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8828922 HSP therapy in conjunction with a low antigenicity diet  
The present invention relates to a method for suppression, prevention, delaying the onset or treatment of diabetes, by administering to an individual in need thereof a fragment of Hsp60 or analog...
8828384 Compounds  
The present invention relates to an antibody which has multiple specificities. In particular the antibody of the present invention binds to (cross react with) human IL-8, Gro-alpha, Gro-beta,...
8828382 Heparin-binding epidermal growth factor-like growth factor binding proteins  
Provided herein are antigen binding proteins, e.g., human and/or monoclonal antibodies that have affinity for heparin-binding epidermal growth factor-like growth factor (HB-EGF) and neutralize the...
8828937 Bone morphogenetic protein 2 (BMP2) variants with reduced BMP antagonist sensitivity  
The present invention is directed to an isolated peptide comprising or consisting of an amino acid sequence with an amino acid identity of at least 90% compared to mature human BMP2 with SEQ ID No....
8828417 Bioactive coating for an implantable device or bioprosthesis  
For an implantable device intended for use in the human body an in-vivo colonization with autologous cells is often desired. The devices, especially prosthetic devices like implant tissues, grafts,...
8829163 Liquid formulations for long-acting erythropoietin conjugate  
Disclosed is a liquid formulation which allows long-acting EPO conjugates, that have improved in vivo duration and stability, to be stable when stored for a long period of time. It comprises a...
8829162 In vitro method for diagnosing prostate cancer  
The invention relates to an in vitro method for diagnosing prostate cancer and to antibodies and fragments thereof directed against CK2-α and their use for the diagnosis and prognosis of prostate ...
8828668 Markers for determination of patient responsiveness  
Compositions and methods are provided for prognostic classification of inflammatory diseases, e.g. inflammatory demyelinating disease, patients into subtypes, which subtypes are informative of the...
8829166 Rapid isolation of osteoinductive protein mixtures from mammalian bone tissue  
A method for purifying bone-derived osteoinductive proteins including a demineralization process, a protein extraction process, a high molecular weight ultrafiltration process, a low molecular...
8828905 Porous base matrix having formyl group, adsorbent using the porous base matrix, method for production of the porous base matrix, and method for production of the adsorbent  
The present invention relates to a porous base matrix having formyl group, which base matrix has a structure represented by the formula (2) as a spacer, which structure is obtained by cleaving a...
8829160 Antibody biomarker specific for mitotic cells and related methods  
An isolated antibody that has a specific binding affinity to a polypeptide comprising the amino acid sequence HTEGKP (SEQ ID NO: 2) phosphorylated at threonine is provided. The antibody may be used...
8828436 Methods and compositions for treating tissue using silk proteins  
Compositions for forming a self-reinforcing composite biomatrix, methods of manufacture and use therefore are herein disclosed. Kits including delivery devices suitable for delivering the...
8828931 Bifunctional molecules for inhibiting HIV entry  
Disclosed herein are bifunctional molecules which inhibit HIV entry into the target cell. Also disclosed are novel anti-HIV therapeutics for treatment of patients infected by HIV, including non-B...
8829159 Plectin-1 targeted agents for detection and treatment of pancreatic ductal adenocarcinoma  
Described herein are compositions and methods for cancer cell biomarkers, such as pancreatic ductal adenocarcinoma (PDAC) cell biomarkers, and binding molecules for diagnosis and treatment of...
8828941 Composition and method for the treatment or prevention of spinal disorders  
The present invention provides compositions of matter suitable for the prevention of and/or treatment of a spinal disorder and/or spinal pain, e.g., caused by and/or associated with intervertebral...
8828413 Peptoid oligomers, pharmaceutical compositions and methods of using the same  
Novel peptoid oligomers are disclosed that have a formula represented by the following formula I: The peptoids demonstrate antimicrobial activity and may be prepared as pharmaceutical compositions...
