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8658409 Polypeptides having acetyl xylan esterase activity and polynucleotides encoding same  
The present invention relates to isolated polypeptides having acetyl xylan esterase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid...
8658764 Peptide fragments for inducing synthesis of extracellular matrix proteins  
Short biologically active tetrapeptides are disclosed that are comprised of the sequences GxxG and PxxP where G (glycine) and P (proline) are maintained and x is a variable amino acid. The peptides...
8658770 Integrin alpha 8-beta 1-specific monoclonal antibody  
[Object] To obtain an anti-integrin α8β1 antibody which binds to integrin α8β1 derived from mammals of different species. Also, to obtain an anti-integrin α8β1 antibody which inhibits binding betwe...
8658858 Polynucleotides encoding proteins involved in plant metabolism  
The invention provides isolated pyruvate dehydrogenase kinase nucleic acids and their encoded polypeptides. The present invention provides methods and compositions relating to altering pyruvate...
8658768 Method for enhancing phagocytosis of phosphatidylserine-exposing cells  
An Annexin A5 variant, comprising one or more RGD (Arg-Gly-Asp) sequences, is suitable for use in the treatment of a disease in mammals, including humans, wherein augmentation of phagocytosis is a...
8658423 Insulin-like growth factor II (IGF-II) binding factors  
This invention relates to modified IGF-II binding domains of the Insulin-like Growth Factor 2 Receptor (IGF2R) which have enhanced binding affinity for IGF-II relative to the wild type IGF-II...
8658382 Proteins with pteridine glycosyltransferase activity and analysis method using the same  
The present invention relates to proteins with pteridine glycosyltransferase activity and an analysis method using the same. Since the proteins glycate tetrahydrobiopterin selectively through an...
8658601 Peptides and nanoparticles for therapeutic and diagnostic applications  
Provided herein are peptides and nanoparticles conjugates thereof useful for the treatment of diseases and disorders mediated by GIPC/synectin, such as cancer.
8658766 Soluble hybrid Fcγ receptors and related methods  
Disclosed are soluble hybrid Fcγ receptor (FcγR) polypeptide compositions and related methods of using such polypeptides to treat IgG-mediated and immune complex-mediated inflammation. Also d...
8658762 Polypeptides that inhibit dopamine D2 receptor-DISC1 interaction and methods of use thereof  
The present invention provides compounds, compositions and methods for inhibiting D2R-DISC1 interaction. Specifically, the present invention provides a polypeptide comprising the amino acid...
8658135 Antagonists of ligands and uses thereof  
The invention provides hetero-multivalent ligand binging agents (traps) for members of the TGF-β superfamily, as well as methods for making and using such constructs. In an embodiment of the ...
8658598 Recombinant melusin fusion protein as pharmacological agent in the treatment of heart pathologies  
A recombinant melusin fusion protein having an improved stability and a capability to reach intracellular compartments as compared to recombinant melusin in vivo, wherein said protein comprises i)...
8658773 Ultrafiltration concentration of allotype selected antibodies for small-volume administration  
Disclosed are methods, compositions and uses of high concentration antibody or immunoglobulin formulations for subcutaneous, intramuscular, transdermal or other local (regional) administration, in...
8658385 Purinergic (P2X) receptors in extra-cellular body fluid  
The invention relates to purinergic (P2X) receptors, to detection of protein in extra-cellular body fluids and to anti-bodies for the diagnosis or condition, especially cancer.
8658160 Composition and method for cancer chemoprevention  
A composition including an effective amount of a treatment agent to inhibit tumor growth in a mammal by manipulating a prostaglandin D2 biosynthetic pathway. A method comprising introducing an...
8658433 Dye compounds as photoactive agents  
Novel azo, azide, and sulfenate photoactive compounds and methods using the compounds for photodiagnostic and/or phototherapeutic procedures. The compounds have the formula E-L-DYE-X—Y, wherein D...
