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4801532 |
Immunological methods for diagnosing neurocysticercosis
Immunological methods are disclosed for diagnosing active human neurocysticercosis, including a serum test and a cerebrospinal fluid test. The serum test involves detecting an antibody in serum...
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4801691 |
Method for removing sodium dodecyl sulfate from sodium dodecyl sulfate solubilized protein solutions
Guanidine hydrochloride (GCl) is used to remove excess sodium dodecyl sulfate (SDS) from SDS-solubilized protein solutions, and particularly from SDS-solubilized inclusion body solutions, GCl is...
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4801686 |
Purification of recombinant interleukin-1
A process is provided for purifying recombinant IL-1 from microbial cells, comprising suspending the cells in an aqueous buffered medium having a pH from about 1 to about 5; disrupting the cells to...
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4797474 |
Solubilization of protein aggregates
A method for the recovery of proteins which method includes providing a source of protein in an insoluble form, a source of at least one cationic surfactant; treating the insoluble protein with the...
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4795804 |
Bone morphogenetic agents
The production and isolation of bone morphogenetic peptide agents displaying the osteoinductive and immunoreactive activity of bone morphogenetic protein (BMP) and deriving from natural, synthetic...
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4794171 |
Calcium-phosphate type hydroxyapatite and process for producing same
A calcium-phosphate type hydroxyapatite which belongs to a series of hexagonal systems has unit lattice constants of 9.58±0.08 Å for the a axis and 7.00±0.05 Å for the c axis. Its Ca/P ratio...
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4794077 |
Detection of human cancer cells with anitbodies to human cancer nucleolar antigen p145
Specific common nucleolar antigens are found in a broad range of human malignant tumor specimens and have been isolated, extracted and purifed. Monoclonal antibodies specific to one of these...
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4789732 |
Bone morphogenetic protein composition
BMP compositions including the human factor and bovine factor thereof, the process of isolating BMP compositions and factors, and the use of such factors and compositions to induce bone formation...
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4788056 |
Combined vaccine for viral and bacterial infections
Vaccines containing both E.coli and herpes virus were found not to provide adequate protection against subsequent herpes virus infections. The present invention is concerned with a E.coli herpes...
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4786501 |
Cylindrical implants for the controlled release of growth hormones
This invention relates to a method for purifying and concentrating biologically active growth hormone to produce growth hormone in a form suitable for incorporation into a controlled release device...
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4784589 |
Purification of pertussis antigens
A process is provided for the production of lymphocytosis promoting factor (LPF), filamentous haemagglutinin (FHA) and at least one fimbrial agglutinogen from a liquid culture of Bordetella...
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4782027 |
Protein detection by negative staining
A polypeptide is located in a gel matrix by treating the matrix with a negative staining agent (i.e. an agent that stains the gel more intensely in regions devoid of polypeptides, so that gel areas...
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4778846 |
Affinity chromatography sorbent
A novel process for the isolation and purification of vancomycin class antibiotics which utilized affinity chromatography by the formation of a sorption complex between the antibiotic and an...
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4777241 |
Proteinaceous substance showing antitumorous action and its preparing method
A proteinaceous substance having the following biochemical characteristics: (A) a strong cytolytic activity against mouse tumor cells L-929, but not cytotoxic activity for normal cells such as...
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4777242 |
Purification of recombinant tumor necrosis factor
A method for purifying recombinant tumor necrosis factor from cultures of microorganisms transformed with vectors that code for the production of tumor necrosis factor is disclosed. A sequence of...
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4774323 |
Purification of von Willebrand Factor solutions using gel permeation chromatography
A method of preparing von Willebrand Factor by disassociating it from a chaotropic agent in solution therewith and preferably treating the same under controlled temperature either in liquid or...
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4774086 |
Process for the purification, solubilization and/or detoxification of protein antigens of bacteria of the Bordetella genus using a carbonate buffer and an acellular anti-whooping cough vaccine
A method for the purification, solubilization and/or detoxification of protein antigens of bacteria of the Bordetella genus involves the use of a carbonate buffer having a pH of 8.3 to 11.6. An...
