|
Match
|
Document |
Document Title |
|
|
7622561 |
IL-21 production in prokaryotic hosts
The expression vectors and methods using an E. coli expression system for the large scale production of IL-21 are described. The vectors utilize the IL-21 coding sequence with specific changes in...
|
|
|
7601515 |
Process of high purity albumin production
A process is provided for the preparation of albumin from a yeast culture medium which has extremely low levels of or is essentially free of colorants, metal ions, human proteins, host proteins,...
|
|
|
7585955 |
Protein separation from a protein mixture
A process for separating a protein from a sample containing a mixture of proteins is disclosed. The process comprises forming an aqueous combination comprising the sample and an ion exchange...
|
|
|
7560030 |
Method for separation and enrichment of phosphopeptides
The present invention relates to phosphopeptide isolation and enrichment, particularly to a highly selective and specific phosphopeptide enrichment method. The method mentioned in the invention is...
|
|
|
7553938 |
Method of providing a purified, virus safe antibody preparation
A method of preparing a purified, virus inactivated and virus safe antibody preparation from a starting solution comprising antibodies and contaminants, the method comprising the steps of: (a)...
|
|
|
7537931 |
Humanized anti-ERBB2 antibodies and treatment with anti-ERBB2 antibodies
The present application describes humanized anti-ErbB2 antibodies and methods for treating cancer with anti-ErbB2 antibodies, such as humanized anti-ErbB2 antibodies.
|
|
|
7531632 |
Clarification of transgenic milk using depth filtration
Processes and apparati are provided for separating molecules of interest from a mixture by depth filtration (DF). The DF of the invention is useful in the clarification and processing of various...
|
|
|
7531645 |
Protein purification
A method for purifying a polypeptide by ion exchange chromatography is described which involves changing the conductivity and/or pH of buffers in order to resolve a polypeptide of interest from one...
|
|
|
7476726 |
Method of producing and purifying endostatin protein
The present invention provides a method for recombinant production, recovery and purification of endostatin protein. This method may be employed for large scale recovery and purification of...
|
|
|
7473781 |
Agent for capturing substance having anionic substituent
A polymer carrier to which a prescribed zinc complex group is binding directly or through a spacer, having property to bond, under a certain condition, to an anionic substituent (a phosphate group,...
|
|
|
7470779 |
Process for decreasing aggregate levels of pegylated protein
The present invention is directed generally to recombinant methods for making a desired pegylated protein and pooling of same. The method(s) yield a polypeptide product containing reduced levels of...
|
|
|
7459542 |
Separation of albumin from protein samples
The present invention generally relates to methods for separating albumin from samples comprising albumin and other proteins based on the pI of albumin. More particularly, the methods relate to...
|
|
|
7385040 |
Antibody purification
The present invention relates to a method of separating antibodies from contaminants in a solution, which method comprises contacting the solution with a chromatography resin comprised of a support...
|
|
|
7375188 |
Vegetarian protein a preparation and methods thereof
The invention relates to methods of producing Protein A without contamination of the Protein A by animal products. The invention also relates to a vegetarian fermentation media in which ...
|
|
|
7371581 |
Process for the monitoring of contaminant removal during the purification process of a pharmaceutical product produced by a host cell
We describe a process for the monitoring of contaminant removal during the purification process of a pharmaceutical product produced by a host cell, wherein at least two different samples taken...
|
|
|
7365173 |
Method for the production of pure virally inactivated butyrylcholinesterase
The present invention provides a method for purifying butyrylcholinesterase from various biological fluids. Biological fluids include, e.g., blood, blood fractions, plasma, and bioreactor broths,...
|
|
|
7355020 |
Stimulus responsive affinity chromatographic material and separation/purification method
A separation material characterized by supporting, in its surface, a linear or crosslinked stimulus responsive polymer to which a substance A having specific affinity for a target substance and a...
