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8992919 Anti-polyubiquitin antibodies and methods of use  
The invention provides anti-polyubiquitin antibodies and methods of using the same.
8993734 Method to produce an immunoglobulin preparation with improved yield  
The present invention provides improved methods for the manufacturing of IVIG products. These methods offer various advantages such as reduced loss of IgG during purification and improved quality...
8993249 Anti-neuropilin antibodies and methods of use  
The invention provides anti-NRP1 antibodies and methods of using the same.
8993726 Antibodies to NTB-A  
Anti-NTB-A antibodies and antigen-binding fragments thereof, as well as pharmaceutical compositions comprising such antibodies and antigen-binding fragments are described. Also described are...
8993728 Anti-human CLCP1 antibody and use thereof  
The present invention provides novel antibodies that recognize the extracellular domain of a human CLCP1 antigen; nucleic acids encoding the antibodies; vectors carrying the nucleic acids in an...
8993345 Method of producing functional molecule-containing silica nanoparticles on which biomolecules are bonded  
A method of producing functional molecule-containing silica nanoparticles on which a biomolecule is bonded, containing the steps of: allowing silica nanoparticles containing a functional molecule...
8993719 Methods and compositions related to mutant Kunitz domain I of TFPI-2  
Disclosed are methods and compositions relating to plasmin inhibition.
8992886 Cyclic peptide analogues for non-invasive imaging of pancreatic beta-cells  
Compositions, methods of using and methods of making a cyclic peptide analog imaging agent that includes at least portions of a peptide or protein that binds specifically to the GLP-1 receptor...
8992936 Altered OspA of Borrelia burgdorferi  
Provided herein are OspA polypeptides from Lyme Disease-causing Borrelia having certain alteration(s). In one embodiment, the alteration(s) increase the conformational stability of the OspA...
8992916 Methods of using anti-IL13 human antibodies  
The present invention relates to human anti-IL-13 binding molecules, particularly antibodies, and to methods for using anti-IL-13 antibody molecules in diagnosis or treatment of IL-13 related...
8993261 Antibodies for the detection of integrin complexes in FFPE material  
The invention relates to antibodies that are capable to bind the extracellular domain of integrin. Another object of the invention concerns the use of said antibodies for detecting integrins in...
8993727 Carrier immunoglobulins and uses thereof  
Disclosed is an isolated immunoglobulin. Also disclosed are pharmaceutical compositions and medicaments comprising the immunoglobulin, isolated nucleic acid encoding it, vectors, host cells,...
8993729 Tissue specific expression of antibodies in chickens  
Transgenes encoding exogenous antibodies are stably integrated into donor cells and are present in the somatic tissue of chimeric birds. The transgenes encode exogenous antibodies and are...
8993724 Process for the preparation of glycosylated interferon beta  
The present invention relates to a process for the production of interferon beta, and to an interferon beta composition having a unique glycosylation pattern.
8993276 Chimeric enzymes with improved cellulase activities  
Nucleic acid molecules encoding chimeric cellulase polypeptides that exhibit improved cellulase activities are disclosed herein. The chimeric cellulase polypeptides encoded by these nucleic acids...
8993736 Photoreactive synthetic regulator of protein function and methods of use thereof  
The present disclosure provides a photoreactive synthetic regulator of protein function. The present disclosure further provides a light-regulated polypeptide that includes a subject synthetic...
8993722 Process for the preparation glatiramer acetate (copolymer-1)  
This invention relates to a convenient and improved process for preparation of glatiramer acetate (copolymer-1) of pharmaceutical grade. The process involves polymerizing N-carboxyanhydrides of...
8993838 Yield increase in plants overexpressing the SHSRP genes  
A transgenic crop plant transformed by a Serine Hydroxymethyltransferase-Like Stress-Related Polypeptide (SHSRP) coding nucleic acid, wherein expression of the nucleic acid sequence in the crop...
8993524 Compositions and methods for targeted immunomodulatory antibodies and fusion proteins  
The present invention is based on the seminal discovery that targeted immunomodulatory antibodies and fusion proteins can counter act or reverse immune tolerance of cancer cells. Cancer cells are...
8993735 Substrate for soil improvement having a water-storing property, method for producing same, and use thereof  
The invention relates to a method for producing a lignin-based substrate for soil improvement having a water-storing property, characterized by the following steps: providing lignin, oxidizing the...
8992920 Anti-IL-6 antibodies for the treatment of arthritis  
The present invention is directed to therapeutic methods using IL-6 antagonists such as anti-IL-6 antibodies and fragments thereof having binding specificity for IL-6 to prevent or treat...
8993531 PKD ligands and polynucleotides encoding PKD ligands  
The invention relates to kinase ligands and polyligands. In particular, the invention relates to ligands, homopolyligands, and heteropolyligands that modulate protein kinase D (PKD) activity. The...
8992929 Monoclonal antibody specific to major neutralizing epitope of influenza H5 hemagglutinin  
The present invention relates to the murine monoclonal antibody 4C2 or to chimeric or humanized monoclonal antibodies specific to a major neutralizing epitope of influenza H5 hemagglutinin and...
8993715 Labeled protein and method for obtaining the same  
It is an object of the present invention to obtain a labeled protein, and specifically, to separate a labeled protein and the same unlabeled protein. There is provided a labeled protein including:...
8992932 Binder-drug conjugates (ADCs) and use thereof  
The present application relates to new binder-drug conjugates (ADCs) of N,N-dialkylauristatins that are directed against the target C4.4a, to active metabolites of these ADCs, to processes for...
