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8980578 Fungal beta-xylosidase variants  
The present invention provides fungal xylanase and/or beta-xylosidase enzymes suitable for use in saccharification reactions. The present application further provides genetically modified fungal...
8980606 Ketoreductase polypeptides for the production of azetidinone  
The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides...
8979992 ***WITHDRAWN PATENT AS PER THE LATEST USPTO WITHDRAWN LIST***
Polypeptide solution, artificial polypeptide fiber production method and polypeptide purification method using same
 
A polypeptide solution of the present invention is a polypeptide solution in which a polypeptide derived from natural spider silk proteins is dissolved in a solvent. The solvent contains at least...
8981049 Aziridine mediated native chemical ligation  
Improved methods of native chemical ligation are provided. The methods involve reacting a thioacid (e.g. a peptide thioacid) with an aziridinyl compound (e.g. an aziridinyl peptide) under mild...
8975059 Polypeptides having endoglucanase activity and polynucleotides encoding same  
The present invention relates to isolated polypeptides having endoglucanase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs,...
8975029 Integrin alpha-2 binding agents and use thereof to inhibit cancer cell proliferation  
The invention provides an integrin alpha-2 binding agent and methods of using an integrin alpha-2 binding agent to, e.g., inhibit proliferation of cancer cells, modulate tumor growth in a subject,...
8975377 Cancer treatment using humanized antibodies that bind to EphB4  
In certain embodiments, this application provides humanized antibodies that bind to the EphB4 protein as well as uses of the antibodies for therapeutic purposes.
8975371 Melanoma antigen peptide and uses thereof  
The present invention relates to novel melanoma antigen peptides and specific T lymphocytes directed to said peptides and the use thereof for treating melanoma.
8975374 Pharmaceutical composition comprising anti-HB-EGF antibody as active ingredient  
An anti-HB-EGF antibody having an internalizing activity is disclosed. A cytotoxic substance is preferably bound to the anti-HB-EGF antibody of the present invention. Also provided are an...
8975375 Identification of tumor-associated antigens for diagnosis and therapy  
The invention relates to genetic products the expression of which is associated with cancer diseases. The invention also relates to the therapy and diagnosis of diseases in which the genetic...
8975380 Annexin V variant and its preparation and application  
The invention provides the design, preparation methods and applications of the variant of annexin V. The variant of annexin V is the protein with amino acid residue sequence in sequence 1 in the...
8975232 Macrocyclic kinase inhibitors and uses thereof  
The present invention provides macrocyclic compounds of Formula (I): pharmaceutically acceptable salts thereof; and pharmaceutical compositions thereof, wherein R1, R2, R3, R4, RE, RF, RG, RH, RI,...
8975231 Bone morphogenic protein binding peptide  
A cyclized peptide designated BMP Binding Peptide (BBP) is a synthetic peptide that avidly binds rhBMP-2, as do endogenous forms of BBP, and sequence conservation between species results in a...
8974784 Anti-pancreatic cancer antibodies  
Described herein are compositions and methods of use of anti-pancreatic cancer antibodies or fragments thereof, such as murine, chimeric, humanized or human PAM4 antibodies. The subject antibodies...
8974774 Compositions and methods for topical diagnostic and therapeutic transport  
Compositions and methods are provided that are useful for the delivery, including transdermal delivery, of biologically active agents, such as non-protein non-nucleotide therapeutics and...
8975472 Compositions and methods for altering alpha- and beta-tocotrienol content using multiple transgenes  
Preparation and use of isolated nucleic acids useful in altering the oil phenotype of plants are described. Isolated nucleic acids and their encoded polypeptides are described that alter the...
8974782 Treatment of stroke comprising anti-MAG antibodies  
The present invention relates to a dosing regimen for use in the treatment of stroke. More particularly, the invention relates to the administration of two doses of anti-MAG antibodies for the...
8975476 Soybean variety A1026329  
The invention relates to the soybean variety designated A1026329. Provided by the invention are the seeds, plants and derivatives of the soybean variety A1026329. Also provided by the invention are...
8975368 Methods for preparing linked peptide rings and peptide nanotubes obtained thereby  
Peptide nanotube polymers and methods of making such are disclosed. The peptide nanotube polymers are comprised of alternating monomers of the first peptide ring and monomers of the second peptide...
8975086 Method for treating or preventing bladder cancer using the DEPDC1 polypeptide  
The present invention provides therapeutic agents and methods for treating cancer using the polypeptides composed of an amino acid sequence which includes a polypeptide fragment of DEPDC1. The...
8975079 Reducible polymers for nonviral gene delivery  
Provided herein are biodegradable copolymers and nanoplex delivery systems comprising the same and a cargo molecule, such as a nucleic acid, a polynucleotide or other biomolecule. The biodegradable...
8975383 Protein refolding method  
The present invention provides a method for producing a protein which has a restored native higher-order structure by bringing a protein which has lost its native higher-order structure into...
8975037 Methods of inhibiting tumor cell aggressiveness using the microenvironment of human embryonic stem cells  
The invention provides compositions comprising one or more isolated factors from a microenvironment of human embryonic stem cells (hESCs), including, but not limited to, Lefty and inhibitors of...
8975493 Maize variety hybrid X18A635  
A novel maize variety designated X18A635 and seed, plants and plant parts thereof, produced by crossing Pioneer Hi-Bred International, Inc. proprietary inbred maize varieties. Methods for producing...
8974798 Anti-bacterial vaccine compositions with a mutated yleA gene  
Gram negative bacterial virulence genes are identified, thereby allowing the identification of novel anti-bacterial agents that target these virulence genes and their products, and the provision of...
