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7622561 |
IL-21 production in prokaryotic hosts
The expression vectors and methods using an E. coli expression system for the large scale production of IL-21 are described. The vectors utilize the IL-21 coding sequence with specific changes in...
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7622112 |
Anti-SARS monoclonal antibodies
Monoclonal antibody reagents that recognize the SARS-coronavirus (SARS-HCoV) are needed urgently. In this report we describe the development and immunochemical characterization of mAbs against the...
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7611831 |
Adsorbing pathogen-inactivating compounds with porous particles immobilized in a matrix
Methods and devices are provided for reducing the concentration of low molecular weight compounds in a biological composition containing cells while substantially maintaining a desired biological...
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7598356 |
Method for purifying a protein of the cystine-knot superfamily
The present invention relates to a two-step method for isolating proteins from the cystine-knot superfamily based on dye ligand affinity chromatography and reversed-phase chromatography....
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7598355 |
Characterization of GRP94-ligand interactions and purification, screening, and therapeutic methods relating thereto
The present invention discloses characterization of interactions between ligands and Hsp90 proteins, including GRP94, wherein ligand binding to the N-terminal nucleotide binding domain of GRP94...
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7589183 |
Prevention of leaching of ligands from affinity-based purification systems
In an affinity-type purification, ligands dissociated from the stationary phase that would otherwise leach into the species being purified are captured by a second ligand that is also incorporated...
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7575745 |
Ligand for herpes simplex virus entry mediator and methods of use
A novel polypeptide ligand, p30, or LIGHT, for herpes virus entry mediator, HVEM, is provided. LIGHT is useful for modulating immune responses and in inhibiting infection and/or subsequent...
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7560030 |
Method for separation and enrichment of phosphopeptides
The present invention relates to phosphopeptide isolation and enrichment, particularly to a highly selective and specific phosphopeptide enrichment method. The method mentioned in the invention is...
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7538197 |
Use of neuregulin-β as an indicator and/or target
The invention relates, inter alia, to the use of neuregulin-β as a target in a screening method for active compounds, in particular for exerting an influence on changes in calcium concentration...
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7528240 |
Method for producing human anti-thymocyte immunoglobulins
Methods for producing improved anti-human thymocyte immunoglobulins from specific-pathogen-free animals are provided, without the need for an adsorption step on human tissues and the consequent...
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7527939 |
Polyclonal-monoclonal ELISA assay for detecting N-terminus proBNP
A specific and sensitive in vitro ELISA assay and diagnostic test kit is disclosed for determining levels of NT-proBNP protein in a variety of bodily fluids, non-limiting examples of which are...
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7485855 |
On-probe sample cleanup system and method for MALDI analysis
A system and method for cleanup of biological samples from contaminants prior to spectroscopy analysis. The system includes a support configured to hold a sample including a liquid having at least...
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7485704 |
Reducing protein A leaching during protein A affinity chromatography
A method for reducing leaching of protein A during protein A affinity chromatography is described which involves reducing temperature or pH of, or by adding one or more protease inhibitors to, a...
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7476726 |
Method of producing and purifying endostatin protein
The present invention provides a method for recombinant production, recovery and purification of endostatin protein. This method may be employed for large scale recovery and purification of...
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7476722 |
Methods for purifying protein
A method is provided for separating a protein from one or more other proteins using hydroxyapatite chromatography in which the protein does not bind to hydroxyapatite but the other protein(s) does....
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7452539 |
Stabilizing polypeptides which have been exposed to urea
Methods for stabilizing polypeptides, such as anti-HER2 antibodies, which have been exposed to urea.
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7449560 |
Phosophoinositoglycan binding proteins
The invention refers to a protein from plasma membrane of adipocytes. The protein has specific binding affinity to phosphoinositoylglycans. It regulates glucose uptake by circumventing the insulin...
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7449116 |
Methods and systems for protein separation
The present disclosure relates to a system and method for protein separation including: fractionating a mixture of proteins on a reversed-phase superficially porous stationary phase at a...
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7442779 |
Isolation of proteins
The present invention relates to a novel method for the isolation or purification of immunoglobulins (a special class of proteins) from a solution containing immunoglobulins, e.g. hybridoma cell...
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7442514 |
Mutants of the factor VII-activating protease and detection methods using specific antibodies
Mutants of the DNA sequence coding for the protease (FSAP) which activates blood clotting factor VII and single-chain plasminogen activators, the mutants comprising a G/C base exchange at...
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7439025 |
Antibodies binding a gamma carboxyglutamic acid displaying epitope
Antibodies are described, which are suitable for identification of γ-carboxyglutamic acid (Gla), said antibodies having an ability of identifying Gla residues in proteins and/or peptides, while...
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7429458 |
Methods of using bioelastomers
Bioelastomers are disclosed for use in methods of binding compounds including immunoassay methods, in biosensors and methods or regenerating biosensors, and in methods for targeting the delivery of...
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7408030 |
Purification of immunoglobulins using affinity chromatography and peptide ligands
An immunoglobulin binding peptide having the general formula, from amino terminus to carboxy terminus, of Z-R 1 —R 2 —R 3 —R 4 —R 5 —R 6 —X, is described, wherein: R 1 is H or Y; R 2 ...
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7402407 |
Chemically targeted positional identification of post-translationally phosphorylated peptides
Methods are provided for determining the position of a post-translationally modified (PTM) amino acid residue such as a phosphorylated amino acid residue or an O-glycosylated amino acid residue in...
