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7622562 |
Rapid isolation of osteoinductive protein mixtures from mammalian bone tissue
A method for purifying bone-derived osteoinductive proteins including a demineralization process, a protein extraction process, a high molecular weight ultrafiltration process, a low molecular...
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7622561 |
IL-21 production in prokaryotic hosts
The expression vectors and methods using an E. coli expression system for the large scale production of IL-21 are described. The vectors utilize the IL-21 coding sequence with specific changes in...
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7622127 |
Clostridial toxin derivatives and methods for treating pain
Agents for treating pain, methods for producing the agents and methods for treating pain by administration to a patient of a therapeutically effective amount of the agent. The agent can include a ...
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7619073 |
Method for purifying erythropoietin
The invention relates to a method for producing recombined erythropoietin having a particularly high degree of purity (≧98%). The method consists of at least 5 chromatographic purification steps,...
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7619072 |
Purification method for recombinant glucose binding protein
The present invention relates to a method for purifying a recombinant glucose binding protein, in particular the lectin Concanavalin A (Con A). The method specifically utilizes a buffer in which...
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7619066 |
IL-1ra variants
The present invention provides for an IL-1ra having reduced aggregation, methods of reducing aggregation of IL-1ra, and kits comprising an IL-1ra having reduced aggregation.
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7615617 |
Use of hydrostatic pressure to inhibit and reverse protein aggregation and facilitate protein refolding
A novel approach is described for reversing aggregation and increasing refolding by application of hydrostatic pressure. A protein of interest in an aggregated, or inclusion body, or other...
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7611831 |
Adsorbing pathogen-inactivating compounds with porous particles immobilized in a matrix
Methods and devices are provided for reducing the concentration of low molecular weight compounds in a biological composition containing cells while substantially maintaining a desired biological...
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7598356 |
Method for purifying a protein of the cystine-knot superfamily
The present invention relates to a two-step method for isolating proteins from the cystine-knot superfamily based on dye ligand affinity chromatography and reversed-phase chromatography....
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7598355 |
Characterization of GRP94-ligand interactions and purification, screening, and therapeutic methods relating thereto
The present invention discloses characterization of interactions between ligands and Hsp90 proteins, including GRP94, wherein ligand binding to the N-terminal nucleotide binding domain of GRP94...
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7598047 |
Difference detection methods using matched multiple dyes
A process and a kit are provided for detecting differences in two or more samples of protein, including proteins bearing post-translational modifications and peptides. Proteins are prepared, for...
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7585955 |
Protein separation from a protein mixture
A process for separating a protein from a sample containing a mixture of proteins is disclosed. The process comprises forming an aqueous combination comprising the sample and an ion exchange...
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7585947 |
IL-7 drug substance, composition, preparation and uses
The present invention relates, generally, to the fields of immunology and molecular biology. The invention discloses, more particularly, new and improved interleukin-7 drug substances,...
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7585815 |
High throughput protein production screening
Methods, compositions, and kits for the cell-free production and analysis of proteins are provided. The invention allows for the production of proteins from prokaryotic sequences or eukaryotic...
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7585645 |
Thioredoxin and thioredoxin reductase containing oil body based products
The present invention provides novel emulsion formulations which comprise oil bodies. The invention also provides a method for preparing the emulsions and the use of the emulsions in a variety of...
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7579448 |
Purification of microbial cell fermentation homogenates
A method for purifying a desired heterologous polypeptide from microbial fermentation broth or homogenate in which it is produced and solubilized is described. This method involves adding to the...
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7579182 |
Use of cross-protection to identify novel vaccine candidates for infectious agents
This invention discloses methods for identifying Francisella tularensis vaccine candidates. It enables identification of novel vaccine candidates and quality assurance for vaccine batches,...
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7575745 |
Ligand for herpes simplex virus entry mediator and methods of use
A novel polypeptide ligand, p30, or LIGHT, for herpes virus entry mediator, HVEM, is provided. LIGHT is useful for modulating immune responses and in inhibiting infection and/or subsequent...
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7572644 |
Hydrogel copolymer, substrate coated with the copolymer, method of producing microarray using the copolymer, and microarray produced by the method
A novel hydrogel copolymer, a substrate coated with the copolymer, a method of producing a microarray using the copolymer, and a microarray produced by the method are provided. The use of the...
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7569671 |
Method and system for corn fractionation
Methods and apparatus for processing corn into one or more corn products. Oil is extracted from corn or corn products or by-products with a solvent. The corn-solvent mixture is separated into...
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7556835 |
High efficiency protein extraction
The invention relates to a process for isolating edible protein from animal muscle by solubilizing the protein in an alkaline aqueous solution.
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7553832 |
Methods and compositions for specific inhibition of protein splicing by small molecules
The present invention relates to compositions (i.e., various organic small molecules as exemplified herein) and methods for the inhibition of protein splicing and especially relates to the...
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7547761 |
Low molecular weight extraction process
A process for isolating low molecular weight (“LMW”) peptides from tissue in situ comprising the steps: a) homogenizing the tissue; b) mixing the homogenized tissue with an organic solvent to...
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7544784 |
Increased recovery of active proteins
The invention provides methods of increasing yields of desired conformation of proteins. In particular embodiments, the invention includes contacting preparations of a recombinant protein with a...
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7544493 |
Method for the purification of an N-terminal fragment of hepatocyte growth factor
A method for the production of the N-terminal four kringle-containing fragment of hepatocyte growth factor (NK4) by expression of a nucleic acid encoding said NK4 in a microbial host cell,...
