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7611831 |
Adsorbing pathogen-inactivating compounds with porous particles immobilized in a matrix
Methods and devices are provided for reducing the concentration of low molecular weight compounds in a biological composition containing cells while substantially maintaining a desired biological...
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7598355 |
Characterization of GRP94-ligand interactions and purification, screening, and therapeutic methods relating thereto
The present invention discloses characterization of interactions between ligands and Hsp90 proteins, including GRP94, wherein ligand binding to the N-terminal nucleotide binding domain of GRP94...
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7566742 |
Phosphoprotein preparations for bioactive metal ion delivery and teeth remineralisation
The invention provides, in one aspect, compositions for delivering a bioactive metal ion to a mammal, the compositions comprising (a) an effective amount of a source of the bioactive metal ion, (b)...
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7476722 |
Methods for purifying protein
A method is provided for separating a protein from one or more other proteins using hydroxyapatite chromatography in which the protein does not bind to hydroxyapatite but the other protein(s) does....
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7423132 |
Method for the enrichment and characterization of phosphorylated peptides or proteins
A method for the separation and assay of phosphorylated peptides or proteins from complex mixtures of proteins and peptides is described. The method uses a diazo moiety linked by an organic group...
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7408045 |
Adsorbent of high-mobility-group protein and body fluid-purification column
An adsorbent of high-mobility-group proteins (HMG protein) which can remove HMG protein in body fluid is disclosed. The adsorbent according to the present invention has a water-insoluble carrier on...
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7385040 |
Antibody purification
The present invention relates to a method of separating antibodies from contaminants in a solution, which method comprises contacting the solution with a chromatography resin comprised of a support...
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7329409 |
Compositions and methods for treatment of microbial infections
The present invention relates to methods and compositions for treatment of microbial infections and for the enhancement of resistance to infection. The invention comprises administration of an...
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7326776 |
Preparation and use of mixed mode solid substrates for chromatography adsorbents and biochip arrays
For certain mixed mode resins having anionic character, a ligand is joined to a solid support via a linkage that includes a mercapto-, ether- or amino-containing moiety. A suitable ligand comprises...
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7279106 |
Adsorbent and method for adsorbing a chemokine in body fluid
A device for body fluid purification, comprising a container having an inlet and an outlet for a fluid and a means for preventing an adsorbent from flowing out of the container and an adsorbent...
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7259243 |
Process for isolation of osteopontin from milk
A process for isolation of milk osteopontin from a material containing milk osteopontin by optionally mixing the milk material with a calcium source and separate the osteopontin containing phase...
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7223595 |
Use of purified Streptomyces griseus trypsin for production of a biomass of cells and viral propagation
The present invention provides methods of isolation and purification of Streptomyces griseus trypsin (SGT) from PRONASE protease mixture in a single affinity chromatography step and uses of the...
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7223848 |
Methods for purifying Fc-containing proteins
The present invention provides a process for dissociating Fc-containing molecules from complexes of Protein A/Fc-containing molecules or mixtures containing Fc-containing molecules and Protein A....
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7211650 |
Purification of fibrinogen from fluids by precipitation and hydrophoic chromatography
The present invention provides a method for the part purification of fibrinogen from milk, the method comprising the transfer of protease enzyme which is present in the milk, into the whey phase...
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7195923 |
Ratiometric determination of glycated protein
The present invention provides methods for determining a ratio of an amount of a glycated form of a protein to a total amount of the protein in a sample containing the glycated protein, the...
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7144743 |
Preparation and use of mixed mode solid substrates for chromatography adsorbents and biochip arrays
For certain mixed mode resins having anionic character, a ligand is joined to a solid support via a linkage that includes a mercapto-, ether- or amino-containing moiety. A suitable ligand comprises...
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7122641 |
Methods for purifying protein
A method is provided for separating a protein from one or more other proteins using hydroxyapatite chromatography in which the protein does not bind to hydroxyapatite but the other protein(s) does....
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7048930 |
Expression of core-glycosylated HCV envelope proteins in yeast
The present invention relates to the general field of recombinant protein expression, purification of recombinant proteins, diagnosis of HCV infection, prophylactic treatment against HCV infection...
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7041798 |
Method for the chromatographic fractionation of plasma or serum, preparations, so obtained, and their use
The invention relates to the fractionation of plasma or serum into at least one albumin fraction and one immunoglobulin fraction by hydrophobic interaction chromatography. The fractionation is...
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7037642 |
Removing compounds from blood products with porous particles immobilized in a matrix
Methods and devices are provided for reducing the concentration of low molecular weight compounds in a biological composition containing cells while substantially maintaining a desired biological...
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7011963 |
Process for synthesis of bead-shaped cross-linked hydrophilic support polymer
The invention relates to a process for synthesis, by inverse bead polymerization of a monomer phase, of a bead-like, cross-linked, hydrophilic copolymer which has binding activity toward ligands...
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6995246 |
Methods for removing suspended particles from soluble protein solutions
The present invention provides soluble protein solutions, free of suspended particles in high yield. More particularly, the current invention provides a method for removing suspended particles from...
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6989436 |
Stabilization of cardiac troponin I subunits and complexes
The present invention provides methods for preparing, and compositions comprising, stabilized protein-polymer conjugates. More particularly, the present invention relates to the stabilization of...
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6967239 |
Method of filtering viruses from a factor VIII solution
Method for preparing a factor VIII solution that is essentially free of viruses and essentially devoid of vWF (von Willebrand factor) and factor VIII-vWF complexes by (a) obtaining a starting...
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6951713 |
Absorbing pathogen-inactivating compounds with porous particles immobilized in a matrix
Methods and devices are provided for reducing the concentration of low molecular weight compounds in a biological composition, while substantially maintaining a desired biological activity of the...
