Matches 151 - 200 out of 511 < 1 2 3 4 5 6 7 8 9 10 11 >
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5525474 Piperidine analogs and conjugates of procainamide and NAPA  
Novel derivatives of procainamide and N-acetylprocainamide (NAPA) are disclosed having the following formula: ##STR1## wherein: X=hydrogen or acetyl; n=1 to p where p=MW of Z/1000; Z=a...
5502037 Pro-cytotoxic drug conjugates for anticancer therapy  
Pro-cytotoxic drug conjugates for anticancer therapy comprising a homing agent first moiety, a spacer molecule second moiety covalently linked to the homing agent, and a third moiety covalently...
5496551 Peptide structures, immunogens containing them and their uses in the control of fertility  
The subject of the present invention is a peptide structure comprising at least the sequence 106-116 of a β-CG or a β-LH a sequence of at least 5 amino acids containing at least one lysine...
5492841 Quaternary ammonium immunogenic conjugates and immunoassay reagents  
This invention relates to novel quaternary ammonium immunogenic conjugates and reporter reagents useful for eliciting antibodies and in immunoassays. Processes for preparing such quaternary...
5492839 Immunogenic ryanodine derivative and related uses  
Disclosed is a novel photo-activatable derivative of ryanodine 9-hydroxy-21-(4-azidobenzoyloxy)-9-epiryanodine. This novel ryanodine derivative has been conjugated to keyhole limpet hemocyanin...
5484709 Immunoassay method for detecting an immunologically non-remarkable compound, its components and a kit for use in performing the same  
An immunoassay method that integrates a sample processing component that enables the testing of samples for the presence of an immunologically non-remarkable compound, such as benzene, by the use...
5480790 Water-soluble proteins modified by saccharides  
A water-soluble protein conjugate modified by saccharides is covalently bound to a carbohydrate backbone via a saccharide group. Such protein conjugates modified by saccharides can be produced in a...
5476939 Certain pyridyl and isoquinolyl carbinolamine derivatives  
The present invention relates to the field of immunoassays for metal ions. The invention presents: metal ion-ligand coordination complexes ("MLC"), novel ligands, antibodies specific for MLC,...
5470573 Immunogens comprising the non-lytic membrane spanning domain of bacteriophages MS2 or PhiX174  
The invention concerns a carrier-bound recombinant protein obtainable by expression of a fusion protein gene in gram-negative bacteria which codes for at least one hydrophobic non-lytically active...
5468486 Vaccine containing a protein alkaloid conjugate for the treatment of fescue toxicosis  
A method for the treatment of the symptoms of fescue toxicosis in mammals comprising injecting a subject mammal with a vaccine which includes from about 5 μg to about 1 mg of a protein-alkaloid...
5464767 Reagents and methods for the quantification of total doxepins in biological fluids  
Immunoassay methods and reagents for the quantification of total doxepins (i.e., E-doxepin, Z-doxepin, E-desmethyldoxepin, and Z-desmethyldoxepin) in a test sample are disclosed. The quantification...
5463024 Fusion proteins and particles  
Fusion proteins comprise a first amino acid sequence and a second amino acid sequence. The first amino acid sequence is derived from a retrotransposon or an RNA retrovirus and confers on the fusion...
5463028 Reagents for generating a polyclonal hydrolytic antibody response against cocaine and the monoclonal hydrolytic antibodies against cocaine derived through these reagents  
This invention provides a compound comprising a methyl ecgonine group chemically attached to a phenylphosphonic group which is an analog to an intermediate of the hydrolysis transition-state of a...
5457183 Hydroxylated texaphyrins  
A method of using texaphyrins as radiosensitizers. Advantageous properties of texaphyrins for use as a radiosensitizer include i) a low redox potential which allows radiation induced solvated...
5455032 Use of phosphocholine hapten conjugates in vaccines  
This invention relates to compositions useful for inducing immunoprotection against infections by pathogenic organisms containing phosphocholine antigens, including Streptococcus pneumoniae and...
5451663 Long wavelength chemically reactive dipyrrometheneboron difluoride dyes and conjugates  
This invention relates to derivatives of dipyrrometheneboron difluoride fluorescent dyes that have an absorption maximum at wavelengths longer than about 525 nm, and are chemically reactive with...
