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7022491 |
Method for determining molecule—molecule interaction analysis
The invention relates to a method for monitoring interactions to a target biomolecule comprising the steps of: providing a biomolecule of interest having specificity for the target biomolecule;...
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7022492 |
Ecstasy haptens and immunogens
Methods, compositions and kits are disclosed. Enzyme conjugates of Formula I are employed in assays for the determination of an methylenedioxyamphetamine, a methylene-dioxyethamphetamine, and/or a...
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7018851 |
Biospecific binding reactants labeled with new luminescent lanthanide chelates and their use
This invention relates to a luminescent lanthanide chelate comprising a lanthanide ion and a chelating ligand of formula (I)
wherein
R 1 is selected from the group consisting H, —COOH,...
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7011968 |
Fragments of virus protein 2 or 3 of the polyoma virus, used for transporting active ingredients
The invention relates to a synthetic, biologically active molecule for fixing an active ingredient to the virus protein 1 (VP1) of the polyoma virus. According to the invention, an amino acid...
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6991911 |
Assay for entactogens
Methods, compositions and kits are disclosed. The methods are directed to determining the presence of entactogen analytes such as, for example, 3,4-methylenedioxyamphetamine (MDA),...
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6979575 |
Fluorochromes for labelling biomolecules and polymer particles and bioanalytical and screening methods based thereon
New reactive dyes are described which can be used to fluorescently label bioorganic molecules such as amino acids, proteins, antibodies, nucleotides and also polymer particles. The color of the new...
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6967240 |
Congener independent detection of microcystin and nodularin congeners
The present invention relates to a protienaceous compound or functionally active derivative or part thereof having a binding site for a group represented by formula (I) which is part of a group of...
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6964769 |
Molecular antigen array
The invention provides compositions and processes for the production of ordered and repetitive antigen or antigenic determinant arrays. The compositions of the invention are useful for the...
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6913936 |
Immunological test kit comprising an immunologically invisible peg copolymer conjugated to one or more immunologically reactive substances
A novel compound comprising an immunologically invisible polyethylene glycol copolymer is used to carry one or more immunologically reactive substances. The novel compounds may be used as part of...
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6824997 |
Process and materials for the rapid detection of streptococcus pneumoniae employing purified antigen-specific antibodies
A process is disclosed for obtaining a C-polysaccharide cell wall antigen containing not more than about 10% protein from Streptococcus pneumoniae bacteria. The antigen thus obtained is...
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6814971 |
Adjuvants for use in vaccines
The invention relates to adjuvants that contain a lecithin, an oil and an amphiphilic surfactant and that are capable of forming a stable oil-in-water emulsion vaccine so as to minimize local...
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6756041 |
Process for preparing conjugate vaccines including free protein and the conjugate vaccines, immunogens, and immunogenic reagents produced by this process
A process for preparing a protein-polysaccharide conjugate includes reacting a protein with a polysaccharide to produce a mixture including a protein-polysaccharide conjugate and free protein. At...
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6723831 |
Neoglycoproteins
Polyamide conjugates comprising either (a) a xenoantigenic group; or (b) a biologically active group and a macromolecular, macro- or microscopic entity; bound to a polyamide backbone, processes for...
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6689870 |
Protein macromolecular dyes
Protein macromolecular dyes, A(B) b are disclosed, wherein A are protein macromolecules including natural protein macromolecules and modified natural protein macromolecules such as casein, gelatin...
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6663869 |
Polyoxime compounds and their preparation
A homogeneous polyoxime composition is provided, in which the polyoxime molecules present comprise a first organic baseplate molecule, which is a polypeptide, wherein the baseplate molecule is...
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6656469 |
Nicotine immunogen
A 5- or 6-nicotinyl-linker-carrier protein compound and immunogen having formula (a) wherein X is —NH—CO— or NH— or —C≡C— or —C═C— or CH 2 —; Y is —(CH 2 ) k — or —(CH 2...
