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7611889 |
Method for noncovalently immobilizing a biomolecule on a solid substrate and microarray produced according to the method
Provided is a method for noncovalently immobilizing a biomolecule on a solid substrate, including: providing a solid substrate having a first functional group attached thereto, the first functional...
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7572644 |
Hydrogel copolymer, substrate coated with the copolymer, method of producing microarray using the copolymer, and microarray produced by the method
A novel hydrogel copolymer, a substrate coated with the copolymer, a method of producing a microarray using the copolymer, and a microarray produced by the method are provided. The use of the...
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RE40596 |
Rapamycin assay
Monoclonal antibodies to rapamycin and to 40-O-alkylated derivatives of rapamycin are provided, together with novel haptens, immunogenic conjugates, and processes for making them and assay kits for...
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7423131 |
Busulfan immunoassay
Novel conjugates of busulfan and novel busulfan immunogens derived from α-substituted derivatives of busulfan and antibodies generated by these busulfan linked immunogens are useful in...
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7420043 |
Reagents for detecting efavirenz
The invention provides derivatives of efavirenz and methods of making derivatives of efavirenz. The derivatives include immunogenic compounds for producing antibodies to efavirenz and labeled...
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7371829 |
Haptens, immunogens, antibodies and conjugates to ketamine and its metabolites
The invention provides haptens, immunogens comprising such haptens coupled to an antigenicity-conferring carrier material, conjugates comprising such haptens bonded to a labelling agent as well as,...
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7364911 |
Methods for isolating and labeling sample molecules
The invention provides methods for labeling a molecule by contacting a sample molecule with a solid support coupled to a chemical group comprising a cleavable functional group, one or more...
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7351797 |
Labeled peptides, and processes and intermediates useful for their preparation
The invention provides intermediates and methods that allow for site-specific modification of peptides after synthesis. Accordingly, functional molecules can be selectively linked to a peptide to...
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7344895 |
Production and use of in situ-modified nanoparticles
A process for synthesizing nanoparticles, in particular metal salt nanoparticles. To the synthesis mixture is added a modifying reagent which binds, by means of a first functional group, to the...
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7326776 |
Preparation and use of mixed mode solid substrates for chromatography adsorbents and biochip arrays
For certain mixed mode resins having anionic character, a ligand is joined to a solid support via a linkage that includes a mercapto-, ether- or amino-containing moiety. A suitable ligand comprises...
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7279562 |
Rapamycin conjugates
Provided are rapamycin conjugates which are useful as immunogenic molecules for the generation of antibodies specific for rapamycin, for measuring levels of rapamycin or derivatives thereof; for...
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7279165 |
Amyloid β1-6 antigen arrays
The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen or...
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7276347 |
Cytoxan antibodies and immunoassay
Novel conjugates of protected aldehyde active metabolites of cyclophosphamide including reagents and immunogens thereof and monoclonal antibodies generated by these immunogens, said reagents and...
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7267994 |
Element-coded affinity tags
The present invention provides compositions and methods for detecting, analyzing, and identifying biomolecules. More particularly, the invention provides Element Coded Affinity Tags comprising a...
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7247502 |
Hapten-carrier conjugates for treating and preventing nicotine addiction
Novel hapten-carrier conjugates are capable of inducing the production of antibodies, in vivo, that specifically bind to nicotine. These conjugates comprise a nicotine hapten conjugated to an...
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7230088 |
Compounds for dual photodiagnosis and therapy
The invention discloses compounds and compositions for dual phototherapy and combined therapy and diagnosis of tumors and other lesions. The compounds have a Dye that, when photoactivated, operates...
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7229782 |
Antibodies specific to multiple beta blockers and methods for their use
The present invention is directed antibodies specific to multiple beta blockers, as well as immunogens used to produce the antibodies and immunoassay kits and methods for using the antibodies.
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7223553 |
Immunoassays for everolimus
Immunoassays for the detection of everolimus are provided. Compounds for producing antibodies for everolimus, as well as antibodies produced therefrom, are also provided.
