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8852583 Compositions and methods of using chondroitinase ABCI mutants  
One aspect of the present invention relates to mutants of chondroitinase ABCI. Such chondroitinase ABCI mutants exhibit altered chondroitin lyase activity or increased resistance to inactivation...
8853367 Compositions and methods for modulating rank activities  
The present invention provides methods for identifying agents capable of modulating RANK-mediated signaling pathways. The present invention also provides compositions and methods of using the same...
8853366 Binding domain-immunoglobulin fusion proteins  
The invention relates to novel binding domain-immunoglobulin fusion proteins that feature a binding domain for a cognate structure such as an antigen, a counterreceptor or the like, a wild-type...
8852602 Immunological herpes simplex virus antigens and methods for use thereof  
The invention provides HSV antigens that are useful for the prevention and treatment of HSV infection. Disclosed herein are antigens and/or their constituent epitopes confirmed to be recognized by...
8853151 Pro-drug complexes and related methods of use  
The present invention provides methods, compositions and applications for efficient, site-specific drug delivery using pro-drug complexes comprising one or more functional groups (e.g., imaging...
8852891 N-acetylglucosamine-2-epimerase and method for producing CMP-neuraminic acid using the same  
The present invention relates to a novel N-acetylglucosamine-2-epimerase and a method for preparing CMP-N-acetylneuraminic acid, more specifically, relates to a N-acetylglucosamine-2-epimerase...
8852593 Antagonist antibodies and their fab fragments against GPVI and uses thereof  
The present invention discloses novel antibodies that specifically bind to the human platelet membrane protein Glycoprotein VI (GPVI) and their monovalent fragments or derivatives. The antibodies...
8853363 Substance binding human IgG Fc receptor IIb (FcγRIIb)  
The invention relates to novel immunogens carrying conformationally discriminating epitopes (CDEs) and to immunization methods for producing antibodies that specifically recognize proteins with...
8853382 Expression of antibody or a fragment thereof in lactobacillus  
Described herein are methods and compositions for expressing an antibody or a fragment thereof in a microorganism and use of the microorganism to treat or prevent a pathogenic infection in a mammal.
8852912 Compositions and methods comprising alpha-amylase variants with altered properties  
Described are compositions and methods relating to variant alpha-amylases having altered biochemical properties and advantageous performance characteristics as compared to a reference...
8853370 Plant-produced glycoprotein comprising human-type sugar chain  
The present invention provides a method for manufacturing a glycoprotein having a human-type sugar chain comprising a step in which transformed plant cell is obtained by introducing to a plant cell...
8852597 Anti-CD154 antibodies having impaired FcR binding and/or complement binding properties  
Improved anti-CD154 antibodies are provided herein which have ablated FcR binding. The use of these antibodies for inducing tolerance and treating immune diseases including autoimmunity,...
8853371 Process for preparing unaggregated antibody Fc domains  
Methods useful for producing a solution of purified Fc peptide chains are disclosed. The methods employ protein A chromatography to separate high molecular weight, aggregated peptide chains...
8853356 Use of pentagastrin to inhibit gastric acid secretion or as a diuretic  
This invention pertains to the discovery that pentagastrin, when administered in conjunction with a proton pump inhibitor (PPI) is synergistic with the PPI and significantly increases the efficacy...
8853150 Chimeric IL-1 receptor type I antagonists  
Featured herein are non-naturally occurring cytokine domains that can be used, inter alia, to modulate cellular signalling responsive to interleukin-1 receptor I (IL-1 RI), to treat disorders, and...
8853369 Anti-Axl antibodies and methods of use  
The invention provides anti-Axl antibodies and methods of using the same.
8853154 Fibronectin based scaffold domain proteins that bind to myostatin  
The present invention relates to fibronectin-based scaffold domain proteins that bind to myostatin. The invention also relates to the use of these proteins in therapeutic applications to treat...
8852435 Purification and separation treatment assembly (PASTA) for biological products  
An assembly capable of capturing and purifying expressed biological products during or at the end of a bioreaction cycle is disclosed wherein a binding resin is kept separated from the contents of...
8853357 High purity lipopeptides  
The invention discloses highly purified daptomycin and to pharmaceutical compositions comprising this compound. The invention discloses a method of purifying daptomycin comprising the sequential...
8853359 Endokinin C/D-derived peptides  
The present invention provides peptides capable of sustaining antagonist activity against substance P for long periods of time. A peptide selected from (a) to (d) can sustain antagonist activity...
8852910 Modified polymerases for improved incorporation of nucleotide analogues  
The invention relates to modified polymerase enzymes which exhibit improved incorporation of nucleotide analogs bearing substituents at the 3′ position of the sugar moiety that are larger in size t...
8853145 BLID; a novel protein domain for interaction with the Bcl-2 family of proteins  
In this invention, a novel protein interaction domain is provided along with several of its variants. This domain is involved in protein-protein interactions with the Bcl-2 family of proteins. It...
8853358 Tissue protective peptides and peptide analogs for preventing and treating diseases and disorders associated with tissue damage  
The present invention provides peptides and peptide analogs that have tissue protective activities while having little or no potentially undesirable hematopoietic effects. The peptides and peptide...
8853165 Peptide having the ability to regenerate bone tissue and for binding to apatite  
The present invention relates to a peptide having bone tissue regeneration capacity and binding to a surface of apatite. More particularly, a peptide is provided having bone tissue regeneration...
8852871 Humanized anti-IL-10 antibodies for the treatment of systemic lupus erythematosus (SLE)  
Provided is a humanized or chimeric antibody or fragment thereof capable of binding to interleukin-10 (Th-10), wherein said antibody or fragment thereof is capable of being administered to a...