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6649591 |
Polydithicarbamate-containing non-targeting marcomolecules and the use thereof for therapeutic and diagnostic applications
In accordance with the present invention, there is provided a new class of drugs for therapeutic treatment of such indications as cerebral stroke and other ischemia/reperfusion injury. Thus, in...
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6635434 |
Immunoassay for pesticides and their degradation products
A hapten-polymer carrier complex was found to be useful for immunoassay purposes, specifically ELISAs, for the detection of pesticides and their degradation products in hydrosoil and ground water....
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6632437 |
Immunogenic polysaccharide-protein conjugates containing poly α(2→8), α(2→9) NeuNAc capsular polysaccharides
The present invention relates to a polysaccharide-protein conjugate. The invention also relates to a method of using the conjugate to prevent systemic infections. The invention further relates to a...
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6602507 |
Synthetic peptides from streptococcal M protein and vaccines prepared therefrom
Synthetic polypeptides from the conserved exposed region of streptococcal M protein are useful to prepare vaccines for oral or intranasal administration which will protect against streptococcal...
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6593148 |
Cyanine dye compounds and labeling methods
A novel cyanine dye having the formula is useful for labeling biological and nonbiological molecules.
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6548645 |
Immunoassay for 2-oxo-3-hydroxy LSD
To improve the detection of LSD, and LSD metabolites in biological samples, antibodies are raised to 2-oxo-3-hydroxy-LSD conjugated to a protein carrier. Selected antibodies are matched with an...
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6506885 |
Monoclonal antibodies to the drug tilmicosin and a method for detecting the same
Hybridoma cell lines have been generated which produce and secrete monoclonal antibodies which selectively bind to tilmicosin. These hybridomas may be obtained by using as an immunization agent or...
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6476199 |
Reagents for lysergic acid diethylamide immunoassay
The present invention provides hapten derivatives that are useful for the preparation of antigens, antibodies and reagents having superior performance characteristics for use in immunoassays for...
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6410696 |
Cyclosporin immunoassay
A method of measuring the amount of cyclosporin in a sample suspected of containing cyclosporin is disclosed. A method of inactivating interfering cross-reactive material in an assay for measuring...
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6399318 |
Immunoassay for phthalic acid esters
The present invention provides an immunoassay for phthalic acid esters, which comprises measuring the phthalic acid esters contained in a sample using an antibody produced with a conjugate of a...
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6383490 |
Anti-cocaine vaccine
An anti-cocaine vaccine employs a cocaine hapten conjugated to a carrier protein. The anti-cocaine vaccine elicits an immune response which reduces the psychoactive effects of cocaine consumption...
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6383766 |
Reduced cortisol conjugates
The present invention relates to compositions comprising novel reduced cortisol conjugates, methods for their preparation and use in immunoassays for cortisol. In another aspect, it relates to...
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6368814 |
Tricyclic antidepressant derivatives and immunoassay
The present invention is directed to novel tricyclic antidepressant drug derivatives synthesized for covalent attachment to proteins or polypeptide antigens for use in the preparation of antibodies...
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6355803 |
Near infrared chemiluminescent acridinium compounds and uses thereof
This application relates to long-wavelength acridinium compounds having electron-donating groups, which may either be: (a) Part of an extended conjugation system attached by appropriate functional...
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6328970 |
Rapamycin position 27 conjugates
Provided are rapamycin conjugates which are useful as immunogenic molecules for the generation of antibodies specific for rapamycin or a derivative thereof, for measuring levels of rapamycin or...
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6309633 |
Amphiphilic drug-oligomer conjugates with hydroyzable lipophile components and methods for making and using the same
The invention provides a drug-oligomer conjugate having the following general formula: ##STR1## wherein D is a therapeutic drug moiety; H and H' are each a hydrophilic moiety, independently...
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6307029 |
Dye-labeled protein conjugate and method for preparing the same
The present invention provides a dye-labeled protein conjugate in which a protein conjugate is labeled with a large number of dye molecules. In the dye-labeled protein conjugate, a protein...