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7220842 |
Immunoassays for buprenorphine and norbuprenorphine
Methods, compositions and kits are disclosed directed at haptens, immunogens and immunoassays for buprenorphine (BUP) and nor buprenorphine (norBUP). The method comprises providing in combination...
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7211445 |
Conjugation of biomolecules using diels-alder cycloaddition
A method is provided for covalently linking carbohydrates, proteins, nucleic acids, and other biomolecules under neutral conditions, using a Diels-Alder cycloaddition reaction. In an example,...
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7211409 |
Standard compound for immunoassay for dioxin and method of immunoassay for dioxin
A compound of formula (1) and an immunoassay method for quantitative determination of dioxins in a sample using as a standard the compound of the following formula (1):
wherein R 1 , R 2 , R 3 ...
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7208148 |
Chemically modified cytokines
The invention concerns a derivative of viral regulatory protein or a fragment of viral regulatory protein or of the alpha interferon or a fragment of alpha interferon, which is carboxymethylated, a...
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7205161 |
Polymer brushes for immobilizing molecules to a surface or substrate having improved stability
Sensors for determining the presence and concentration of biomolecules in a biological sample are provided in the form of polymer brushes, which comprise a substrate having a surface modified with...
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7205116 |
5-Fluoro-uracil immunoassay
Novel conjugates of 5-fluoro-uracil and novel 5-fluoro-uracil immunogens and monoclonal antibodies generated by these immunogens which are useful in immunoassays for the quantification and...
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7202092 |
Indinavir derivatives useful in immunoassay
Derivatives and conjugates of indinavir for generation of antibodies and labeled conjugates for use for detection of indinavir in biological samples. The derivatives are synthesized out of the...
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7195882 |
Monoclonal antibodies specific for buprenorphine and metabolites thereof
The present invention relates to monoclonal antibodies that specifically bind buprenorphine and/or at least one metabolic product thereof. The present invention further relates to buprenorphine...
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7193065 |
Protease inhibitor conjugates and antibodies useful in immunoassay
Activated haptens useful for generating immunogens to HIV protease inhibitors, immunogens useful for producing antibodies to HIV protease inhibitors, and antibodies and labeled conjugates useful in...
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7189582 |
Compositions and methods for detection of sirolimus
Compounds are disclosed comprising a moiety, such as a poly(amino acid), a non-poly(amino acid) label moiety, or a non-poly(amino acid) immunogenic carrier, linked to a sirolimus compound at...
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7186568 |
Electrochemiluminescence from acridan compounds
Methods are disclosed for producing electrochemiluminescence by electrochemically oxidizing an acridan compound at an electrode in the presence of a peroxide. Maintaining a sufficiently positive...
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7183116 |
Methods for isolation and labeling of sample molecules
The invention provides methods for labeling a molecule by contacting a sample molecule with a solid support coupled to a chemical group comprising a cleavable functional group, one or more...
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7169907 |
Derivatives, immunogens, and antibodies for detecting ecstasy-class drugs
Compounds including haptens, intermediates, and immunogens that are useful in the production of antibodies specific for the methylenedioxy class of amphetamine derivatives are described. Antibodies...
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7166708 |
Process for preparing conjugate vaccines and the conjugate vaccines
This invention relates to a process for preparing a hapten-protein-polysaccharide conjugate and a hapten-protein conjugate by reacting a protein with a hapten to produce a hapten-protein conjugate,...
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7166440 |
2,4,5-trichlorophenoxyalkyl carboxylic acid and a method for determining dioxins using the same
An immunoassay of dioxins using 2,4,5-trichlorophenoxyalkyl amide derivative represented by the following formula (II) as an antigen for a competitive immunoassay is provided:
where n is...
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7161031 |
Amino-substituted sulfonanilides and derivatives thereof for treating proliferative disorders
Compounds useful as antiproliferative agents, including, for example, anticancer agents, are provided according to formula I: wherein: Ar, X, X 1 , g, R and R 3 are as defined herein.