8975381 Anti-VEGF antibodies  
Anti-VEGF antibodies and variants thereof, including those having high affinity for binding to VEGF, are disclosed. Also provided are methods of using phage display technology with naïve libraries ...
8975382 Amino acid sequences directed against HER2 and polypeptides comprising the same for the treatment of cancers and/or tumors  
The present invention relates to amino acid sequences and Nanobodies that are directed against Epidermal Growth Factor Receptor 2 (HER2), as well as to compounds or constructs, and in particular...
8975373 Multi-protein quantitation standard  
Provided is a protein quantitation standard having polypeptides of different molecular weights that functions as a mass quantitation standard in one lane of an electrophoretic gel. The protein...
8975378 Human anti-human influenza virus antibody  
Provided is a human antibody having a neutralization activity against a human influenza virus. More specifically, provided is a human antibody which recognizes a highly conserved region in a human...
8975372 Collagen scaffolds, medical implants with same and methods of use  
The subject invention concerns non-degradable three dimensional porous collagen scaffolds and coatings. These scaffolds can be prepared around sensors for implantation into a body. A specific...
8974794 C(epsilon)mX peptides for inducing immune responses to human mIgE on B lymphocytes  
The invention pertains to methods of using CεmX peptides (e.g., GLAGGSAQSQRAPDRVL; SEQ ID NO:2) that can bind effectively induce immune responses to membrane-bound IgE (mIgE) expressed on the ...
8975477 Soybean variety A1026620  
The invention relates to the soybean variety designated A1026620. Provided by the invention are the seeds, plants and derivatives of the soybean variety A1026620. Also provided by the invention are...
8974785 Fully humanized anti-HER2 antibody, preparation method and use thereof  
The invention provides a fully human anti-HER2 monoclonal antibody, which has an amino acid sequence of heavy chain variable region as shown in SEQ ID NO: 6 and an amino acid sequence of light...
8975384 Tag peptide and use thereof  
The present invention provides a tag peptide comprising an amino acid sequence represented by the following formula (I): X1-Tyr-X2-Gly-Gln-X3 (I) (wherein X1, X2 and X3 are the same or different...
8975227 Intraoral dosage forms of glucagon  
The present invention provides a composition (e.g., a pharmaceutical composition) comprising at least one delivery agent compound and glucagon. Preferably, the composition includes a...
8975379 Identification of cancer protein biomarkers using proteomic techniques  
The claimed invention describes methods to diagnose or aid in the diagnosis of cancer. The claimed methods are based on the identification of biomarkers which are particularly well suited to...
8975475 Soybean variety S110157  
The invention relates to the soybean variety designated S110157. Provided by the invention are the seeds, plants and derivatives of the soybean variety S110157. Also provided by the invention are...
8975488 Tomato hybrid PS02420487 and parent lines thereof  
The invention provides seed and plants of tomato hybrid PS02420487 and the parent lines thereof. The invention thus relates to the plants, seeds and tissue cultures of tomato hybrid PS02420487 and...
8975230 Method of treating ischemic injury with follistatin-like 1 polypeptide  
Described herein are methods and compositions related to the discovery that the Follistatin-like 1 protein (Fstl-1) has metabolic and cardioprotective effects in vivo. Fstl-1 and portions and...
8975222 Stable high lipid liquid formula  
The present invention provides a ketogenic diet in the form of a sterile shelf stable ready to use formula, in particular a tube feed, comprising casein and dietary fiber.
8975370 Inhibitor proteins of a protease and use thereof  
The present invention relates to a chimeric inhibitor protein of a protease comprising an inhibiting polypeptidic sequence and at least one polypeptidic sequence of a substrate-enzyme interaction...
8974781 P-cadherin antibodies  
The present invention relates to antibodies including human antibodies and antigen-binding portions thereof that bind to P-cadherin, and that function to inhibit P-cadherin. The invention also...
8975036 Methods for improved diagnosis of dysplasias  
The present invention relates to a method for improved diagnosis of dysplasias based on simultaneous detection of INK4a gene products and at least one marker for cell proliferation. Particularly...
8974797 Virus-like particles as vaccines for paramyxovirus  
The invention provides expression vectors and virus-like particles (VLPs) containing Newcastle Disease Virus Sequences in combination with sequences encoding proteins of interest. The vectors are...
8975043 Enzymatic degradation of lipid A fatty acids of bacterial LPS  
Novel enzymes, processes and antigenic structures useful in producing vaccines and compounds useful in combating gram-negative bacteria are described. Enzymes were isolated from the slime mold...
8974786 Humanized antibodies to CA215  
Provided herein are humanized forms of murine RP215 monoclonal antibodies and methods of using the same. These humanized RP215 monoclonal antibodies were characterized in terms of their respective...
8975056 Variant alpha-amylases from Bacillus subtilis and methods of uses, thereof  
Alpha-amylases from Bacillus subtilis (AmyE), variants thereof, nucleic acids encoding the same, and host cells comprising the nucleic acids are provided. Methods of using AmyE or variants thereof...
8974799 Conjugation of Staphylococcus aureus type 5 and type 8 capsular polysaccharides  
The invention provides a process for preparing a conjugate of a S. aureus type 5 or type 8 capsular polysaccharide and a carrier molecule, comprising the steps of: (a) depolymerizing the capsular...
8975490 Maize variety hybrid X7H246  
A novel maize variety designated X7H246 and seed, plants and plant parts thereof, produced by crossing Pioneer Hi-Bred International, Inc. proprietary inbred maize varieties. Methods for producing...
8974783 Methods of treating pain using an IL-31Ra or OSMR-b antagonist  
Use of antagonists to IL-31Ra and OSMRb are used to treat inflammation and pain by inhibiting, preventing, reducing, minimizing, limiting or minimizing stimulation in neuronal tissues. Such...