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4985542 |
Kit for the determination and diagnosis of non-goodpasture glomerulonephritis
Purified glomerular proteoglycans are used as a basis for a diagnostic test for glomerulonephritis in humans involving an immunological reaction between the purified proteoglycans and patient area....
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4985541 |
Novel cytotoxic protein
Purified cytotoxic proteins for use within therapeutic compositions are disclosed. The proteins inhibit protein synthesis in vitro, exhibit abortifacient activity in mice, and contain proline...
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4985544 |
Process for renaturing fish growth hormone
Reactivation of cysteine-containing protein in a process, in which a reduced and denatured cysteine-containing protein such as salmon growth hormone I or eel growth hormone I can be efficiently...
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4985144 |
Affinity chromatography material for antigens of the bacteria of the Bordetella genus
A chromatography material comprises a solid support on which is fixed, as a ligand, desialyled gycolprotein selected from desialyled fetuin and desialyled haptoglobin. This material is used to...
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4981951 |
Lectin affinity chromatography of factor VIII
A method of purifying a recombinant protein from a solution, such as tissue culture fluid, containing gylcoproteins. The affinity of lectins for specific glycoproteins is assessed and used to...
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4981952 |
Method for the purification of vitamin K-dependent proteins
The recovery of vitamin K-dependent proteins produced by transformed microorganisms can be effected from the cell culture medium utilizing the changes in the protein which occur in the presence of...
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4977248 |
Process for the production of a protein
A method for the renaturation of unfolded proteins comprises reversibly immobilizing the denatured protein on a solid phase and inducing folding of the immobilized protein by progressively reducing...
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4977244 |
Uromodulin and a process of purifying it
This invention relates to processes for producing uromodulin, a glycoprotein having a molecular weight of 85 kilo daltons. This glycoprotein, which is isolated from crude urine, as well as its...
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4976865 |
Method for the separation of biological macromolecules by chromatography
A method for allowing biological macromolecules contained in a solution to be separated by selective absorption comprising supplying with a solution each stage (3, 4) of a column containing a...
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4970152 |
Reagents for determining peptidoglycan and β-1,3-glucan
A reagent comprising a fraction obtained from plasma of an insect such as silkworm larvae and capable of reacting specifically with β-1,3-glucan or peptidoglycan can be used for determining...
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4965344 |
Process for obtaining active proteins from a biologically inactive form
A process for the preparation of a spatial form, which has biological activity, of a protein from a biologically inactive spatial form is described and comprises the protein being dissolved with...
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4963657 |
Monoclonal antibodies to the light chain region of human factor XII and methods of preparing and using the same
Novel cell lines produce monoclonal antibody to the light chain region of human factor XII. Three such cell lines, ATCC #HB-9703 through ATCC #HB-9704, are formed by fusing SP2/0-Ag14 myeloma cells...
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4955363 |
Process of recovering lactose from whey
A method of recovering lactose from milk whey or cheese whey with a high yield, wherein the whey is concentrated, part of the lactose is crystallized, and the crystals are separated and dried; the...
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4946943 |
Purification of ribotoxins and their conjugates
The invention herein is directed to methods using Procion dyes to perform separations of interest in manipulating the NAD + -independent ribotoxins. The methods are useful for preparing...
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4946944 |
Process for the selective extraction of metalloproteins from whey by adsorption and elution
Process for the selective extraction of metalloproteins from whey, by adsorption on a porous inorganic support in the form of particles, followed by elution of the metalloproteins thus absorbed by...
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4945157 |
Novel Extraction procedure for protein G
Protein G from wild-type group G or group C streptococci is obtained by an extracting process using cyanogen bromide. The process gives yields ranging up to 60-fold better than the best prior art...
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4942136 |
Method for production of fluorescence-labeled Fab'
A fluorescence-labeled Fab' is produced by causing a fluorescent substance to react with a Fab', dialyzing the resultant reaction solution, allowing the dialyzate to stand at rest thereby effecting...
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4937324 |
Chromatographic purification of human proteins having anticoagulant and anti-inflammatory activity
Proteins having therapeutic potential as both anticoagulants and as anti-inflammatory agents are disclosed. The present invention also discloses the use of lipocortins in reducing blood coagulation...
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4933433 |
Recombinant interleukin-2 composition and process for making it
There are disclosed a recombinant interleukin-2 composition consisting essentially of water, recombinant interleukin-2, and optionally a polyol, said composition having a specific activity of at...
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4931543 |
Process for recovering microbially produced interleukin-2
A process for recovering substantially pure rIL-2 from transformed microorganisms in which the cells are disrupted, impure insoluble rIL-2 is separated from the bulk of the cellular components, the...
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4929700 |
Production of purified, biologically active, bacterially produced recombinant human CSF-1
A process for recovering dimeric, biologically active CSF-1 from bacterially expressed recombinant CSF1 genes is described. The process comprises recovery of the solubilized monomeric form,...
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4927755 |
Process for preparing polynucleotides
This invention relates to a process of preparation of nucleotide polymers wherein a lysate of a bacterial culture is passed successively through three columns (ion exchange resin, hydrophobic resin...
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4925574 |
Purification of hemoglobin and modified hemoglobin by affinity chromatography
The invention disclosed relates to a method for the purification of hemoglobin by the technique of affinity chromatography. Contrary to current belief, the binding of oxygen and selected polyanions...
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4923978 |
Process for purifying nucleic acids
The process for separating the proteinaceous materials from nucleic acids involves contacting a solution containing the proteinaceous materials and nucleic acids with a solid phase extraction...
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4920196 |
Human lymphotoxin
Biologically active lymphotoxin polypeptide species, and derivatives, fragments, aggregates and pharmaceutically acceptable salts are provided. The lymphotoxins are substantially homogenous, and...