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7157561 |
Methods of inhibiting transmission of a costimulatory signal of lymphocytes
Activated haptens useful for generating immunogens to the HIV protease inhibitor atazanavir, immunogens useful for producing antibodies to atazanavir, and antibodies and labeled conjugates useful...
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7148029 |
Immunoassay for neonicotinyl insecticides
The present invention provides immunogens for generating anti-neonicotinoid antibodies as well as antibodies, methods, reagents and kits for determining the presence of one or more neonicotinoid...
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7132513 |
Bifunctional chelating agent
The invention concerns a ligand comprising wherein n is an integer from 1 to 5, X represents —NO 2 , —NH 2 , —NCS, —NHCOCH 2 -Z. NHCO—W—COCNHS, —NH-Q, —NHCS-Q, —NHCOCH 2 -Q, or...
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7115718 |
Haptens, immunogens, antibodies and conjugates to 2-oxo-3-hydroxy-LSD
The invention provides a hapten derivatized with a crosslinker at the nitrogen of the 8β-carboxamide of 2-oxo-3-hydroxy LSD. The invention also provides an immunogen comprising the aforementioned...
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7115383 |
Assays for amphetamine and methamphetamine
Methods, compositions and kits are disclosed. The compounds disclosed comprise an amphetamine moiety and a methamphetamine moiety linked together by a first linking group. A second linking group...
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7109310 |
Method and kit for detecting, or determining the quantity of, metabolites of fentanyl and metabolites of fentanyl analogs
The invention provides an immunogen comprising a hapten coupled to an antigenicity-conferring carrier material, a conjugate comprising the aforementioned hapten coupled to a labelling agent, as...
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7101980 |
Derivatives, conjugates, and antibodies for detecting ecstasy-class analytes
Compounds including haptens, intermediates, and immunogens that are useful in the production of antibodies specific for the methylenedioxy class of amphetamine derivatives are described. Antibodies...
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7090993 |
Method of assaying pyrrole-containing biological compounds
This invention relates to a method of assaying pyrrole-containing biological compounds and chemical compositions that can be used in the method. The method involves contacting a biological compound...
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7067267 |
Method of assaying pyrrole-containing biological compounds
This invention relates to a method of assaying pyrrole-containing biological compounds and chemical compositions that can be used in the method. The method involves contacting a biological compound...
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7045606 |
Bifunctional chelating agent for actinium
The invention concerns a ligand comprising (I) wherein n is an integer from 1 to 5 Y is CO2H or PO3H2T represents —X or -phenyl-X, wherein X represents NO2, NH2, NCS, NHCOCH2-Z,...
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7038021 |
Anti-dioxins monoclonal antibody suitable for assaying dioxins in environment and hybridoma producing the same
The object of present invention is to provide an immunoassay for dioxins which can rapidly and simply afford measured values having a good correlation with analytical values of dioxins by the...
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7037669 |
Assays for amphetamine and methamphetamine using stereospecific reagents
Methods, compositions and kits are disclosed. Enzyme conjugates of Formula I may be employed in assays for the determination of an amphetamine and/or a methamphetamine. Immunogenic conjugates of...
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7026134 |
Haptens, immunogens and antibodies to oxycodone and its metabolites
Novel haptens, which can be conjugated to form immunogens, are of formula I, II or III
wherein R is a divalent alkyl, cycloalkyl or aryl group having 1 to 10 carbon atoms, and X is a functional...
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7022673 |
Method for increasing the serum half-life of a biologically active molecule
A method is provided for preparing a biologically active molecule having an increased serum half-life. The method involves conjugating a polymer such as polyethylene glycol to the biologically...
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7022492 |
Ecstasy haptens and immunogens
Methods, compositions and kits are disclosed. Enzyme conjugates of Formula I are employed in assays for the determination of an methylenedioxyamphetamine, a methylene-dioxyethamphetamine, and/or a...
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7022491 |
Method for determining molecule—molecule interaction analysis
The invention relates to a method for monitoring interactions to a target biomolecule comprising the steps of: providing a biomolecule of interest having specificity for the target biomolecule;...
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