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8871913 Antigen binding proteins to proprotein convertase subtilisin kexin type 9 (PCSK9)  
Antigen binding proteins that interact with Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) are described. Methods of treating hypercholesterolemia and other disorders by administering a...
8871904 Processes and intermediates  
The invention relates to compounds and processes useful for the preparation of protease inhibitors, particularly serine protease inhibitors. The protease inhibitors are useful for treatment of HCV...
8871907 Glycosylated immunoglobulin and immunoadhesin comprising the same  
The present invention relates to a glycosylated immunoglobulin or a fragment thereof, in which an immunoglobulin variant, comprising one or more amino acid modifications selected from the group...
8871707 Elastin producing fibroblast formulations and methods of using the same  
The present invention describes therapeutic compositions comprising fibroblasts that have been stimulated to increase expression of extracellular matrix components or elastin, or to produce...
8871909 Antibodies inhibiting c-Met dimerization and uses thereof  
The present inventions relates to a process for the selection of anti c-Met antibodies capable to inhibit both ligand-dependent and ligand-independent activation of c-Met. More particularly, said...
8871456 Probe incorporation mediated by enzymes  
The invention provides compositions and methods of use thereof for labeling peptide and proteins in vitro or in vivo. The methods described herein employ lipoic acid ligase or mutants thereof, and...
8871902 Immunogenic POTE peptides and methods of use  
POTE has recently been identified as a tumor antigen expressed in a variety of human cancers, including colon, ovarian, breast, prostate, lung and pancreatic cancer. Described herein are...
8871721 Methods for inhibiting peritoneal dissemination of cancer cells  
A pharmaceutical composition for treating or preventing peritoneal dissemination is provided. The pharmaceutical composition includes an effective dose of connective tissue growth factor (CTGF) and...
8871906 Deletions in domain II of pseudomonas exotoxin a that remove immunogenic epitopes  
The invention provides mutated, cytotoxic forms of Pseudomonas exotoxin A (PE) comprising a furin cleavage sequence conjugated or fused directly to residues 395-613 of PE or variants of that...
8871437 Construction of protein-responsive shRNA/RNAi control system using RNP motif  
An object of the present invention is to provide an RNAi control system using an RNA-protein interaction motif. The present invention provides an shRNA comprising: a guide strand having a sequence...
8871915 Peptides targeting TNF family receptors and antagonizing TNF action, compositions, methods and uses thereof  
The present invention provides modulators of TNF, particularly peptides and their derivatives, particularly GEP peptides, which antagonize TNF and TNF-mediated responses, activity or signaling. The...
8871899 Control of viral-host membrane fusion with hydrogen bond surrogate-based artificial helices  
The present invention relates to a peptide having one or more stable, internally-constrained HBS α-helices, where the peptide mimics at least a portion of a class I C-peptide helix or at least a ...
8871454 Biomarkers and methods for determining disease progression in nonalcoholic steatohepatitis (NASH)  
Diets high in saturated fat and fructose have been implicated in the development of obesity and nonalcoholic steatohepatitis (NASH) in humans. Provided herein are biomarkers, methods, and animal...
8871468 Synthetic genes for plant gums and other hydroxyproline-rich glycoproteins  
A new approach in the field of plant gums is described which presents a new solution to the production of hydroxyproline(Hyp)-rich glycoproteins (HRGPs), repetitive proline-rich proteins (RPRPs)...
8871206 Anti-human folate receptor beta antibodies and methods of use  
Human anti-human folate receptor beta (FRβ) antibodies and antigen-binding fragments thereof are described, as well as methods of using such antibodies and fragments to treat inflammatory ...
8871724 Oligopeptidic compounds and uses thereof  
The present invention provides an oligopeptidic compound comprising a PCNA interacting motif, or a nucleic acid molecule comprising a sequence encoding said oligopeptidic compound, for use in...
