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8778653 Method for reducing DNA impurities in viral compositions  
A method for purification of viral compositions is provided. In particular, a method for reduction of unwanted residual DNA in a viral composition while retaining the immunogenicity of the virus...
8779093 Neuronal viability factor and use thereof  
This invention relates to methods and compositions for detection and treatment of neurodegenerative diseases. In particular, the invention relates to polypeptides that can protect against neuron...
8778678 Composition of activated CD4 cells  
The composition of activated CD4 cells is derived from a healthy human donor. The composition from the healthy human donor is suspended in an infusion media and packaged in a vehicle for...
8778845 Composition, device and associated method  
A composition includes a first probe and a first initiator bonded to the first probe. The first probe is capable of binding to an analyte and the first initiator is capable of initiating a...
8778874 Glycopeptide antibiotic monomer derivatives  
Novel glycopeptide antibiotic derivatives. These derivatives are represented by the formula (aglycon part of glycopeptide antibiotic derivative)-(Sac-NH)—RA [wherein (aglycon part of glycopeptide a...
8779097 Accelerated gelation of regenerated fibroin  
The invention discloses a process for the acceleration of gelling time of regenerated silk fibroin using gelling agent, preferably silica to create a porous structure, devoid of microbial growth.
8779110 Purification of low isoelectric point isoforms of darbepoietin  
The invention provides an efficient method of purification of a modified cytokine. The process includes the use of a chromatographic technique for the purification of the desired cytokine. The...
8778346 Anti-IL-23 antibodies  
The present invention relates to anti-IL-23p19 binding compounds, in particular new humanized anti-IL-23p19 antibodies and therapeutic and diagnostic methods and compositions for using the same.
8771968 Biomarker for osteoarthritis and/or other ageing-related diseases, and use thereof  
The invention relates to the identification of a biomarker whose abundance in biological sample is changed in subjects with osteoarthritis and/or other ageing-related diseases. The biomarker has...
8771969 Peptide antibody depletion and its application to mass spectrometry sample preparation  
The present invention relates, e.g., to a method for pre-processing a sample for mass spectral analysis, comprising cleaving proteins in the sample to peptides and immunodepleting highly abundant...
8772453 Compositions for linking zinc finger modules  
Disclosed herein are compositions for linking DNA binding modules to allow for specific and selective binding to module subsites separated by 1 or more base pairs. Also described are methods of...
8771682 Methods and compositions for reducing interleukin-4 or interleukin-13 signaling  
The present invention relates generally to methods and compositions for reducing Interleukin-4 or Interleukin-13 signaling, in particular to treat asthma and atopic dermatitis. The inventors have...
8771697 Methods of treatment using anti-IL-17A/IL-17F cross-reactive antibodies  
This invention provides fully human monoclonal antibodies that recognize IL-17F, the IL-17F homodimer, IL-17A, the IL-17A homodimer, and/or the heterodimeric IL-17A/IL-17F protein complex. The...
8772452 Calcium-binding photoprotein  
The invention provides calcium-binding photoproteins which can detect light emission with a higher sensitivity. The proteins of the invention comprising the amino acid sequence of SEQ ID NO: 2 can...
8772018 Media for affinity chromatography  
The invention relates generally to solid supports for chromatography. In specific embodiments the invention provides for solid supports suitable for affinity chromatography along with methods,...
8771708 Biologically-active radiolabeled Cry1Fa and receptor binding assay methods  
Cysteine-specific radiolabeled Cry1Fa protein retains insecticidal activity against insect pests and binds to insect brush border membrane vesicle receptors in a saturable manner. The...
8772245 Crystalline form of cyclosporine A, methods of preparation, and methods for use thereof  
The present invention relates generally to crystalline forms of cyclosporine A and particularly to a newly identified form of cyclosporine A. The invention further relates to methods for its...
8772575 Nucleic acids useful in the manufacture of oil  
Novel gene sequences from microalgae are disclosed, as well as novel gene sequences useful in the manufacture of triglyceride oils. Also disclosed are sequences and vectors that allow microalgae to...
8771694 Immunoconjugates and humanized antibodies specific for B-cell lymphoma and leukemia cells  
A chimeric LL2 monoclonal antibody (mAb) is described in which the variable regions of the murine LL2 mAb are recombinantly joined to the human constant region domains, which retains the...
8772237 Compositions and methods for counteracting effects of reactive oxygen species and free radicals  
Peptide compounds and methods for upregulating expression of a gene encoding an antioxidative enzyme, such as superoxide dismutase or catalase, to counteract harmful oxidative effects of reactive...
8771685 Anti-BV8 antibodies and uses thereof  
The present invention concerns antibodies to Bv8 and the uses of same.
8772233 Method for promoting regeneration of pancreatic beta-cells by administering neurturin  
The present invention relates generally to methods for preventing and/or treating pancreatic disorders, particularly those related to diabetes, by administering a neurturin protein product.
8772458 Crystalline anti-hTNFalpha antibodies  
The present invention relates to a batch crystallization method for crystallizing an anti-hTNFalpha antibody which allows the production of said antibody on an industrial scale; antibody crystals...
8772229 Methods for synthesis and uses of inhibitors of ghrelin O-acyltransferase as potential therapeutic agents for obesity and diabetes  
The invention provides inhibitors of ghrelin O-acyltransferase, and methods of making and using them. In some embodiments, the invention provides bisubstrate analog inhibitors of ghrelin...
8772227 Glucosamine pro-drug  
To develop glucosamine (GlcN) pro-drugs with properties superior to the presently available GlcN products, we have synthesized derivatives with improved pharmaceutical properties. The synthesized...
