a sample.
8900599 Conjugates of Plasmodium falciparum surface proteins as malaria vaccines  
Conjugates of ookinete surface protein Pfs25 are provided that are efficacious as vaccines against Plasmodium falciparum, the most severe form of malaria. Conjugates of ookinete surface protein...
8900822 Fibrinogen assay  
The present invention is directed to a method of detecting intact fibrinogen, comprising the steps of: a) providing a sample containing at least some fibrinogen optionally converted at least in...
8900830 Process for producing optically active succinimide derivatives  
A process for efficiently producing optically active succinimide derivatives as key intermediates of...
8901017 Formaldehyde-free proteinaceous binder compositions  
Binder compositions are described, where the compositions include a protein, a first crosslinking compound that includes a carbohydrate, and a second crosslinking compound that includes two or more...
8901082 Immunity-inducing agent and method for detection of cancer  
An immunity-inducing agent comprising as an effective ingredient(s) at least one polypeptide selected from the following polypeptides, the polypeptide(s) having an immunity-inducing...
8901282 Reagents and methods for detecting a polymorphic protein  
The present invention provides antibodies that differentially react with allelic variants of a polymorphic protein, methods of identifying same, an antigen binding fragment comprised therein,...
8900825 Immunogenic proteins of Leptospira  
The invention provides novel immunogenic proteins LigA and LigB from Leptospira for use in the development of effective vaccines and antibodies, as well as improved diagnostic methods and kits.
8901279 Humanized antibodies with anti-tumor activity  
The present invention provides humanised antibodies and binding domains thereof with anti-tumor activity. In particular the humanised antibodies have specific binding to and direct killing of human...
8901245 Rosin-derived cationic compounds and polymers  
Methods for forming rosin-derived cationic compounds are provided. The method can include attaching a cationic group to a conjugated diene on a hydrophenathrene-based ring of a resin acid (e.g.,...
8900639 Process for obtaining a rabbit skin comprising biological active substances  
The present invention relates to a process for obtaining a rabbit skin containing biologically active substances. The rabbit skin extract is obtained by the process including vaccinating a rabbit...
8900551 Peptide which passes through blood-brain barrier and targets apoptosis of neurodegenerative brain disease site and uses thereof  
The present invention relates to a peptide that passes through a blood-brain barrier and binds specifically to apoptotic cells in neurodegenerative brain disease-affected sites, and uses thereof....
RE45272 β-glucuronide-linker drug conjugates  
Ligand Drug conjugate compounds comprising a β-glucuronide-based linker and methods of using such compounds are provided.
8901281 ILT3 binding molecules and uses therefor  
The present invention provides binding molecules that specifically bind to ILT3, e.g., human ILT3 (hILT3), on antigen presenting cells, such as for example, monocytes, macrophages and dendritic...
8900580 ***WITHDRAWN PATENT AS PER THE LATEST USPTO WITHDRAWN LIST***
Methods of treating or diagnosing conditions associated with elevated IL-6 using anti-IL-6 antibodies or fragments
 
The invention relates to the use of anti-IL-6 antibodies or antibody fragments containing a specific epitopic specificity to treat conditions involving elevated Il-6. In some embodiments the...
8900846 Nucleic acid modifying enzymes  
This invention provides for an improved generation of novel nucleic acid modifying enzymes. The improvement is the fusion of a sequence-non-specific nucleic-acid-binding domain to the enzyme in a...
8901277 Interferon alpha mutant and its polyethylene glycol derivative  
IFN-alpha mutants are obtained by substituting Cys for Tyr at position 85 or 86 in existing IFN-alpha. Their polyethylene glycol derivatives with high in vitro antiviral activity and prolonged in...
8901085 ***WITHDRAWN PATENT AS PER THE LATEST USPTO WITHDRAWN LIST***
Modulations of protease activated receptors
 