5441867 Pre-activated proteins for labelling oligonucleotide probes  
Pre-activated stable protein reagents are provided. The reagents can be made by reaction of the protein and a heterobifunctional linker and have extended stability especially after lyophilisation....
5440023 Method for making valproic acid derivatives  
A method for making a valproic acid derivative comprising a functionalized spacer arm attached to a δ carbon atom of a valproic acid molecule is disclosed. The method proceeds by attaching a...
5424402 Non-destructive method for radiolabelling biomolecules by halogenation  
A kit and method of non-destructively radiolabelling a biomolecule substrate by halogenation, including the steps of: a) reacting a secondary amine with a chlorinating agent to produce an N-chloro...
5420010 Assay for evaluating inhibition of polymorphonuclear leukocyte elastase by N-substituted azetidinones  
N-substituted azetidinones are a class of inhibitors of human leukocytes elastase which are known to be useful in the treatment of a wide variety of antiinflammatory and antidegenerative diseases....
5418284 Surface-modified polyacrylonitrile beads  
A bead composition is disclosed herein which comprises a core of a polyacrylonitrile homopolymer or copolymer and a surface of pendant N-haloamide groups. Also disclosed is a process for the...
5411869 Immunological analogs for captan  
There is provided a standard for use in testing for captan in immunoassays. This standard has the structure THPD--(CH 2 ) x --(R 3 ) y --R 1 wherein THPD is cis-1,2,3,6-tetrahydrophthalimido, x...
5399672 Process for preparing immunoconjugates  
The invention relates to a novel process for preparing immunoconjugates consisting of haptens which are sparingly soluble or insoluble in aqueous solution and proteins/polypeptides using special...
5380825 AZT immunoassays, derivatives, conjugates and antibodies  
This invention relates to a method for the immunoassay of AZT (3'-azido-3'-deoxythymidine), also known as zidovudine, in biological fluids such as serum, semen, plasma and urine, as well as other...
5378815 Process for indirect targeted immunocytolysis  
A process is disclosed for treating cancer by the process of indirect targeted immunocytolysis, which comprises conjugating an immunogenic sensitizing agent to a targeting agent which is capable of...
5373092 Derivatives of hydroxymethoxy mandelic acid (HMMA), homovanillic acid (HVA), antibodies and labelled substances prepared therefrom, and immunoassays using these  
This invention relates to the production of derivatives of hydroxymethoxy mandelic acid (HMMA) and homvanillic acid (HVA), to their use in raising antibodies, and in the production of labelled...
5371197 Protein-dimeric polysaccharide conjugate vaccine  
A conjugate immunogen, having polysaccharide moieties derived from bacterial sources, provides a multivalent vaccine with a low protein to polysaccharide ratio. The vaccine reduces complications...
5370872 Escherichia coliO-polysaccharide-protein conjugate vaccine  
The present invention relates to a method of producing an E. coli vaccine and to the vaccine produced thereby. The method involves purifying lipopolysaccharide from E. coli expressing complete...
5367061 Method of detecting nitrate esters  
A method of detecting the presence and amount of a nitrate ester of a polyol in an unknown comprises preparing an antigen based on such an ester and using that antigen to raise antibodies for use...
5362852 Modified peptide derivatives conjugated at 2-hydroxyethylamine moieties  
A process is disclosed for site-directed chemical modification of peptides and proteins that consists of two steps; (a) selective oxidation of a 2-hydroxyethylamine moiety, --CH(NH 2 )--CH(OH)--,...
5362859 High-capacity affinity supports and methods for the preparation and use of same  
An affinity support having an improved capacity for binding target compounds. The support includes an immobilized modified ligand of increased molecular weight. The molecular weight of the ligand...
5360897 Immunogenic conjugates of streptococcus pneumonial capsular polymer and toxin or in toxiad  
An immunogenic conjugate which is the reductive amination product of an immunogenic capsular polymer fragment having at least one reducing group and derived from a bacterial capsular polymer of a...
5354848 Chemically modified allergens and process for the preparation thereof  
Chemically modified allergens, whose allergenic activity is reduced with respect to that of the corresponding native allergenic material, which are capable of inducing specific antibodies addressed...
