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8993731 PD-1 antibody  
A humanized agonistic antibody which binds human PD-1 comprising a heavy chain wherein the variable domain of the heavy chain comprises the sequence given in SEQ ID NO:1 for CDR-H1, the sequence...
8987415 Recombinant bacterial lipocalin blc and uses thereof  
The present inventors have solved the crystal structure of an Escherichia coli bacterial lipocalin polypeptide, which depicts a monomeric protein. Previous crystal structures have been reported,...
8987173 Compositions and methods for monitoring and altering protein folding and solubility  
The present invention relates to the fields of microbiology, molecular biology and protein biochemistry. More particularly, it relates to compositions and methods for analyzing and altering (e.g.,...
8987418 Dual specific binding proteins directed against IL-1β and/or IL-17  
Engineered multivalent and multispecific binding proteins that bind IL-1β and/or IL-17 are provided, along with methods of making and uses in the prevention, diagnosis, and/or treatment of disease.
8987207 Peptides which have analgesic effects and which inhibit ASIC channels  
Novel isolated peptides which induce analgesia and which inhibit ASIC channels (Acid Sensing Ion Channels), to the polynucleotides encoding these peptides, and also to the pharmaceutical...
8987202 Factor VII or Factor VIIa Gla domain variants  
Gla domain variants of human Factor VII or human Factor VIIa, comprising 1-15 amino acid modifications relative to the human Factor VII or human Factor VIIa sequence shown in SEQ ID NO:1, wherein a...
8987414 Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles  
Provided herein are peptidomimetic macrocycles and methods of using such macrocycles for the treatment of disease.
8987426 Immunotoxin fusion proteins and means for expression thereof  
The present invention described and shown in the specification and drawings provides novel recombinant DT-based immunotoxins, and, more specifically anti-T cell immunotoxin fusion proteins. Also...
8987562 Soybean variety A1026312  
The invention relates to the soybean variety designated A1026312. Provided by the invention are the seeds, plants and derivatives of the soybean variety A1026312. Also provided by the invention are...
8987421 Chimeric and humanized anti-histone antibodies  
The present invention concerns chimeric or humanized antibodies or antigen-binding fragments thereof that comprise specific CDR sequences, disclosed herein. Preferably, the antibodies or fragments...
8986688 WAP domain fusion polypeptides and methods of use thereof  
This invention relates to fusion proteins that include a whey acidic protein (WAP) domain-containing polypeptide and a second polypeptide. Additionally, the invention relates to fusion proteins...
8987412 Hydrogen bond surrogate macrocycles as modulators of Ras  
The present invention relates to peptides having one or more stable, internally-constrained HBS α-helices, where the peptide is capable of interacting with Ras and related proteins.
8987424 CA6 antigen-specific cytotoxic conjugate and methods of using the same  
Cytotoxic conjugates comprising a cell binding agent and a cytotoxic agent, therapeutic compositions comprising the conjugate, methods for using the conjugates in the inhibition of cell growth and...
8987419 Amyloid-beta binding proteins  
The present invention relates to amyloid-beta (Aβ) binding proteins. Antibodies of the invention have high affinity to Aβ(20-42) globulomer or any Aβ form that comprises the globulomer epitope. Me...
8986704 Mutant fragments of OspA and methods and uses relating thereto  
The present invention relates to a polypeptide comprising a mutant fragment of an outer surface protein A (OspA), a nucleic acid coding the same, a pharmaceutical composition (particularly for use...
8987205 Polynucleotides encoding recombinant lubricin molecules and uses thereof  
Recombinant lubricin molecules and uses thereof. Novel recombinant lubricin molecules and their uses as lubricants, anti-adhesive agents and/or intra-articular supplements for, e.g., synovial...
8987423 MAGE antigen binding proteins  
Antigen binding proteins, such as antibodies, which bind to human MAGE-A3, polynucleotides encoding such antigen binding proteins, and uses and manufacture thereof.