8828391 Method for EGFR directed combination treatment of non-small cell lung cancer  
The present invention relates to a method of treating patients suffering from cancers driven by deregulated Human Epidermal Growth Factor Receptor (HER/Human EGFR), wherein an irreversible tyrosine...
8828699 Eukaryotic amadoriase, gene and recombinant DNA for the eukaryotic amadoriase, and process for production of the eukaryotic amadoriase  
Disclosed are: a eukaryotic amadoriase which is prepared by introducing a mutation into DNA encoding a eukaryotic amadoriase derived from a microorganism belonging to the genus Coniochaeta or...
8828542 Nanoparticles  
Nanoparticles can include a core linked to a polymerizable moiety that can be polymerized, cross-linked or cured. The polymerizable nanoparticles can be included in a composition for a...
8828238 Thermophilic bacterium and uses of extracellular proteins therefrom  
A novel thermophilic bacterium is provided, which has a 16S rDNA sequence as set forth in SEQ ID NO. 1. The thermophilic bacterium excretes extracellular proteins having excellent metal-ion binding...
8829157 Process for the synthesis of cyclic heptapeptide  
The present invention relates to an improved process for the large scale synthesis of cyclic heptapeptide using Fmoc solid phase synthesis technique. The described process assembles the peptide on...
8828949 Aprotinin polypeptides for transporting a compound across the blood-brain barrier  
The invention relates to improvements in the field of drug delivery. More particularly, the invention relates to polypeptides derived from aprotinin and from aprotinin analogs as well as conjugates...
8828942 Means for treating synucleinopathies  
The present invention relates to peptides or polypeptides for producing medicaments for preventing and/or treating synucleinopathies.
8828939 Modified vitamin K dependent polypeptides  
The present invention relates to modified cDNA sequences coding for vitamin K-dependent polypeptides, in particular human Factor VII, human Factor VIIa, human Factor IX and human protein C and...
8828685 Monomeric forms of human aminoacyl-t-RNA synthetases having non-canonical biological activities  
Isolated monomelic aminoacyl-tRNA synthetase polypeptides and polynucleotides having non-canonical biological activities are provided, as well as compositions and methods related thereto.
8828400 Antibody that binds to H-1 parvovirus  
Described is an antibody or an antigen binding fragment thereof specifically binding to a full or empty H-1 parvovirus capsid. Such an antibody is useful for various diagnostic and therapeutic...
8828676 Methods for differentiating plasma-derived protein from recombinant protein in a sample  
The present invention relates, in general, to methods for detecting and quantitating plasma-derived protein and recombinant protein in a sample based on the difference in protein glycosylation,...
8829164 Anti-ron antibodies  
Monoclonal antibodies that bind and inhibit activation of human RON (Recepteur d'Origine Nantais) are disclosed. The antibodies can be used to treat certain forms of cancer that are associated with...
8828701 Cellobiohydrolase variants and polynucleotides encoding same  
The present invention relates to variants of a parent cellobiohydrolase. The present invention also relates to polynucleotides encoding the cellobiohydrolase variants; nucleic acid constructs,...
8828395 Antibodies that bind tyrosyl-tRNA synthetases  
Hematopoietic-modulating compositions are provided comprising aminoacyl-tRNA synthetase polypeptides, including active fragments and/or variants thereof, as well as compositions comprising related...
8828717 Framework residue substituted humanized COL-1 antibodies and their use  
The present disclosure provides humanized COL-1 monoclonal antibodies that retain CEA binding affinity, compared to a parent antibody. Also disclosed herein are humanized COL-1 monoclonal...
8828658 Spatio-temporal control of protein interactions using phytochromes  
The invention provides methods, materials and systems of regulating association between proteins of interest using light. In an aspect, the invention takes advantage of the ability of phytochromes...
8828389 Methods of diagnosing ALS  
The invention relates to an epitope protection assay for use in diagnosis, prognosis and therapeutic intervention in diseases, for example, involving polypeptide aggregation, such as prion...