8871490 Alpha-4-beta-7 heterodimer specific antagonist antibody  
There are disclosed alpha4beta7 heterodimer-specific antigen binding proteins, nucleic acids encoding them, and methods of making and using them.
8871215 Flagellin related polypeptides and uses thereof  
The use of flagellin and flagellin related polypeptides for the protection of mammals from the effects of apoptsis is described.
8871719 Modified MELK peptides and vaccines containing the same  
Isolated peptides composed of the amino acid sequence of the modified MELK epitope peptide or immunologically active fragments thereof that bind to HLA antigens and have higher cytotoxic T...
8871905 Modification of CXCR4 using engineered zinc finger proteins  
Disclosed herein are methods and compositions for modulating activity of CXCR4 genes, for example using zinc finger transcription factors (ZF-TFs) or zinc finger nucleases (ZFNs) comprising a zinc...
8871914 Antigen binding proteins to proprotein convertase subtilisin kexin type 9 (PCSK9)  
Antigen binding proteins that interact with Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) are described. Methods of treating hypercholesterolemia and other disorders by administering a...
8865176 Methods and compositions for generating bioactive assemblies of increased complexity and uses  
The present invention concerns methods and compositions for making and using bioactive assemblies of defined compositions, which may have multiple functionalities and/or binding specificities. In...
8865122 Methods and compositions for protein labelling  
A modular platform is provided for rapid preparation of various water-soluble prosthetic groups capable to efficiently introduce 18F into proteins with 18F labelling reagents.
8865865 N-terminally modified tetrapeptide derivatives having a C-terminal arginine mimetic  
The invention refers to multibasic, N-terminally modified tetrapeptide mimetics with a C-terminal P1-arginine mimetic, methods for their production and use for therapy and prophylaxis of diseases,...
8865656 Beta-hairpin peptidomimetics having CXCR4 antagonizing activity  
β-Hairpin peptidomimetics of the general formula Cyclo(-Xaa1-Xaa2-Xaa3-Cys4-Xaa5-Xaa6-Xaa7-Xaa8-Arg9-Tyr10-Cy s11-Xaa12-Xaa13-Xaa14-Xaa15-Xaa16-), disulfide bond between Cys4 and Cys11, and ...
8865430 Fusion polypeptides capable of activating receptors  
A fusion polypeptide comprising (A)x-M-(A′)y, wherein A and A′ are each polypeptides capable of binding a target receptor. The fusion polypeptides of the invention form multimeric proteins whi...
8865179 Aptameric IgE peptides in a protein scaffold as an allergy vaccine  
A method is disclosed wherein an antigenic B-cell epitope is discovered by in vitro transcription and translation of pre-determined sequence on thermostable protein scaffolds detected by antibodies...
8865424 Anti-FDP monoclonal antibody, FDP measurement reagent and reagent kit using same, and FDP measurement method  
The present invention relates to an anti-FDP monoclonal antibody selected from the first, second and third monoclonal antibodies having different reactivity towards FDP. The present invention also...
8865922 Method of treating tall oil pitch  
A method of treating tall oil pitch, which comprises sterol esters of fatty acids. According to the present invention, the esters of sterols and fatty acids are broken down, in which case...
8865171 Soluble forms of Hendra and Nipah virus G glycoprotein  
This invention relates to soluble forms of G glycoprotein from Hendra and Nipah virus. In particular, this invention relates to compositions comprising soluble forms of G glycoprotein from Hendra...
8865864 Mutant epidermal growth factor polypeptides with improved biological activity and methods of their making and use  
Compositions that are EGF polypeptides that possess improved biological activity as compared to the biological activity exhibited by wild-type EGF are provided. Also provided are methods for the...
8865414 Detection conjugate and method for analysis  
The invention provides a combination of reagents as a test kit containing a detection conjugate having a binding portion and a reagent for deactivating of the fluorochrome portion by interaction...
