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4789702 |
Feline leukemia virus vaccine
Polypeptides that are synthesized or expressed directly in microorganisms, include an amino acid sequence that is homologous to at least a portion of gp70 envelope protein of FELV, and are...
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4788058 |
B. pertussis vaccine production using carbodiimides
The present invention provides a method of preparing a substantially non-toxic immunogenic preparation of pertussis toxic comprising treatment of pertussis toxin with a carbodiimide. The...
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4785080 |
Labeled analytes
A highly sensitive, immunoassay method for determining the amount of an analyte in a sample containing a known analyte in an unknown concentration is provided. Sample; a polypeptide-labeled analog...
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4784955 |
Immunogen conjugates and the use thereof in a dihydropyridine assay
Disclosed are 1,4-dihydropyridine immunogen conjugates of immunogenic carrier materials coupled to a 1,4-dihydropyridine derivative. Said conjugates are useful for the preparation of antibodies...
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4780408 |
Antibody for detection and quantification of trifluralin
An antibody specific to trifluralin can be produced by first substituting a soluble, straight chain amino acid for a propyl group of α,α, α-trifluoro-2,6-dinitro-N-N-dipropyl-p-toluidine. The...
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4780312 |
Birth control vaccine
A polyvalent vaccine for control of fertility is disclosed, the vaccine having a multiplicity of determinant antigens in the reproductive system of mammals, the antigens being linked to at least...
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4772548 |
Radioisotopicassay using isotope transfer to chelator-target recognition molecule conjugate
A method of forming a therapeutic or diagnostic agent labeled with a radioactive metal ion, which comprises: contacting an unlabeled therapeutic or diagnostic agent, consisting of a substantially...
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4771127 |
Nontoxic pseudomonas aeruginosa polysaccharide-tetanus toxoid and polysaccharide-toxin a conjugate vaccines
Polysaccharide-protein conjugates were synthesized utilizing polysaccharide derived from hydrolyized Pseudomonas aeruginosa lipopolysacharide covalently coupled to either tetanus toxoid or P....
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4767609 |
Therapeutic and diagnostic processes using isotope transfer to chelator-target recognition molecule conjugate
A method of forming a therapeutic or diagnostic agent labeled with a radioactive metal ion, which comprises: contacting an unlabeled therapeutic or diagnostic agent, consisting of a substantially...
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4762915 |
Protein-liposome conjugates
A lipid coupling reagent for use in coupling amine-containing molecules, such as proteins, to liposomes. The reagent includes phosphatidylethanolamine coupled to a 3-20 atom carbon-containing...
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4762710 |
Novel method of preparing toxoid by oxidation and metal ions
A method of preparing toxoid by treating a toxin with an oxidizing agent is described. Preparation of a vaccine against pertussis in accordance with the method is illustrated.
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4752638 |
Synthesis and use of polymers containing integral binding-pair members
Conjugate monomers, polymers, and methods for the de novo synthesis of the polymers are provided. Conjugate organic monomers contain binding-pair members which upon polymerization become integrally...
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4749566 |
Pharmaceutical composition comprising a combination of at least one immunotoxin and at least one mannose-containing polymer
The invention relates to pharmaceutical compositions comprising a combination of at least one immunotoxin and at least one mannose-containing polymer. This combination makes it possible to inhibit...
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4745180 |
Solubilization of proteins for pharmaceutical compositions using heparin fragments
A pharmaceutical composition is prepared wherein a biologically active conjugated protein which is β-interferon, interleukin-2, or an immunotoxin is dissolved in an aqueous carrier medium without...
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4740476 |
Immunoassay for estriol-3-sulfate
A process for producing an antibody having a specificity to estriol-3-sulfate, which comprises administering a 6-substituted-estriol-3-sulfate protein conjugate of the formula: ##STR1## wherein A...
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4727136 |
Modified meningococcal group B polysaccharide for conjugate vaccine
The group B polysaccharide of Neisseria meningitidis is chemically modified to enhance the immune response thereto, thereby providing cross-reactive antibodies of high affinity. The N-acetyl group...
