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5861491 |
Isolation of lactoferrin from milk
The invention provides methods for purification of human lactoferrin from milk, especially milk of nonhuman species, and for separation of human lactoferrin from undesired macromolecular species...
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5858368 |
Vaccine comprising a baculovirus produced influenza hemagglutinin protein fused to a second protein
A method of preparing a recombinant influenza vaccine using DNA technology is provided. The resulting vaccine is a multivalent, preferably trivalent, influenza vaccine based on a mixture of...
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5851400 |
Method for eliminating the displacer in displacement chromatography of proteins
The present invention provides a method for eliminating the use of a displacer in displacement chromatography of proteins. Elimination of displacer is accomplished by producing an appropriate...
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5851554 |
Purified cardiac troponin I
A method is provided for isolating substantially intact cardiac troponin I from cardiac tissue comprising extracting the, troponin I and purifying it in the presence of an effective amount of a...
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5851907 |
Method for removal of binding proteins from ligands
The present invention provides methods for separating ligands from binding proteins. The methods include acidic separation and size separation. The methods of the present invention are particularly...
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5849886 |
Extraction of myelin basic protein
A process for extraction of myelin basic protein from myelin containing tissue, such as central nervous system tissue, which process comprises the following steps: extraction of the myelin basic...
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5849713 |
Chemotactic factors for human spermatozoa and their use in human assisted fertilization
The invention relates to chemotactic factors for human spermatozoa that are purifiable from human follicular fluid. The factors are of peptidic and hydrophilic nature and have, one, a molecular...
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5849883 |
Method for purifying granulocyte colony stimulating factor
Processes for isolating and purifying granulocyte colony stimulating factor (G-CSF) from a G-CSF producing microorganism are disclosed. The simplified processes include steps of lysing the...
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5847084 |
Process for obtaining platelet factor-4
The present invention, using a readily available sulfated chitin as an adsorbent, can permit platelet factor-4 to be recovered through specific adsorption from a solution containing the same...
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5846929 |
Purification of type G botulinum neurotoxin and pharmaceutical compositions thereof
The isolation and purification of type G botulinum neurotoxin and complexes thereof is disclosed. Compositions containing the type G neurotoxin and the preparation of a type G toxoid are also...
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5840700 |
Methods of producing transfer factor
The invention relates to substantially pure transfer factor with a specific activity of at least 5000 units per absorbance unit at 214 nm. The present invention also relates to a process for...
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5833861 |
Perfusive chromatography
Disclosed are chromatography methods and matrix geometries which permit high resolution, high productivity separation of mixtures of solutes, particularly biological materials. The method involves...
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5834427 |
Casein phosphopeptide, casein containing same and process for the preparation thereof
The present invention relates to a purified casein phosphopeptide(CPP) having a novel amino acid sequence and a purified casein including same wherein the 25th Arg from N-terminal in a conventional...
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5831022 |
Purification of recombinant human IL-1α
A process for the production of essentially homogeneous soluble, stable, endotoxin free human recombinant interleukin-1α of enhanced specific activity is described. The process involves breaking...
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5831026 |
Process for purifying factor VIII
A process for reducing degradation of recombinant coagulation factor VIII caused by metal-dependent proteases requiring Zn 2 + for activity or containing Zn 2 + as an integral part of their...
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5821336 |
Cytokine which mediates inflammation
The invention concerns polypeptides with an apparent molecular weight of around 160 kD which are mediators or precursors for mediators of inflammation, derivatives thereof such as mutants and...
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5814504 |
Protein involved in regenerating firefly luciferin
A purified protein having a molecular weight of 40 kD by SDS-PAGE that produces firefly luciferin when combined with D-cysteine and firefly oxyluciferin and isolated from firefly species is...
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5808010 |
Method for derivatization of cellulosic stationary phase
A solid sorbent material comprising cellulose which has been modified by hydrolysis with a cellulase enzyme for a duration sufficient to increase the protein adsorption capacity of the solid...
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5807553 |
Immonogenic oligosaccharide compositions
The invention provides immunogenic oligosaccharide compositions and methods of making and using them. In particular, the compositions comprise oligosaccharides covalently coupled to carrier...
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5808008 |
Method of producing human pluripotent hematopoietic colony stimulating factor
Highly purified Pluripotent hematopoietic colony-stimulating factor (pluripotent CSF), a glycoprotein (MW 19,600) constitutively produced by human tumor cells has been highly purified from low...
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5783396 |
Method of detecting rupture of the amniotic membranes in pregnant mammals
The present invention relates to the method of detecting rupture of the amniotic membranes in pregnant mammals including humans using an immunoassay and reagents useful in such an assay. The method...
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5780247 |
Process for separating and measuring trace components
Two or more analytes having the same action, or having different actions in spite of their similar structures, or two or more analytes having the same action and the same detectable chemical...
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5776704 |
Method of detecting angiogenic protein
The present invention is directed to methods of detecting angiostatin protein which is an endothelial cell inhibitor. The angiostatin protein is a protein isolated from blood or urine that is...
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5770698 |
Process for the purification of aqueous extracts containing allergenically active proteins, extracts obtainable according to this process as well as their use
The invention concerns the removal of various allergologically irrelevant low-molecular weight components from the usual aqueous extracts of allergenically active proteins of plant pollens....
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5767240 |
Activity-dependent neurotrophic factor
The present invention relates to a purified non-neuronal activity-dependent neurotrophic factor (ADNF) protein that increase the survival of spinal cord neuron cells, cerebral cortical cells and...
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5763583 |
Process for producing solubilized protein
A process for the production of a solubilized protein is disclosed, which is obtained by reducing disulfide bonds in a disulfide bond-containing water-insoluble protein material into mercapto...