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4772397 |
Process for removing nucleic acids and purine bases from gelatin
The invention relates to a process for removing nucleic acids and purine bases from gelatine by (a) adding cyclodextrin bead polymer having a particle size of 20 to 600 μ, a cyclodextrin content...
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4771125 |
Human soluble immune response suppressor
Human soluble immune response suppressor (SIRS) having a molecular weight of about 10,000 to 15,000, an isoelectric point of about 7 and a defined amino acid composition distinctly different from...
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4770781 |
Purification of human interleukin-1 species
Human interleukin-1 (IL-1) charged species (pI 6.8, 6.0, 5.4 and 5.2) are separated and purified by a rapid and efficient two or three stage chromatographic process. Interleukin-1 species present...
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4766224 |
Purification and activation of proteins from insoluble inclusion bodies
Purification and solubilization of proteins produced in transformant microorganisms as insoluble, biologically inactive inclusion bodies is effected by solubilizing the inclusion bodies in SDS;...
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4765903 |
Purification of monomeric interferon
Fast moving monomers of alpha-2 interferon ("IFN-alpha-2") are purified from slow moving monomers and oligomers of interferon and from noninterferon proteins using a combination of immunoaffinity...
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4766205 |
Method for isolation of recombinant polypeptides in biologically active forms
Disclosed are improved methods for orienting polypeptide molecules containing multiple disulfide bonds into their native conformation through (1) treating the polypeptide with (a) a denaturing...
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4762617 |
Size-exclusion chromatography system for macromolecular interaction analysis
A low pressure, microcomputer controlled system employing high performance liquid chromatography (HPLC) allows for precise analysis of the interaction of two reversibly associating macromolecules...
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4758657 |
Method of purifying Factor VIII:C
Disclosed is a process for purifying Factor VIII:C in high yield and potency from source material containing Factor VIII:C, Factor VIII:R and other plasma proteins and factors comprising the steps...
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4753983 |
Polymeric matrix for affinity chromatography and immobilization of ligands
A matrix useful for immobilizing organic ligands, such as biologically active materials, is prepared by reacting a hydroxyl group containing polymer with polyethyleneimine.
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4746647 |
Purifying protein or peptide recombinant DNA products by electroseparation
A method of purifying a contaminated product (protein/peptide) produced by rDNA technique, from hydrophobic contaminants which are charged and originate from the microbial cloning host employed,...
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4740306 |
Chromatographic column
A chromatographic column and process for isolating or purifying steroid hormone or cell membrane receptors using the column are provided in which the column contains at least three resin layers...
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4738926 |
Method for purification of HBs antigen
Industrially useful method for the purification of HBs antigen produced by a recombinant organism being capable of producing HBs antigen which is prepared by means of DNA recombination technique,...
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4736020 |
Purification of hTNF
The purification of hTNF by ion exchange chromatography is described.
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4736019 |
Process for the separation of antifactor VIII:C antibodies, more particularly usable for the purification of the blood plasma of a type a hemophiliac
The process for the separation of antiVIII:C antibodies present in a liquid consists of contacting said liquid with a solid support constituted by a polymer or a copolymer having in its chain...
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4732683 |
Purification method for alpha interferon
A process for the purification of human interferon alpha involving a three-step chromatography sequence under highly dissociating conditions is disclosed. The purification method involves a first...
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4730036 |
Purifications of B-cell inducing factor (BIF) and B-cell growth factor (BGF)
Highly purified T cell replacing factor (TRF or BIF) essentially free of IL-2 and Interferon activities is obtained in the invention. BIF is useful for treatment of immunoregulatory disorders...
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4725673 |
Plasma fraction purification using silica resin bound to a ligand
There is provided, in accordance with practice of this invention, a process for separating Factor IX and/or Factor X from an impure protein fraction containing protein in addition to Factors IX and...