8852588 Treating allergic airway disorders using anti-IL-20 receptor antibodies  
Treatment of an allergic airway disorder (e.g., asthma or bronchial airway obstruction) using anti-IL-20R1 antibodies such as mAb51D, mAb7GW, or functional variants thereof.
8853361 Preparation, for use, in particular, for tissue augmentation and healing  
The invention relates to a sterile preparation which can be implanted on or in organic tissues, comprising: a natural or modified globin material which is insoluble at physiological pH and/or a...
8852606 Capsular polysaccharide solubilisation and combination vaccines  
Precipitated bacterial capsular polysaccharides can be efficiently re-solubilized using alcohols as solvents. The invention provides a process for purifying a bacterial capsular polysaccharide,...
8853131 Modified Stefin A scaffold proteins  
The invention provides novel scaffold proteins for the display of peptides such as peptide aptamers. The novel scaffold proteins are modifications of Stefin A or STM (a variant of Stefin A) and are...
8853164 Oligopeptide improving differentiation of osteoblasts  
The present disclosure relates to oligopeptides applicable to a dental implant, which are selected from the group consisting of PEP7 (SEQ ID NO:1), PEP71 (SEQ ID NO:2), EP72 (SEQ ID NO:3), PEP73...
8853490 Antifungal proteins and methods of use  
Compositions and methods for protecting a plant from a pathogen, particularly a fungal pathogen, are provided. Compositions include amino acid sequences, and variants and fragments thereof, for...
8852603 Inhibition of secretion from non-neuronal cells  
The present invention relates to treatment of disease by inhibition of cellular secretory processes, to agents and compositions therefor, and to manufacture of those agents and compositions. The...
8853376 Stabilized aptamers to platelet derived growth factor and their use as oncology therapeutics  
Materials and methods are provided for producing and using aptamers useful as oncology therapeutics capable of binding to PDGF, PDGF isoforms, PDGF receptor, VEGF, and VEGF receptor or any...
8852877 Apparatus and method for identifying a hook effect and expanding the dynamic range in point of care immunoassays  
The present invention relates to systems and methods for the rapid in situ determination of the existence of a hook effect and expansion of the dynamic range of a point of care immunoassay. For...
8852913 Variants of beta-glucosidases  
The present invention relates to variants of a parent beta-glucosidase, comprising a substitution at one or more positions corresponding to positions 142, 183, 266, and 703 of amino acids 1 to 842...
8852883 Rapid FRET-based diagnosis of bacterial pathogens  
Substrates for detecting microorganisms are provided, wherein the substrate comprises a set of molecular markers linked, optionally with linker molecules or moieties, to a di-, or tripeptide...
8853364 Prostate stem cell antigen (PSCA) variants and subsequences thereof  
PSCA and its encoded protein, and variants thereof, are described wherein PSCA exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table...
8852592 Systems and methods for anti-PAX8 antibodies  
The present invention is related to the anti-PAX8 antibodies, kits, cocktails, and use of anti-PAX8 antibodies for detection of cancer.
8852953 Immunodetection and quantification of pyrazolopyrimidine sedatives  
The invention relates to novel immunogens, antibodies, methods and kits for use in immunoassays to detect and quantify zaleplon, metabolites of zaleplon and indiplon. These are the first described...
8853368 Human antibodies against human glycoprotein VI and their use  
Specific binding members directed to human glycoprotein VI (GPVI), in particular human antibodies, may employ the antibody VH and/or VL domain of the scFv fragment herein termed 10B12 or one or...
8853353 Membrane type-1 matrix metalloprotein inhibitors and uses thereof  
Based on the discovery that a soluble polypeptide including a nonphosphorylatable form of the MT1-MMP cytoplasmic domain is capable of inhibiting MT1-MMP in a dominant negative manner, the present...
8852468 Phosphonate-substituted lignin as a flame retardant  
Modified lignin having covalently attached phosphorous containing groups and methods for preparing such compounds are described herein. The modified lignin described herein provides a renewable...
8852608 Antibodies against and methods for producing vaccines for respiratory syncytial virus  
The present invention relates to novel respiratory syncytial virus (RSV) F peptides and compositions comprising them. The present invention also relates to methods of evaluating anti-RSV antibody...
8853494 Stress tolerant transgenic crop plants  
Disclosed herein are novel variant bacterial cold shock proteins and recombinant DNA for expressing such proteins to produce transgenic plants with enhanced stress tolerance and/or enhanced yield.
8852585 Method of treatment and prophylaxis of diseases related to amyloid deposition using IgM  
The invention relates to a method of treating or preventing disease associated with β-amyloid polypeptides comprising administration of an immunoglobulin preparation enriched in immunoglobulin M ...
8852599 Immunoconjugates, compositions for making them, and methods of making and use  
An immunoconjugate in which a phosphate-prodrugged DNA minor groove binding agent of formula (I), where X is a nucleophilically displaceable leaving group, is conjugated to an antibody or an...
8853325 Water-soluble polymer alkanals  
The present invention is directed to alkanal derivatives of water-soluble polymers such as poly(ethylene glycol), their corresponding hydrates and acetals, and to methods for preparing and using...
8846389 AAV4 vector and uses thereof  
The present invention provides an adeno-associated virus 4 (AAV4) virus and vectors and particles derived therefrom. In addition, the present invention provides methods of delivering a nucleic acid...
8846341 Marker panels for idiopathic pulmonary fibrosis diagnosis and evaluation  
The present invention relates to the discovery that of a panel of serum or plasma markers may be used to diagnose Idiopathic Pulmonary Fibrosis (“IPF”) and distinguish this condition from other lun...
8846352 Genetically engineered microorganisms that metabolize xylose  
The invention provides methods of cultivating oil-bearing microbes using xylose as a fixed carbon source. Also provided are microorganisms that have been genetically engineered to metabolize xylose...