8772241 Peptide and use thereof  
The present invention provides a peptide represented by formula (I) of X1-Leu-X2-Leu-X3 wherein X1 represents Glu or Asp, X2 represents His, Lys or Arg, X3 represents Asp or Glu, with Glu, Asp,...
8772450 Beta-amino acids  
Disclosed are β-amino acid monomers containing cylcoalkyl, cycloalkenyl, and heterocylic substituents which encompass the α and β carbons of the peptide backbone and β-polypeptides made from suc...
8771964 Compositions and methods for detection of methadone metabolite  
Methods and reagents are disclosed for conducting assays for EDDP. The reagents include a moiety selected from the group consisting of poly(amino acid) label moieties, non-poly (amino acid) label...
8772459 J591 minibodies and Cys-diabodies for targeting human prostate specific membrane antigen (PSMA) and methods for their use  
In one embodiment, a minibody monomer that binds PSMA is provided. The minibody monomer is encoded by a nucleotide sequence comprising, from N-terminus to C-terminus, an scFv sequence that can bind...
8772449 Cell-penetrating peptides  
A cell-penetrating peptide of (A) to (D) below gives cell membrane permeability and transmucosal absorbability to a physiologically active substance: (A) a peptide having the amino acid sequence of...
8771728 Stable lipid-comprising drug delivery complexes and methods for their production  
Novel stable, concentrated, biologically active and ready-to-use lipid-comprising drug delivery complexes and methods for their production are described. The biological activity of the complexes...
8772445 Production and use of antitumoral cyclodepsipeptides  
A compound having the general structure R1, R2, R3 and R4 being selected from the group consisting of a hydrogen atom (H) and a C1-C20 alkyl, and R5 being a phenyl radical.
8772501 Fluorescent dyes and uses thereof  
The present invention provides fluorescent dyes that are based on firefly luciferin structure. These dyes are optimally excited at shorter wavelengths and have Stokes shift of at least 50 nm. The...
RE45003 Lantibiotic biosynthetic gene clusters from A. garbadinensis and A. liguriae  
Characterization of the biosynthetic gene cluster for the lantibiotic actagardine, identification of a novel variant of actagardine and its biosynthetic cluster, and methods of production and use...
8772025 Methods and compositions for inactivating alpha 1,6 fucosyltransferase (FUT8) gene expression  
Disclosed herein are methods and compositions for inactivating a FUT8 gene, using fusion proteins comprising a zinc finger protein and a cleavage domain or cleavage half-domain. Polynucleotides...
8771932 Rationally designed antibodies  
Antibodies or fragments thereof having CDR regions replaced or fused with biologically active peptides are described. Flanking sequences may optionally be attached at one or both the...
8772232 Protracted exendin-4 compounds  
Novel protracted exendin-4 compounds and therapeutic uses thereof.
8771700 Interferon antagonists, antibodies thereto and associated methods of use  
Described are compositions and methods useful for modulating the immune system of a subject. Also included are diagnostic methods for monitoring an immunologic condition. In particular the...
8772006 Compositions and methods utilizing DNA polymerases  
The invention features a novel isolated Family B DNA polymerase, a Thermococcus polymerase JDF-3, and mutant recombinant forms thereof. Mutant polymerases of the invention are deficient in 3′ to 5...
8772236 Truncated cystine-knot proteins  
The invention relates to the fields of protein chemistry, biology and medicine. More specifically, it relates to the design and preparation of proteinmimics of members of the cystine-knot growth...
8771995 Enzymatic synthesis of sulfated polysaccharides  
Heparin is synthesized from a polysaccharide comprised of a 1-4 glycosidically linked alternating polymer of uronic acid and glucosamine residues, wherein the uronic acid is selected from iduronic...
8772457 BACE1 antibodies  
The invention provides antibodies to specific neural proteins and methods of using the same.
8769841 Lyophilisation targeting defined residual moisture by limited desorption energy levels  
A process of freeze drying of an essentially aqueous solution comprising at least one first step having a first temperature and pressure level (i.e. primary drying phase) and at least one second...
8772225 Biomarkers for multiple sclerosis  
The present invention relates to the diagnosis of neurological disorders, more specifically to the diagnosis of multiple sclerosis. A biomarker panel is provided which can be used to detect if a...
8772235 Compounds having peptides conjugated to bone targeting moieties and methods of making and using thereof  
Described herein are compositions having a peptide sequence that includes at least one bone targeting moiety, wherein the bone targeting moiety is bonded to the peptide sequence by a linker,...
8772228 Aligned nanofibers and related methods of use  
The present invention relates to nanofibers. In particular, the present invention provides aligned nanofiber bundle assemblies. In some embodiments, the aligned nanofiber bundle assemblies are used...
8772234 BMP10 propeptides and related methods  
In certain aspects, the present invention provides BMP10 propeptides for use in treating a variety of disorders including heart disorders and other disorders associated with unwanted activity of...
8772456 Fibrous protein fusion and use thereof in the formation of advanced organic/inorganic composite materials  
The claimed invention provides a fusion polypeptide comprising a fibrous protein domain and a mineralization domain. The fusion is used to form an organic-inorganic composite. These...
8772257 SDF-1 binding nucleic acids and the use thereof  
The present invention is related to a nucleic acid molecule binding to SDF-1, whereby the nucleic acid molecule influences migration of cells.
8772447 Chromatography ligand comprising domain C from staphylococcus aureus protein A for antibody isolation  
The present invention relates to a chromatography ligand, which comprises Domain C from Staphylococcus protein A (SpA), or a functional fragment or variant thereof. The chromatography ligand...