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7541167 |
Porous glass composite material
A porous glass composite material comprising at least one alkoxodisilane (precursor) having the general formula (or 1 ) 3 Si-spacer-Si(OR 2 ) 3 ,wherein R 1 and R 2 are the same or different and...
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7538197 |
Use of neuregulin-β as an indicator and/or target
The invention relates, inter alia, to the use of neuregulin-β as a target in a screening method for active compounds, in particular for exerting an influence on changes in calcium concentration...
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7537931 |
Humanized anti-ERBB2 antibodies and treatment with anti-ERBB2 antibodies
The present application describes humanized anti-ErbB2 antibodies and methods for treating cancer with anti-ErbB2 antibodies, such as humanized anti-ErbB2 antibodies.
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7531632 |
Clarification of transgenic milk using depth filtration
Processes and apparati are provided for separating molecules of interest from a mixture by depth filtration (DF). The DF of the invention is useful in the clarification and processing of various...
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7531317 |
Fluorescence polarization assay to detect protease cleavage
The invention discloses a method of determining protease activity, in real time, using fluorescence polarization technology. In particular, the invention provides vectors and a method for their...
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7524940 |
OB protein compositions and methods
The present invention provides methods and compositions for treating excess weight by administering OB protein in a form for constant supply, at a dosage of less than or equal to about 1 mg...
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7521422 |
Use of aspartic proteases in cosmetics and therapeutics
The invention provides a cosmetic or pharmaceutical composition comprising, in a physiologically acceptable medium, at least one purified natural or synthetic polypeptide wherein the peptide...
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7517968 |
Rapid and inexpensive method for the purification of proteorhodopsin
A method for purifying a membrane protein is disclosed which includes providing a test sample potentially including a target membrane protein; adding incremental amounts of a precipitating agent to...
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7507412 |
Glycoprotein VI fusion proteins
The present invention relates to Glycoprotein VI (GPVI) fusion proteins (GPVI-fusion proteins) comprising a tag like myc, GST, HA, FLAG, STREP but preferably a Immunoglobulin molecule (Ig), more...
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7504486 |
Determination and uses of the atomic structures of ribosomes and ribosomal subunits and their ligand complexes
The present invention provides methods for producing high resolution crystals of ribosomes and ribosomal subunits as well as the crystals produced by such methods. The x-ray diffraction patterns of...
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7501495 |
Method for improving recovery yield in protein purification with gel filtration chromatography
A method to more quantitatively recover a peak of a protein and associated aggregates, hydrophobic proteins, or hydrophobic peptides which are typically difficult to recover and detect as a peak,...
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7501492 |
Processed soybean β-conglycinin protein
By heating a solution or paste containing soybean β-conglycinin protein under acidic conditions, it is possible to provide soybean β-conglycinin protein whose high hydration property and high...
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7498412 |
Process for preparing porous collagen matrix from connective tissue
The subject invention provides a process for preparing a porous collagen matrix from connective tissue, said process comprising: a porous structure forming step to treat said connective tissue with...
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7485855 |
On-probe sample cleanup system and method for MALDI analysis
A system and method for cleanup of biological samples from contaminants prior to spectroscopy analysis. The system includes a support configured to hold a sample including a liquid having at least...
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7485704 |
Reducing protein A leaching during protein A affinity chromatography
A method for reducing leaching of protein A during protein A affinity chromatography is described which involves reducing temperature or pH of, or by adding one or more protease inhibitors to, a...
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7482162 |
Determination of vitamin D metabolite and displacement from plasma or serum binding proteins
We disclose methods for measuring vitamin D metabolite in plasma or serum samples. The methods comprise a step of adding to the plasma or serum samples a non-competitive displacement agent...
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7482148 |
Recombinant calf-chymosin and a process for producing the same
The present invention relates to a recombinant calf-Chymosin protein as set forth in SEQ ID No. 1; a recombinant calf-Chymosin gene as set forth in SEQ ID No. 2 encoding the protein comprising...
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7479540 |
Adipomodulin and related molecules and methods
Adipomodulin (a light chain molecule) and related molecules and methods useful in the treatment of obesity and obesity-related disorders.
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7479281 |
Botulinum toxin for treating postherpetic neuralgia
Methods for treating conditions in an animal or human subject. The conditions may be pain, skeletal muscle conditions, smooth muscle conditions, glandular conditions and cosmetic conditions. The...
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7476726 |
Method of producing and purifying endostatin protein
The present invention provides a method for recombinant production, recovery and purification of endostatin protein. This method may be employed for large scale recovery and purification of...
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7473764 |
Protein composition obtained from a muscle source
A process is provided for isolating a protein component of animal muscle tissue by mixing a particulate form of the tissue with an acidic aqueous liquid having a pH below about 3.5 to produce a...
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7473532 |
Liquid tissue preparation from histopathologically processed biological samples, tissues and cells
The current invention provides a method for directly converting histopathologically processed biological samples, tissues, and cells into a multi-use biomolecule lysate. This method allows for...
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7470778 |
Use of ionic liquids for protein extraction
The present invention relates to a method for the extraction of proteins, protein fragments and/or peptides from biological samples, where the extractants employed are ionic liquids of the general...
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7470776 |
Glycosulfopeptide inhibitors of leukocyte rolling and methods of use thereof
Compounds, compositions and methods for treating conditions characterized by leukocyte rolling are described. The compounds contain glycosulfopeptide structures comprising sulfated tyrosines and...
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7468188 |
Multi-step therapy for injured muscles
Methods for treating an injured muscle by local administration of a neurotoxin, such as a botulinum toxin, to promote healing and/or to reduce the pain associated with an injured muscle.
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