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7626004 |
Protein purification
The present invention relates to a method of purifying a protein of interest from its fusion analog, comprising obtaining a protein solution comprising a protein of interest and its fusion analog;...
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7604961 |
VP1 of foot-and-mouth disease virus
A pure, water-soluble polypeptide containing one or more monomers of a VP1 protein of a foot-and-mouth disease virus; or a pure, water-insoluble polypeptide comprising two or more monomers of a VP1...
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7601515 |
Process of high purity albumin production
A process is provided for the preparation of albumin from a yeast culture medium which has extremely low levels of or is essentially free of colorants, metal ions, human proteins, host proteins,...
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7598355 |
Characterization of GRP94-ligand interactions and purification, screening, and therapeutic methods relating thereto
The present invention discloses characterization of interactions between ligands and Hsp90 proteins, including GRP94, wherein ligand binding to the N-terminal nucleotide binding domain of GRP94...
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7560030 |
Method for separation and enrichment of phosphopeptides
The present invention relates to phosphopeptide isolation and enrichment, particularly to a highly selective and specific phosphopeptide enrichment method. The method mentioned in the invention is...
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7547770 |
Colostral fractionation process
A method ( 100 ) and a system ( 200 ) for processing mammalian bodily fluids to isolate target peptides and proteins. The method can include the steps of passing a mammalian bodily fluid through at...
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7544784 |
Increased recovery of active proteins
The invention provides methods of increasing yields of desired conformation of proteins. In particular embodiments, the invention includes contacting preparations of a recombinant protein with a...
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7528240 |
Method for producing human anti-thymocyte immunoglobulins
Methods for producing improved anti-human thymocyte immunoglobulins from specific-pathogen-free animals are provided, without the need for an adsorption step on human tissues and the consequent...
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7510875 |
Methods for producing purified adenoviral vectors
The present invention addresses the need to improve the yields of viral vectors when grown in cell culture systems. In particular, it has been demonstrated that for adenovirus, the use of...
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7501495 |
Method for improving recovery yield in protein purification with gel filtration chromatography
A method to more quantitatively recover a peak of a protein and associated aggregates, hydrophobic proteins, or hydrophobic peptides which are typically difficult to recover and detect as a peak,...
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7476726 |
Method of producing and purifying endostatin protein
The present invention provides a method for recombinant production, recovery and purification of endostatin protein. This method may be employed for large scale recovery and purification of...
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7473532 |
Liquid tissue preparation from histopathologically processed biological samples, tissues and cells
The current invention provides a method for directly converting histopathologically processed biological samples, tissues, and cells into a multi-use biomolecule lysate. This method allows for...
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7473781 |
Agent for capturing substance having anionic substituent
A polymer carrier to which a prescribed zinc complex group is binding directly or through a spacer, having property to bond, under a certain condition, to an anionic substituent (a phosphate group,...
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7449116 |
Methods and systems for protein separation
The present disclosure relates to a system and method for protein separation including: fractionating a mixture of proteins on a reversed-phase superficially porous stationary phase at a...
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7442779 |
Isolation of proteins
The present invention relates to a novel method for the isolation or purification of immunoglobulins (a special class of proteins) from a solution containing immunoglobulins, e.g. hybridoma cell...
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7422863 |
Molting hormone receptor and method for screening ligand to the receptor
The present invention provides a completely novel molting hormone receptor, which is used for efficiently screening a substance that can be applied to a disinfestant or the like. An insect molting...
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7408045 |
Adsorbent of high-mobility-group protein and body fluid-purification column
An adsorbent of high-mobility-group proteins (HMG protein) which can remove HMG protein in body fluid is disclosed. The adsorbent according to the present invention has a water-insoluble carrier on...
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7396468 |
Methods and system for protein separation
The present disclosure relates to a system and method for membrane protein separation including: fractionating a membrane sample on a reversed-phase superficially porous stationary phase at a...
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7338935 |
Chromatographic separation of therapeutic polypeptides
The present invention is directed to the purification and commercialization of therapeutic polypeptides that have. In one aspect of the invention, a method of purifying Interferon β-1b using size...
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RE40070 |
Antibody purification
This invention relates to the application of hydrophobic interaction chromatography combination chromatography to the purification of antibody molecule proteins. The questions raised in...
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7329409 |
Compositions and methods for treatment of microbial infections
The present invention relates to methods and compositions for treatment of microbial infections and for the enhancement of resistance to infection. The invention comprises administration of an...
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7329353 |
LC/MS method of analyzing high molecular weight proteins
The present invention is directed to a novel method of analysis of high molecular weight proteins. More specifically, it is directed to a novel reversed-phase LC/MS method of analysis of high...
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7276590 |
Ion exchange chromatography of proteins and peptides
The present invention relates to an ion exchange chromatography process for purifying a peptide from a mixture containing the peptide and related impurities, and to an industrial method including...
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7223561 |
Process of high purity albumin production
A process is provided for the preparation of albumin which has extremely low levels of or is essentially free of colorants, metal ions, human proteins, host proteins, fragments of albumin, polymers...
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7223848 |
Methods for purifying Fc-containing proteins
The present invention provides a process for dissociating Fc-containing molecules from complexes of Protein A/Fc-containing molecules or mixtures containing Fc-containing molecules and Protein A....
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7214778 |
Glycoprotein with antidiabetic, antihypertensive, antiobesity and antihyperlipidemic effects from Grifola frondosa, and a method for preparing same
A glycoprotein extracted from the fruiting body of Grifola frondosa is demonstrated to have antidiabetic, antihypertensive, antiobesity and antihyperlipidemic effects, and has great potential as...