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7396468 |
Methods and system for protein separation
The present disclosure relates to a system and method for membrane protein separation including: fractionating a membrane sample on a reversed-phase superficially porous stationary phase at a...
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7385040 |
Antibody purification
The present invention relates to a method of separating antibodies from contaminants in a solution, which method comprises contacting the solution with a chromatography resin comprised of a support...
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7374936 |
Method and means for site directed therapy
The present invention relates to the field of site directed therapy. More specifically the invention relates to site directed radio therapy, and provides a method for production of radioconjugates...
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7351801 |
Method, use and kit for separating albumin from contaminants in a liquid
The present invention is a method of separating recombinant human serum albumin (rHSA) from low molecular weight contaminants in a liquid, which method comprises the steps of: (a) providing a...
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7348416 |
Selective capture and enrichment of proteins expressed on the cell surface
The present invention provides a method for enriching cell surface proteins by oxidizing glycosylated protein with periodate. The present invention further provides that the cell surface proteins...
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RE40070 |
Antibody purification
This invention relates to the application of hydrophobic interaction chromatography combination chromatography to the purification of antibody molecule proteins. The questions raised in...
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7329409 |
Compositions and methods for treatment of microbial infections
The present invention relates to methods and compositions for treatment of microbial infections and for the enhancement of resistance to infection. The invention comprises administration of an...
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7329353 |
LC/MS method of analyzing high molecular weight proteins
The present invention is directed to a novel method of analysis of high molecular weight proteins. More specifically, it is directed to a novel reversed-phase LC/MS method of analysis of high...
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7316919 |
Composite materials comprising supported porous gels
This invention relates to a composite material that comprises a support member that has a plurality of pores extending through the support member and, located in the pores of the support member,...
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7309488 |
Adsorbents for dilated cardiomyopathy
An adsorbent which comprises a water-insoluble carrier and a compound, which is immobilized on said carrier, having a binding affinity for an antibody against β1-adrenoceptor and/or an antibody...
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7306934 |
Porous solid ion exchange wafer for immobilizing biomolecules
A porous solid ion exchange wafer having a combination of a biomolecule capture-resin and an ion-exchange resin forming a charged capture resin within said wafer. Also disclosed is a porous solid...
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7303885 |
Screening method for candidate drugs
The present invention relates to methods for screening molecules and methods to detect protein-protein interactions and means used therein. More specifically, the present invention relates to...
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7271256 |
Method for producing circular or multimeric protein species in vivo or in vitro and related methods
Methods are provided for intein mediated trans-splicing of immobilized polypeptides and for producing cyclic polypeptides in vivo or in vitro.
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7270961 |
In vitro assay for quantitating secreted antibodies in lymphocyte supernatant for evaluation of vaccine or antigen induced specific antibody secretion from ex vivo circulating antibody-secreting lymphocytes
The present invention provides methods of quantitating recent secreted antigen specific antibodies from supernatant of antibody secreting cells (ASC) in vitro culture for evaluation of vaccine or...
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7264939 |
Method of detecting native proBNP
The present invention relates to antibodies specifically binding to native proBNP, a method for specific detection of native proBNP, a method of correlating the level of native proBNP to the...
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7258980 |
Determining non-nucleic acid molecule binding to target by competition with nucleic acid ligands
A competitive binding assay is used to determine whether a non-nucleic acid molecule from a library of non-nucleic acid molecules binds to a target. The non-nucleic acid molecule competes with a...
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7256270 |
Immunogen adherence inhibitor and method of making and using same
A microbial adherence inhibitor in the form of fowl egg antibodies is disclosed, along with the method of making it and methods of using it. The inhibitor functions by substantially preventing the...
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7253265 |
Antibody and a method for producing an antibody that specifically binds to a full length amino acid sequence of human Delta-1
An antibody and a method for producing an antibody that specifically binds to a full length amino acid sequence of human Delta-1.
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7252973 |
Protein and processes for producing the same
A novel protein and a process of producing the protein is provided. The protein is a glycoprotein having activity of suppressing the differentiation and/or maturation of adipocyte, having a...
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7235362 |
Compositions and methods for protein isolation
The invention provides for polynucleotides and vectors comprising at least two tag sequences. In particular, preferred vectors are viral vectors. The invention also provides for polynucleotides and...
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7223848 |
Methods for purifying Fc-containing proteins
The present invention provides a process for dissociating Fc-containing molecules from complexes of Protein A/Fc-containing molecules or mixtures containing Fc-containing molecules and Protein A....
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7220356 |
Method of purifying polypeptides by simulated moving bed chromatography
Provided are methods of separating an immunoreactive compound from at least one immaterial component, using a simulated moving bed (“SMB”) system and a SMB apparatus for use in these methods....
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7195923 |
Ratiometric determination of glycated protein
The present invention provides methods for determining a ratio of an amount of a glycated form of a protein to a total amount of the protein in a sample containing the glycated protein, the...
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7193066 |
Preparation of highly pure toxin fragments
Toxin derivatives are prepared by proteolytic treatment of holotoxin, and their toxicity is reduced by contacting the preparation with a ligand, which can be a metal or an antibody or another...
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7193041 |
Method for purification of recombinant proteins
Purification of poly-amino acid-tagged recombinant proteins has been improved by the use of a carboxymethylated aspartate ligand complexed with a third-block transition metal having an oxidation...
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7189324 |
High-affinity, low molecular-mass displacers for ion-exchange chromotography
A method for separating one or more components of a biomolecule mixture by means of an ion exchange chromatographic system operated in the displacement mode includes sequentially perfusing the...
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