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4720385 |
Protein compositions substantially free from infectious agents
Compositions containing therapeutically or immunologically active proteins are rendered substantially free from infectious agents such as viable viruses and bacteria without substantial loss of...
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4714759 |
Immunotoxin therapy of allergy
A product and process for treating allergy are described. An immunotoxin specific for the IgE isotype is used to eliminate the IgE producing B-lymphocytes responsible for allergy.
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4707352 |
Method of radioactively labeling diagnostic and therapeutic agents containing a chelating group
A method of forming a therapeutic or diagnostic agent labeled with a radioactive metal ion, which comprises: contacting an unlabeled therapeutic or diagnostic agent, consisting of a substantially...
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4701323 |
Vaccines for counteracting inhibition of neutrophil degranulation
Vaccines for counteracting inhibition of neutrophil degranulation by pathogenic cellular microorganisms comprise one or more purines conjugated to antigenic carriers. The purines include adenine...
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4698420 |
Antibody hybrid molecules and process for their preparation
Antibodies which contain reduced sulfhydryl groups in proximity of the carboxyl terminal end of their heavy chain are coupled to another moiety which has an available sulfhydryl for forming a...
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4695624 |
Covalently-modified polyanionic bacterial polysaccharides, stable covalent conjugates of such polysaccharides and immunogenic proteins with bigeneric spacers, and methods of preparing such polysaccharides and conjugates and of confirming covalency
Covalently modified bacterial polysaccharides and proteins; covalent conjugates of such polysaccharides linked by a bigeneric spacer, which permits proof of covalency and facilitates purification...
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4694074 |
Process for the purification of HBsAg
A process for the purification of HBsAg is disclosed, which comprises adsorbing specifically on a carrier, in the presence of an inorganic salt in an amount of 5 to 25 W/V %, an HBsAg obtained by...
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4683135 |
DSCG binding protein and process for preparing same
According to the present invention there is provided an essentially pure protein found in nature in mast cells and in basophiles, which protein is involved in the transfer of calcium into such...
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4642335 |
Anthracycline compounds bound to hydrophilic polypeptides
This invention relates to an antitumor composition of anthracycline compounds bonded to hydrophilic polypeptides having a molecular weight between 10,000 and 15,000.
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4615884 |
Method and vaccine for treatment of demyelinating diseases
Inactivated staphylococcal alpha toxin which is in a detoxified immunogenically active form prepared as a vaccine and administered parenterally to patients having multiple sclerosis or other...
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4609707 |
Synthesis of polymers containing integral antibodies
A method is disclosed for the de novo synthesis of antibody-containing polymers and the preparation of a class of polymerizable compounds used in the synthesis of such antibody-containing polymers....
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4608252 |
Chloramphenicol derivatives antigens and antibodies
Chloramphenicol derivatives are provided for use in the preparing of antigen conjugates for the production of antibodies specifically for chloramphenicol. Specifically, the aryl amino group is...
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4599197 |
Purification and activity assurance of precipitated heterologous proteins
A heterologous expression product in host cells is separated from the host cell material by suspending the material in a buffered solution, disrupting the cells and separating the product as...
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4598064 |
Alpha-alpha cross-linked hemoglobins
Blood substitute and blood plasma expanders comprising alpha-alpha cross-linked stroma-free hemoglobin, which is substantially free of hemoglobin derivatives modified at other sites. The hemoglobin...
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4597967 |
Synthetic polypeptide fragments
Peptide fragments of streptococcal M protein named CB3, CB4, and CB5 and related synthetic peptides have been identified. When linked to a protein carrier which is polylysine the conjugates of CB3,...
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4596768 |
Antibodies for penicilloic acid their preparation and use
Conjugates of penicilloic acid derivatives and certain poly(amino acids), which are either antigenic or enzymatic, are provided. Antibodies raised against the antigenic poly(amino acids) and the...
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4591573 |
Sensitive radioimmunoassay using antibody to L-hyoscyamine
A sensitive and specific radioimmunoassay is developed for L-hyoscyamine ulting from atropine administration with which a concentration as low as 25 pg/ml using 0.1 ml of sample can be measured...