|
|
|
7329409 |
Compositions and methods for treatment of microbial infections
The present invention relates to methods and compositions for treatment of microbial infections and for the enhancement of resistance to infection. The invention comprises administration of an...
|
|
|
7294614 |
Phosphoprotein affinity resins and methods for making and using the same
Phosphorylated protein (i.e., phosphoprotein) affinity resins and methods for making and using the same are provided. The subject resins include a substrate bonded to aspartate-based tetradentate...
|
|
|
7279309 |
Process for manufacture of Nematode-extracted Anticoagulant Protein (NAP)
The present invention provides a process for manufacture of purified Nematode-extracted Anticoagulant Proteins (NAPs), wherein the NAP manufactured by the claimed process method is a NAP drug...
|
|
|
7276590 |
Ion exchange chromatography of proteins and peptides
The present invention relates to an ion exchange chromatography process for purifying a peptide from a mixture containing the peptide and related impurities, and to an industrial method including...
|
|
|
7252973 |
Protein and processes for producing the same
A novel protein and a process of producing the protein is provided. The protein is a glycoprotein having activity of suppressing the differentiation and/or maturation of adipocyte, having a...
|
|
|
7247331 |
Milk protein isolate and method for preparing same
The invention concerns a method for isolating milk proteins from milk or from whey comprising steps which consist in passing the milk or whey over a cation-ex-changing resin, eluting the fraction...
|
|
|
7232893 |
Method of manufacturing a stellate cell death factor
The present invention provides compositions and methods for selectively inhibiting the proliferation of stellate cells, which are important for the development of liver fibrosis upon liver injury....
|
|
|
7229789 |
Methods and compositions for extracting proteins from cells
A process is disclosed for releasing proteins from cells and/or inactivating viruses. In the process, a host cell containing a protein of interest is contacted with a solution of an effective...
|
|
|
7226757 |
Formulation, solubilization, purification, and refolding of tissue factor pathway inhibitor
Compositions are described that are suitable for formulating TFPI. Solubilizers and stabilizers facilitate the preparation of pharmaceutically acceptable compositions of TFPI at various...
|
|
|
7223561 |
Process of high purity albumin production
A process is provided for the preparation of albumin which has extremely low levels of or is essentially free of colorants, metal ions, human proteins, host proteins, fragments of albumin, polymers...
|
|
|
7223848 |
Methods for purifying Fc-containing proteins
The present invention provides a process for dissociating Fc-containing molecules from complexes of Protein A/Fc-containing molecules or mixtures containing Fc-containing molecules and Protein A....
|
|
|
7202211 |
Methods of preventing or treating brain ischemia or brain injury
The present invention relates to use of Narp inhibitor in order to promote or enhance recovery from ischemic events, particularly focal ischemia of the central nervous system, as well as for...
|
|
|
7195923 |
Ratiometric determination of glycated protein
The present invention provides methods for determining a ratio of an amount of a glycated form of a protein to a total amount of the protein in a sample containing the glycated protein, the...
|
|
|
7193066 |
Preparation of highly pure toxin fragments
Toxin derivatives are prepared by proteolytic treatment of holotoxin, and their toxicity is reduced by contacting the preparation with a ligand, which can be a metal or an antibody or another...
|
|
|
7189324 |
High-affinity, low molecular-mass displacers for ion-exchange chromotography
A method for separating one or more components of a biomolecule mixture by means of an ion exchange chromatographic system operated in the displacement mode includes sequentially perfusing the...
|
|
|
7148048 |
Process for purification of recombinant porphobilinogen deaminase
A process for purification of recombinant porphobilinogen deaminase (rhPBGD) on an industrial scale by starting from a rhPBGD containing extract obtained from a fermentation of a recombinant cell...
|
|
|
7138120 |
Process for producing immunoglobulins for intravenous administration and other immunoglobulin products
The present invention relates to a process for purifying immunoglobulin G from a crude immunoglobulin-containing plasma protein fraction. Said process includes a number of steps of which the anion...
