|
Match
|
Document |
Document Title |
|
|
8404802 |
Peptide-based compounds
The invention relates to new peptide-based compounds for use as diagnostic imaging agents or as therapeutic agents wherein the agents comprise a targeting vector which binds to receptors associated...
|
|
|
8399610 |
HPV vaccine comprising peptides from host cell proteins
The present invention relates to an immunogenic composition for a human papillomavirus (HPV) vaccine that comprises BAX peptides from BAX host cell proteins and more particularly, a vaccine...
|
|
|
8399614 |
Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides
Disclosed herein are non-natural amino acids and polypeptides that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides. The non-natural...
|
|
|
8399218 |
Engineered zinc finger proteins targeting 5-enolpyruvyl shikimate-3-phosphate synthase genes
The present disclosure relates to engineered zinc finger proteins that target 5-enolpyruvyl shikimate-3-phosphate synthase (EPSPS) genes in plants and methods of using such zinc finger proteins in...
|
|
|
8399630 |
Engineered anti-IL-13 antibodies, compositions, methods and uses
The present invention relates to engineered antibodies immuno specific for human interleukin-13 (IL-13) protein or fragment thereof, as well as methods of making and using thereof, including...
|
|
|
8399405 |
Peptidomimetic macrocycles
Biologically active crosslinked polypeptides with improved properties relative to their corresponding precursor polypeptides; and methods of making and identifying such improved polypeptides.
|
|
|
8398998 |
Therapeutic composition comprising a botulinum neurotoxin
A pharmaceutical preparation comprising one of the botulinum neurotoxins from Clostridium botulinum of types A, B, C, D, E, F or G or a mixture of two or more of these neurotoxins, wherein the...
|
|
|
8399627 |
Antibodies to TNFα
Provided herein are antibodies, antigen binding portions, and derivatives thereof that are capable of binding tumor necrosis factor alpha (TNFα); nucleic acids encoding the antibodies, antigen ...
|
|
|
8399613 |
Tumour-associated peptides that bind to MHC molecules
The invention relates to a tumor-associated peptide containing an amino sequence, which is selected from the group consisting of SEQ ID NO:1 to SEQ ID NO:79 of the enclosed listing. The peptide has...
|
|
|
8399400 |
Fusion proteins
A single chain, polypeptide fusion protein, comprising: a non-cytotoxic protease, or a fragment thereof, which protease or protease fragment is capable of cleaving a protein of the exocytic fusion...
|
|
|
8399000 |
Haemophilus influenzae type IV pili
The invention described herein relates to a Haemophilus influenzae (H. influenzae) regulon encoding type IV pili. In particular, the invention relates to type pili from nontypeable H. influenzae...
|
|
|
8399250 |
Anti-mpl ligand (thromobpoietin) antibodies
Isolated mpl ligand, isolated DNA encoding mpl ligand, and recombinant methods of preparing mpl ligand are disclosed. These mpl ligands are shown to influence the replication, differentiation or...
|
|
|
8399621 |
Anti-CD4 antibody
An anti-CD4 antibody which binds to CD4, has a high affinity and has a high effector activity, such as an antibody-dependent cellular cytotoxicity (ADCC activity) or complement-dependent cellular...
|
|
|
8399633 |
Removal of lipopolysaccharides from protein-lipopolysaccharide complexes by non flammable solvents
During the production of recombinant proteins from gram negative bacteria, lipopolysaccharides (LPS, endotoxin) are released along with the protein of interest. In many instances, LPS will copurify...
|
|
|
8399619 |
Injectable collagen material
A collagen material is disclosed and can include a plurality of particles. Each particle can include an elongated, thin body having one or more arcuate portions and one or more straight portions....
|
|
|
8399202 |
Peptides for development of diagnostic and therapeutic agents and methods of using same
Novel immuno-interactive fragments of the αC portion of a mammalian inhibin α subunit, together with their variants and derivatives, produce antigen-binding molecules that are interactive with t...
|
|
|
8398976 |
Antibodies to EGFL7 and methods for their use
The invention provides anti-EGFL7 antibodies, and compositions comprising and methods of using these antibodies.
