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8748112 Methods of determining cancer cell responsiveness to a notch inhibitory agent  
The present invention is based on the discovery that the Notch signaling pathway is associated with cancer. Accordingly, the invention provides methods and compositions for treating cancer. Also...
8748696 Increased stress tolerance and enhanced yield in plants  
The present invention provides methods and compositions for improving biomass, as well as, the drought resistance of plants. More specifically, the present invention utilizes expression of...
8748146 Engineered nucleases and their uses for nucleic acid assembly  
Aspects of the invention provide engineered endonucleases that are characterized by both a long recognition sequence and specific cleavage outside of the recognition site. Engineered endonucleases...
8748145 Mutants of pyrroloquinoline quinine-dependent soluble glucose dehydrogenase  
The present invention relates to novel mutants of PQQ s-GDH containing an amino acid substitution in position 428 of the protein sequence of the wild type PQQ s-GDH of Acinetobacter calcoaceticus...
8748143 Ketoreductase polypeptides for the reduction of acetophenones  
The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides...
8748367 Use of antisecretory factor  
The present invention relates to the use of an antisecretory protein or homologues thereof having the same properties, or certain fragments thereof in the manufacture of a medicament or a medical...
8748576 Compositions and polyeptides related to type 1 diacylgycerol O-acyltransferase (DGAT)  
Compositions related to the quantitative trait locus 6 (QTL6) in maize and methods for their use are provided. The compositions are novel molecular marker loci genetically linked with QTL6 and...
8748580 ***WITHDRAWN PATENT AS PER THE LATEST USPTO WITHDRAWN LIST***
Device for enhancing immunostimulatory capabilities of T-cells
 
T-cells are generated with enhanced immunostimulatory capabilities for use in self therapy treatment protocols, by utilizing a biodegradable device with a biodegradable support that has one or more...
8747850 Anti-cMET antibody  
Antibody capable of binding specifically to the human c-Met receptor and/or capable of specifically inhibiting the tyrosine kinase activity of said receptor, with an improved antagonistic activity,...
8748147 High processivity polymerases  
Chimeric proteins comprising a sequence nonspecific single-stranded nucleic-acid-binding domain joined to a catalytic nucleic-acid-modifying domain are provided. Methods comprising contacting a...
8748388 Antitumoral compounds  
Antitumoral compounds of Formula I, and pharmaceutically acceptable salts, derivatives, tautomers, prodrugs or stereoisomers thereof useful as antitumour agents.
8748577 Conjugates of biologically active polypeptides having an increased in vivo half-life  
Disclosed are biologically active protein conjugates that comprise a biologically active polypeptide coupled via a peptide bond to a polypeptide comprising from 2 to about 500 units of a repeating...
8747848 Immunoglobulins with reduced aggregation  
The present disclosure relates to immunoglobulins with reduced aggregation and compositions, methods of generating such immunoglobulins with computational tools and methods of using such...
8748114 ZAP-70 expression as a marker for chronic lymphocytic leukemia / small lymphocytic lymphoma (CLL/SLL)  
It has been surprisingly found that ZAP-70 expression, both at the protein and mRNA levels, is indicative of clinical subgroups of CLL/SLL patients. In particular, high ZAP-70 expression is...
8748566 Pharmacologically active antiviral peptides and methods of use  
This invention relates to peptides having antiviral properties. The antiviral peptides comprise membrane transiting peptides, and active fragments and derivatives of such peptides. The antiviral...
8748392 Methods of treatment using cysteine variants of interleukin-11  
Disclosed are cysteine variants of interleukin-11 (IL-11) and methods of making and using such proteins in therapeutic applications.
8748569 Peptide amphiphiles and methods to electrostatically control bioactivity of the ikvav peptide epitope  
The present invention is directed to peptide amphiphile compounds, compositions and methods of use, wherein nanofiber bundling or epitope aggregation is inhibited. In certain embodiments, the...
8748567 Method for delivery across the blood brain barrier  
The present invention provides compositions and methods useful for delivering agents to target cells or tissues, for example nerve cells and other cells in the central nervous system. The...
8748127 Truncated L1 protein of human papillomavirus type 6  
The invention relates to a truncated L1 protein of the Human Papillomavirus Type 6, a virus-like particle consisting of the protein, a vaccine comprising said virus-like particle, and the use of...
8748579 Collagen-based matrix for use as restorative material, and method for preparing the same  
Disclosed herein are a collagen-based matrix for use as a restorative material and a method for the preparation thereof. An atelocollagen dispersion is spread at a predetermined thickness over a...
8747847 Monoclonal antibodies for tumor treatment  
The present invention relates to methods for inhibiting tumor growth, increasing survival of a subject having a tumor and inducing protection against tumor recurrence in a mammal. The methods...
8748135 α-1,4-galactosyltransferase (CgtD) from Campylobacter jejuni  
α-1,4-galactosyltransferase (CgtD) polypeptides, nucleic acids that encode the polypeptides, including a polypeptide from Campylobacter jejuni strain LIO87 have been isolated and characterized. A ...
8748390 Immunogenic epitopes of NGEP antigen  
The invention provides a peptide comprising a human cytolytic T lymphocyte (CTL) epitope from the human tumor-associated antigen (TAA) New Gene Expressed in Prostate (NGEP), which can be used in...
8748572 RNase a peptides, fragments and uses thereof  
The present invention features isolated polypeptides that have bactericidal and angiogenic activities. The invention features isolated polypeptides comprising amino acid sequences of RNase A...
8748570 Insulin analogues  
A dicarba analogue of insulin comprising an A-chain and a B-chain or fragments, salts, solvates, derivatives, isomers or tautomers of the A-chain, the B-chain or both, provided that the dicarba...