|
|
|
7122344 |
Methods for the production of purified recombinant human uteroglobin for the treatment of inflammatory and fibrotic conditions
The present invention relates generally to the production of recombinant human uteroglobin (rhUG) for use as a therapeutic in the treatment of inflammation and fibrotic diseases. More particularly,...
|
|
|
7112453 |
Retentate chromatography and protein chip arrays with applications in biology and medicine
This invention provides methods of retentate chromatography for resolving analytes in a sample. The methods involve adsorbing the analytes to a substrate under a plurality of different selectivity...
|
|
|
7098026 |
Human desert hedgehog protein
Disclosed are a novel hedgehog protein, i.e., a Desert hedgehog protein of human origin including mature and precursor forms, a DNA encoding the protein, a monoclonal antibody recognizing the...
|
|
|
7084262 |
Analysis and separation of platelet-derived growth factor proteins
Methods for improving purification and quantification of platelet derived growth factor (PDGF) proteins having structural heterogeneity are provided. Preparation of substantially pure isoforms of...
|
|
|
7071313 |
Methods of purifying authentic IGF from yeast hosts
Methods for purifying authentic, properly folded IGF polypeptides from yeast transformants are disclosed. The methods include a refolding step and provide for high yields of authentic IGF from a...
|
|
|
7033610 |
Growth-promoting agent
The invention relates to pharmaceutical or veterinary compositions for the treatment of surface wounds; pharmaceutical or veterinary compositions for the treatment of gastrointestinal injuries,...
|
|
|
7022822 |
Highly purified gonadotropin compositions and process for preparing them
Purification process of humanPurification process of human urinary gonadotropins of high biological activity and chemical purity absolutely free of foreign contaminating materials derived from the...
|
|
|
7022744 |
Ion exchanger for lipoproteins separation and lipoproteins separation method using the same
A composition useful for separating lipoproteins, such as high density lipoprotein (HDL), low density lipoprotein (LDL), very low density lipoprotein (VLDL) and modified lipoproteins with a high...
|
|
|
6992061 |
Purification method
The invention relates to a method of removing endotoxin from preparation of alpha-1-acid glycoprotein (orosomucoid) by contact with a finely divided non-toxic resin such as fumed silica. The...
|
|
|
6989438 |
Process for the purification of EPI-HNE proteins
The present invention concerns a process for the purification of EPI-HNE proteins, from the culture medium of a host strain for the expression of said proteins, comprising the steps of: (a) passing...
|
|
|
6967241 |
Process for protein extraction
The invention includes a process for extracting a target protein from E. coli cells that includes lowering the pH of a whole E. coli cell solution to form an acidic solution, disrupting the...
|
|
|
6967239 |
Method of filtering viruses from a factor VIII solution
Method for preparing a factor VIII solution that is essentially free of viruses and essentially devoid of vWF (von Willebrand factor) and factor VIII-vWF complexes by (a) obtaining a starting...
|
|
|
6953844 |
Isolation of neurotrophins from a mixture containing neurotrophin variants using hydrophobic interaction chromatography
Methods are provided for large scale purification of neurotrophins, including mature NGF, suitable for clinical use. The methods provide means to separate neurotrophins from various less desirable...
|
|
|
6949629 |
Methods for purifying selected CEA family member proteins
Improved methods are provided for purifying selected carcinoembryonic antigen (CEA) family member proteins. Disclosed method steps include cation-exchange chromatography below pH 4.0 and...
|
|
|
6936423 |
Anti-LTNF for in vitro assay of biological toxins
Lethal Toxin Neutralizing Factor has been isolated in purity from opossum serum by high pressure liquid chromatography (HPLC) fractionation. The amino acid sequence from the N-terminal for the...
|
|
|
6924267 |
Methods and active substances for protecting organs
The present invention comprises a method of protecting organs or tissue susceptible to reperfusion-induced dysfunction after ischemia. The method comprises parenterally administering to a patient a...
|