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7208585 |
Protein purification
The present invention relates to a method of purifying a protein of interest from its fusion analog, comprising obtaining a protein solution comprising a protein of interest and its fusion analog;...
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7202211 |
Methods of preventing or treating brain ischemia or brain injury
The present invention relates to use of Narp inhibitor in order to promote or enhance recovery from ischemic events, particularly focal ischemia of the central nervous system, as well as for...
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7195923 |
Ratiometric determination of glycated protein
The present invention provides methods for determining a ratio of an amount of a glycated form of a protein to a total amount of the protein in a sample containing the glycated protein, the...
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7193066 |
Preparation of highly pure toxin fragments
Toxin derivatives are prepared by proteolytic treatment of holotoxin, and their toxicity is reduced by contacting the preparation with a ligand, which can be a metal or an antibody or another...
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7189324 |
High-affinity, low molecular-mass displacers for ion-exchange chromotography
A method for separating one or more components of a biomolecule mixture by means of an ion exchange chromatographic system operated in the displacement mode includes sequentially perfusing the...
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7186811 |
Osteogenic device and a method for preparing the device
The present invention is related to an osteogenic device and its preparation. Said device comprises a bone morphogenetic protein (BMP), preferably a modified BMP complex obtainable by a...
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7179592 |
Size-exclusion-based extraction of affinity ligands and active compounds from natural samples
The invention encompasses an improved, rapid, size-exclusive method for screening for small molecular weight ligands that bind specifically to a protein target, using size-exclusion separation,...
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7136759 |
Method for enhanced accuracy in predicting peptides using liquid separations or chromatography
A method for predicting the elution time of a peptide in chromatographic and electrophoretic separations by first providing a data set of known elution times of known peptides, then creating a...
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7122344 |
Methods for the production of purified recombinant human uteroglobin for the treatment of inflammatory and fibrotic conditions
The present invention relates generally to the production of recombinant human uteroglobin (rhUG) for use as a therapeutic in the treatment of inflammation and fibrotic diseases. More particularly,...
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7119166 |
Universal procedure for refolding recombinant proteins
A universal folding method that has been demonstrated to be effective in refolding a variety of very different proteins expressed in bacteria as inclusion bodies has been developed. Representative...
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7098026 |
Human desert hedgehog protein
Disclosed are a novel hedgehog protein, i.e., a Desert hedgehog protein of human origin including mature and precursor forms, a DNA encoding the protein, a monoclonal antibody recognizing the...
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7087719 |
Method for the crystallization of human serum albumin
The present invention relates to the purification and production of human albumin from various sources through crystallization and repeated crystallization. Basic features of the invented process...
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7071313 |
Methods of purifying authentic IGF from yeast hosts
Methods for purifying authentic, properly folded IGF polypeptides from yeast transformants are disclosed. The methods include a refolding step and provide for high yields of authentic IGF from a...
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7060460 |
Method for reconstituting a recombinant protein to its biologically active form
In a method for reconstituting a recombinant protein from a denatured state to its active form, a feed solution containing the recombinant protein in its denatured and/or in biologically inactive...
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7034128 |
Method for recovering proteins from the interstitial fluid of plant tissues
A method for extracting proteins from the intercellular space of plants is provided. The method is applicable to the large scale isolation of many active proteins of interest synthesized by plant...
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7022822 |
Highly purified gonadotropin compositions and process for preparing them
Purification process of humanPurification process of human urinary gonadotropins of high biological activity and chemical purity absolutely free of foreign contaminating materials derived from the...
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6998470 |
Process for large-scale isolation and purification of hypothalamic inhibitory factor
The present invention relates to a method of isolating and/or purifying hypothalamic inhibitory factor (HIF) from a sample (e.g., tissue fluid) containing HIF. The present invention provides for...
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6967239 |
Method of filtering viruses from a factor VIII solution
Method for preparing a factor VIII solution that is essentially free of viruses and essentially devoid of vWF (von Willebrand factor) and factor VIII-vWF complexes by (a) obtaining a starting...
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6953844 |
Isolation of neurotrophins from a mixture containing neurotrophin variants using hydrophobic interaction chromatography
Methods are provided for large scale purification of neurotrophins, including mature NGF, suitable for clinical use. The methods provide means to separate neurotrophins from various less desirable...
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6951734 |
Methods for producing proteins by using cell-free protein synthesis systems
A method for producing a protein suitable for X-ray crystallographic analysis, in a cell-free protein synthesis system comprising a cell-free extract, a nucleic acid coding for said protein, and...
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6946075 |
Purification of biological substances
A process and apparatus for purifying one or more target substances from a source liquid, employing one or more cross-flow filter elements, and one or more types of chromatography resins, in...
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6924267 |
Methods and active substances for protecting organs
The present invention comprises a method of protecting organs or tissue susceptible to reperfusion-induced dysfunction after ischemia. The method comprises parenterally administering to a patient a...
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6908740 |
Methods and apparatus for gel-free qualitative and quantitative proteome analysis, and uses therefore
Methods and apparatus for qualitative and quantitative proteome analysis are provided. The methods and apparatus allow for the isolation of a subset of peptides out of complex mixtures of peptides....
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6908985 |
HspBP polypeptides and peptide fragments that bind Hsp 70
Human heat-shock protein-binding proteins (HspBP-1 and HspBP-2) and fragments thereof are disclosed with the polynucleotides which identify and encode them. Genetically engineered expression...
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