5350574 Derivatives of cyclosporina A, antibodies directed thereto and uses thereof  
This invention provides a molecule comprising cyclosporine A or a congener of cyclosporine A which is photochemically attached to a ligand containing a reactive group. This invention also provides...
5342771 Functionalized imidazolinone haptens and protein conjugates thereof useful in assays for the detection of imidazolinone herbicides  
This invention provides enzyme conjugates, antigens, antibodies and diagnostic test kits used in an enzyme-linked immunosorbent assay method for determining the presence and concentration of...
5334379 Cytokine and hormone carriers for conjugate vaccines  
This invention pertains to immunogenic conjugates comprising a carbohydrate containing antigen or other antigen bound to or genetically fused with a cytokine, lymphokine, hormone or growth factor...
5331109 Phencyclidine derivatives and protein and polypeptide phencyclidine derivative conjugates and labels  
The present invention is directed to novel PCP derivatives which are synthesized for the covalent attachment to antigens or receptors (proteins or polypeptides) for the preparation of antibodies or...
5328991 Preparation of alkali-modified cat dander allergen (Fel d I) for immunotherapeutic purposes  
Proteins, referred to as modified human T cell reactive feline proteins, which have reduced ability to bind immunoglobulin E from cat allergic individuals and substantially unaltered ability to...
5324825 Terpyridine derivatives  
The invention pertains to terpyridine compounds having structure (I). These compounds form fluorescent lanthanide chelates with the appropriate metal ions. The fluorescent metal chelates are useful...
5324512 [Gln']-luteinizing hormone releasing hormone conjugate of tetanus vaccine and its uses  
The present prevention provides an effective, fast acting method of vaccination useful in suppressing gonadotropic hormone release. The vaccine utilizes LHRH conjugated at its amino terminus to a...
5312903 Lysine-glycosylated recombinant interleukin-2  
This invention relates to chemical modification of biologically active proteins which alters the chemical, physical and biological properties of the proteins. More specifically, this invention...
5306809 Acid-labile linker molecules  
This invention relates to the field of immune therapy of cancer, more specifically to immunoconjugates of a cytotoxic moiety with a targeting moiety, more specifically to immunoconjugates of...
5306492 Oligosaccharide conjugate vaccines  
The present invention relates to an improved method for producing oligosaccharide conjugate vaccines. In an additional aspect of the invention, oligosaccharide vaccines are produced which elicit a...
5302700 Radiohalogenation conjugate technology  
Compounds of the formulae, ##STR1## are provided where L is a linking group of the formula, ##STR2## is --Sn(n--C 4 H 9 ) 3 or --Sn(CH 3 ) 3 , HgCl or --N 2 + ; R is hydrogen, methyl, mono-, di-...
5302701 Polypeptide having human fibronectin-like cell adhesive activity  
This present invention is directed to an artificial functional polypeptide represented by the following structural formula [I]: X--(Y)m--Z [I]...
5302703 Tetrahydrocannabinol derivatives and protein and polypeptide tetrahydrocannabinol derivative conjugates and labels  
The present invention is directed to novel THC derivatives which are synthesized for the covalent attachment to antigens (proteins or polypeptides) for the preparation of antibodies or receptors to...
5302386 Bacterial antigens, antibodies, vaccines and methods of manufacture  
Antigens and vaccines containing purified oligomers (1-50 units) of the repeating pentasaccharide unit of type III Group B Stretococcus (III GBS) polysaccharide capsule. Methods of making the...
5294536 Conjugates  
A compound represented by the formula ##STR1## wherein X is a spacer group. The compound is useful for conjugating a compound having an alcohol group or an amine group to a compound having a thiol...
5292868 Chelating agents for attaching metal ions to proteins  
A new series of bifunctional chelating agents useful for attaching metal ions to proteins, polypeptides and other polymers and methods for their preparation are described. These reagents are unique...
5284911 Surface-modified polyacrylonitrile substrates  
A composition is disclosed herein which comprises a core of a polyacrylonitrile homopolymer or copolymer and a surface of N-haloamides. Also disclosed is a process for the production of said...
Matches 151 - 200 out of 511 < 1 2 3 4 5 6 7 8 9 10 11 >