8986952 Anti-human NGF antibody  
[Task] To provide an anti-human NGF antibody or an antigen-binding fragment thereof that is excellent in safety by reducing the risk of side effects such as effects on a fetus and thrombus...
8986712 Peptides derived from HIV-1 gp41 transmembrane domain for t-immunomodulation  
The present invention relates to peptides, derivatives and analogs comprising an amino acid sequence derived from the transmembrane domain of HIV gp41 protein, pharmaceutical compositions...
8987428 Lignin-based surfactants  
Methods for converting waste streams from the wood pulping industry to high-value surfactants are described. For example, isolated lignin and lignosulfonate or waste streams containing lignin and...
8987416 Viral fusion protein treatment for CCR8 mediated diseases  
Compositions, methods, and kits are provided for treating CCR8 mediated diseases with applicability to atopic dermatitis and potential applicability to asthma, prurigo nodularis, nummular...
8986655 Compositions, devices, and methods related to prostate-specific membrane antigen  
PSMA ligands, compositions, and methods therefore are disclosed where the ligand is a peptide having the sequence X1X2CVEVX3QNSCX4X5 where X1-X5 are independently a natural or non-natural amino...
8986703 Peptide sequences and compositions  
Provided is a polypeptide composition comprising one or more polypeptides, which polypeptides are immunogenic in a vertebrate such that they cause the vertebrate to produce immune system cells...
8986686 Stabilized liquid anti-RSV antibody formulations  
The present invention provides liquid formulations of SYNAGIS® or an antigen-binding fragment thereof that immunospecifically bind to a respiratory syncytial virus (RSV) antigen, which ...
8987194 Mutant Nisin ser 29 derivatives and the use thereof  
A Nisin derivative or variant, comprising an amino acid substitution at amino acid position 29 in the amino acid sequence. The Nisin derivative exhibits enhanced antimicrobial activity when...
8986651 Compounds with reduced ring size for use in diagnosing and treating melanoma, including metastatic melanoma and methods related to same  
The present invention is directed to novel non-invasive diagnostic tools/compounds to image cancers, especially, melanoma, including metastatic melanoma in vivo. The present compounds exhibit...
8987210 Chemokine-immunoglobulin fusion polypeptides, compositions, method of making and use thereof  
This application is directed to chemokine-immunoglobulin fusion polypeptides and chemokine-polymer conjugates. The fusion polypeptides and conjugates can be used for treating chemokine...
8987427 Highly efficient lignin-based water-reducing agent with high degree of sulfonation and high molecular weight, and preparation method thereof  
This invention discloses a high-performance lignin-based water reducer with high degree of sulfonation and high molecular weight and its preparation method. This water reducer exhibits an excellent...
8987203 Methods for controlling mineralization of extracellular matrix, therapeutic methods based thereon and medicaments for use therein  
The present invention relates to methods for selecting a candidate therapeutic agent for controlling mineralization of an extracellular matrix in a tissue of a subject. The invention further...
8986710 Neisseria meningitidis compositions and methods thereof  
In one aspect, the invention relates to an isolated polypeptide comprising an amino acid sequence that is at least 95% identical to SEQ ID NO: 71. In another aspect, the invention relates to an...
8987377 Poly(amide) polymers for the delivery of oligonucleotides  
The present invention provides poly(amide) polymers, polyconjugates, compositions and methods for the delivery of oligonucleotides for therapeutic purposes.
8986728 Soluble implantable device comprising polyelectrolyte with hydrophobic counterions  
The present invention provides an implantable device having a biosoluble coating or a biosoluble body structure comprising a polyelectrolyte and a counterion and the methods of making and using the...
8987551 Modified oil encapsulating proteins and uses thereof  
The invention provides modified oleosins, including at least one artificially introduced cysteine, and methods and compositions for producing the modified oleosins. Also provided are...