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4722999 |
Cyclophilin
Homogeneous cyclophilin, a soluble binding protein, having a specific binding activity of above 50 ug cyclosporin A per mg protein and a molecular weight of about 17,600 daltons, reversibly binds...
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4723000 |
Human interferon gamma and interleukin-2
A process for producing unique human interferon gamma and interleukin-2 by chromatographic fractionation utilizing ion exchange and metal chelate chromatography. The interferon gamma and...
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4721573 |
Use of sulfonic derivatives of acylated polyethyleneimine bonded phase silica products
Sulfonic derivatives of N-acylated covalently bound, non-crosslinked polyethyleneimine bonded phase silicas of the formula: ##STR1## wherein is the backbone of a silica gel or glass, n is an...
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4716219 |
Adsorbent for protein purification
Adsorbents, which are suitable for the affinity chromatography of proteins, especially of interferons, and which consist of an electroneutral carrier matrix, --O--CH 2 --CH(OH)--CH 2 --NH- groups...
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4710566 |
Purification of the messenger RNA cap-binding protein
The synthesis of a new affinity medium, the p-aminophenyl-γ-ester of 7-methylguanosine-5'-triphosphate coupled to Sepharose, for use in affinity chromatography is claimed. An improved method in...
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4707542 |
Immunogenic HbsAg derived from transformed yeast
The surface antigen protein of human Hepatitis B virus is synthesized in Saccharomyces cerevisiae as a 23,000-26,000 dalton polypeptide, essentially free of intermolecular disulfide bonds. This...
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4694074 |
Process for the purification of HBsAg
A process for the purification of HBsAg is disclosed, which comprises adsorbing specifically on a carrier, in the presence of an inorganic salt in an amount of 5 to 25 W/V %, an HBsAg obtained by...
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4687820 |
Modified polypeptide supports
A modified polypeptide material comprising an insoluble polypeptide carrier and synthetic polymer, the synthetic polymer made from (a) a polymerizable compound which has a chemical group capable of...
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4681761 |
Major iron-regulated protein of Neisseria gonorrhoeae and its use as vaccine
The major iron-regulated protein of a pathogenic species of the genus Neisseria, the gonococcal congener of which (MIRP) protein has a molecular weight of approximately 37,000 daltons and...
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4680120 |
Bonded phase of silica and carboalkoxyalkyl silanes for solid phase extraction
The reaction product of silica gel or controlled pore glass and carboalkoxyalkyl silanes are suitable for use as packing in solid phase extraction columns for cleanup of urine samples for analysis...
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4680121 |
Bonded phase of silica for solid phase extraction
A bonded phase silica product of the formula: ##STR1## in which ##STR2## is the backbone of a silica gel or controlled pore glass, X is selected from --O--, --S--, ##STR3## each R and R 1 are each...
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4677197 |
Purification method for tumor necrosis factor
An improved method for purifying TNF, especially recombinantly produced TNF in bacteria, is disclosed. The purification employs a hydrophobic support in a chromatographic column which is then...
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4675383 |
Purification of T-cell growth factor
Substantially homogenous T-cell growth factor is isolated. A multiple-step purification procedure of T-cell growth factor-containing biological sample includes at least one reverse-phase HPLC...
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4675384 |
Fractionation/purification of plasma by ion exchange chromatography
The plasma proteins contained in a plasma solution thereof are chromatographically fractioned, e.g., to obtain a high purity therapeutic grade albumin product, by successively contacting said...
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4667024 |
Process for the preparation of purified vancomycin class antibiotics
A novel process for the isolation and purification of vancomycin class antibiotics which utilized affinity chromatography by the formation of a sorption complex between the antibiotic and an...
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4667018 |
Process for the purification of proteins using acidic polysaccharide gels
A process for the purification of proteins from a fluid medium wherein said proteins have an isoelectric pH higher than the pH of said fluid medium, said process comprising passing the liquid...
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