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6943239 |
Antigenic fusionprotein carrying Galα1,3Gal epitopes
The present invention relates to an antigenic fusionprotein, which carries multiple Galα1,3Gal epitopes. The fusion protein according to the invention may also be comprised of a heavily...
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6906183 |
Process for the separation of glycosylated and nonglycosylated proteins
A process for the partial or complete separation of glycosylated and nonglycosylated proteins is described, in which: a) a triazine dye immobilized on a matrix is incubated with a mixture of...
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6881540 |
High throughtput screening of potential displacer molecules
An effective technique for the high throughput screening of displacers is described. In this technique, potential displacers are employed to displace a biomolecule (e.g., protein) adsorbed on a...
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6866846 |
Patient-specific immunoadsorbers for the extracorporeal apheresis and methods for their preparation
A process for preparing a patient-specific immunoadsorber, which comprises (i) extracting a body fluid from a patient having an immunopathological condition, the fluid containing immune complexes...
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6849722 |
Polymerized oligopeptide-surfactant chiral micelles
Chiral separations can be enhanced through the use of polymerized dipeptide-surfactant or oligopeptide-surfactant chiral micelles. Because polymerized micelles eliminate much of the complex dynamic...
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6822081 |
Process for the isolation and/or purification of a proteinaceous material
The invention relates to a process for the isolation and/or purification of a proteinaceous material, wherein a solid phase comprising a mixture of hydrophobic and hydrophilic groups is used.
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6818617 |
EC-3, an inhibitor of α4β1 and α4β7 integrins
This invention relates to the identification, purification, and characterization of a novel heterodimeric disintegrin, EC-3, from Echis carinatus viper venom. EC-3 inhibits α4 integrins in an...
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6811969 |
Retentate chromatography—profiling with biospecific interaction adsorbents
This invention provides methods of retentate chromatography for resolving analytes in a sample. The methods involve adsorbing the analytes to a substrate under a plurality of different selectivity...
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6783962 |
Particulate material for purification of bio-macromolecules
The present invention relates to particulate material having a density of at least 2.5 g/ml, where the particles of the particulate material have an average diameter of 5-75 μm, and the particles...
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6713611 |
Method for removing endotoxin from the samples containing basic protein
The present invention relates to a method of removing an endotoxin from solution containing basic proteins. More specifically, the method of the present invention comprises the steps of adding the...
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6686455 |
Tumor necrosis factor
A cytotoxic protein designated tumor necrosis factor is identified in nature. It is recovered in substantially homogeneous form by treatment with hydrophobic substances and ion exchange resins. The...
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6683159 |
Methods for producing factor VIII proteins
Methods are provided for purification of Factor VIII polypeptides by immunoaffinity chromatography and ion exchange chromatography, in which the eluate from the immunoaffinity column is diluted...
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6677440 |
Process for the preparation in pure form of the protease activating blood clotting factor VII, its proenzyme or a mixture of both proteins by means of ion-exchange chromatography
A process for the preparation of a pure form of protein, wherein the protein is protease activating blood clotting factor VII, the proenzyme for the protease, or a mixture of both the-protease and...
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6660498 |
Malaria immunogenic composition
We utilized the silkworm ( Bombyx mori )/baculovirus system to produce recombinant Major Merozoite Surface Protein 1 (MSP1 42 ) because of the low cost and potential high yield of this expression...
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6646108 |
Process for isolating IgG and IgA
A method for the separation of IgG and IgA from an immunoglobulin-containing starting material is described, whereby the method is characterized in that (i) IgG and optionally IgA are adsorbed to a...
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6638725 |
Method for assaying receptor binding property and reagent for the assay
The present invention provides a method capable of simultaneous processing of plural test samples for the receptor binding property of a chemical substance, which does not require immobilization of...
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6635285 |
Shark cartilage extract: process of making, methods of using, and compositions thereof
The present invention relates to cartilage extracts and to a method of producing the same. Shark cartilage extracts having anti-angiogenic, anti-tumor, anti-inflammatory and anti-collagenolytic...
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6627737 |
Factor IX purification methods
Provided by the present invention are novel methods of factor IX protein recovery and purification.
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6627404 |
Methods for improving the recovery of troponin I and T in membranes, filters and vessels
A method to facilitate recovery troponin I and/or troponin T from a sample comprising addition of troponin C to the sample or to a surface from which the troponin I and/or troponin T are recovered.
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6617133 |
Process for purifying recombinant human serum albumin
The invention provides a process for purifying recombinant human serum albumin (rHSA) by heating a-culture medium containing rHSA and the rHSA-producing host cells, feeding said heated solution...
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6610630 |
Chromatography adsorbents utilizing mercapto heterocyclic ligands
A pseudobioaffinity chromatography adsorbent adapted for use in selectively adsorbing immunoglobulins. In one embodiment, the adsorbent includes: (a) a solid support material; and (b) a ligand...
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6602697 |
Process for purifying human papillomavirus virus-like particles
A process for purifying papillomavirus virus-like particles (VLPs) includes the step of passing a partially purified VLP-containing solution through a hydroxyapatite chromatography column. The VLPs...
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6599620 |
Cellulosic particles, spherical object comprising cross-linked polymer particles, and adsorbent for body fluid purification
The present invention relates to a cellulosic particle body comprising interconnected cellulosic small particles with small interparticle spaces and to a method of producing said cellulosic...
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6559290 |
Method for removing a chemokine
An adsorbent for removing a chemokine except interleukin-8 in body fluid, which comprises a solid material having an anionic functional group, a method for efficiently removing a chemokine except...
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6548646 |
Reference control for high-sensitivity C-reactive protein testing
Low-concentration reference controls for C-reactive protein assays are prepared from higher-level starting materials by simple filtration using silica-type filter media formerly used for removing...
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