8828928 Amphiphilic peptides and peptide particles  
The inventions provided herein relate to amphiphilic peptides and particles comprising the amphiphilic peptides. Such amphiphilic peptides and particles described herein can be used as a delivery...
8828396 Silent Fc variants of anti-CD40 antibodies  
The present invention relates to silent Fc variants of anti-CD40 antibodies and compositions and methods of use of said antibodies for treating pathological disorders such as autoimmune and...
8829295 Soybean cultivar 28241823  
A soybean cultivar designated 28241823 is disclosed. The invention relates to the seeds of soybean cultivar 28241823, to the plants of soybean cultivar 28241823, to the plant parts of soybean...
8828390 Uses of NOGO-A inhibitors and related methods  
The present invention is directed to Nogo-A antagonists useful for the control of blood glucose or blood insulin levels in a subject and related use and formulation thereof. In particular, the...
8828932 Bifunctional molecules for inactivating HIV and blocking HIV entry  
Disclosed herein are bifunctional molecules which inactivate human immunodeficiency virus (HIV) even before the virus attacks the target cell and inhibits HIV entry into the target cell. Also...
8828700 SSB-polymerase fusion proteins  
Fusion proteins comprising a single strand DNA binding protein and a nucleic acid polymerase (e.g. DNA polymerase or reverse transcriptase). These high fidelity proteins are suitable for use in...
8828923 Insulin derivatives  
The present invention relates to insulin derivatives which are naturally occurring insulins or analogues thereof which have a side chain attached either to the α-amino group of the N-terminal ...
8828926 Uses of natriuretic peptide constructs  
Use of constructs which bind to one or more natriuretic peptide receptors and include a plurality of amino acid residues and at least one amino acid surrogate of formula I: where R, R′, Q, Y, W, Z...
8829158 Peptides, derivatives and analogs thereof, and methods of using same  
Human proIslet Peptides (HIP) and HIP analogs and derivatives thereof, derived from or homologous in sequence to the human REG3A protein, chromosome 2p12, are able to induce islet neogenesis from...
8829165 Antigen binding proteins to proprotein convertase subtilisin kexin type 9 (PCSK9)  
Antigen binding proteins that interact with Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) are described. Methods of treating hypercholesterolemia and other disorders by administering a...
8828401 Cytotoxic peptides and antibody drug conjugates thereof  
The present invention is directed to cytotoxic pentapeptides, to antibody drug conjugates thereof, and to methods for using the same to treat cancer.
8828933 Mutant tat proteins and uses thereof  
Disclosed are viral proteins associated with Human Immunodeficiency Virus (HIV) infections and mutants thereof, particularly, mutant Tat proteins capable of modulating multiple steps of the HIV-1...
8828386 Method for extending pregnancy by reducing intraventricular hemorrhaging in patients exhibiting at least one symptom of preeclampsia and eclampsia  
A method lessening intraventricular hemorrhage in the fetus of a gravid human patient is provided where the patient is administered a therapeutically effective amount of digoxin antibody.
8828927 Elastin digest compositions and methods utilizing same  
The present invention provides compositions for the therapeutic and/or cosmetic treatment of Elastin comprising tissues. Therapeutic and cosmetic compositions comprising an elastin digest stimulate...
8829044 Stabilized vitamin C derivatives having a peptide molecule, preparation method thereof, and composition containing the same  
The present invention relates to a stabilized vitamin C derivative with a peptide molecule linked to vitamin C or a pharmaceutically acceptable salt thereof, a method of preparing the same, and a...
8829293 Soybean cultivar 22170671  
A soybean cultivar designated 22170671 is disclosed. The invention relates to the seeds of soybean cultivar 22170671, to the plants of soybean cultivar 22170671, to the plant parts of soybean...
8828399 Cytomegalovirus surface protein complex for use in vaccines and as a drug target  
Immunogenic compositions and prophylactic or therapeutic vaccines for use in protecting and treating against human cytomegalovirus (CMV) are disclosed. Subunit vaccines comprising a human CMV...