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8933039 Glucagon-like peptide-2 analogs  
Analogs of glucagon-like peptide 2, a product of glucagon gene expression, have been identified as intestinal tissue growth factors. Their formulation as pharmaceutical, and therapeutic use in...
8933033 Chaperonin 10 variants  
The invention relates generally to chaperonin 10 N-terminal variants. More specifically, the invention relates to chaperonin 10 N-terminal variants with enhanced immunomodulatory capacity and/or...
8933206 Benzimidazole compounds and their use as chromatographic ligands  
The present invention provides a new method for isolation and/or purification of immunoglobulins from a solution containing one or more immunoglobulins using a solid phase matrix represented by the...
8933205 Process for preparing purified drug conjugates  
The invention provides a process for preparing a cell-binding agent chemically coupled to a drug. The process comprises covalently attaching a linker to a cell-binding agent, a purification step,...
8933038 Method of treating cancer with an HLA-A*3303-restricted WT1 peptide and pharmaceutical composition comprising the same  
Disclosed are: a peptide comprising an amino acid sequence composed of contiguous nine amino acid residues derived from a WT1 protein, wherein an amino acid residue at position 2 in the amino acid...
8933035 Transglutaminase-activating peptide and cosmetic or pharmaceutical composition containing same  
A peptide of general formula (I): R1-(AA)nX1-X2-Arg-Arg-Gly-X3-X4-(AA)p-R2, and cosmetic and pharmaceutical compositions are disclosed that include at least one peptide of general formula (I), in a...
8932592 Compositions and methods for treating inflammatory disorders  
The present invention features compositions and methods related to humanized antibodies and FKN-binding fragments thereof that bind fractalkine.
8927688 PAR4 agonist peptides  
PAR4 agonist peptides are disclosed. These peptides are useful for developing robust PAR4 receptor assays.
8927483 Neuregulins for prevention and treatment of damage from acute assault on vascular and neuronal tissue and as regulators of neuronal stem cell migration  
Neuregulin, a known neuroprotein, has been found to ameliorate or prevent damage caused by mechanical or chemical assault to blood vessels and, when administered into the cerebral spinal fluid, can...
8927692 Consensus prostate antigens, nucleic acid molecule encoding the same and vaccine and uses comprising the same  
Provided herein are consensus amino acid sequences of prostate antigens that are capable of breaking tolerance in a targeted species, including PSA, PSMA, STEAP and PSCA antigens. Also provided are...
8927694 Human serum albumin linkers and conjugates thereof  
Disclosed is a human serum albumin (HSA) linker and HSA linker with binding, diagnostic, and therapeutic agents conjugated thereto. Also disclosed is a conjugate in which the HSA linker is...
8927240 Thermal fractionation of biomass of non-lignocellulosic origin for multiple high-quality biofuels  
Methods for production of multiple biofuels through thermal fractionation of biomass feedstocks are described.
8927823 Tomato hybrid PS01819578  
The invention provides seed and plants of tomato hybrid PS01819578 and the parent lines thereof. The invention thus relates to the plants, seeds and tissue cultures of tomato hybrid PS01819578 and...
8927205 Recombinant polypeptides of the members of the TNF ligand family and use thereof  
The invention relates to polypeptides comprising, as constituent A, at least three monomers of a member of the TNF ligand family and, as constituent B, at least two peptide linkers that link the...
8926982 Reagents and methods for detecting influenza virus proteins  
Two universally conserved sequences from influenza type A neuraminidases were identified by large scale sequence analysis then chemically modified and conjugated to carrier proteins to generate...
8926971 Humanized anti-CCR2 antibodies and methods of use therefor  
The present invention relates to a humanized antibody or functional fragment thereof which binds to a mammalian (e.g., human) CC-chemokine receptor 2 (CCR2) or a portion of the receptor and blocks...
8927500 Peptidomimetic macrocycles  
Provided herein are peptidomimetic macrocycles containing amino acid sequences with at least two modified amino acids that form an intramolecular cross-link that can help to stabilize a secondary...