|
|
|
8399653 |
Transferrin/transferrin receptor-mediated siRNA delivery
The invention provides interfering RNA molecule-ligand conjugates useful as a delivery system for delivering interfering RNA molecules to a cell in vitro or in vivo. The conjugates comprise a...
|
|
|
8399257 |
Transposition of maize Ac/Ds elements in vertebrates
The present invention is directed to the use of the maize Ac/Ds transposable elements in vertebrates.
|
|
|
8399414 |
Analgesics
The object of this invention is to provide a novel pharmaceutical composition for getting rid of pains and anxiety in patients. This invention relates to a pharmaceutical composition containing...
|
|
|
8401622 |
Biopsy marker with in situ-generated imaging properties
A biopsy marker having radio-opaque properties that are derived in situ, based on a natural a biological response, such as for example, calcification, accumulation or tissue-concentration of a...
|
|
|
8398980 |
Subtypes of humanized antibody against interleuken-6 receptor
As a subtype of humanized PM-1 antibody against interleukin-6 receptor (IL-6R), there is provided antibody sub-type (1) whose one heavy chain C terminus consists of Pro-NH2 (447). As another...
|
|
|
8399618 |
Immunoglobulin insertions, deletions, and substitutions
An Fc variant of a parent Fc polypeptide, wherein said Fc variant exhibits altered binding to one or more FcγRs, wherein said Fc variant comprises at least one amino acid insertion in the Fc ...
|
|
|
8399403 |
Chemical linkers and conjugates thereof
The present disclosure provides drug-ligand conjugates that are potent cytotoxins, wherein the drug is linked to the ligand through either a peptidyl, hydrazine, or disulfide linker. The disclosure...
|
|
|
8399043 |
Whey protein micelles
The present invention relates to whey protein micelles, particularly to whey protein micelle concentrates or powders thereof and to a method for producing them. The present invention also pertains...
|
|
|
8399617 |
Non-functional P2X7 receptor
The present invention provides antibodies that specifically bind to P2X7 receptors and distinguish between function and non-functional P2X7 receptors, pharmaceutical compositions and kits...
|
|
|
8399207 |
Monoclonal antibodies against osteopontin
The present invention relates to reagents and methods for the detection of osteopontin fragments and distinguishing them from each other and from the full-length osteopontin protein. The present...
|
|
|
8399620 |
Purification of factor VIII using a mixed-mode or multimodal resin
A method for purifying a recombinant protein using a multimodal or mixed mode resin containing ligands which comprise a hydrophobic part and a negatively charged part is described. The invention is...
|
|
|
8399629 |
Antibody modulators of hepatocyte growth factor activator
The invention provides methods and compositions for modulating hepatocyte growth factor activator function.
|
|
|
8399623 |
Human antibodies that bind mesothelin, and uses thereof
The present disclosure provides isolated monoclonal antibodies that specifically bind to mesothelin with high affinity, particularly human monoclonal antibodies. Preferably, the antibodies bind...
|
|
|
8399609 |
Treating or preventing extracellular matrix build-up
A method of treatment for treating, preventing, inhibiting or reducing extracellular matrix build-up in a body tissue or a bodily fluid transport vessel, in a subject, includes administering to a...
|
|
|
8399408 |
Method for treating diabetes using neurturin
The present invention relates generally to methods for preventing and/or treating pancreatic disorders, particularly those related to diabetes, by administering a neurturin protein product.
|
|
|
8399401 |
Fusion proteins
A single chain, polypeptide fusion protein, comprising: a non-cytotoxic protease, or a fragment thereof, which protease or protease fragment is capable of cleaving a protein of the exocytic fusion...
|
|
|
8398979 |
Polypeptides, antibody variable domains and antagonists
The invention relates to anti-TNFR1 polypeptides and antibody single variable domains (dAbs) that are resistant to degradation by a protease, as well as antagonists comprising these. The...
|
|
|
8398940 |
USB-interfaceable portable test module for electrochemiluminescent detection of targets
A test module for excitation of electrochemiluminescent probes configured to detect target nucleic acid sequences, the test module having an outer casing having a receptacle for receiving a fluid...