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4585740 |
Prolactin immunoassay using synthetic peptide
A peptide having the formula ##STR1## is synthesized. The peptide is conjugated, e.g., with bis-diazotized benzidine, at its C-terminus to a carrier, such as bovine serum albumin, to form a...
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4565643 |
Antifreezing agent
An antifreezing agent used in an aqueous medium system comprising a protein which is enzymatically modified with covalent incorporation of an amino acid ester. The antifreezing agent can keep an...
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4551275 |
Desmethylimipramine derivatives and poly(amino acid) conjugates
Desmethylimipramine functionalized compounds are provided for conjugation to antigenic compounds, particularly poly(amino acids) and enzymes. The antigenic conjugates are employed for the...
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4550019 |
Manufacture and use of fowl egg antibodies
Immunological preparations are prepared by immunizing hens with an immunogen having a molecular or particle weight of at least 30,000, to a stage of hyper-immunization at which there occurs a...
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4544640 |
Anti immune complex antibody for determining SLE, rheumatoid arthritis or tetanus
An antibody is obtained by using as an antigen a complex of an antigen and the F(ab') 2 fragment of the human antibody of this antigen or an aggregate of the F(ab') 2 fragment of human...
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4533493 |
Theophylline immunogens, antibodies, labeled conjugates, and related derivatives
Theophylline immunogens, antibodies prepared therefrom, labeled theophylline conjugates, synthetic intermediates, and the use of such antibodies and labeled conjugates in immunoassays for...
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4530786 |
Antibody for the detection and quantification of atrazine
This invention relates to an antibody capable of both specifically detecting and quantifying minute quantities of the herbicide, atrazine, left in biological samples, such antibody having been made...
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4521510 |
Hybridoma cell lines and monoclonal antibodies to theophylline
Monoclonal antibodies to theophylline having 5% or less cross-reactivity with caffeine and the continuous hybrid monoclonal cell lines for their production are provided. These antibodies are useful...
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4500637 |
Prevention of graft versus host disease following bone marrow transplantation
A monoclonal antibody known as TA-1 directed against human T-cells is covalently linked to the toxin ricin and used to treat human donor bone marrow before the marrow is infused into a human...
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4496479 |
Chloramphenicol derivatives, antigens and antibodies
Chloramphenicol derivatives are provided for use in preparing antigen conjugates for the production of antibodies specific for chloramphenicol. Specifically, the aryl group is derivatized with a...
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4495281 |
Tricyclic antidepressant drug immunogens, antibodies, labeled conjugates, and related derivatives
Tricyclic antidepressant drug (e.g., imipramine, desipramine, amitriptyline, or nortriptyline) immunogens, antibodies prepared therefrom, labeled conjugates, synthetic intermediates, and the use of...
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4493793 |
Soluble immunoassay reagent comprising lectin covalently bonded to reactive component
A lectin is covalently bonded to an immunological conjugate such as an antibody-antigen or its equivalent. Then, the lectin-conjugate is isolated from the reaction product mixture by one of a...
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4490473 |
Labeled antibodies and methods
Sandwich immunoassays are provided wherein an anti-analyte antibody is coupled with a detector labeled antibody, the anti-analyte antibody being substituted with a N,N,N-trimethylammoniumphenyl...
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4488991 |
Bacterial toxoids and gram-negative immune globulin therefrom
ADP-Ribosylating toxins are rendered enzymatically inactive by reactions with photolabile affinity reagents. The toxoids retain the antigenic and immunogenic properties of the original toxins....
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4486344 |
Urea-linked immunogens, antibodies, and preparative method
Immunogen conjugates comprising amino-functionalized haptens coupled through a carbonyl bridge to amino groups in immunogenic proteins and polypeptides. The resulting simple urea linkage in the...
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4485177 |
Creatinine specific antibody
The present invention provides a creatinine antibody and a process for the preparation thereof, wherein a conjugate of creatinine and a material suitable for antiserum formation, which are...
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4481136 |
Alkyl substituted fluorescent compounds and conjugates
Fluorescent antigen conjugates are provided comprising antigens covalantly bonded to at least one 2,7-dialiphatic substituted-9-phenyl-6-hydroxy-3H-xanthen-3-one, wherein the 1- and 8-positions are...
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