8926990 Treatment and diagnosis of inflammatory disorders and HIV  
This invention concerns compositions and methods of treating or diagnosing inflammatory disorders and other disorders, as well as compositions and methods of treating HIV.
8926978 Antibodies directed against nerve growth factor (NGF)  
The invention relates to an isolated immunoglobulin heavy chain polypeptide and an isolated immunoglobulin light chain polypeptide that binds to Nerve Growth Factor (NGF). The invention provides an...
8927696 Humanized anti-human CD34 monoclonal antibody and uses thereof  
A novel humanized antibody against the CD34 surface antigen on the human stem cells is provided. The humanized antibody contains a heavy chain variable region comprising an amino sequence as set...
8927210 Conjugate complexes for analyte detection  
The present invention relates to novel conjugate complexes for immunoassays as well as kits comprising these conjugate complexes, methods of producing these complexes, and methods of detecting an...
8927485 Site-specific modification of proteins through chemical modification enabling protein conjugates, protein dimer formation, and stapled peptides  
The present invention generally provides methods for the site-specific modification of peptides, polypeptides, and proteins, e.g., granulocyte macrophage colony-stimulating factor, human superoxide...
8927695 Protein-based assays for screening of the IgE-receptor interaction  
Embodiments of the invention are related to a polypeptide comprising the amino acid sequence of a human IgE-Fc Cε3-Cε4, wherein said Cε3-Cε4 starts at amino acid 328 and ends at amino acid 547 of ...
8927691 Transducible polypeptides for modifying metabolism  
Methods and compositions for modifying the metabolism of a subject are provided. One embodiment provides a recombinant polypeptide having a polynucleotide-binding domain, a protein transduction...
8927232 Fusion protein capable of binding VEGF-A and TNF-alpha  
The present application describes an isolated nucleic acid molecule encoding a polypeptide capable of synchronously binding VEGF polypeptide and TNF polypeptide comprising: (a) a nucleotide...
8927290 Compositions and methods for the detection of antibodies to native human leukocyte antigen  
Provided herein are compositions comprising native and denatured human leukocyte antigens (HLA) and methods of making said compositions. Also provided herein are methods and kits for the detection...
8926970 Rspondin antibodies as inhibiting factors of angiogenesis and vaculogenesis  
The present invention relates to the use of Rspondins, particularly Rspondin2 (Rspo2) or Rspondin3 (Rspo3) or Rspondin nucleic acids, or regulators or effectors or modulators of Rspondin, e.g....
8926989 Compositions and methods for screening for Lyme disease  
The invention provides compositions, methods, and kits for the diagnosis or detection of infection by a pathogen that causes Lyme disease in a subject.
8926959 System for optical stimulation of target cells  
Stimulation of target cells using light, e.g., in vivo, is implemented using a variety of methods and devices. According to an example embodiment of the present invention, target cells are...
8926956 Antibody recognizing human leukemia inhibitory factor (LIF)  
The invention relates to antibodies directed against human Leukemia Inhibitory Factor (LIF) and to a hybridoma cell line producing said antibodies. The invention also relates to a method for...
8927689 Peptide nanostructures and methods of generating and using the same  
A tubular or spherical nanostructure composed of a plurality of peptides, wherein each of the plurality of peptides includes no more than 4 amino acids and whereas at least one of the 4 amino acids...
8927244 Organophosphorus hydrolase  
The present disclosure provides methods, devices, systems and compositions for detecting and/or modifying chemical agents. In some embodiments, a biosensor may be configured to detect a chemical...
8927492 Fibroblast growth factor 21 proteins  
This present invention relates to pharmacologically potent and stable human fibroblast growth factor 21 (FGF21) proteins, pharmaceutical compositions comprising FGF21 proteins, and methods for...