8865418 Immunoanalytical method and system using mass spectrometry technology  
An immunoanalytical system in which, after a sample such as a patient's serum is subjected to a pretreatment by an immunological pretreatment device, the sample is subjected to light detection by...
8865655 Depsipeptides and their therapeutic use  
A compound of the general Structure (VII) or (VIII) including isoteres and pharmaceutically acceptable salts thereof, wherein R1, R2 (where X=—CONR6—), R3 and R7 are the same or different and eac...
8865863 MCR dendrimers  
The invention relates to a method for producing peptoidic, peptidic and chimeric peptidic-peptoidic dendrimers by multiple iterative multi-component reactions (MCR), in particular Ugi or Passerini...
8865188 Methods and compositions for controlling assembly of viral proteins  
Provided herein are methods and compositions for controlling assembly of modified viral core proteins, for example, into a viral capsid or a nanocage. In some embodiments, the disclosed modified...
8865174 Methods of treatment using human antibodies that bind IL-12  
Human antibodies, preferably recombinant human antibodies, that specifically bind to human interleukin-12 (hIL-12) are disclosed. Preferred antibodies have high affinity for hIL-12 and neutralize...
8865867 Lectins and uses thereof  
The present invention relates to chemical compounds, methods for their discovery, and their therapeutic and research use. In particular, the present invention provides antiviral and antimicrobial...
8865647 Pharmaceutical solution of non covalently bound albumin and acylated insulin  
If albumin is added to a pharmaceutical formulation containing acylated insulin described in WO 2009/022005 and WO 2009/022013, the acylated insulin can be kept in solution after subcutaneous...
8865866 Diphtheria toxin variant  
The present invention relates to methods and compositions of modified variants of diphtheria toxin (DT) that reduce binding to vascular endothelium or vascular endothelial cells, and therefore,...
8865868 Conjugated proteins with prolonged in vivo efficacy  
The invention relates to conjugated proteins, in particular but not exclusively, blood coagulation factors, to processes for preparing the conjugated proteins which contain the steps of reacting a...
8865877 Compositions and methods for solubilizing membrane proteins without the use of detergent  
Disclosed are compositions and methods for isolating proteins from lipids. The isolation methods may utilize derivatives of apolipoprotein A1 for isolating membrane proteins from membranes without...
8865168 Methods and compositions to regulate hepcidin expression  
The present invention provides new systems and strategies for the regulation of iron metabolism in mammals. In particular, methods of using agonists and antagonists of TGF-β superfamily members to ...
8865175 Increasing anti-IL-1α antibodies in a subject  
Method of detecting individuals at risk for atherosclerosis and related vascular diseases involving the detection of IL-1α autoantibodies, as well as therapeutic methods to prevent or treat ...
8865967 Defensin variants and methods of use  
Compositions and methods for protecting a plant from a pathogen, particularly a fungal pathogen, are provided. Compositions include amino acid sequences, and variants and fragments thereof, for...
8865871 Antibodies and kits for immunodetection of epitope tags  
The instant invention provides antibodies which recognize new epitope tags. Related kits for detecting these epitope tags or fusion proteins having these epitope tags are also provided.
8864892 Tailorable lignosulfonate carbonate adhesives  
A two component adhesive system is described. The first component of the system is made from a sulfonated lignin having at least one amine group containing side arm and at least one hydroxyl group...
8865658 Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides  
Disclosed herein are non-natural amino acids and polypeptides that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides. The non-natural...
8865398 Combination hepatitis C virus antigen and antibody detection method  
An in vitro method that allows detection of hepatitis C by detecting hepatitis C virus (HCV) core protein and antibodies to HCV core protein (anti-core antibodies) in a single assay is provided....
8865186 Genetically engineered clostridial genes, proteins encoded by the engineered genes, and uses thereof  
The present invention relates to an isolated Clostridial neurotoxin propeptide having a light chain region, a heavy chain region, where the light and heavy chain regions are linked by a disulfide...