8658774 Meditopes and related meditope-monoclonal antibody delivery systems, synthesis and therapeutic uses thereof  
Meditope variants and methods for their use are provided herein. A meditope variant as described herein comprises a peptide having a sequence CQFDLSTRRLKC (SEQ ID NO:1) or CQYNLSSRALKC (SEQ ID...
8658592 Biologically active peptides and their new uses  
Novel peptides are disclosed with their use as a pharmaceutical composition. A method is also disclosed for making pharmaceutical compositions and treatment of an individual.
8658178 Carbon nanotube compositions and methods of use thereof  
Carbon nanotube (CNT)-based compositions for activating cellular immune responses are provided. The CNTs function as high surface area scaffolds for the attachment of T cell ligands and/or...
8658381 Detection conjugate  
The invention relates to a detection conjugate composed of a filament fragment, e.g. a cytoskeletal filament such as actin filaments or microtubules, and recognition elements bound to this fragment...
8658165 Method of treating aberrant mucus production in respiratory disease  
The present invention relates to modulators of the Neuregulin (NRG) family, particularly NRG1 and more particularly NRG1β, and most particularly NRG1β1. The present invention also relates to the u...
8658769 Diagnostic marker for hepatocellular carcinoma comprising anti-FASN autoantibodies and a diagnostic composition for hepatocellular carcinoma comprising antigens thereof  
The present invention relates to an autoantibody specifically recognizing the epitope sequence of FASN (fatty acid synthase), more particularly, to the autoantibody or a fragment comprising an...
8658354 Anti-(influenza a virus subtype H5 hemagglutinin) monoclonal antibody  
A method of immunoassay of H5 subtype influenza A virus by which the virus can be accurately assayed even in cases where a certain level of mutation has occurred in the H5 subtype influenza A...
8658767 Lipidated polyepitope vaccines  
This invention relates to, inter alia, an isolated lipidated polypeptide including a lipid moiety at the N-terminus and a plurality of epitopes, and methods of making and using the polypeptide.
8658400 Biocatalysts for manufacturing duloxetine alcohol  
The present invention relates to novel phenylethanol dehydrogenase mutants, to a method for the manufacture thereof; to coded nucleic acid sequences therefor, to expression cassettes, to vectors...
8658594 Peptide inhibitors of protein kinase C  
PKC V5 isozyme-specific peptides are described. The sequences and compositions comprising the sequences are useful for treating disease states associated with the PKC isozyme from which they are...
8658596 Biglycan and related therapeutics and methods of use  
The invention provides compositions and methods for treating, preventing, and diagnosing diseases or conditions associated with an abnormal level or activity of biglycan; disorders associated with...
8660753 Control method of wheel alignment apparatus using motor driven power steering  
The present invention relates to a control method of a wheel alignment apparatus using an MDPS, which determines whether or not to cancel center alignment control due to a trouble or error is...
8658772 Selective extraction of proteins from freshwater algae  
Methods for selective extraction and fractionation of algal proteins from an algal biomass or algal culture are disclosed. A method of selective removal of products from an algal biomass provides...
8658597 Stabilised compositions of factor VII polypeptides  
The invention relates to chemically as well as physically stable kits and compositions comprising polypeptides, in particular Factor VII or Factor VII-related polypeptides, such that these...
8658175 Anti-EGFR antibodies and their uses  
The present invention relates to antibodies directed to EGFR and uses of such antibodies, for example, to treat diseases associated with the activity and/or overproduction of EGFR.
8658771 Humanized antibodies against human interferon-alpha  
The present invention provides humanized anti-human IFN-α monoclonal antibodies useful for therapeutic applications in humans. Preferred antibodies are humanized versions of murine antibodies ...
8653038 HLA-A* 1101-restricted WT1 peptide and pharmaceutical composition comprising the same  
An HLA-A*1101-restricted WT1 peptide, specifically, a peptide comprising an amino acid sequence consisting of 9 contiguous amino acids from a WT1 protein, wherein the peptide has an ability to bind...