8927496 Process for the synchronization of ovulation for timed breeding without heat detection  
A method for synchronizing ovulation in sows and gilts by a single injection of hormones is disclosed. A hormone, gonadotropin releasing hormone (GnRH), luteinizing hormone (LH), follicle...
8927693 Fibronectin based scaffold domain proteins that bind IL-23  
The present invention relates to fibronectin based scaffold domain protein that bind interleukin 23 (IL-23), specifically the p19 subunit of IL-23. The invention also relates to the use of the...
8927697 PD-1 specific antibodies and uses thereof  
One aspect of the present disclosure provides antibodies that can act as agonists of PD-1, thereby modulating immune responses regulated by PD-1. Another aspect of the disclosure provides...
8927489 Sustained release preparation of pro-insulin C-peptide  
The present invention provides a pharmaceutical composition for the sustained release of C-peptide. The composition is in the form of a gel containing C-peptide. The gel formation is achieved by...
8927687 Microcrystalline Y receptor agonists  
The disclosure provides microcrystals of Y receptor agonists; microcrystalline pellets of Y receptor agonists, and microcrystalline suspensions of Y receptor agonists. Pharmaceutical compositions...
8926972 Anti-angiogenesis fusion proteins  
The disclosure provides a novel anti-angiogenesis fusion protein. The present invention combines a chimeric vascular endothelial cell growth factor (VEGF) receptor or a fragment thereof with a...
8926981 Methods of using chimeric receptors to identify autoimmune disease  
The present invention provides methods and compositions useful in the diagnosis and management of autoimmune diseases. In particular, the present invention provides improved methods and...
8927503 Modulations of protease activated receptors  
The present invention provides novel compounds of the Formula (1), pharmaceutical compositions comprising such compounds and methods for using such compounds as tools for biological studies or as...
8927225 Human catechol-O-methyltransferase (COMT) assay  
Disclosed is an assay (method) to quantify the amounts of catecholamine-O-methyltransferase (COMT) protein in samples, such as extracts from cell cultures, body fluids, tissues, and environmental...
8926977 Antibodies to the E1 extracellular loop of ion channels  
An anti-E1 ion channel antibody or binding fragment thereof, pharmaceutical compositions comprising said antibodies, use of the antibodies and compositions comprising the same, in treatment, for...
8927247 I-CreI derived single-chain meganuclease and uses thereof  
A new I-CreI derived single-chain meganuclease comprising two domains, each domain comprising a portion of a parent I-CreI monomer which extends at least from the beginning of the first alpha helix...
8927690 Process for purifying cyclolipopeptide compounds or the salts thereof  
A process for purifying cyclic lipopeptide compounds or salts thereof comprising the steps of: (1) charging a crude compound of Formula I onto a macroporous adsorption resin; (2) washing the...
8927486 Compounds  
The present invention relates to prodrugs of vascular disrupting agents comprising a vascular disrupting agent (VDA) associated with a matrix metalloproteinase (MMP) proteolytic cleavage site and...
8926946 Peptides for transport of therapeutics and their carriers in mouse models and humans  
A system for targeted delivery of agents (e.g., molecular probes, diagnostic agents, therapeutic agents, imaging agents, research or analytical compounds, enzymes, peptides, proteins, lipids,...
8926980 Compositions against bacterial toxins  
Anti-toxin compositions are described that include avian antibodies against bacterial toxins. Administration of the anti-toxin compositions binds and neutralizes the bacterial toxin in the animals....
8926979 Treatment of cancer or pre-malignant conditions using anti-CD40 antibodies  
Methods for treating a human patient for a cancer or pre-malignant condition that is associated with CD40-expressing cells are provided, where the human patient is heterozygous or homozygous for...
8927495 Use of GnRH and analogs thereof for the prevention and treatment of pet ferret adrenocortical hyperplasia  
Adrenocortical disease (ACD) in ferrets develops as a result of the effect of increased concentration of Luteinizing Hormone (LH) on adrenal LH receptors. This increase in LH often results from the...