8986690 Modulation of activity of neurotrophins  
The present invention relates to methods for modulating the activity of one or more neurotrophins, such as neural growth factor (NGF), brain derived neurotrophic factor (BDNF), neurotrophin-3, and...
8986954 DNA encoding function modifying Nav1.7 antibodies  
A Nav1.7 binding entity that after binding functionally modifies the activity of the ion channel, in particular an anti-Nav1.7 antibody or binding fragment thereof, pharmaceutical compositions...
8986936 Post-translation modified cardiac troponin T as a biomarker of a risk for heart failure  
The present invention relates to methods and kits for the prediction of risk for heart failure using post-translation modified forms of cardiac troponin T as a biomarker.
8986951 Tear lipocalin in muteins binding IL-4 R alpha  
The present invention relates to novel muteins derived from human tear lipocalin, which bind to IL 4 receptor alpha. The sequences of the muteins comprise particular combinations of amino acids. In...
8986700 Immunogenic lipopeptides comprising T-helper and cytotoxic T-lymphocyte (CTL) epitopes  
The present invention provides synthetic immunogenic lipopeptide molecules comprising co-linear T-helper and CTL epitopes, and methods for their production and use in the generation of primary and...
8987209 N-carboxyalkyl-auristatin and the use thereof  
The present application relates to new derivatives of monomethylauristatin F, substituted on the N terminus by a carboxyalkyl group, processes for preparing these derivatives, their use for the...
8987192 Potent and selective mediators of cholesterol efflux  
The present invention provides a family of non-naturally occurring polypeptides having cholesterol efflux activity that parallels that of full-length apolipoproteins (e.g., Apo AI and Apo E), and...
8986972 Nucleic acid encoding DLL3 antibodies  
Novel modulators, including antibodies and derivatives thereof, and methods of using such modulators to treat proliferative disorders are provided.
8986699 Anti-CD74 immunoconjugates and methods of use  
Disclosed are compositions that include anti-CD74 immunoconjugates and optionally a therapeutic and/or diagnostic agent. In preferred embodiments, the immunoconjugates comprise one or more...
8987197 Protease stabilized, pegylated insulin analogues and uses thereof  
Novel PEGylated insulin analogs exhibiting resistance towards proteases can, effectively, be administered pulmonary or orally. The insulin analogs contain B25H and A14E or A14H. The PEGylation is...
8986689 Compositions and methods for brain delivery of analgesic peptides  
The present invention relates to non-invasive brain delivery technology for centrally-acting analgesic peptides. Specifically, the invention is directed to compounds comprising an antibody or...
8986990 Human antibodies against Pseudomonas aeruginosa LPS  
The invention described herein provides for human antibodies produced in non-human animals that specifically bind to Pseudomonas aeruginosa Lipopolysaccharide (LPS). The invention further provides...
8987190 Treatment of acute ischemic stroke or intracranial bleeding with tPa and carbamylated erythropoietin  
The present invention relates a method for the treatment of intracranial bleeding comprising administration of a therapeutically effective amount of tPa and a therapeutically effective amount of...
8987417 Covalently dimerized bivalent binding agents  
The present invention addresses limitations of prior art receptor-based traps through a methodology called the clamp/click/cleave (CCC) approach. Two fusion proteins each comprising a binding...
8986685 Compositions and methods for increasing bone mineralization  
Described herein are pharmaceutical compositions comprising an anti-sclerostin antibody and an inhibitor of bone resorption.
8987563 Soybean variety A1035304  
The invention relates to the soybean variety designated A1035304. Provided by the invention are the seeds, plants and derivatives of the soybean variety A1035304. Also provided by the invention are...
8987213 Peptides that selectively home to heart vasculature and related conjugates and methods  
The present invention provides a variety of isolated peptides and peptidomimetics, which can be useful, for example, in constructing the conjugates of the invention or, where the peptide itself has...