8652474 Composition comprising antibody that binds to domain II of HER2 and acidic variants thereof  
A composition comprising a main species HER2 antibody that binds to domain II of HER2 and acidic variants thereof is described. Pharmaceutical formulations comprising the composition, and...
8653039 Peptide based inhibition of caPCNA interaction in cancer  
Peptides derived from cancer specific isoform of proliferating cell nuclear antigen (caPCNA, also known as csPCNA) or from nmPCNA-interacting proteins interfere with intracellular protein-protein...
8653032 Pharmaceutical composition for preventing / treating TRPV1 activity-related and inflammation-related diseases or conditions containing maillard peptide separated from well-aged traditional soy sauce as active ingredient  
Disclosed is a pharmaceutical composition for preventing or treating TRPV1 activity-related or inflammation-related, diseases or conditions, containing a Maillard peptide separated from well-aged...
8652465 Methods and compositions for the treatment of persistent infections  
The present invention provides methods and compositions for the treatment, prevention, or reduction of persistent infections, such as chronic infections, latent infections, and slow infections and...
8652473 Antibodies to EGF receptor epitope peptides and uses thereof  
The present invention relates generally to growth factor receptor epitope peptides, particularly EGF family receptor epitope peptides. The invention also relates to the use of the receptor peptides...
8652409 Photoelectrocatalytic fluid analyte sensors including reference electrodes  
Fluid analyte sensors include a photoelectrocatalytic element that is configured to be exposed to the fluid, if present, and to respond to photoelectrocatalysis of at least one analyte in the fluid...
8652459 Splitting GP41  
The present invention deals with a method for therapeutic or prophylactic treatment of HIV, in particular a prophylactic vaccinal method, comprising at least: administering to a patient a first...
8653241 Phospholipase polypeptide and a DNA encoding same  
The invention relates to a DNA sequence that encodes a polypeptide with phospholipase activity and was isolated from Aspergillus and sequences derived therefrom, polypeptides with phospholipase...
8653031 Process for the preparation of compositions of AT1 receptor antagonist and Angiotensin—(1-7)  
We describe preparation of compounds of an AT1 receptor antagonist(s) and Angiotensin (1-7), for example, Angiotensin-(1-7) losartanate and analogues thereof, and/or mixtures of these systems,...
8653236 Therapeutic agents  
A purified anti-cancer peptide consisting of amino acids 266 to 287 of Genbank Accession No. O68604 (SEQ ID No. 4), and modified and homologous forms of the peptide are described. The modified or...
8652472 Compositions and methods for diagnosing and treating cancer  
An isolated antibody that specifically binds to an extracellular domain of human DDR2 and has a therapeutic effect on a solid tumor is described. Also described is a method of treating cancer, the...
8653238 Compositions and methods for transport of molecules with enhanced release properties across biological barriers  
Conjugates of a cargo molecule with a transporter molecule are disclosed, where the cargo molecule and the transporter molecule are linked covalently by a releasable linker. The cargo of the...
8653028 Erythropoietin-derived short peptide and its mimics as immuno/inflammatory modulators  
The present invention provides isolated stabilized EPO-derived peptides and their mimics that protect against tissue damage in subjects having diverse forms of neural and non-neural organ system...
8652790 Conformational entropy in molecular recognition  
The present invention provides methods for the determination of the degree of molecular recognition of a protein with a ligand, including a first protein with a second protein. The methods may...
8653237 Peptide analogues  
Some embodiments relate to analogs of peptides corresponding to class I MHC-restricted T cell epitopes and methods for their generation. These analogs can contain amino acid substitutions at...
8653240 Thiosulfonate compound, reversible cationization agent for protein and/or peptide, and method for solubilization  
The object of the present invention is to provide a novel thiosulfonate compound, a reversible cationization agent for protein and/or peptide, which can reversibly cationize a wider range of...
8652330 Asymmetric porous adsorptive bead  
The present invention relates to an asymmetric chromatography media suitable for separations applications, particularly as packed bed, fluidized bed or magnetized bed chromatography media. In...