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4915945 |
Process for the preparation of the C1 inactivator
The invention relates to a process for the preparation of C1 inactivator, which, if appropriate, is hepatitis-free and, if appropriate, can be lyophilized, and its use as a medicament.
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4916055 |
Detection of human cancer with a monoclonal antibody specific for antigen gp650
A specific high molecular weight antigen (gp650) is detected in the sera of cancer patients with gastrointestinal cancer, cancer of the liver, breast cancer, cancer of the lung, cancer of the...
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4909941 |
High performance liquid chromatography mobile phase
There is described a mobile phase for use in the purification of proteins using reversed phase HPLC on a preparative scale. The mobile phase is an aqueous solution containing 0.005 to 1M of a...
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4908434 |
Process for preparing purified interleukin-2
Interleukin 2 (IL 2; T-cell growth factor), produced with and without costimulation by Burkitt's lymphoma line Daudi, is highly purified approximately over 37,000-fold to apparent homogeneity from...
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4902782 |
Isolation of fibroblast growth factor
Basic Fibroblast Growth Factor (FGF) is substantially purified by the employment of affinity chromatography using heparin-linked support material. Described is a simplified three step procedure for...
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4902615 |
Detection of human cancer cells with antibodies to human cancer nucleolar antigen p120
Tumor nucleoli were treated with polyclonal antisera to normal human tissue nucleoli to block determinants common to tumor and normal tissue nucleoli. Immunization of mice with these...
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4897197 |
Using liquid chromatography packing materials
Packing material for use in liquid chromatographic analysis are prepared by contacting a porous support, such as porous silica, with a ketal silane to form ketal blocked diol groups on the surfaces...
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4895807 |
Membrane channel protein and related therapeutic compounds
A channel protein has a molecular weight of approximately 280 kD and is capable of affecting K + and Cl - membrane transport. Furosemide and quinine derivatives, and polysaccharide or...
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4894439 |
N-terminal derivatives of tumor necrosis factor purified by microporous PTFE membranes
A process is disclosed for the purification of recombinantly produced biologically active proteins in which a solution containing a mixture of materials, including the biologically active protein,...
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4894468 |
Substituted silica
The invention relates to modified silica, substituted with a variety of substituents. There is provided a product termed primary hydroxyl silica where there are attached to the silica substituents...
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4874520 |
Chromatographic process
A new class of chromatographic columns for reverse phase and ion exchange chromatography based on organotitanate coupling is disclosed along with separation processes using such media. The...
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4873316 |
Isolation of exogenous recombinant proteins from the milk of transgenic mammals
This invention relates to the production of recombinant proteins in mammals' milk. Particularly, this invention relates to an expression system comprising the mammal's casein promoter which when...
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4873317 |
Method of separating or purifying proteins and other biopolymers
A method for the separation or purification of biopolymers comprises adsorbing the biopolymer on the surface of liquid oil droplets; and separating the adsorbed biopolymer from the oil droplets....
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4870053 |
Novel compositions and processes
A novel process for the preparation of water-soluble acyl glycoprotein extracted from Klebsiella Pneumoniae containing 30 to 45% by weight of proteins, 30 to 40% by weight of neutral saccharides,...
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4865990 |
Protein adsorbent including a colored compound containing a quaternary ammonium especially amidinium or guanidimium cationic group and a cellulose reactive group
A colored compound containing a cationic group and a cellulose reactive group, especially a compound of the formula: A--Y--B I Y'--B ...
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4863732 |
Injectable composition for inductive bone repair
Aqueous suspensions of fibrillar atelopeptide collagen and osteogenic factor are effective injectable preparations for the repair of bone defects.
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4855054 |
Using liquid chromatography dual zone packing materials
Dual zone reverse phase packing materials for use in liquid chromatographic blood serum analysis are prepared by contacting a porous support, such as porous silica, with a fluorocarbon silane, such...
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4855408 |
Antigens for diagnosing neurocysticercosis
Two substantially purified larval T. solium antigens found circulating in the cerebrospinal fluid of patients infected with T. solium, having molecular weights of 190 KD and 230 KD, are disclosed....
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4845080 |
Human calcitonin peptide with salmon calcitonin-like characteristics
The invention relates to a substance from the calcitonin group, which substance can be isolated from the human body or can be obtained in a different manner, but clearly differs from the known...
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4841024 |
Purification of antibodies
I(g)G3 antibody is purified by affinity chromatography and collection of released antibody at a pH of 9.0 to 9.6. The purification is effected in a column containing both an affinity matrix and a...
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4832849 |
Extraction and purification of an anticoagulant principle from the south american leech, haementeria ghilianii
Applicant has isolated a Factor X a inhibiting substance from the salivary gland extract of the leech H.ghilianii. The extract is subjected to separation using both DEAE-cellulose and...
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4830969 |
Process for the rapid and simple isolation of nucleic acids
A process for the separation from other cellular materials of heat agglomeration resistant water soluble nitrogen containing organic compounds such as plasmids, RNA's, mitochondrial DNA's, viral...
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4831118 |
Flouroplastic immunoaffinity columns for purification of blood proteins
The present invention is a protein purification column comprising an organic substrate matrix having low reactivity to proteins, said matrix being capable of maintaining monoclonal antibodies...
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4820348 |
Process for the specific separation of lactose from milk
The invention relates to a process for accomplishing specific chromatographic separation of lactose from milk. Milk is treated in a column with a cation exchange resin balanced in such a manner...
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4816400 |
Basement membrane collagen degrading enzyme and method of purifying same
Basement membrane collagen degrading enzymes are provided which are useful for the detection of malignant cells with metastatic activity. Means for detecting such cells are also provided.
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