The present invention provides novel compounds of the Formula (1), pharmaceutical compositions comprising such compounds and methods for using such compounds as tools for biological studies or as...
8901069 Protein matrix for light-initiated electron transfer  
The present invention provides selective modification of polypeptide sequences with electron transfer moieties. The resulting polypeptide assemblies represent a novel class of electron transfer...
8900584 Human CDR-grafted antibody and antibody fragment thereof  
A human CDR-grafted antibody or the antibody fragment thereof which specifically reacts with the extracellular region of human CC chemokine receptor 4 (CCR4) but does not react with a human blood...
8900589 Anthracycline derivative conjugates, process for their preparation and their use as antitumor compounds  
The present invention relates to conjugates of therapeutically useful anthracyclines with carriers such as polyclonal and monoclonal antibodies, proteins or peptides of natural or synthetic origin;...
8901078 Crosslinked human or animal tissue products and their methods of manufacture and use  
Degradable bioprostheses made of collagen-based material having amine-based and ester-based crosslinks are provided, as are methods for their formation and use. Some embodiments of the present...
8900586 Antibody that binds domain 2 of ICAM-1 and methods of treatment  
The present invention relates to an antibody binding to the domain 2 of human intercellular adhesion molecules-1 (ICAM-1) where the antibody is able to modulate the differentiation status of...
8901276 Peptide reagents and methods for detection of colon dysplasia  
The present invention is directed to peptide reagents, methods for detecting colon pre-cancer (dysplasia with non-polypoid or polypoid morphology) or cancer using the peptide reagents, and methods...
8900600 Identification, optimization and use of cryptic HLA-A24 epitopes for immunotherapy  
The present invention discloses peptides such as an isolated peptide consisting of an immunogenic HLA-A*2402-restricted epitope. For example, the isolated peptide may be selected from the group...
8901484 Quantification of impurities for release testing of peptide products  
The present invention relates to a method for the quantitative determination of an impurity present in a peptide product, wherein the impurity cannot be separated from other impurities or the main...
8901376 Methods and compositions for the improvement of plant tolerance to environmental stresses  
The invention provides methods, polynucleotides and polypeptides useful for producing or selecting plants with increased tolerance to at least one environmental stress selected from drought, cold,...
8901081 Uses of GRS proteins or fragments thereof  
The present invention is related to a anticancer composition comprising full length GRS protein or a fragment thereof, a nucleic acid encoding the GRS protein or a fragment thereof. Since the GRS...
8900819 ADRB2 cancer markers  
The present invention relates to compositions and methods for cancer diagnosis, research and therapy, including but not limited to, cancer markers. In particular, the present invention relates to...
8901284 Methods and compositions for exosome isolation  
Disclosed are methods, compositions and kits for the isolation of exosomes from biological fluids and tissues. Volume-excluding polymers are used to precipitate exosomes from biological samples...
8901283 Anti-NKG2A antibodies and uses thereof  
Described herein are anti-NKG2A antibodies suitable for human therapy, including humanized versions of murine anti-NKG2A antibody Z270, as well as related methods and materials for producing and...
8900598 Multicomponent or monocomponent vaccine to be used against Chagas disease, pharmaceutical compositions containing them, procedure for the obtention of immunogen of said vaccines, and nucleic acid used in said procedure  
A vaccine against the Chagas disease, capable of stimulating the immune response against the trans-sialidase virulence factor of the Trypanosoma cruzi parasite, which is a multicomponent vaccine...
8900592 Protein constructs designed for targeting and lysis of cells  
The invention relates to a protein construct, comprising (i) a targeting moiety that is capable of binding to a target cell, and (ii) an effector immunogenic moiety that is capable of triggering an...
8900587 Antibodies to human programmed death receptor PD-1  
Antibodies which block binding of hPD-1 to hPD-L1 or hPD-L2 and their variable region sequences are disclosed. A method of increasing the activity (or reducing downmodulation) of an immune cell...
8900880 Viral citrullinated peptides and uses thereof  
The present invention relates to an antigenically effective peptide comprising, from the amino to the carboxylic terminal, the amino acid sequence: G P P W W P P I C D P P Q P S K T Q G Q S X1 G Q...
8901076 Binding proteins inhibiting the VEGF-A receptor interaction  
The present invention relates to binding proteins specific for VEGF-A, in particular to recombinant binding proteins comprising a binding domain, which inhibits VEGF-Axxx binding to VEGFR-2....
8901280 Antibody against RGD in amino acid sequence of extracellular matrix protein and production method and use of the same  
The present invention provides a monoclonal antibody which specifically recognizes RGD in the amino acid sequence of extracellular matrix proteins of a human and a mouse. By specifically inhibiting...
8901083 Administration of angiocidin for the treatment of leukemia  
Methods are presented for the therapeutic administration of angiocidin in the treatment of cancers such as glioma, breast cancer, and leukemia. Methods are also presented for inducing growth arrest...
8901278 Pharmaceutical antibody compositions with resistance to soluble CEA  
The present invention relates to pharmaceutical compositions for the treatment of an epithelial tumor in a human, said pharmaceutical composition comprising an IgG1 antibody specifically binding to...
8900849 Oxygen-regulated microorganisms  
The present invention relates to novel strains of microorganisms with oxygen-regulated metabolism. The microorganisms have higher growth rates and are more efficient than parental strains. The...
8900597 Compositions relating to a mutant Clostridium difficile toxin and methods thereof  
In one aspect, the invention relates to an immunogenic composition that includes a mutant Clostridium difficile toxin A and/or a mutant Clostridium difficile toxin B. Each mutant toxin includes a...
8900582 Deimmunized anti c-Met humanized antibodies and uses thereof  
A deimmunized anti c-Met humanized antibody and a pharmaceutical composition including the same, and method for the prevention and treatment of cancer.
8901070 Pharmaceutical compositions comprising pore-forming proaerolysin protein (PRX302)  
The present disclosure includes methods and compositions for treating any condition involving prostatitis and similar diseases and/or conditions. These methods and compositions involve the use of...
8900590 Anti-hemagglutinin antibody compositions and methods of use thereof  
The present invention provides novel human anti-Influenza antibodies and related compositions and methods. These antibodies are used in the prevention, inhibition, neutralization, diagnosis, and...
8900593 Glucagon/GLP-1 receptor co-agonists  
Modified glucagon peptides are disclosed having enhanced potency at the glucagon receptor relative to native glucagon. Further modification of the glucagon peptides by forming lactam bridges or the...
8900581 ***WITHDRAWN PATENT AS PER THE LATEST USPTO WITHDRAWN LIST***
Antibodies against human CSF-1R and uses thereof
 
The present invention relates to antibodies against human CSF-1R (anti-CSF-1R antibody), methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.