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5760179 |
Purification of soluble laminin 5
A method for purifying soluble laminin 5 from conditioned cell culture medium. A nonionic or anionic detergent is added to conditioned medium to a final concentration of between 0.1% and 1.0%. The...
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5760177 |
Lipopolysaccharide binding protein and process for producing the same
The invention provides a lipopolysaccharide (LPS) binding protein isolated from horseshoe crab. The LPS binding protein is isolated by (i) extracting the hemocyte membrane fraction of horseshoe...
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5756717 |
Protein imaging
Disclosed are specifically designed binding, "protein imaged" sorbents which reversibly bind with high specificity and affinity a preselected macromolecule, specifically a protein. The sorbents...
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5756687 |
Isolation of components of interest from milk
Methods of isolating components of interest from a milk sample are described. The methods include a step wherein the solubility of at least a portion of the total milk protein is stabilized in such...
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5753123 |
Method for purifying thrombomodulin
The present invention permits human urinary thrombomodulin to be purified by a simple and practical procedure, while it enables even a starting material with a lowered content of thrombomodulin to...
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5750377 |
Process for preparing mammalian T cell growth factor P40
The present invention relates generally to a T cell growth factor. More particularly, the present invention relates to a T cell growth factor which comprises a glycoprotein which supports...
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5750650 |
Fibrinolytic protein and production method thereof
A novel peptide having molecular weight of 31,000 (SDS-PAGE) is obtained from aqueous extract of Natto or the culture of Bacillus natto by purification procedures including alcohol fractionation...
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5747653 |
Method of producing of an antimeningococcic hyperimmune gamma globulin and gamma globulin produced by method
A vaccine effective against infection caused by group B Nesseria meningitidis microorganism is provided which comprises a purified protein antigenic complex weighing from 65 to 95 kDa, vesicles,...
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5734024 |
Method for determining the biological activity of recombinant human growth hormone
A method is provided for determination of the biological activity, purity and/or homogeneity of recombinant human growth hormone ("rhGH") using an analytical chemistry test. The method is based on...
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5734025 |
Adsorbent for cellular fibronectin, a method for fractional purification of fibronectin and a method of hemocatharisis
This invention provides a selective cellular fibronectin (cFN) adsorbent utilizing a nonwoven cellulose sulfate fabric and a method for fractional purification of FN which-comprises contacting an...
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5728804 |
Use of cyclodextrins for protein renaturation
A method for renaturing a denatured protein is provided comprising contacting a solution or suspension of said denatured protein in a detergent-free liquid medium with an amount of a cyclodextrin...
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5728553 |
High purity albumin and method of producing
A process for the preparation of albumin which has extremely low levels of or is essentially free of colorants, metal ions, human proteins, fragments of albumin, polymers or aggregates of albumin,...
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5717070 |
Filamentous fungus proteins for binding and transporting lipids, method for preparing them and their applications
The present invention is directed to a family of phospholipid binding and transporting proteins, a method for preparing same from fungi, and their use in cosmeticology, the agri-foodstuffs industry...
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5700914 |
Purification of Factor VII
The present invention describes a method for controlled activation and degradation of FVII during purification whereby a solution of Factor VII is subjected to a number of chromatographic...
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5698104 |
Purification process for hirudin using affinity chromatography
Disclosed herein is a process for purifying hirudin from a solution containing hirudin and other substances, characterized in that the process comprises a step of subjecting the solution to a metal...
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5696238 |
Purified GP120 composition retaining natural conformation
A method for purifying recombinant HIV gp120 so as to provide a glycopeptide having protein/protein binding properties substantially identical to natural viral HIV gp120, which comprises...
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5686577 |
T cell factors influencing B cell development
The present invention relates to an isolated protein or polypeptide capable of production by T cells and capable of ultimately activating production of B cells. The present invention further...
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5683916 |
Membrane affinity apparatus and purification methods related thereto
A method and apparatus for carrying out affinity purification of a ligate. The method comprising, (a) providing a ligate containing liquid to a first side of at least one porous hollow fiber...
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5681936 |
Method of purification of recombinant human interleukin-5
Disclosed is a method for purifying Human interleukin-5 (IL-5) a single chromatographic step. After removing cells from a cell culture expressing human interleukin-5, IL-5 is purified by first...
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5679776 |
Process for preparing a concentrate of blood coagulation factor VIII-von willebrand factor complex from total plasma
The invention relates to a process for preparing a concentrate of Factor VIII-von Willebrand factor complex having high specific activity from total (non-cryoprecipitated) plasma. The process...
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5679775 |
Process and device for the simultaneous extracorporeal elimination of tumour necrosis factor and bacterial lipopolysaccharides from whole blood and/or blood plasma
In order to remove tumor necrosis factor α (TNFα) or/and bacterial lipopolysaccharides (LPS, endotoxin) extracorporeally from whole blood or/and blood plasma in an extracorporeal perfusion...
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5679260 |
Process for simultaneously removing tumour necrosis factor α and bacterial lipopolysaccharides from an aqueous liquid
Disclosed is a process to remove tumour necrosis factor α (TNFα) or/and bacterial lipopolysaccharides (LPS) from an aqueous liquid, in particular blood, blood plasma or serum, in an...
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5679281 |
Gelled material compositions with modified halopolymer
Gelled material compositions for use as adsorbents and ion exchangers. The composition including a specific extractant, an organic solvent and a halopolymer modified by substitution with a radical...
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5679539 |
Oxidized polyethylene or polypropylene particulate supports
Polyolefin particles are chemically modified by oxidation to provide a large surface area and high loading. The particles result in low back pressure in column systems, and are economical to...
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