8748383 Method for treating bone related diseases and calcium disorders  
Solid pharmaceutical compositions and methods of their use suitable for the oral delivery of pharmacologically active agents, e.g. peptides, comprising a therapeutically-effective amount of a...
8748386 Immunological targeting of pathological Tau proteins  
The present invention relates to methods and compositions for treating, preventing, and diagnosing Alzheimer's Disease or other tauopathies in a subject by administering an immunogenic tau peptide...
8748588 Methods of protein extraction from substantially intact algal cells  
Methods for selective extraction and fractionation of algal proteins from an algal biomass or algal culture are disclosed. A method of selective removal of products from an algal biomass provides...
8748395 Cell-permeable peptide inhibitors of the JNK signal transduction pathway  
Protein kinase inhibitors and more specifically inhibitors of the protein kinase c-Jun amino terminal kinase are described. Additionally, JNK inhibitor sequences, chimeric peptides, nucleic acids...
8748380 Albumin variants  
The present invention relates to variants of a parent albumin having altered plasma half-life compared with the parent albumin. The present invention also relates to fusion polypeptides and...
8748378 Therapies for acute renal failure  
The present invention provides methods for the treatment, and pharmaceuticals for use in the treatment, of mammalian subjects in, or at risk of, acute renal failure, or subject to, or at risk of,...
8748389 Treating cancer  
The present invention provides a peptide comprising an amino acid sequence that is part of the amino acid sequence of CDK4 protein, or homologous to part of the amino acid sequence of CDK4 protein,...
8748136 Producing methionine without N-acyl-methionine  
The present invention relates to a method for the production of methionine or its derivatives by culturing a microorganism in an appropriate culture medium comprising a source of carbon and a...
8748393 Inhibitors of mitochondrial fission and methods of use thereof  
The present disclosure provides peptides and constructs that inhibit mitochondrial fission, and compositions comprising the peptides or constructs. The present disclosure provides methods of...
8748581 Anti-IL-6R polypeptides and pharmaceutical compositions thereof  
The present invention relates to amino acid sequences that are directed against/and or that can specifically bind Interleukin-6 Receptor (IL-6R) with improved affinity and/or avidity, and/or that...
8747808 Radiolabeled annexins  
A radiolabeled annexin comprising at least 2 up to 20 histidine residues at its N-terminus is disclosed. At least two of said histidine residues are adjacent or separated by no more than one other...
8748110 Methods of treating cardiovascular diseases and predicting the efficacy of exercise therapy  
Methods of treating a subject having a cardiovascular disease, selecting a therapy for a subject having a cardiovascular disease, identifying a subject having a cardiovascular disease that will...
8742073 Method for the preparation of a high-temperature stable oxygen-carrier-containing pharmaceutical composition and the use thereof  
A high temperature-stable and highly purified α-α cross-linked tetrameric hemoglobin suitable for use in mammals without causing renal injury and vasoconstriction is provided. The dimeric form of h...
8741847 Agent and methods for reducing inflammatory markers  
A method for treating an autism spectrum condition includes administering an effective dose of a TNF-α inhibiting agent to a person having an autism spectrum condition or pervasive development ...
8742028 Solid support for Fmoc-solid phase synthesis of peptide acids  
The present invention provides a solid support for Fmoc-solid phase synthesis of peptides. In particular, the solid supports of the invention may be utilized to produce peptide acids.
8741814 T cell receptor display  
A proteinaceous particle, for example a bacteriophage, ribosome or cell, displaying on its surface a T-cell receptor (TCR). The displayed TCR is preferably a heterodimer having a non-native...
8741290 Anti-cMet antibody  
Antibodies capable of binding to the human c-Met receptor and/or capable of inhibiting the tyrosine kinase activity of said receptor, with an improved antagonistic activity, the antibodies...
8742069 Concentrated aqueous silk fibroin solution and use thereof  
The present invention provides for concentrated aqueous silk fibroin solutions and an all-aqueous mode for preparation of concentrated aqueous fibroin solutions that avoids the use of organic...
8741272 Use of novel amino acid derivatives as agents for treating human perspiration, and compositions containing them  
The invention relates to the use, as an agent for treating human perspiration, in a cosmetic composition, of amino acid derivatives of formula (I) below: The invention also relates to a cosmetic...
8742076 Nemorubicin metabolite and analog reagents, antibody-drug conjugates and methods  
The present invention relates to antibody-drug conjugate compounds of Formula I: Ab-(L-D)p I where one or more nemorubicin metabolite or analog drug moieties (D) are covalently attached by a linker...
8741594 Mitochondrial enoyl coenzyme A hydratase 1 as marker for diagnosing stomach cancer  
The present invention relates to mitochondrial protein that can be used as a marker for diagnosing stomach cancer. According to the present invention, the marker for diagnosing stomach cancer...
8741591 pH-insensitive glucose indicator protein  
The present invention encompasses a glucose indicator protein, a biosensor comprising one or more glucose indicator proteins, and methods of use thereof.
8742236 Maize variety hybrid X18C115  
A novel maize variety designated X18C115 and seed, plants and plant parts thereof, produced by crossing Pioneer Hi-Bred International, Inc. proprietary inbred maize varieties. Methods for producing...
8741286 Serene protease derivatives and uses in the prevention or the treatment of blood coagulation disorders  
The present invention relates to chimeric derivatives of serine protease zymogen containing the activation peptide of factor X or a fragment thereof for improving the half-life of said derivatives....
8742072 Bone growth particles and osteoinductive composition thereof  
A biocompatible synthetic bone growth composition comprising a fibrillar collagen component and a calcium phosphate component. The composition is formed into particles, and then formed into a...