|
|
|
8399749 |
Tomato line FDR 16-2082
The invention provides seed and plants of tomato hybrid EX01420200 and the parent lines thereof. The invention thus relates to the plants, seeds and tissue cultures of tomato hybrid EX01420200 and...
|
|
|
8398999 |
Chimeric, hybrid and tandem polypeptides of meningococcal NMB1870
NMB1870 is a protein in Neisseria meningitidis. Three families of NMB1870 are known. To increase the ability of a NMB1870 protein to elicit antibodies that are cross-reactive between the families,...
|
|
|
8398996 |
Staphylococcus aureus proteins and nucleic acids
The invention provides proteins from Staphylococcus aureus including amino acid sequences and the corresponding nucleotide sequences. The proteins are useful for vaccines, immunogenic compositions,...
|
|
|
8399231 |
Thermus thermophilus nucleic acid polymerases
The invention provides novel nucleic acid polymerases from strains GK24 and RQ-1 of Thermus thermophilus, and nucleic acids encoding those polymerases, as well as methods for using the polymerases...
|
|
|
8401799 |
Antibody design using anti-lipid antibody crystal structures
Methods for designing optimized antibodies, including optimized humainized or human antibodies, to target bioactive lipids are provided. These methods may be performed in silico and may be intended...
|
|
|
8398972 |
Methods of treating dementia using a GM-CSF antagonist
The invention is based on the discovery that GM-CSF antagonists can be used for the treatment of a patient that has Alzheimer's disease or vascular dementia, or is at risk for developing...
|
|
|
8399612 |
Asymmetric synthesis of peptides
A process comprising substitution of an acceptor molecule comprising a group —XC(O)— wherein X is O, S, or NR8, where R8 is C1-6 alkyl, C6-12 aryl or hydrogen, with a nucleophile, wherein the acc...
|
|
|
8399631 |
Compositions and methods for purifying calreticulin
The present invention relates to compositions, methods for expressing, and related methods for purifying calreticulin that is free of an affinity label or tag (i.e., non-tagged calreticulin). The...
|
|
|
8399417 |
Food
A low-fat food containing an amino acid or a peptide which is able to activate a calcium receptor, examples of which include γ-Glu-X-Gly, γ-Glu-Val-Y, γ-Glu-Ala, γ-Glu-Gly, γ-Glu-Cys, γ-Gl...
|
|
|
8398984 |
Removal promoters and inhibitor for apoptosis cells in vivo
The present invention is to provide a removal promoter for apoptotic cells which is capable of immediately removing apoptotic cells in vivo by macrophages, or a removal inhibitor which inhibits the...
|
|
|
8398987 |
Use of platelet glycopeptide IIIa epitopes in the treatment of immune thrombocytopenic purpura
The present invention relates to a composition for treating diseases associated with autoantibodies specific for platelet proteins, in particular autoimmune thrombocytopenic purpura. The...
|
|
|
8399628 |
Protein belonging to the TNF superfamily involved in signal transduction, nucleic acids encoding same and methods of use thereof
A method of modulating immune response in an animal is disclosed. Such a method interacting the immature dendritic cells from the animal with an antigen ex vivo so that the immature dendritic cells...
|
|
|
8398939 |
Microfluidic test module with low-volume hybridization chambers for electrochemiluminescent detection of target nucleic acid sequences in a fluid
A microfluidic test module for detecting target nucleic acid sequences in a fluid, the test module having an outer casing configured for hand-held portability, the outer casing having an inlet for...
|
|
|
8398995 |
Method of inducing immune tolerance to type I diabetes
A method for inducing immune tolerance to type I diabetes in a mammal by mucosal delivery of an antigen involved in the induction of type I diabetes such as pro-insulin or insulin is disclosed. The...
|
|
|
8399616 |
Fusion protein having luminescence activity
The fusion protein comprising (1) a first region comprising the amino acid sequence of SEQ ID NO: 18 and (2) a second region comprising an amino acid sequence for a polypeptide containing at least...
|