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6303757 |
Indirect polymerized and labelled antibody and method for manufacturing the same
A high-sensitive indirect polymerized and labelled antibody is disclosed. The antibody facilitates detection of a low concentration of antigen as an analyte in a sample solution. The indirect...
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6299881 |
Uronium salts for activating hydroxyls, carboxyls, and polysaccharides, and conjugate vaccines, immunogens, and other useful immunological reagents produced using uronium salts
A method for producing a conjugate vaccine includes mixing a uronium salt reagent with a first moiety (e.g., a polysaccharide). According to the invention, the uronium salt reagent has a chemical...
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6291423 |
Lipid complexes for transferring at least a therapeutically active substance, in particular a polynucleotide into a target cell and use in gene therapy
The invention concerns a complex comprising at least a lipid and at least a therapeutically active substance useful for transferring said substance into a target cell, characterised in that said...
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6291198 |
Antibody that recognizes pyrazine derivative and method for measuring 1,2-dicarbonyl derivative using said antibody
A method for simply measuring a 1,2-dicarbonyl derivative in multiple specimens is provided, which comprises converting a 1,2-dicarbonyl derivative to a pyrazine derivative represented by the...
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6277984 |
Monomethine cyanines rigidized by a two-carbon chain
Fluorescent monomethine cyanine complexes rigidized a two-carbon alkyl group between the nitrogen's of the cyanine's heterocycles are provided and having the structure ##STR1## wherein R 1 through...
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6252087 |
Nitroaromatic compounds for the detection of hypoxia
Nitroaromatic compounds and immunogenic conjugates comprising a novel nitroaromatic compound and a carrier protein are disclosed. The invention further presents monoclonal antibodies highly...
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6250469 |
Formulations for protection of peg-interferon alpha conjugates
The present invention provides formulations that prevent loss and damage of PEG-interferon alpha conjugates during and following lyophilization. The formulations of the present invention protect...
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6225073 |
Immunoassay for mycophenolic acid
The present invention provides antibodies useful in assays for mycophenolic acid (MPA). These antibodies bind MPA and are able to distinguish MPA from its esters, such as morpholinoethyl...
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6210674 |
GreA from Staphylococcus aureus
The invention provides greA polypeptides and DNA (RNA) encoding greA polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing greA...
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6207398 |
Cyclosporine derivatives and uses thereof
The present invention provides novel cyclosporine C (CsC) derivatives having improved protein conjugatibility and hydrolytic stability. The present invention further provides a CsC derivative...
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6190873 |
Cyclosporin assay and kit
A method of measuring the amount of cyclosporin in a sample suspected of containing cyclosporin is disclosed. A method of inactivating interfering cross-reactive material in an assay for measuring...
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6174530 |
Homogeneous polyoxime compositions and their preparation by parallel assembly
Provided by this invention are essentially homogeneous, defined compositions of matter comprising a baseplate structure having a plurality of oxime bonds, wherein each oxime bond links a...
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6174858 |
Conjugates useful in the treatment of prostate cancer
Chemical conjugates which comprise oligopeptides, having amino acid sequences that are selectively proteolytically cleaved by free prostate specific antigen (PSA) and known cytotoxic agents are...
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6160098 |
Method for control of functionality during cross-linking of hemoglobins
The present invention relates to cross-linked hemoglobins, and particularly to methods of controlling the functionality of such hemoglobins. The controlled functionalities include the P 50 and the...
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6140137 |
Conjugates and specific immunoassays for the methadone metabolite 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine
Novel chemical analogs of the methadone metabolite 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP) are disclosed. The derivatives can be used for formation of EDDP-protein conjugates. The...
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6127448 |
Biocompatible polymeric coating material
The invention provides a biocompatible polymeric coating material, wherein the polymeric material is selected from the group consisting of linear, dendrimeric and branched polymers which contain...
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6120777 |
High fluorescence specific immune enhancing factor and methods of use for same
The present invention relates to a malondialdehyde-acetaldehyde adduct which acts as a specific immune-enhancing factor. In addition to its highly specific and immunogenic properties, the factor is...
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