8993350 Sensitive method to analyse free PEG-maleimide  
The present invention relates generally to a novel method using HPLC and fluorescence detection of free PEG-mal in PEGylated proteins and PEG-mal raw materials by adding a fluorescent label to the...
8992935 Means of controlling infection persistence of Helicobacter pylori  
The present invention relates to a means of controlling infection persistence of Helicobacter pylori (H. pylori). In particular, the present invention relates to an isolated, genetically modified...
8992922 Antagonists of IL-17A, IL-17F, and IL-23P19  
The present invention relates to blocking, inhibiting, reducing, antagonizing or neutralizing the activity of IL-17A, IL-17F, and IL-23. Antagonists include antibodies and antibody fragments that...
8993717 Gadd45beta targeting agents  
Compounds based around tetrapeptide, tripeptide and dipeptide moeties and corresponding peptiod moeties. Related methods and pharmaceutical compositions for use in treatment of cancer,...
8993723 Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of alanyl-tRNA synthetases  
Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use...
8987563 Soybean variety A1035304  
The invention relates to the soybean variety designated A1035304. Provided by the invention are the seeds, plants and derivatives of the soybean variety A1035304. Also provided by the invention...
8987173 Compositions and methods for monitoring and altering protein folding and solubility  
The present invention relates to the fields of microbiology, molecular biology and protein biochemistry. More particularly, it relates to compositions and methods for analyzing and altering (e.g.,...
8987194 Mutant Nisin ser 29 derivatives and the use thereof  
A Nisin derivative or variant, comprising an amino acid substitution at amino acid position 29 in the amino acid sequence. The Nisin derivative exhibits enhanced antimicrobial activity when...
8986936 Post-translation modified cardiac troponin T as a biomarker of a risk for heart failure  
The present invention relates to methods and kits for the prediction of risk for heart failure using post-translation modified forms of cardiac troponin T as a biomarker.
8986728 Soluble implantable device comprising polyelectrolyte with hydrophobic counterions  
The present invention provides an implantable device having a biosoluble coating or a biosoluble body structure comprising a polyelectrolyte and a counterion and the methods of making and using...
8987412 Hydrogen bond surrogate macrocycles as modulators of Ras  
The present invention relates to peptides having one or more stable, internally-constrained HBS ╬▒-helices, where the peptide is capable of interacting with Ras and related proteins.
8987551 Modified oil encapsulating proteins and uses thereof  
The invention provides modified oleosins, including at least one artificially introduced cysteine, and methods and compositions for producing the modified oleosins. Also provided are...
8987415 Recombinant bacterial lipocalin blc and uses thereof  
The present inventors have solved the crystal structure of an Escherichia coli bacterial lipocalin polypeptide, which depicts a monomeric protein. Previous crystal structures have been reported,...
8986703 Peptide sequences and compositions  
Provided is a polypeptide composition comprising one or more polypeptides, which polypeptides are immunogenic in a vertebrate such that they cause the vertebrate to produce immune system cells...
8987424 CA6 antigen-specific cytotoxic conjugate and methods of using the same  
Cytotoxic conjugates comprising a cell binding agent and a cytotoxic agent, therapeutic compositions comprising the conjugate, methods for using the conjugates in the inhibition of cell growth and...
8987202 Factor VII or Factor VIIa Gla domain variants  
Gla domain variants of human Factor VII or human Factor VIIa, comprising 1-15 amino acid modifications relative to the human Factor VII or human Factor VIIa sequence shown in SEQ ID NO:1, wherein...
8986686 Stabilized liquid anti-RSV antibody formulations  
The present invention provides liquid formulations of SYNAGIS® or an antigen-binding fragment thereof that immunospecifically bind to a respiratory syncytial virus (RSV) antigen, which...
8986651 Compounds with reduced ring size for use in diagnosing and treating melanoma, including metastatic melanoma and methods related to same  
The present invention is directed to novel non-invasive diagnostic tools/compounds to image cancers, especially, melanoma, including metastatic melanoma in vivo. The present compounds exhibit...
8987209 N-carboxyalkyl-auristatin and the use thereof  
The present application relates to new derivatives of monomethylauristatin F, substituted on the N terminus by a carboxyalkyl group, processes for preparing these derivatives, their use for the...
8987377 Poly(amide) polymers for the delivery of oligonucleotides  
The present invention provides poly(amide) polymers, polyconjugates, compositions and methods for the delivery of oligonucleotides for therapeutic purposes.
8987427 Highly efficient lignin-based water-reducing agent with high degree of sulfonation and high molecular weight, and preparation method thereof  
This invention discloses a high-performance lignin-based water reducer with high degree of sulfonation and high molecular weight and its preparation method. This water reducer exhibits an...
8986685 Compositions and methods for increasing bone mineralization  
Described herein are pharmaceutical compositions comprising an anti-sclerostin antibody and an inhibitor of bone resorption.
8987425 Pharmaceutical composition for preventing or treating cancer  
The invention provides a fusion protein comprising (a) a first protein comprising a polypeptide which specifically binds to Annexin A1 and (b) a second protein comprising a polypeptide which...
8987203 Methods for controlling mineralization of extracellular matrix, therapeutic methods based thereon and medicaments for use therein  
The present invention relates to methods for selecting a candidate therapeutic agent for controlling mineralization of an extracellular matrix in a tissue of a subject. The invention further...
8986954 DNA encoding function modifying Nav1.7 antibodies  
A Nav1.7 binding entity that after binding functionally modifies the activity of the ion channel, in particular an anti-Nav1.7 antibody or binding fragment thereof, pharmaceutical compositions...